tripartite motif proteins


Summary: A protein family defined by the presence of three ZINC FINGER domains, one of which is a RING FINGER DOMAIN, a coiled-coil region, and a highly variable C-terminal region. They function in many cellular processes including APOPTOSIS and CELL CYCLE regulation.

Top Publications

  1. Qin X, Qiu F, Zou Z. TRIM25 is associated with cisplatin resistance in non-small-cell lung carcinoma A549 cell line via downregulation of 14-3-3?. Biochem Biophys Res Commun. 2017;493:568-572 pubmed publisher
  2. Lu T, Sun X, Li Y, Chai Q, Wang X, Lee H. Role of Nrf2 Signaling in the Regulation of Vascular BK Channel ?1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice. Diabetes. 2017;66:2681-2690 pubmed publisher
    ..Hence, Nrf2 is a novel regulator of BK channel function with therapeutic implications in diabetic vasculopathy. ..
  3. Das A, Qian J, Tsang W. USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesis. PLoS Genet. 2017;13:e1006791 pubmed publisher
    ..At the same time, BBS11 K63 ubiquitinates NPHP5. Our data suggest that dynamic ubiquitination and deubiquitination of NPHP5 plays a crucial role in the regulation of ciliogenesis. ..
  4. Bharaj P, Atkins C, Luthra P, Giraldo M, Dawes B, Miorin L, et al. The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication. J Virol. 2017;91: pubmed publisher
    ..Therefore, our study identifies a new host factor, TRIM6, as a potential target in the development of antiviral drugs against EBOV. ..
  5. Burse M, Shi J, Aiken C. Cyclophilin A potentiates TRIM5? inhibition of HIV-1 nuclear import without promoting TRIM5? binding to the viral capsid. PLoS ONE. 2017;12:e0182298 pubmed publisher
    ..Our results indicate that CypA inhibits HIV-1 infection in Vero cells not by promoting TRIM5? binding to the capsid but by blocking nuclear import of the HIV-1 preintegration complex. ..
  6. Fuentes E, Zuloaga R, Almarza O, Mendez K, Valdés J, Molina A, et al. Upwelling-derived oceanographic conditions impact growth performance and growth-related gene expression in intertidal fish. Comp Biochem Physiol B Biochem Mol Biol. 2017;214:12-18 pubmed publisher
    ..Future studies are required to gain further knowledge about molecular differences between U and NU animals, as well as the possible applications of this knowledge in the aquaculture industry. ..
  7. Cui H, Liu Y, Huang Y. Roles of TRIM32 in Corneal Epithelial Cells After Infection with Herpes Simplex Virus. Cell Physiol Biochem. 2017;43:801-811 pubmed publisher
    ..In conclusion, our data suggested that TRIM32 as a crucial positive regulator of HSV-1 induced IFN-? production in corneal epithelial cells, and it played a predominant role in clearing HSV-1 from the cornea. ..
  8. Unuma K, Aki T, Nagano S, Watanabe R, Uemura K. The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. Biochem Biophys Res Commun. 2018;495:1668-1674 pubmed publisher
    ..These results confirm the protective action of exogenously administered CO against myocardial depression during sepsis, and reveal a novel mechanism underling cardiac dysfunction during sepsis. ..
  9. Schmidt F, Kny M, Zhu X, Wollersheim T, Persicke K, Langhans C, et al. The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy. Crit Care. 2014;18:545 pubmed publisher
    ..It could play a role in the pathogenesis of ICUAW by activating and maintaining inflammation in myocytes. Current Controlled Trials ID: ISRCTN77569430 (registered 13 February 2008). ..

More Information


  1. Treiber T, Treiber N, Plessmann U, Harlander S, Daiß J, Eichner N, et al. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Mol Cell. 2017;66:270-284.e13 pubmed publisher
    ..We provide an extended database of RBPs that interact with pre-miRNAs in extracts of different cell types, highlighting a widespread layer of co- and posttranscriptional regulation of miRNA biogenesis. ..
  2. Borlepawar A, Rangrez A, Bernt A, Christen L, Sossalla S, Frank D, et al. TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels. J Biol Chem. 2017;292:10180-10196 pubmed publisher
    ..In conclusion, we provide here a novel mechanism of post-translational regulation of dysbindin and hypertrophy via TRIM24 and TRIM32 and show the importance of TRIM32 in cardiomyocyte apoptosis in vitro. ..
  3. Dawidziak D, Sanchez J, Wagner J, Ganser Pornillos B, Pornillos O. Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase. Proteins. 2017;85:1957-1961 pubmed publisher
    ..Our results indicate that TRIM23 enzymatic activity requires RING dimerization, consistent with the general model of TRIM activation. ..
  4. Nishimura S, Inai M, Takagi T, Nonaka Y, Urashima S, Honda K, et al. Preventive Effects of the Dietary Intake of Medium-chain Triacylglycerols on Immobilization-induced Muscle Atrophy in Rats. J Oleo Sci. 2017;66:917-924 pubmed publisher
    ..Collectively, these results indicate that the dietary intake of MCTs at least partly alleviates immobilization-induced muscle atrophy by inhibiting the ubiquitin-proteasome pathway. ..
  5. Wallenhammar A, Anandapadamanaban M, Lemak A, Mirabello C, Lundström P, Wallner B, et al. Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain. PLoS ONE. 2017;12:e0181551 pubmed publisher
  6. Zhao L, Zhang P, Su X, Zhang B. The ubiquitin ligase TRIM56 inhibits ovarian cancer progression by targeting vimentin. J Cell Physiol. 2017;: pubmed publisher
    ..Cumulatively, our data reveals for the first time a novel post-translational regulatory mechanism of regulating vimentin expression, EMT, and metastatic progression in ovarian cancer cells. ..
  7. Yang Q, Liu T, Lin H, Zhang M, Wei J, Luo W, et al. TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLoS Pathog. 2017;13:e1006600 pubmed publisher
    ..Furthermore, TRIM32 links TRIF and TAX1BP1 through distinct domains. These findings suggest that TRIM32 negatively regulates TLR3/4-mediated immune responses by targeting TRIF to TAX1BP1-mediated selective autophagic degradation. ..