regulatory factor x transcription factors


Summary: A family of eukaryotic transcription factors that recognize and bind to a highly-conserved cis-regulatory sequence (X-box) within the promoter region of MHC CLASS II GENES. They contain a conserved winged-helix DNA binding domain and function as homo or heterodimers.

Top Publications

  1. Fondaneche M, Villard J, Wiszniewski W, Jouanguy E, Etzioni A, Le Deist F, et al. Genetic and molecular definition of complementation group D in MHC class II deficiency. Hum Mol Genet. 1998;7:879-85 pubmed
    ..The RFXAP coding region was found to be mutated in all patients. Mutations were found to be recurrent since only three different mutations have been found in the eight unrelated families reported to date. ..
  2. Masternak K, Muhlethaler Mottet A, Villard J, Zufferey M, Steimle V, Reith W. CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev. 2000;14:1156-66 pubmed
    ..CIITA therefore represents a paradigm for a novel type of regulatory and gene-specific transcriptional cofactor. ..
  3. Kähärä J, Lähdesmäki H. Evaluating a linear k-mer model for protein-DNA interactions using high-throughput SELEX data. BMC Bioinformatics. 2013;14 Suppl 10:S2 pubmed publisher
    ..For protein GATA1 the model can distinquish between true ChIP-seq peaks and negative peaks. For proteins RFX3 and NFATC1 the performance of the model was no better than chance. ..
  4. Gambella M, Rocci A, Passera R, Gay F, Omede P, Crippa C, et al. High XBP1 expression is a marker of better outcome in multiple myeloma patients treated with bortezomib. Haematologica. 2014;99:e14-6 pubmed publisher
  5. Mhaidat N, Alzoubi K, Abushbak A. X-box binding protein 1 (XBP-1) enhances colorectal cancer cell invasion. J Chemother. 2015;27:167-73 pubmed publisher
    ..Inhibition of XBP-1 expression significantly decreased levels of VEGF-R2.In conclusion, XBP-1 might be regarded as a novel predictive biomarker in CRC invasion and metastasis. ..
  6. Reith W, Satola S, Sanchez C, Amaldi I, Lisowska Grospierre B, Griscelli C, et al. Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell. 1988;53:897-906 pubmed
    ..We propose that the molecular defect in this congenital HLA class II regulatory deficiency is a lack of RF-X and that this factor plays an important role in the normal regulation of MHC class II gene expression. ..
  7. Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, et al. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol. 2000;20:6755-67 pubmed
    ..Based on these and other findings, we concluded that specific and direct interactions between ATF6 and ERSE are critical for transcriptional induction not only of ER chaperones but also of CHOP and XBP-1. ..
  8. Byun S, Namba T, Lee S. Losing p53 loosens up ER-stress. Aging (Albany NY). 2015;7:895-6 pubmed
  9. Namba T. Regulation of endoplasmic reticulum functions. Aging (Albany NY). 2015;7:901-2 pubmed