mef2 transcription factors


Summary: Activating transcription factors of the MADS family which bind a specific sequence element (MEF2 element) in many muscle-specific genes and are involved in skeletal and cardiac myogenesis, neuronal differentiation and survival/apoptosis.

Top Publications

  1. Ma H, Wang L, Yin C, Liu J, Qian L. In vivo cardiac reprogramming using an optimal single polycistronic construct. Cardiovasc Res. 2015;108:217-9 pubmed publisher
  2. Papait R, Serio S, Pagiatakis C, Rusconi F, Carullo P, Mazzola M, et al. Histone Methyltransferase G9a Is Required for Cardiomyocyte Homeostasis and Hypertrophy. Circulation. 2017;136:1233-1246 pubmed publisher
  3. Pulimood N, Rodrigues W, Atkinson D, Mooney S, Medina A. The Role of CREB, SRF, and MEF2 in Activity-Dependent Neuronal Plasticity in the Visual Cortex. J Neurosci. 2017;37:6628-6637 pubmed publisher
  4. Li M, Liu Z, Zhang Z, Liu G, Sun S, Sun C. miR-103 promotes 3T3-L1 cell adipogenesis through AKT/mTOR signal pathway with its target being MEF2D. Biol Chem. 2015;396:235-44 pubmed publisher
    ..In conclusion, we found that miR-103 can promote 3T3-L1 cells differentiation by targeting MEF2D and activating AKT/mTOR signal pathway. These results will shed a light on further study of microRNAs. ..
  5. Hashemi S, Wales S, Miyake T, McDermott J. Heart disease: recruitment of MEF2 activity by ?-blockers wards off cardiomyocyte death. Cell Death Dis. 2015;6:e1916 pubmed publisher
  6. Lu Y, Lowery A, Sun L, Singer H, Dai G, Adam A, et al. Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina. Arterioscler Thromb Vasc Biol. 2017;37:1380-1390 pubmed publisher
    ..These results indicate that endothelial Mef2c regulates the endothelial actin cytoskeleton and inhibits smooth muscle cell migration into the intima. ..
  7. Desjardins C, Naya F. Antagonistic regulation of cell-cycle and differentiation gene programs in neonatal cardiomyocytes by homologous MEF2 transcription factors. J Biol Chem. 2017;292:10613-10629 pubmed publisher
  8. Nagar S, Trudler D, McKercher S, Piña Crespo J, Nakanishi N, Okamoto S, et al. Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. Invest Ophthalmol Vis Sci. 2017;58:3741-3749 pubmed publisher
    ..These results suggest that the MEF2-PGC1α cascade may represent a new therapeutic target for drugs designed to protect photoreceptors from developmental- and age-dependent loss. ..
  9. Xiang J, Sun H, Su L, Liu L, Shan J, Shen J, et al. Myocyte enhancer factor 2D promotes colorectal cancer angiogenesis downstream of hypoxia-inducible factor 1α. Cancer Lett. 2017;400:117-126 pubmed publisher
    ..HIF-1α transactivates MEF2D expression by binding to the MEF2D gene promoter. These results demonstrate that the HIF-1α/MEF2D axis can serve as a therapeutic target for the treatment of CRC. ..

More Information


  1. Wu R, Wang J, Yao J, Dong Z, Liu Y, Liu M. MEF2A regulates Calpain 3 expression in L6 myoblasts. Gene. 2018;: pubmed publisher
    ..Based on these results, we proposed that MEF2A is a transcriptional regulator for Capn3 gene expression. ..
  2. Chen D, Chen F, Xu Y, Zhang Y, Li Z, Zhang H, et al. AKT2 deficiency induces retardation of myocyte development through EndoG-MEF2A signaling in mouse heart. Biochem Biophys Res Commun. 2017;493:1410-1417 pubmed publisher
    ..We also proved a novel pathway of heart development involving EndoG and MEF2A regulated by AKT2...
  3. Sawada H, Rateri D, Moorleghen J, Majesky M, Daugherty A. Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:1722-1726 pubmed publisher
    ..Both CNC- and SHF-derived SMCs populate the media throughout the ascending aorta. The outer medial cells of the ascending aorta form a sleeve populated by SHF-derived SMCs. ..
  4. Raices M, Bukata L, Sakuma S, Borlido J, Hernandez L, Hart D, et al. Nuclear Pores Regulate Muscle Development and Maintenance by Assembling a Localized Mef2C Complex. Dev Cell. 2017;41:540-554.e7 pubmed publisher
  5. Srivastava D, Ieda M. Critical factors for cardiac reprogramming. Circ Res. 2012;111:5-8 pubmed publisher
  6. Di Giorgio E, Franforte E, Cefalù S, Rossi S, Dei Tos A, Brenca M, et al. The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness. PLoS Genet. 2017;13:e1006752 pubmed publisher
    ..However, these repressed MEF2-targets are poised in terms of chromatin signature. Overall our results candidate class IIa HDACs and HDAC9 in particular, as druggable targets for a therapeutic intervention in LMS. ..
  7. Lilljebjörn H, Agerstam H, Orsmark Pietras C, Rissler M, Ehrencrona H, Nilsson L, et al. RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib. Leukemia. 2014;28:977-9 pubmed publisher
  8. Shi X, Li W, Liu H, Yin D, Zhao J. ?-Cyclodextrin induces the differentiation of resident cardiac stem cells to cardiomyocytes through autophagy. Biochim Biophys Acta Mol Cell Res. 2017;1864:1425-1434 pubmed publisher
    ..In addition, the clarified molecular mechanisms supported the new targets for inducing cardiomyocyte differentiation. ..