soxd transcription factors


Summary: A subclass of closely-related SOX transcription factors. In addition to a conserved HMG-BOX DOMAIN, members of this group contain a leucine zipper motif which mediates protein DIMERIZATION.

Top Publications

  1. Lulli V, Romania P, Morsilli O, Ilari R, Gabbianelli M, Testa U, et al. SCF-mediated ?-globin gene expression in adult human erythroid cells is associated with KLF1, BCL11A and SOX6 down-regulation. Blood Cells Mol Dis. 2015;54:1-3 pubmed publisher
  2. Wang L, Ye S, Wang J, Gu Z, Zhang Y, Zhang C, et al. HuR Stabilizes lnc-Sox5 mRNA to Promote Tongue Carcinogenesis. Biochemistry (Mosc). 2017;82:438-445 pubmed publisher
    ..These results suggest that lnc-Sox5, which was stabilized by HuR, could regulate carcinogenesis of tongue cancer and may serve as a predicted target for tongue carcinoma therapies. ..
  3. Li Y, Xiao M, Guo F. The role of Sox6 and Netrin-1 in ovarian cancer cell growth, invasiveness, and angiogenesis. Tumour Biol. 2017;39:1010428317705508 pubmed publisher
    ..Moreover, our findings suggest a new role of SOX6 and netrin-1 for understanding the progression of ovarian cancer and have the potential for the development of new diagnosis and treatment strategies for ovarian cancer. ..
  4. Tian R, Wang J, Yan H, Wu J, Xu Q, Zhan X, et al. Differential expression of miR16 in glioblastoma and glioblastoma stem cells: their correlation with proliferation, differentiation, metastasis and prognosis. Oncogene. 2017;36:5861-5873 pubmed publisher
    ..The inhibitory effects of miR16 on its target genes were also found in nude mice xenograft model. Our findings revealed that the miR16 functions as a tumor suppressor in GSCs and its association with prognosis in GBM. ..
  5. Kurtsdotter I, Topcic D, Karlén A, Singla B, Hagey D, Bergsland M, et al. SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells. Cancer Res. 2017;77:4985-4997 pubmed publisher
    ..Altogether, these results provide evidence that SOX5/6/21 play a central role in driving a tumor suppressor response in brain stem cells upon oncogenic insult. Cancer Res; 77(18); 4985-97. ©2017 AACR. ..
  6. Hu J, Vogt D, Lindtner S, Sandberg M, Silberberg S, Rubenstein J. Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons. Development. 2017;144:2837-2851 pubmed publisher
    ..These results have identified, in mouse, a transcriptional pathway that controls SST-PV fate. ..
  7. Martynova N, Eroshkin F, Оrlov E, Zaraisky A. HMG-box factor SoxD/Sox15 and homeodomain-containing factor Xanf1/Hesx1 directly interact and regulate the expression of Xanf1/Hesx1 during early forebrain development in Xenopus laevis. Gene. 2018;638:52-59 pubmed publisher
    ..This finding explains how Xanf1/Hesx1 could escape the repressive activity of its own protein during early patterning of the forebrain rudiment. ..