Genomes and Genes
mef2 transcription factors
Summary: Activating transcription factors of the MADS family which bind a specific sequence element (MEF2 element) in many muscle-specific genes and are involved in skeletal and cardiac myogenesis, neuronal differentiation and survival/apoptosis.
- Wu R, Wang J, Yao J, Dong Z, Liu Y, Liu M. MEF2A regulates Calpain 3 expression in L6 myoblasts. Gene. 2018;: pubmed publisher..Based on these results, we proposed that MEF2A is a transcriptional regulator for Capn3 gene expression. ..
- Chen D, Chen F, Xu Y, Zhang Y, Li Z, Zhang H, et al. AKT2 deficiency induces retardation of myocyte development through EndoG-MEF2A signaling in mouse heart. Biochem Biophys Res Commun. 2017;493:1410-1417 pubmed publisher..We also proved a novel pathway of heart development involving EndoG and MEF2A regulated by AKT2...
- Sawada H, Rateri D, Moorleghen J, Majesky M, Daugherty A. Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:1722-1726 pubmed publisher..Both CNC- and SHF-derived SMCs populate the media throughout the ascending aorta. The outer medial cells of the ascending aorta form a sleeve populated by SHF-derived SMCs. ..
- Di Giorgio E, Franforte E, Cefalù S, Rossi S, Dei Tos A, Brenca M, et al. The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness. PLoS Genet. 2017;13:e1006752 pubmed publisher..However, these repressed MEF2-targets are poised in terms of chromatin signature. Overall our results candidate class IIa HDACs and HDAC9 in particular, as druggable targets for a therapeutic intervention in LMS. ..
- Shi X, Li W, Liu H, Yin D, Zhao J. ?-Cyclodextrin induces the differentiation of resident cardiac stem cells to cardiomyocytes through autophagy. Biochim Biophys Acta Mol Cell Res. 2017;1864:1425-1434 pubmed publisher..In addition, the clarified molecular mechanisms supported the new targets for inducing cardiomyocyte differentiation. ..