forkhead box protein m1


Summary: A forkhead box transcription factor that is expressed primarily in adult organs which contain proliferating cells such as the thymus, testis, ovary, and small intestine. It controls the expression of CELL CYCLE genes essential for DNA REPLICATION and MITOSIS, and also functions in DNA REPAIR.

Top Publications

  1. Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa E, et al. Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation. Cell Metab. 2017;25:868-882.e5 pubmed publisher
    ..These data implicate the insulin-FoxM1/PLK1/CENP-A pathway-regulated mitotic cell-cycle progression as an essential component in the β cell adaptation to delay and/or prevent progression to diabetes. ..
  2. Yaffe M. Highlight: A new way to block the development of asthma from dust mites. Sci Signal. 2017;10: pubmed publisher
    ..Targeting a transcription factor, generally considered to be "nondruggable," may help to prevent asthma from developing. ..
  3. Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, et al. ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. Cardiovasc Res. 2017;113:760-769 pubmed publisher
    ..The different effects of ELA and Apelin on the expression of ACE and ACE2 implicate fine-tuned mechanisms for a ligand-induced APJ activation and downstream signalling. ..
  4. Fujiwara Y, Okada K, Omori T, Sugimura K, Miyata H, Ohue M, et al. Multiple therapeutic peptide vaccines for patients with advanced gastric cancer. Int J Oncol. 2017;50:1655-1662 pubmed publisher
    ..The survival benefit of peptide vaccine monotherapy may not have been shown and further trials are needed to confirm these results. ..
  5. Wang X, Arceci A, Bird K, Mills C, Choudhury R, Kernan J, et al. VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1. Mol Cell Biol. 2017;37: pubmed publisher
    ..These data suggest that FoxM1 abundance and activity are controlled by VprBP and highlight the functional repurposing of E3 ligase substrate receptors independent of the ubiquitin system. ..
  6. Feng J, Wang X, Zhu W, Chen S, Feng C. MicroRNA-630 Suppresses Epithelial-to-Mesenchymal Transition by Regulating FoxM1 in Gastric Cancer Cells. Biochemistry (Mosc). 2017;82:707-714 pubmed publisher
    ..Protein expression of E-cadherin, vimentin, and Forkhead box protein M1 (FoxM1) was tested by Western blot...
  7. Li M, Yang J, Zhou W, Ren Y, Wang X, Chen H, et al. Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer. Br J Cancer. 2017;117:974-983 pubmed publisher
    ..Our findings elucidate an additional common mechanism for TKI resistance and provide a promising therapeutic target for reversing TKI resistance in NSCLC. ..
  8. Liu Y, Zhu L, Wen T, Wan J, Lei Y, Chen H. [Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:611-616 pubmed
    ..Conclusion FDI-6 could induce cell apoptosis and inhibit cell proliferation, invasion and migration in Hep-2 cells. This may be related to the down-regulation of FoxM1 in the nucleus. ..
  9. Valverde A, Peñarando J, Cañas A, Lopez Sanchez L, Conde F, Guil Luna S, et al. The addition of celecoxib improves the antitumor effect of cetuximab in colorectal cancer: role of EGFR-RAS-FOXM1-?- catenin signaling axis. Oncotarget. 2017;8:21754-21769 pubmed publisher
    ..Results also support that FOXM1 could be a predictive marker of response of mCRC patients to cetuximab therapy. ..

More Information


  1. Sun L, Ren X, Wang I, Pradhan A, Zhang Y, Flood H, et al. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci Signal. 2017;10: pubmed publisher
    ..These results suggest that RCM-1 is an inhibitor of goblet cell metaplasia and IL-13 signaling, providing a new therapeutic candidate to treat patients with asthma and other chronic airway diseases. ..
  2. Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, et al. Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. J Clin Invest. 2017;127:3835-3844 pubmed publisher
    ..These studies reveal age-dependent signaling mechanisms regulating human β cell proliferation, and identify elements that could be adapted for therapeutic expansion of human β cells. ..
  3. Xue J, Lin X, Chiu W, Chen Y, Yu G, Liu M, et al. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-?-dependent cancer metastasis. J Clin Invest. 2014;124:564-79 pubmed publisher
    ..This study highlights the critical interaction of FOXM1 and SMAD3 for controlling TGF-? signaling during metastasis. ..
  4. Zhang S, Zhao B, Zhou A, Lin K, Zheng S, Lu Z, et al. m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017;31:591-606.e6 pubmed publisher
    ..Depleting ALKBH5 and FOXM1-AS disrupted GSC tumorigenesis through the FOXM1 axis. Our work uncovers a critical function for ALKBH5 and provides insight into critical roles of m6A methylation in glioblastoma. ..
  5. Weiler S, Pinna F, Wolf T, Lutz T, Geldiyev A, Sticht C, et al. Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer. Gastroenterology. 2017;152:2037-2051.e22 pubmed publisher
    ..Agents that disrupt this pathway might be developed as treatments for liver cancer. Transcriptome data are available in the Gene Expression Omnibus public database (accession numbers: GSE32597 and GSE73396). ..
  6. Fuller M, Majumder K, Pintel D. Minute Virus of Mice Inhibits Transcription of the Cyclin B1 Gene during Infection. J Virol. 2017;91: pubmed publisher
  7. Jin C, Marsden I, Chen X, Liao X. Sequence specific collective motions in a winged helix DNA binding domain detected by 15N relaxation NMR. Biochemistry. 1998;37:6179-87 pubmed
    ..Since the winged helix DNA binding motif is highly conserved, this unique dynamic property observed in Genesis is also likely to be conserved in other winged helix family members and important in DNA binding. ..
  8. Li X, Wu H, Mao X, Jiang L, Wang Y. USP5 promotes tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein. Biochem Biophys Res Commun. 2017;492:48-54 pubmed publisher
  9. Iwahori S, Kalejta R. Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus. Virology. 2017;512:95-103 pubmed publisher
    ..This survey extends the influence of UL97 beyond simply the Rb proteins themselves to their binding partners, as well as past the G1/S transition into later stages of the cell cycle. ..
  10. Gartel A. FOXM1 in Cancer: Interactions and Vulnerabilities. Cancer Res. 2017;77:3135-3139 pubmed publisher
    ..In this review, I will discuss the protein-protein interactions of FOXM1 that are critical for cancer development and may represent novel targets for anticancer drugs. Cancer Res; 77(12); 3135-9. ©2017 AACR. ..
  11. Liu L, Shen H, Wang Y. CRY2 is suppressed by FOXM1 mediated promoter hypermethylation in breast cancer. Biochem Biophys Res Commun. 2017;490:44-50 pubmed publisher
  12. Pandit B, Halasi M, Gartel A. p53 negatively regulates expression of FoxM1. Cell Cycle. 2009;8:3425-7 pubmed
    ..These data suggest that p53 negatively regulates FoxM1 expression and therefore inactivation of p53 in tumors could partially explain the phenomenon of FoxM1 overexpression in human cancers. ..
  13. Ma N, Zhang W, Qiao C, Luo H, Zhang X, Liu D, et al. The Tumor Suppressive Role of MiRNA-509-5p by Targeting FOXM1 in Non-Small Cell Lung Cancer. Cell Physiol Biochem. 2016;38:1435-46 pubmed publisher
    ..Collectively, these findings provide further evidence that miR-509-5p may be considered as a novel and potential target for the diagnosis, prognosis and treatment of NSCLC. ..