nf kappa b p52 subunit


Summary: A component of NF-kappa B transcription factor. It is proteolytically processed from NF-kappa B p100 precursor protein and is important for maturation of B-LYMPHOCYTES and adaptive HUMORAL IMMUNITY.

Top Publications

  1. Castro I, Wright J, Damdinsuren B, Hoek K, Carlesso G, Shinners N, et al. B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2. J Immunol. 2009;182:7729-37 pubmed publisher
    ..Thus, acquisition of resistance to apoptosis during transitional B cell maturation is achieved by integration of BCR and BAFF-R signals. ..
  2. Liu H, Zheng H, Duan Z, Hu D, Li M, Liu S, et al. LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells. Mol Cancer. 2009;8:92 pubmed publisher
  3. Tanaka S, Nakano H. NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis. J Clin Invest. 2009;119:2879-81 pubmed publisher
    ..These results suggest that blockade of the processing of p100 is a novel strategy to treat TNF-alpha-related bone diseases such as RA. ..
  4. Kang M, Kim M, Kim S, Ahn C, Yoo N, Lee S. NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas. Pathology. 2009;41:622-5 pubmed publisher
  5. Seo S, Song S, Kang M, Kim M, Oh J, Kim Y, et al. Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers. APMIS. 2009;117:623-8 pubmed publisher
  6. Rajanbabu V, Pan C, Lee S, Lin W, Lin C, Li C, et al. Tilapia hepcidin 2-3 peptide modulates lipopolysaccharide-induced cytokines and inhibits tumor necrosis factor-alpha through cyclooxygenase-2 and phosphodiesterase 4D. J Biol Chem. 2010;285:30577-86 pubmed publisher
    ..In conclusion, TH2-3 inhibits TNF-? and other proinflammatory cytokines through COX-2-, PDE4D-, and pERK1/2-dependent mechanisms...
  7. Demchenko Y, Glebov O, Zingone A, Keats J, Bergsagel P, Kuehl W. Classical and/or alternative NF-kappaB pathway activation in multiple myeloma. Blood. 2010;115:3541-52 pubmed publisher
    ..Our results suggest that MM tumors can achieve increased autonomy from the bone marrow microenvironment by mutations that activate either NF-kappaB pathway. ..
  8. Savinova O, Hoffmann A, Ghosh G. The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol Cell. 2009;34:591-602 pubmed publisher
    ..Our biochemical evidence suggests an assembly pathway in which kinetic mechanisms control NF-kappaB dimer formation via processing and assembly of large complexes that contain IkappaB activities. ..
  9. Panzer U, Steinmetz O, Turner J, Meyer Schwesinger C, von Ruffer C, Meyer T, et al. Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases. Am J Physiol Renal Physiol. 2009;297:F429-39 pubmed publisher
    ..In conclusion, our studies indicate that NF-kappaB subunit p50 proteins have critical in vivo functions in immunologically mediated renal disease by downregulating inflammation during the resolution period. ..

More Information


  1. Nie J, Lu Y, Liu X, Guo S. Immunoreactivity of progesterone receptor isoform B, nuclear factor kappaB, and IkappaBalpha in adenomyosis. Fertil Steril. 2009;92:886-9 pubmed publisher
  2. Jin X, Jin H, Jung H, Lee S, Lee J, Lee J. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. J Biol Chem. 2010;285:30539-47 pubmed publisher
    ..These data clearly indicate that ZFP91 is an important regulator of the noncanonical NF-?B pathway. ..
  3. Bista P, Zeng W, Ryan S, Bailly V, Browning J, Lukashev M. TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J Biol Chem. 2010;285:12971-8 pubmed publisher
    ..Modulation of cellular TRAF3 levels may thus contribute to regulation of NFkappaB-dependent gene expression by LTBR by affecting the balance of LTBR-dependent activation of canonical and non-canonical NFkappaB pathways. ..
  4. Hassan N, Gul S, Flett F, Hollingsworth E, Dunne A, Emmons A, et al. Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm. Biochem J. 2009;419:65-73 pubmed publisher
  5. Shen J, Yang M, Ju D, Jiang H, Zheng J, Xu Z, et al. Disruption of SM22 promotes inflammation after artery injury via nuclear factor kappaB activation. Circ Res. 2010;106:1351-62 pubmed publisher
    ..Our findings show that SM22 downregulation can induce proinflammatory VSMCs through activation of ROS-mediated NF-kappaB pathways. This study provides initial evidence linking VSMC cytoskeleton remodeling with arterial inflammation. ..
  6. Bednarski B, Baldwin A, Kim H. Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin. PLoS ONE. 2009;4:e6992 pubmed publisher
    ..Therefore, combination therapies incorporating NF-kappaB inhibitors together with standard chemotherapies remains a viable method to improve the clinical outcomes in patients with advanced stage malignancies. ..
  7. Kanno Y, Sakurai D, Hase H, Kojima H, Kobata T. TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling. J Recept Signal Transduct Res. 2010;30:121-32 pubmed publisher
    ..Taken together, the regulation of NIK by TACI through the interaction of TANK/TRAF2/cIAP1 plays a pivotal role in the suppression of non-canonical NF-kappaB signaling. ..
  8. Keutgens A, Zhang X, Shostak K, Robert I, Olivier S, Vanderplasschen A, et al. BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1. J Biol Chem. 2010;285:25831-40 pubmed publisher
    ..Thus, our data defined a unique motif of BCL-3 that is needed for its recruitment to the proteasome and identified PSMB1 as a key protein required for the proteasome-mediated degradation of a nuclear and oncogenic IkappaB protein. ..
  9. Fritz R, Radziwill G. CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling. Mol Cancer Res. 2010;8:395-406 pubmed publisher
    ..Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy. ..
  10. Yang C, Murti A, Pfeffer L. Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival. J Biol Chem. 2005;280:31530-6 pubmed
  11. Nadiminty N, Dutt S, Tepper C, Gao A. Microarray analysis reveals potential target genes of NF-kappaB2/p52 in LNCaP prostate cancer cells. Prostate. 2010;70:276-87 pubmed publisher
    ..This study provides a comprehensive analysis of genes potentially regulated by NF-kappaB2/p52 in the LNCaP prostate cancer cell line and provides a rationale for the induction of castration-resistant growth by p52 in LNCaP cells. ..
  12. Roos C, Wicovsky A, Muller N, Salzmann S, Rosenthal T, Kalthoff H, et al. Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. J Immunol. 2010;185:1593-605 pubmed publisher
  13. Chuong C, Katz J, Pauley K, Bulosan M, Cha S. RAGE expression and NF-kappaB activation attenuated by extracellular domain of RAGE in human salivary gland cell line. J Cell Physiol. 2009;221:430-4 pubmed publisher
  14. Suto H, Katakai T, Sugai M, Kinashi T, Shimizu A. CXCL13 production by an established lymph node stromal cell line via lymphotoxin-beta receptor engagement involves the cooperation of multiple signaling pathways. Int Immunol. 2009;21:467-76 pubmed publisher
    ..Taken together, it is suggested that the maturation of lymphoid stromal cells mediated by LTbetaR is accomplished by the cooperation of multiple signaling cascades. ..
  15. Robert I, Aussems M, Keutgens A, Zhang X, Hennuy B, Viatour P, et al. Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes. Oncogene. 2009;28:1626-38 pubmed publisher
  16. Keats J, Fonseca R, Chesi M, Schop R, Baker A, Chng W, et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell. 2007;12:131-44 pubmed
    ..These results highlight the critical importance of the NF-kappaB pathway in the pathogenesis of multiple myeloma. ..
  17. Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, et al. Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation. J Bone Miner Res. 2010;25:1058-67 pubmed publisher
    ..Our data provide a new finding for a previously unappreciated role for NF-kappaB in osteoclast differentiation. ..
  18. Wang F, Shi Y, Yadav S, Wang H. p52-Bcl3 complex promotes cyclin D1 expression in BEAS-2B cells in response to low concentration arsenite. Toxicology. 2010;273:12-8 pubmed publisher
  19. Morris G. An alternative to lung inflammation and fibrosis. Am J Pathol. 2010;176:2595-8 pubmed publisher
    ..This Commentary discusses the role of NFkappaB signaling in lung inflammation and fibrosis. ..
  20. Jin H, Jin X, Lee J. Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-?B pathway. Biochem Biophys Res Commun. 2010;400:581-6 pubmed publisher
    ..These data clearly indicate that ZFP91 is a key regulator in LIGHT-induced activation of non-canonical NF-?B pathway in LT?R signaling. ..
  21. Yang L, Cui H, Wang Z, Zhang B, Ding J, Liu L, et al. Loss of negative feedback control of nuclear factor-kappaB2 activity in lymphocytes leads to fatal lung inflammation. Am J Pathol. 2010;176:2646-57 pubmed publisher
    ..These findings demonstrate the physiological relevance of the NF-kappaB2 p100 precursor protein in limiting the potentially detrimental effects of constitutive NF-kappaB2 signaling in lymphocytes. ..
  22. Rauert H, Wicovsky A, Muller N, Siegmund D, Spindler V, Waschke J, et al. Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2). J Biol Chem. 2010;285:7394-404 pubmed publisher
    ..Thus, we identified activation of the alternative NFkappaB pathway as a TNF signaling effect that can be specifically assigned to TNFR2 and membrane TNF. ..
  23. Saito T, Sasaki C, Rezanka L, Ghosh P, Longo D. p52-Independent nuclear translocation of RelB promotes LPS-induced attachment. Biochem Biophys Res Commun. 2010;391:235-41 pubmed publisher
    ..Taken together, the results suggest that RelB was responsible for the LPS-mediated attachment and may play an important role in the progression of some cancers. ..
  24. Yao Z, Xing L, Boyce B. NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism. J Clin Invest. 2009;119:3024-34 pubmed publisher
    ..These findings suggest that upregulation of TRAF3 or NF-kappaB p100 expression or inhibition of NF-kappaB p100 degradation in OCPs could limit bone destruction and inflammation-induced bone loss in common bone diseases. ..
  25. Nishina T, Yamaguchi N, Gohda J, Semba K, Inoue J. NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells. Biochem Biophys Res Commun. 2009;388:96-101 pubmed publisher
    ..Therefore, NIK might be a novel target for the treatment of pancreatic cancer. ..
  26. Claudio E, Saret S, Wang H, Siebenlist U. Cell-autonomous role for NF-kappa B in immature bone marrow B cells. J Immunol. 2009;182:3406-13 pubmed publisher
    ..Therefore, the lifelong dependency of B cells on NF-kappaB-mediated survival functions is set in motion at the time of first expression of a full BCR. ..
  27. Debnath I, Roundy K, Weis J, Weis J. Analysis of the regulatory role of BAFF in controlling the expression of CD21 and CD23. Mol Immunol. 2007;44:2388-99 pubmed
  28. Misra U, Kaczowka S, Pizzo S. Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation. Biochem Biophys Res Commun. 2010;392:538-42 pubmed publisher
    ..These studies demonstrate that antibody directed against the carboxyl terminal domain of GRP78 inhibits the pro-proliferative NF-kappaB signaling cascade in cancer cells. ..
  29. Keller U, Huber J, Nilsson J, Fallahi M, Hall M, Peschel C, et al. Myc suppression of Nfkb2 accelerates lymphomagenesis. BMC Cancer. 2010;10:348 pubmed publisher
    ..Nfkb2 is suppressed by c-Myc and harnesses Myc-driven lymphomagenesis. These data thus link Myc-driven lymphomagenesis to the non-canonical NF-kappaB pathway. ..