serum response factor

Summary

Summary: A MADS domain-containing transcription factor that binds to the SERUM RESPONSE ELEMENT in the promoter-enhancer region of many genes. It is one of the four founder proteins that structurally define the superfamily of MADS DOMAIN PROTEINS.

Top Publications

  1. Niu Z, Li A, Zhang S, Schwartz R. Serum response factor micromanaging cardiogenesis. Curr Opin Cell Biol. 2007;19:618-27 pubmed
    b>Serum response factor (SRF), a cardiac-enriched transcription factor, is required for the appearance of beating sarcomeres in the heart...
  2. Stern S, Debre E, Stritt C, Berger J, Posern G, Knöll B. A nuclear actin function regulates neuronal motility by serum response factor-dependent gene transcription. J Neurosci. 2009;29:4512-8 pubmed publisher
    ..R62D-induced phenotypes strongly resemble neurons lacking SRF (Serum Response Factor). SRF controls gene transcription of various actin isoforms (e.g...
  3. Medjkane S, Perez Sanchez C, Gaggioli C, Sahai E, Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol. 2009;11:257-68 pubmed publisher
    ..activation through myocardin-related transcription factors (MRTFs), which are co-activators for serum response factor (SRF)...
  4. Hirose K, Abramovich C, Argiropoulos B, Humphries R. Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor. Oncogene. 2008;27:6056-67 pubmed publisher
    ..expressed in hematopoietic cells, and first identified for its role in enhancing the binding of the serum response factor (SRF) to the serum responsive element (SRE)...
  5. Miano J, Ramanan N, Georger M, de Mesy Bentley K, Emerson R, Balza R, et al. Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A. 2004;101:17132-7 pubmed
    b>Serum response factor (SRF) directs programs of gene expression linked to growth and muscle differentiation...
  6. Tomasek J, McRae J, Owens G, Haaksma C. Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element. Am J Pathol. 2005;166:1343-51 pubmed
    ..Taken together, these results provide the first in vivo evidence for the importance of the intronic CArG and TCE cis-elements in the regulation of alpha-SMA expression in myofibroblasts in granulation tissue. ..
  7. Lu P, Ramanan N. A critical cell-intrinsic role for serum response factor in glial specification in the CNS. J Neurosci. 2012;32:8012-23 pubmed publisher
    ..Here we show that deletion of the stimulus-dependent transcription factor, serum response factor (SRF), in neural precursor cells (NPCs) (Srf-Nestin-cKO) results in nearly 60% loss in astrocytes and 50% ..
  8. Charvet C, Houbron C, Parlakian A, Giordani J, Lahoute C, Bertrand A, et al. New role for serum response factor in postnatal skeletal muscle growth and regeneration via the interleukin 4 and insulin-like growth factor 1 pathways. Mol Cell Biol. 2006;26:6664-74 pubmed
    b>Serum response factor (SRF) is a crucial transcriptional factor for muscle-specific gene expression. We investigated SRF function in adult skeletal muscles, using mice with a postmitotic myofiber-targeted disruption of the SRF gene...
  9. René C, Taulan M, Iral F, Doudement J, L honoré A, Gerbon C, et al. Binding of serum response factor to cystic fibrosis transmembrane conductance regulator CArG-like elements, as a new potential CFTR transcriptional regulation pathway. Nucleic Acids Res. 2005;33:5271-90 pubmed
    ..shift assays and chromatin immunoprecipitation analyses demonstrated the CFTR CArG-like motif binds serum response factor both in vitro and in vivo...

More Information

Publications61

  1. Luxenburg C, Pasolli H, Williams S, Fuchs E. Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation. Nat Cell Biol. 2011;13:203-14 pubmed publisher
    ..To elucidate how epidermal embryogenesis is governed, we conditionally targeted serum response factor (Srf), a transcription factor that is essential for epidermal differentiation...
  2. Buller B, Chopp M, Ueno Y, Zhang L, Zhang R, Morris D, et al. Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation. Glia. 2012;60:1906-14 pubmed publisher
    b>Serum response factor (SRF) is a transcription factor that transactivates actin-associated genes and has been implicated in oligodendrocyte (OL) differentiation. To date, it has not been investigated in cerebral ischemia...
  3. Kim J, Kee H, Kim J, Joung H, Nam K, Eom G, et al. Enhancer of polycomb1 acts on serum response factor to regulate skeletal muscle differentiation. J Biol Chem. 2009;284:16308-16 pubmed publisher
    ..Here we report that Epc1 recruits both serum response factor (SRF) and p300 to induce skeletal muscle differentiation. Epc1 interacted physically with SRF...
  4. Werth D, Grassi G, Konjer N, Dapas B, Farra R, Giansante C, et al. Proliferation of human primary vascular smooth muscle cells depends on serum response factor. Eur J Cell Biol. 2010;89:216-24 pubmed publisher
    ..The transcription factor serum response factor (SRF) has been implicated in the regulation of gene expression profiles determining both phenotypes...
  5. Parkitna J, Bilbao A, Rieker C, Engblom D, Piechota M, Nordheim A, et al. Loss of the serum response factor in the dopamine system leads to hyperactivity. FASEB J. 2010;24:2427-35 pubmed publisher
    The serum response factor (SRF) is a key regulator of neural development and cellular plasticity, which enables it to act as a regulator of long-term adaptations in neurons...
  6. Olson E, Nordheim A. Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol. 2010;11:353-65 pubmed publisher
    ..myocardin-related transcription factor (MRTF) cofactors, thereby inducing the nuclear transcription factor serum response factor (SRF) to modulate the expression of genes encoding structural and regulatory effectors of actin dynamics...
  7. Li J, Shiroyanagi Y, Lin G, Haqq C, Lin C, Lue T, et al. Serum response factor, its cofactors, and epithelial-mesenchymal signaling in urinary bladder smooth muscle formation. Differentiation. 2006;74:30-9 pubmed
    ..we identified regulators of vascular smooth muscle differentiation in bladder mesenchyme, including serum response factor (SRF) and its cofactors, ELK1 and SRF accessory protein (SAP)1, as well as two SRF-associated pathways, ..
  8. Kim M, Merlo X, Wilson C, Lough J. Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor. J Biol Chem. 2006;281:15082-9 pubmed
    ..is suggested by immunoprecipitation experiments showing that Tip60alpha, Tip60beta, and Tip55 can bind serum response factor (SRF) and by transient transfection assessments showing that Tip60 and SRF cooperatively activate the ..
  9. Franco C, Mericskay M, Parlakian A, Gary Bobo G, Gao Li J, Paulin D, et al. Serum response factor is required for sprouting angiogenesis and vascular integrity. Dev Cell. 2008;15:448-61 pubmed publisher
    b>Serum response factor (SRF) is a transcription factor that controls the expression of cytoskeletal proteins and immediate early genes in different cell types...
  10. Paul A, Pohl Guimaraes F, Krahe T, Filgueiras C, Lantz C, Colello R, et al. Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. J Neurosci. 2010;30:2513-20 pubmed publisher
    ..levels, activating transcription factors such as the cAMP response element binding protein (CREB) and the serum response factor (SRF)...
  11. Zhang X, Azhar G, Huang C, Cui C, Zhong Y, Huck S, et al. Alternative splicing and nonsense-mediated mRNA decay regulate gene expression of serum response factor. Gene. 2007;400:131-9 pubmed
    b>Serum response factor (SRF) is an important transcription factor that regulates a variety of genes in many tissues during development, maturation and aging...
  12. Kawai Kowase K, Kumar M, Hoofnagle M, Yoshida T, Owens G. PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins. Mol Cell Biol. 2005;25:8009-23 pubmed
    ..of the protein inhibitor of activated STAT (PIAS) family interact with class I bHLH factors as well as serum response factor (SRF)...
  13. Chen J, Yuan K, Mao X, Miano J, Wu H, Chen Y. Serum response factor regulates bone formation via IGF-1 and Runx2 signals. J Bone Miner Res. 2012;27:1659-68 pubmed publisher
    b>Serum response factor (SRF) plays vital roles in numerous cellular processes; however, the physiological function of SRF in skeletal tissue remains unknown...
  14. Kim H, Kim K, Park H, Jang K, Chung M, Shong M, et al. The expression and role of serum response factor in papillary carcinoma of the thyroid. Int J Oncol. 2009;35:49-55 pubmed
    b>Serum response factor (SRF) is a transcription factor of the MADS box family...
  15. Creemers E, Sutherland L, McAnally J, Richardson J, Olson E. Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development. Development. 2006;133:4245-56 pubmed
    Myocardin is a transcriptional co-activator of serum response factor (Srf), which is a key regulator of the expression of smooth and cardiac muscle genes...
  16. Philippar U, Schratt G, Dieterich C, Müller J, Galgoczy P, Engel F, et al. The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Mol Cell. 2004;16:867-80 pubmed
    RhoA signaling regulates the activity of the transcription factor SRF (serum response factor) during muscle differentiation...
  17. Brandt D, Baarlink C, Kitzing T, Kremmer E, Ivaska J, Nollau P, et al. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol. 2009;11:557-68 pubmed publisher
    ..it binds and inhibits the myocardin-related transcription factor MAL by forming a ternary complex with serum response factor (SRF)...
  18. Martin Garrido A, Brown D, Lyle A, Dikalova A, Seidel Rogol B, LASSEGUE B, et al. NADPH oxidase 4 mediates TGF-?-induced smooth muscle ?-actin via p38MAPK and serum response factor. Free Radic Biol Med. 2011;50:354-62 pubmed publisher
    ..or NADPH oxidase-derived reactive oxygen species impairs the TGF-?-induced phosphorylation of Ser103 on serum response factor (SRF) and reduces its transcriptional activity...
  19. Hu Q, Guo C, Li Y, Aronow B, Zhang J. LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration. Mol Cell Biol. 2011;31:3223-40 pubmed publisher
    b>Serum response factor (SRF) is a ubiquitously expressed transcription factor that regulates cell-specific functions such as muscle development and breast cancer metastasis...
  20. Zhang X, Azhar G, Zhong Y, Wei J. Identification of a novel serum response factor cofactor in cardiac gene regulation. J Biol Chem. 2004;279:55626-32 pubmed
    The transcription factor serum response factor (SRF) plays an important role in the regulation of a variety of cardiac genes during development and during adult aging...
  21. Boros J, Donaldson I, O Donnell A, Odrowaz Z, Zeef L, Lupien M, et al. Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Genome Res. 2009;19:1963-73 pubmed publisher
  22. Cai Z, Wang Y, Yu W, Xiao J, Li Y, Liu L, et al. hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor. Biochem Biophys Res Commun. 2006;343:973-81 pubmed
    ..Overexpression of hnulp1 protein in COS-7 cells inhibits the transcriptional activity of serum response factor (SRF), suggesting that hnulp1 may act as a novel bHLH transcriptional repressor in SRF signaling pathway ..
  23. Muehlich S, Wang R, Lee S, Lewis T, Dai C, Prywes R. Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization. Mol Cell Biol. 2008;28:6302-13 pubmed publisher
    Megakaryoblastic leukemia 1 (MKL1) is a myocardin-related coactivator of the serum response factor (SRF) transcription factor, which has an integral role in differentiation, migration, and proliferation...
  24. Vickers E, Kasza A, Kurnaz I, Seifert A, Zeef L, O Donnell A, et al. Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol Cell Biol. 2004;24:10340-51 pubmed
    ..elements (SREs) in the promoters of target genes in a ternary complex with a second transcription factor, serum response factor (SRF)...
  25. Petit M, Lindskog H, Larsson E, Wasteson P, Athley E, Breuer S, et al. Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin. Circ Res. 2008;103:61-9 pubmed publisher
    ..In particular, we investigate whether LPP is directly regulated by serum response factor (SRF)...
  26. Dash P, Orsi S, Moore A. Sequestration of serum response factor in the hippocampus impairs long-term spatial memory. J Neurochem. 2005;93:269-78 pubmed
    ..protein kinase/extracellular signal-regulated kinase (MAPK/ERK), can lead to the phosphorylation of serum response factor (SRF) and Elk-1, enhancing the expression of target genes...
  27. Staus D, Blaker A, Taylor J, Mack C. Diaphanous 1 and 2 regulate smooth muscle cell differentiation by activating the myocardin-related transcription factors. Arterioscler Thromb Vasc Biol. 2007;27:478-86 pubmed
    ..These results indicate that RhoA-dependent signaling through mDia1/2 and the MRTFs is important for SMC-specific gene expression in SMCs. ..
  28. Kwon C, Kim K, Choi H, Chung M, Noh S, Kim D, et al. The role of serum response factor in hepatocellular carcinoma: implications for disease progression. Int J Oncol. 2010;37:837-44 pubmed
    b>Serum response factor (SRF) regulates transcription of the immediate early genes and triggers proliferation, migration and differentiation in several types of cells...
  29. Paul A, Medina A. Overexpression of serum response factor in astrocytes improves neuronal plasticity in a model of early alcohol exposure. Neuroscience. 2012;221:193-202 pubmed publisher
    ..Recently, we showed that this deficit could be reversed by overexpression of serum response factor (SRF) in the primary visual cortex during the period of monocular deprivation (MD)...
  30. Rieker C, Schober A, Bilbao A, Schutz G, Parkitna J. Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress. Eur J Neurosci. 2012;35:735-41 pubmed publisher
    ..Here we investigate the role of the serum response factor (SRF), an important regulator of anti-apoptotic responses, for the survival of DA neurons in mice...
  31. Sandström J, Heiduschka P, Beck S, Philippar U, Seeliger M, Schraermeyer U, et al. Degeneration of the mouse retina upon dysregulated activity of serum response factor. Mol Vis. 2011;17:1110-27 pubmed
    ..a transgenic mouse line expressing a constitutively active variant of the transcription regulatory protein serum response factor (SRF), namely the SRF-VP16 protein...
  32. Patten L, Belaguli N, Baek M, Fagan S, Awad S, Berger D. Serum response factor is alternatively spliced in human colon cancer. J Surg Res. 2004;121:92-100 pubmed
    b>Serum response factor (SRF) is a transcription factor that plays an important role in cellular differentiation and cell cycle regulation. SRF function is regulated in part by alternative splicing...
  33. Sandbo N, Kregel S, Taurin S, Bhorade S, Dulin N. Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta. Am J Respir Cell Mol Biol. 2009;41:332-8 pubmed publisher
    ..In the present study, we examined the role of serum response factor (SRF) in the mechanism of TGF-beta-induced pulmonary myofibroblast differentiation of human lung ..
  34. Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schutz G, Linden D, et al. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci. 2005;8:759-67 pubmed
    ..Here, we show that deletion of serum response factor (SRF) in specific neuronal populations in adult mice results in profound deficits in activity-dependent ..
  35. Rensen S, Niessen P, Long X, Doevendans P, Miano J, van Eys G. Contribution of serum response factor and myocardin to transcriptional regulation of smoothelins. Cardiovasc Res. 2006;70:136-45 pubmed
    Smoothelin-A and -B isoforms are highly restricted to contractile smooth muscle cells (SMCs). Serum response factor (SRF) and myocardin are essential for contractile SMC differentiation...
  36. Konhilas J, Leinwand L. Partnering up for cardiac hypertrophy. Circ Res. 2006;98:985-7 pubmed
  37. Han Y, Hu W, Chernaya O, Antic N, Gu L, Gupta M, et al. Increased myosin light chain kinase expression in hypertension: Regulation by serum response factor via an insertion mutation in the promoter. Mol Biol Cell. 2006;17:4039-50 pubmed
    Regulation of gene transcription in vascular smooth muscle cells (VSMCs) by serum response factor (SRF) plays a crucial role in vascular development and in the pathophysiology of vascular diseases...
  38. Heemers H, Regan K, Dehm S, Tindall D. Androgen induction of the androgen receptor coactivator four and a half LIM domain protein-2: evidence for a role for serum response factor in prostate cancer. Cancer Res. 2007;67:10592-9 pubmed
    ..Androgen induction of FHL2 depended on active transcription of the FHL2 gene, mediated by action of serum response factor (SRF) on its proximal promoter...
  39. Verdoni A, Aoyama N, Ikeda A, Ikeda S. Effect of destrin mutations on the gene expression profile in vivo. Physiol Genomics. 2008;34:9-21 pubmed publisher
    ..Among genes that belong to these categories, a considerable number of serum response factor target genes were found, indicating the possible existence of an actin-SRF pathway of transcriptional ..
  40. Sun K, Battle M, Misra R, Duncan S. Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice. Hepatology. 2009;49:1645-54 pubmed publisher
    b>Serum response factor (SRF) is a transcription factor that binds to a CarG box motif within the serum response element of genes that are expressed in response to mitogens...
  41. Fan L, Sebe A, Péterfi Z, Masszi A, Thirone A, Rotstein O, et al. Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway. Mol Biol Cell. 2007;18:1083-97 pubmed
    ..responsible mechanisms, we investigated the localization of the main SMA-inducing transcription factors, serum response factor (SRF), and its coactivator myocardin-related transcription factor (MRTF)...
  42. Azhar G, Zhang X, Wang S, Zhong Y, Quick C, Wei J. Maintaining serum response factor activity in the older heart equal to that of the young adult is associated with better cardiac response to isoproterenol stress. Basic Res Cardiol. 2007;102:233-44 pubmed
    ..the effect of transcription regulation in modulating cardiac aging, we sought to study the role of serum response factor (SRF), a key transcription factor in the heart that is normally increased with senescence and also in ..
  43. Zaromytidou A, Miralles F, Treisman R. MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain. Mol Cell Biol. 2006;26:4134-48 pubmed
    The transcription factor serum response factor (SRF) interacts with its cofactor, MAL/MKL1, a member of the myocardin-related transcription factor (MRTF) family, through its DNA-binding domain...
  44. Zhang X, Azhar G, Helms S, Wei J. Regulation of cardiac microRNAs by serum response factor. J Biomed Sci. 2011;18:15 pubmed publisher
    b>Serum response factor (SRF) regulates certain microRNAs that play a role in cardiac and skeletal muscle development...
  45. Caposio P, Luganini A, Bronzini M, Landolfo S, Gribaudo G. The Elk-1 and serum response factor binding sites in the major immediate-early promoter of human cytomegalovirus are required for efficient viral replication in quiescent cells and compensate for inactivation of the NF-kappaB sites in proliferating c. J Virol. 2010;84:4481-93 pubmed publisher
    ..Gribaudo, Cell. Microbiol. 9:2040-2054, 2007). We now show that the inactivation of either the Elk-1 or serum response factor (SRF) binding site within the enhancer also reduces MIEP activation and viral replication of recombinant ..
  46. Etkin A, Alarcon J, Weisberg S, Touzani K, Huang Y, Nordheim A, et al. A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron. 2006;50:127-43 pubmed
  47. Nelson T, Balza R, Xiao Q, Misra R. SRF-dependent gene expression in isolated cardiomyocytes: regulation of genes involved in cardiac hypertrophy. J Mol Cell Cardiol. 2005;39:479-89 pubmed
    b>Serum response factor (SRF) is a transcription factor required for the regulation of genes important for cardiac structure and function...
  48. Mack C, Hinson J. Regulation of smooth muscle differentiation by the myocardin family of serum response factor co-factors. J Thromb Haemost. 2005;3:1976-84 pubmed
  49. Zhe X, Yang Y, Schuger L. Imbalanced plasminogen system in lymphangioleiomyomatosis: potential role of serum response factor. Am J Respir Cell Mol Biol. 2005;32:28-34 pubmed
    ..We previously demonstrated that serum response factor (SRF), a critical smooth muscle transcription factor, is highly expressed in LAM cells...
  50. Wheaton K, Riabowol K. Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. Mol Cell Biol. 2004;24:7298-311 pubmed
    ..The serum response factor (SRF), a major transcriptional activator of immediate-early gene promoters, loses the ability to bind to ..
  51. Hoggatt A, Kim J, Ustiyan V, Ren X, Kalin T, Kalinichenko V, et al. The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells. J Biol Chem. 2013;288:28477-87 pubmed publisher
    ..Mechanistically, Foxf1 directly binds to and activates the telokin promoter. Foxf1 also directly binds to serum response factor (SRF) and myocardin-related transcription factors (MRTFs)...
  52. Xie L, Sullivan A, Collier J, Glass C. Serum response factor indirectly regulates type I interferon-signaling in macrophages. J Interferon Cytokine Res. 2013;33:588-96 pubmed publisher
    b>Serum response factor (SRF) is required for diverse aspects of development and homeostasis, but potential roles in the regulation of inflammation and immunity have not been systematically investigated...