nuclear receptor coactivator 3
Summary: A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.
Blattner M, Liu D, Robinson B, Huang D, Poliakov A, Gao D, et al
. SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer Cell. 2017;31:436-451 pubmed publisher
..Using these models and human prostate cancer samples, we show that SPOP mutation activates both PI3K/mTOR and androgen receptor signaling, effectively uncoupling the normal negative feedback between these two pathways. ..
Rusinga F, Weis D. Soft interactions and volume exclusion by polymeric crowders can stabilize or destabilize transient structure in disordered proteins depending on polymer concentration. Proteins. 2017;85:1468-1479 pubmed publisher
..Proteins 2017; 85:1468-1479. © 2017 Wiley Periodicals, Inc. ..
Wu M, Cheng W, Chen S, Nieh S, O Connor C, Liu C, et al
. miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. Nat Cell Biol. 2017;19:1286-1296 pubmed publisher
Rohira A, Lonard D. Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers. Biochem Pharmacol. 2017;140:1-7 pubmed publisher
..These early studies demonstrate that targeting the SRCs might prove effective for cancer treatment and more effort should be made to realize the untapped potential of developing drugs designed to target these coactivators. ..
Rohira A, Yan F, Wang L, Wang J, Zhou S, Lu A, et al
. Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017;77:4293-4304 pubmed publisher
..i>Cancer Res; 77(16); 4293-304. ©2017 AACR. ..
Al Naqshabandi M, Weis D. Quantifying Protection in Disordered Proteins Using Millisecond Hydrogen Exchange-Mass Spectrometry and Peptic Reference Peptides. Biochemistry. 2017;56:4064-4072 pubmed publisher
..Third, we find that measurements of HX by reference peptides from the proteins of interest provide the most accurate approach for quantifying the extent of transient structure in disordered proteins by millisecond HX-MS. ..
Yi P, Wang Z, Feng Q, Chou C, Pintilie G, Shen H, et al
. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017;67:733-743.e4 pubmed publisher
..This study reveals a structural role for a coactivator sequential recruitment and biochemical process in ER-mediated transcription. ..
Murakami S, Nagari A, Kraus W. Dynamic assembly and activation of estrogen receptor ? enhancers through coregulator switching. Genes Dev. 2017;31:1535-1548 pubmed publisher
..More broadly, our results demonstrate the unexpectedly dynamic nature of coregulator interactions within enhancer complexes, which are likely to be a defining feature of all enhancers. ..