soxc transcription factors


Summary: A subclass of closely-related SOX transcription factors. Members of the group have been found expressed in developing neuronal tissue, LYMPHOCYTES, and during EMBRYONIC DEVELOPMENT.

Top Publications

  1. Dai W, Xu X, Li S, Ma J, Shi Q, Guo S, et al. SOX4 Promotes Proliferative Signals by Regulating Glycolysis through AKT Activation in Melanoma Cells. J Invest Dermatol. 2017;137:2407-2416 pubmed publisher
  2. Oliemuller E, Kogata N, Bland P, Kriplani D, Daley F, Haider S, et al. SOX11 promotes invasive growth and ductal carcinoma in situ progression. J Pathol. 2017;243:193-207 pubmed publisher
    ..2017 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. ..
  3. Palomero J, Vegliante M, Eguileor A, Rodriguez M, Balsas P, Martinez D, et al. SOX11 defines two different subtypes of mantle cell lymphoma through transcriptional regulation of BCL6. Leukemia. 2016;30:1596-9 pubmed publisher
  4. Norsworthy M, Bei F, Kawaguchi R, Wang Q, Tran N, Li Y, et al. Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others. Neuron. 2017;94:1112-1120.e4 pubmed publisher
    ..We conclude that Sox11 can reprogram adult RGCs to a growth-competent state, suggesting that different growth-promoting interventions promote regeneration in distinct neuronal types. ..
  5. Liu Y, Zeng S, Jiang X, Lai D, Su Z. SOX4 induces tumor invasion by targeting EMT-related pathway in prostate cancer. Tumour Biol. 2017;39:1010428317694539 pubmed publisher
    ..This study provided evidence that SOX4 could serve as a potential therapeutic target in prostate cancer. ..
  6. Chen B, Liu J, Qu J, Song Y, Li Y, Pan S. MicroRNA-25 suppresses proliferation, migration, and invasion of osteosarcoma by targeting SOX4. Tumour Biol. 2017;39:1010428317703841 pubmed publisher
    ..Taken together, these results suggest that miR-25 functions as a tumor suppressor in the progression of osteosarcoma by repressing SOX4. ..
  7. Balsas P, Palomero J, Eguileor A, Rodríguez M, Vegliante M, Planas Rigol E, et al. SOX11 promotes tumor protective microenvironment interactions through CXCR4 and FAK regulation in mantle cell lymphoma. Blood. 2017;130:501-513 pubmed publisher
    ..Inhibition of this pathway may represent an efficient strategy to overcome stromal-mediated chemotherapy refractoriness in aggressive MCL. ..
  8. Li W, Liu X, Zhang G, Zhang L. [Role of SOX4 on DDP Resistance in Non-small Cell Lung Cancer Cell of A549]. Zhongguo Fei Ai Za Zhi. 2017;20:298-302 pubmed publisher
    ..7???????????P<0.001??????????????????????????????P<0.05???A549?????????A549/DDP???SOX4????????P<0.001????SOX4??A549/DDP?????????????SOX4??A549/DDP????-catenin?Survivin?mRNA?????????????? SOX4???????????????A549????????. ..
  9. Xu E, Sasaki S, Speckmann T, Nian C, Lynn F. SOX4 Allows Facultative ?-Cell Proliferation Through Repression of Cdkn1a. Diabetes. 2017;66:2213-2219 pubmed publisher
    ..Altogether, this study demonstrates that SOX4 is necessary for adult ?-cell replication through direct regulation of the ?-cell cycle. ..

More Information


  1. Sharma S, Nagpal N, Ghosh P, Kulshreshtha R. P53-miR-191-SOX4 regulatory loop affects apoptosis in breast cancer. RNA. 2017;23:1237-1246 pubmed publisher
  2. Lin C, Fang C, Hseu Y, Chen C, Wang J, Hsu S, et al. Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer. PLoS ONE. 2013;8:e67128 pubmed publisher
    ..001). Overexpression of nuclear SOX4 may be used as a marker to predict the outcome of patients with colon cancer. ..
  3. Eriksson P, Aine M, Sjödahl G, Staaf J, Lindgren D, Hoglund M. Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p. PLoS ONE. 2013;8:e67222 pubmed publisher
    ..We further demonstrate three separate target regions for amplification at 1q21-24 and identified BCL9, CHD1L, and MCL1, SETDB1, and HIF1B as putative target genes within these regions. ..
  4. Yang W, Wang Y, Yu Z, Li Z, An G, Liu W, et al. SOX11 regulates the pro-apoptosis signal pathway and predicts a favorable prognosis of mantle cell lymphoma. Int J Hematol. 2017;106:212-220 pubmed publisher
    ..Conclusively, our data suggest that SOX11 represents a useful prognostic marker in mantle cell lymphoma. ..
  5. Shen Q, Shi H, Tian C, Ghai V, Liu J. The C. elegans Spalt-like protein SEM-4 functions through the SoxC transcription factor SEM-2 to promote a proliferative blast cell fate in the postembryonic mesoderm. Dev Biol. 2017;429:335-342 pubmed publisher
  6. Chang K, Hertz J, Zhang X, Jin X, Shaw P, Derosa B, et al. Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development. J Neurosci. 2017;37:4967-4981 pubmed publisher
  7. Lord M, Wasik A, Christensson B, Sander B. The utility of mRNA analysis in defining SOX11 expression levels in mantle cell lymphoma and reactive lymph nodes. Haematologica. 2015;100:e369-72 pubmed publisher
  8. Parvani J, Schiemann W. Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT. Breast Cancer Res. 2013;15:R72 pubmed
    ..This viewpoint highlights Sox4 as a 'new' master of EMT programs and metastatic breast cancer. ..