Genomes and Genes
soxc transcription factors
Summary: A subclass of closely-related SOX transcription factors. Members of the group have been found expressed in developing neuronal tissue, LYMPHOCYTES, and during EMBRYONIC DEVELOPMENT.
- Lin C, Fang C, Hseu Y, Chen C, Wang J, Hsu S, et al. Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer. PLoS ONE. 2013;8:e67128 pubmed publisher..001). Overexpression of nuclear SOX4 may be used as a marker to predict the outcome of patients with colon cancer. ..
- Eriksson P, Aine M, Sjödahl G, Staaf J, Lindgren D, Hoglund M. Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p. PLoS ONE. 2013;8:e67222 pubmed publisher..We further demonstrate three separate target regions for amplification at 1q21-24 and identified BCL9, CHD1L, and MCL1, SETDB1, and HIF1B as putative target genes within these regions. ..
- Yang W, Wang Y, Yu Z, Li Z, An G, Liu W, et al. SOX11 regulates the pro-apoptosis signal pathway and predicts a favorable prognosis of mantle cell lymphoma. Int J Hematol. 2017;106:212-220 pubmed publisher..Conclusively, our data suggest that SOX11 represents a useful prognostic marker in mantle cell lymphoma. ..
- Parvani J, Schiemann W. Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT. Breast Cancer Res. 2013;15:R72 pubmed..This viewpoint highlights Sox4 as a 'new' master of EMT programs and metastatic breast cancer. ..