Genomes and Genes
polycomb repressive complex 1
Summary: A multisubunit polycomb protein complex with affinity for CHROMATIN that contains methylated HISTONE H3. It contains an E3 ubiquitin ligase activity that is specific for HISTONE H2A and works in conjunction with POLYCOMB REPRESSIVE COMPLEX 2 to effect EPIGENETIC REPRESSION.
- Almozyan S, Colak D, Mansour F, Alaiya A, Al Harazi O, Qattan A, et al. PD-L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation. Int J Cancer. 2017;141:1402-1412 pubmed publisher..This study demonstrates a novel role for PD-L1 in sustaining stemness of breast cancer cells and identifies the subpopulation and its associated molecular pathways that would be targeted upon anti-PD-L1 therapy. ..
- Luo H, Yang R, Li C, Tong Y, Fan L, Liu X, et al. MicroRNA-139-5p inhibits bladder cancer proliferation and self-renewal by targeting the Bmi1 oncogene. Tumour Biol. 2017;39:1010428317718414 pubmed publisher..Our study also suggests that miR-139-5p has the potential to be used as a therapeutic molecule for bladder cancer treatment. ..
- Zhang Y, Kim M, Jia B, Yan J, Zuniga Hertz J, Han C, et al. Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature. 2017;548:52-57 pubmed publisher..In conclusion, ageing speed is substantially controlled by hypothalamic stem cells, partially through the release of exosomal miRNAs. ..
- Pemberton H, Anderton E, Patel H, Brookes S, Chandler H, Palermo R, et al. Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts. Genome Biol. 2014;15:R23 pubmed publisher..Mammalian cells encode multiple permutations of the prototypic Polycomb repressive complex 1 (PRC1) with little evidence for functional specialization...
- Pintacuda G, Wei G, Roustan C, Kirmizitas B, Solcan N, Cerase A, et al. hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing. Mol Cell. 2017;68:955-969.e10 pubmed publisher..Our findings define a key pathway for Polycomb recruitment by Xist RNA, providing important insights into mechanisms of chromatin modification by non-coding RNA. ..
- Maezawa S, Hasegawa K, Yukawa M, Sakashita A, Alavattam K, Andreassen P, et al. Polycomb directs timely activation of germline genes in spermatogenesis. Genes Dev. 2017;31:1693-1703 pubmed publisher..Our study identifies a novel mechanism by which Polycomb directs the developmental process by activating a group of lineage-specific genes. ..
- Kaneta Y, Arai M, Ishikawa N, Toume K, Koyano T, Kowithayakorn T, et al. Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata. J Nat Prod. 2017;80:1853-1859 pubmed publisherB-Cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) is a core component of the polycomb repressive complex 1 (PRC1)...
- Nishioka K, Wang X, Miyazaki H, Soejima H, Hirose S. Mbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman. Development. 2018;145: pubmed publisher..i>In vitro, Mbf1 protected E(z) RNA from Pcm activity. Our results suggest that Mbf1 buffers fluctuations in Pcm activity to maintain an E(z) mRNA expression level sufficient for Polycomb silencing. ..
- Zhang R, Real C, Liu C, Baba H, Gerken G, Lu M, et al. Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen-transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro. Int J Cancer. 2017;141:354-363 pubmed publisher..These findings suggest that innate immunity may link inflammation and tumor progression during chronic HBV infection, involving the oncogenes BMI1 and DKK1. ..
- Lee J, Won H, Park J, Kim H, Choi H, Shin D, et al. MEL-18 loss mediates estrogen receptor-Î± downregulation and hormone independence. J Clin Invest. 2015;125:1801-14 pubmed publisher..These findings demonstrate that MEL-18 is a SUMO-dependent regulator of hormone receptors and suggest MEL-18 expression as a marker for determining the antihormonal therapy response in patients with breast cancer. ..
- Martin A, Cano A. Tumorigenesis: Twist1 links EMT to self-renewal. Nat Cell Biol. 2010;12:924-5 pubmed publisher..A molecular link between EMT and stemness now emerges with the finding that Bmi1, a polycomb protein that promotes self-renewal of certain stem-cell populations, is a direct transcriptional target of the EMT inducer, Twist1. ..
- Ohtaka M, Itoh M, Tohda S. BMI1 Inhibitors Down-regulate NOTCH Signaling and Suppress Proliferation of Acute Leukemia Cells. Anticancer Res. 2017;37:6047-6053 pubmed..B cell-specific Moloney murine leukemia virus integration site 1 (BMI1) is up-regulated in several cancers; therefore, we investigated the effects of BMI1 inhibitors on leukemia cells...
- Gherardi S, Ripoche D, Mikaelian I, Chanal M, Teinturier R, Goehrig D, et al. Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification. Biochim Biophys Acta Gene Regul Mech. 2017;1860:427-437 pubmed publisher..Our data suggests therefore that Menin could take an important part to the Ezh2-epigenetic repressive landscape in many cells and tissues through its capacity to modulate Akt phosphorylation. ..
- Zhang X, Tian T, Sun W, Liu C, Fang X. Bmi-1 overexpression as an efficient prognostic marker in patients with nonsmall cell lung cancer. Medicine (Baltimore). 2017;96:e7346 pubmed publisher..In conclusion, Bmi-1 overexpression was correlated with tumor size, poor differentiation, distant metastasis, and worse OS in NSCLC. Therefore, Bmi-1 could be recommended as an efficient prognostic marker for NSCLC. ..
- Kar G, Kim J, Kolodziejczyk A, Natarajan K, Torlai Triglia E, Mifsud B, et al. Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression. Nat Commun. 2017;8:36 pubmed publisher..Here, the authors use single-cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in expression. ..
- . Large-scale discovery of novel genetic causes of developmental disorders. Nature. 2015;519:223-8 pubmed publisher..Our findings demonstrate the value of adopting a comprehensive strategy, both genome-wide and nationwide, to elucidate the underlying causes of rare genetic disorders. ..
- Dong Q, Sharma S, Liu H, Chen L, Gu B, Sun X, et al. HDAC inhibitors reverse acquired radio resistance of KYSE-150R esophageal carcinoma cells by modulating Bmi-1 expression. Toxicol Lett. 2014;224:121-9 pubmed..When combined with IR, HDIs inhibited Bmi-1 expression in KYSE-150R cells and their ability to repair DNA damage. The results demonstrate the potential utility of HDIs in augmenting the efficacy of fractionated radiotherapy. ..
- Chen S, Liu S, Xu L, Yang L, Jin Z, Ma Y, et al. The characteristic expression pattern of BMI-1 and SALL4 genes in placenta tissue and cord blood. Stem Cell Res Ther. 2013;4:49 pubmed publisher..Placental tissue with higher expression level of both genes may be considered as a potential resource for SALL4-related HPC expansion. ..
- Hu P, Xia Q, Wu F, Li D, Qi Y, Hu Y, et al. NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma. Oncogene. 2017;36:4706-4718 pubmed publisher..Thus, our results demonstrate that NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of ATRA via targeting RDH16 and may provide novel targets for glioma treatment in the future. ..
- Simoes Da Silva C, Fereres S, Simón R, Busturia A. Drosophila SCE/dRING E3-ligase inhibits apoptosis in a Dp53 dependent manner. Dev Biol. 2017;429:81-91 pubmed publisher..This function may generate a homeostatic balance between apoptosis and proliferation during development that provides cell survival during the initiation and progression of disease processes. ..
- Li X, Song Y, Liu D, Zhao J, Xu J, Ren J, et al. MiR-495 Promotes Senescence of Mesenchymal Stem Cells by Targeting Bmi-1. Cell Physiol Biochem. 2017;42:780-796 pubmed publisher..Molecular mechanism studies confirmed that Bmi-1 mediated these effects of miR-495 on MSCs. Taken together, our data demonstrated that miR-495 induced senescence of MSCs may be involved in the pathogenesis of PE. ..
- Jang K, Kim M, Gilbert C, Simpkins F, Ince T, Slingerland J. VEGFA activates an epigenetic pathway upregulating ovarian cancer-initiating cells. EMBO Mol Med. 2017;9:304-318 pubmed publisher..Thus, VEGFA stimulates OVCA stem-like cells through Src-DNMT3A-driven miR-128-2 methylation and Bmi1 upregulation. ..
- Li L, Zhao Y, Zhang H. P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury. Cell Death Dis. 2017;8:e2752 pubmed publisher..This study therefore elucidates a novel mechanism whereby TBK1 regulates p16 expression and RGC senescence, suggesting a potential novel treatment strategy for minimizing RGC senescence in retinal ischemia and glaucoma. ..