gata1 transcription factor

Summary

Summary: A GATA transcription factor that is specifically expressed in hematopoietic lineages and plays an important role in the CELL DIFFERENTIATION of ERYTHROID CELLS and MEGAKARYOCYTES.

Top Publications

  1. Miyauchi J, Ito Y, Tsukamoto K, Takahashi H, Ishikura K, Sugita K, et al. Blasts in transient leukaemia in neonates with Down syndrome differentiate into basophil/mast-cell and megakaryocyte lineages in vitro in association with down-regulation of truncated form of GATA1. Br J Haematol. 2010;148:898-909 pubmed publisher
  2. Ferreira R, Wai A, Shimizu R, Gillemans N, Rottier R, von Lindern M, et al. Dynamic regulation of Gata factor levels is more important than their identity. Blood. 2007;109:5481-90 pubmed
    ..Our data show that the dynamic spatiotemporal regulation of Gata factor levels is more important than their identity and provide a paradigm for developmental control mechanisms that are hard-wired in cis-regulatory elements. ..
  3. Miccio A, Blobel G. Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Mol Cell Biol. 2010;30:3460-70 pubmed publisher
    ..These results suggest that, unexpectedly, NuRD is required for FOG-1-dependent activation of adult-type globin gene expression but is dispensable for human gamma-globin silencing in vivo. ..
  4. Lamonica J, Vakoc C, Blobel G. Acetylation of GATA-1 is required for chromatin occupancy. Blood. 2006;108:3736-8 pubmed
    ..These findings point to a novel function for transcription factor acetylation, perhaps by facilitating protein interactions required for stable association with chromatin templates in vivo. ..
  5. Cheng Y, Wu W, Kumar S, Yu D, Deng W, Tripic T, et al. Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res. 2009;19:2172-84 pubmed publisher
    ..More broadly, these studies illustrate how a "master regulator" transcription factor coordinates tissue differentiation through a panoply of DNA and protein interactions...
  6. Miccio A, Wang Y, Hong W, Gregory G, Wang H, Yu X, et al. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J. 2010;29:442-56 pubmed publisher
    ..These results show that NuRD is a critical co-factor for FOG-1 and underscore the versatile use of NuRD by lineage-specific transcription factors to activate and repress gene transcription in the appropriate cellular and genetic context...
  7. Alford K, Slender A, Vanes L, Li Z, Fisher E, Nizetic D, et al. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood. 2010;115:2928-37 pubmed publisher
  8. Qiu Z, Dyer K, Xie Z, Radinger M, Rosenberg H. GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) gene. J Biol Chem. 2009;284:13099-109 pubmed publisher
    ..Taken together, our data suggest that GATA-2 functions directly via interactions with the EDN promoter and also indirectly, via its ability to regulate the expression of GATA-1 in differentiating eosinophils and eosinophil cell lines. ..
  9. Tunstall Pedoe O, Roy A, Karadimitris A, de la Fuente J, Fisk N, Bennett P, et al. Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations. Blood. 2008;112:4507-11 pubmed publisher
    ..These data indicate that T21 itself profoundly disturbs FL hemopoiesis and they provide a testable hypothesis to explain the increased susceptibility to GATA1 mutations in DS-AMKL and DS-associated transient myeloproliferative disorder. ..

More Information

Publications62

  1. Cho Y, Song S, Lee J, Choi N, Kim C, Dean A, et al. The role of transcriptional activator GATA-1 at human beta-globin HS2. Nucleic Acids Res. 2008;36:4521-8 pubmed publisher
  2. Woon Kim Y, Kim S, Geun Kim C, Kim A. The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal ?-globin genes. Nucleic Acids Res. 2011;39:6944-55 pubmed publisher
    ..This idea is supported by the distinctive binding pattern of CBP and Brg1 in the ?-globin locus. Furthermore GATA-1-dependent loop formation between HS5 and 3'HS1 suggests correlation between histone modifications and chromatin looping. ..
  3. Khan I, Malinge S, Crispino J. Myeloid leukemia in Down syndrome. Crit Rev Oncog. 2011;16:25-36 pubmed
    ..Given that trisomy 21 is a relatively common event in hematologic malignancies, greater knowledge of how the genes on chromosome 21 contribute to DS-AMKL will increase our understanding of a broader class of patients with leukemia. ..
  4. Jing H, Vakoc C, Ying L, Mandat S, Wang H, Zheng X, et al. Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol Cell. 2008;29:232-42 pubmed publisher
    ..This work shows that a GATA factor exchange reconfigures higher-order chromatin organization, and suggests that de novo chromatin loop formation is employed by nuclear factors to specify repressive outcomes. ..
  5. Lurie L, Boyer M, Grass J, Bresnick E. Differential GATA factor stabilities: implications for chromatin occupancy by structurally similar transcription factors. Biochemistry. 2008;47:859-69 pubmed
  6. Stumpf M, Waskow C, Krötschel M, van Essen D, Rodriguez P, Zhang X, et al. The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A. 2006;103:18504-9 pubmed
    ..In chromatin immunoprecipitation experiments, we find Mediator components at GATA-1-occupied enhancer sites. Thus, we conclude that Mediator subunit Med1 acts as a pivotal coactivator for GATA-1 in erythroid development. ..
  7. Ghinassi B, Sanchez M, Martelli F, Amabile G, Vannucchi A, Migliaccio G, et al. The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood. 2007;109:1460-71 pubmed
    ..These results confirm the crucial role played by Gata1 in hematopoietic commitment and identify, as a new target for the Gata1 action, the restriction point at which common myeloid progenitors become either MEPs or MCPs. ..
  8. Dore L, Chlon T, Brown C, White K, Crispino J. Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood. 2012;119:3724-33 pubmed publisher
    ..Finally, by comparing GATA1 occupancy in erythroid cells and megakaryocytes, we find that the presence of ETS factor motifs is a major discriminator of megakaryocyte versus red cell specification...
  9. Deng W, Lee J, Wang H, Miller J, Reik A, Gregory P, et al. Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell. 2012;149:1233-44 pubmed publisher
    ..Our findings establish Ldb1 as a critical effector of GATA1-mediated loop formation and indicate that chromatin looping causally underlies gene regulation. ..
  10. Song S, Hou C, Dean A. A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell. 2007;28:810-22 pubmed
  11. Wang H, Zhang Y, Cheng Y, Zhou Y, King D, Taylor J, et al. Experimental validation of predicted mammalian erythroid cis-regulatory modules. Genome Res. 2006;16:1480-92 pubmed
    ..Genome-wide predictions based on RP and a large set of well-defined transcription factor binding sites are available through servers at http://www.bx.psu.edu/. ..
  12. Yao X, Kodeboyina S, Liu L, Dzandu J, Sangerman J, Ofori Acquah S, et al. Role of STAT3 and GATA-1 interactions in gamma-globin gene expression. Exp Hematol. 2009;37:889-900 pubmed publisher
    ..Therefore, we completed studies to determine if interactions between these two factors influence gamma-globin gene expression...
  13. Kadri Z, Shimizu R, Ohneda O, Maouche Chretien L, Gisselbrecht S, Yamamoto M, et al. Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis. PLoS Biol. 2009;7:e1000123 pubmed publisher
    ..These findings clarify the previously suspected cell-autonomous role of pRb during erythropoiesis and may provide a unifying molecular mechanism for several mouse phenotypes and human diseases associated with GATA-1 mutations. ..
  14. Stankiewicz M, Crispino J. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood. 2009;113:3337-47 pubmed publisher
    ..These findings provide evidence for synergy between alterations in GATA-1 and overexpression of ETS proteins in aberrant megakaryopoiesis. ..
  15. Xu J, Shao Z, Glass K, Bauer D, Pinello L, Van Handel B, et al. Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Dev Cell. 2012;23:796-811 pubmed publisher
  16. Suzuki M, Moriguchi T, Ohneda K, Yamamoto M. Differential contribution of the Gata1 gene hematopoietic enhancer to erythroid differentiation. Mol Cell Biol. 2009;29:1163-75 pubmed publisher
    ..These results demonstrate the physiological significance of the dynamic regulation of Gata1 gene expression in a differentiation stage-specific manner. ..
  17. Papetti M, Wontakal S, Stopka T, Skoultchi A. GATA-1 directly regulates p21 gene expression during erythroid differentiation. Cell Cycle. 2010;9:1972-80 pubmed
    ..Our findings indicate that p21 is a crucial downstream gene target and effector of GATA-1 during red blood cell terminal differentiation. ..
  18. Song S, Kim A, Ragoczy T, Bender M, Groudine M, Dean A. Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood. 2010;116:2356-64 pubmed publisher
    ..Ldb1 contributes these critical functions at both embryonic and adult stages of globin gene expression. These results implicate Ldb1 as a factor that facilitates nuclear relocation for transcription activation. ..
  19. Shimizu R, Trainor C, Nishikawa K, Kobayashi M, Ohneda K, Yamamoto M. GATA-1 self-association controls erythroid development in vivo. J Biol Chem. 2007;282:15862-71 pubmed
    ..These results provide the first convincing line of evidence that the self-association of GATA-1 is important for proper mammalian erythroid development in vivo. ..
  20. Hamlett I, Draper J, Strouboulis J, Iborra F, Porcher C, Vyas P. Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation. Blood. 2008;112:2738-49 pubmed publisher
    ..Finally, as ETO2 expression is restricted to immature megakaryocytes, these data suggest that ETO2 directly represses inappropriate early expression of a subset of terminally expressed megakaryocyte genes by binding to GATA1 and SCL. ..
  21. Huang S, Guo Y, May G, Enver T. Bifurcation dynamics in lineage-commitment in bipotent progenitor cells. Dev Biol. 2007;305:695-713 pubmed
  22. Kiefer C, Lee J, Hou C, Dale R, Lee Y, Meier E, et al. Distinct Ldb1/NLI complexes orchestrate ?-globin repression and reactivation through ETO2 in human adult erythroid cells. Blood. 2011;118:6200-8 pubmed publisher
    ..We conclude that alternative NLI complexes mediate ?-globin transcription or silencing through long-range LCR interactions involving an intergenic site of noncoding RNA transcription and that ETO2 is critical to this process...
  23. Woo A, Moran T, Schindler Y, Choe S, Langer N, Sullivan M, et al. Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development. Mol Cell Biol. 2008;28:2675-89 pubmed publisher
  24. Tallack M, Whitington T, Yuen W, Wainwright E, Keys J, Gardiner B, et al. A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res. 2010;20:1052-63 pubmed publisher
    ..Additionally, we suggest new mechanisms for KLF1 cooperation with other transcription factors, in particular the erythroid transcription factor GATA1, to maintain homeostasis in the erythroid compartment...
  25. Rodriguez P, Braun H, Kolodziej K, de Boer E, Campbell J, Bonte E, et al. Isolation of transcription factor complexes by in vivo biotinylation tagging and direct binding to streptavidin beads. Methods Mol Biol. 2006;338:305-23 pubmed
    ..Thus, BirA-mediated tagging is an efficient approach for the direct capture and characterization of transcription factor complexes. ..
  26. Zhu Y, Wang D, Wang F, Li T, Dong L, Liu H, et al. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Res. 2013;41:4129-43 pubmed publisher
    ..Furthermore, a protein tyrosine phosphatase, SHP2, was identified as a downstream target of miR-23a that mediated its regulation of erythropoiesis. Taken together, our data identify a key GATA-1-miRNA axis in erythroid differentiation...
  27. Kanezaki R, Toki T, Terui K, Xu G, Wang R, Shimada A, et al. Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia. Blood. 2010;116:4631-8 pubmed publisher
    ..001) and lower white blood cell counts (P = .004). Our study indicates that quantitative differences in mutant protein levels have significant effects on the phenotype of TAM and warrants further investigation in a prospective study. ..
  28. Malinge S, Bliss Moreau M, Kirsammer G, Diebold L, Chlon T, Gurbuxani S, et al. Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest. 2012;122:948-62 pubmed publisher
    ..Given that calcineurin/NFAT pathway inhibition has been implicated in the decreased tumor incidence in adults with DS, our results show that the same pathway can be both proleukemic in children and antitumorigenic in adults. ..
  29. Wontakal S, Guo X, Smith C, MacCarthy T, Bresnick E, Bergman A, et al. A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation. Proc Natl Acad Sci U S A. 2012;109:3832-7 pubmed publisher
  30. Huang Z, Dore L, Li Z, Orkin S, Feng G, Lin S, et al. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol. 2009;29:5168-80 pubmed publisher
    ..Moreover, our data reveal that overexpression of GATA-2 facilitates aberrant megakaryopoiesis. ..
  31. Kobayashi E, Shimizu R, Kikuchi Y, Takahashi S, Yamamoto M. Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domain. J Biol Chem. 2010;285:773-83 pubmed publisher
    ..The present study demonstrates that the IE exon is instrumental to adult erythropoiesis by regulating the proper level of transcription and selecting the correct transcription start site of the Gata1 gene. ..
  32. Layon M, Ackley C, West R, Lowrey C. Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression. J Mol Biol. 2007;366:737-44 pubmed
    ..These results imply that GATA-1 is sufficient to direct chromatin structure reorganization within the beta-globin LCR and an erythroid pattern of gene expression in the absence of other hematopoietic transcription factors. ..
  33. Johnson K, Boyer M, Kang J, Wickrema A, Cantor A, Bresnick E. Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function. Blood. 2007;109:5230-3 pubmed
    ..The identification of genes repressed by GATA-1 independent of FOG-1 defines a novel mode of GATA-1-mediated transcriptional regulation. ..
  34. Ayala R, Martinez Lopez J, Albizua E, Diez A, Gilsanz F. Clinical significance of Gata-1, Gata-2, EKLF, and c-MPL expression in acute myeloid leukemia. Am J Hematol. 2009;84:79-86 pubmed publisher
    ..Our study has identified expression of EKLF as a factor with a favorable impact on prognosis in AML. ..
  35. Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc C, Gregory G, et al. SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood. 2009;113:2191-201 pubmed publisher
    ..Together, these studies identify the SCL complex as a critical and consistent determinant of positive GATA-1 activity in multiple GATA-1-regulated hematopoietic cell lineages. ..
  36. Harju Baker S, Costa F, Fedosyuk H, Neades R, Peterson K. Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site. Mol Cell Biol. 2008;28:3101-13 pubmed publisher
  37. Nei Y, Obata Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, et al. GATA-1 regulates the generation and function of basophils. Proc Natl Acad Sci U S A. 2013;110:18620-5 pubmed publisher
    ..Our findings demonstrate that GATA-1 plays a key role in the generation and function of basophils and underscore the need for careful distinction of the cell lineage responsible for each phenotype observed in ?dblGATA mice. ..
  38. Kim S, Bultman S, Jing H, Blobel G, Bresnick E. Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation. Mol Cell Biol. 2007;27:4551-65 pubmed
    ..These studies defined a hierarchical order of GATA-1-triggered events at a complex locus and establish a novel mechanism of long-range gene regulation. ..
  39. Gutierrez L, Nikolic T, van Dijk T, Hammad H, Vos N, Willart M, et al. Gata1 regulates dendritic-cell development and survival. Blood. 2007;110:1933-41 pubmed
    ..Our findings show that Gata1 is a transcriptional regulator of dendritic cell differentiation and suggest that Gata1 is involved in the dendritic cell and macrophage lineage separation. ..
  40. Hasle H, Abrahamsson J, Arola M, Karow A, O Marcaigh A, Reinhardt D, et al. Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML. Leukemia. 2008;22:1428-30 pubmed
  41. McCrann D, Yezefski T, Nguyen H, Papadantonakis N, Liu H, Wen Q, et al. Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice. Blood. 2008;111:4092-5 pubmed publisher
    ..We conclude that elevated survivin expression does not alter MK/erythroid lineage development and that elevated survivin, alone, does not interfere with MK ploidy in vivo. ..
  42. Steger D, Lefterova M, Ying L, Stonestrom A, Schupp M, Zhuo D, et al. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol. 2008;28:2825-39 pubmed publisher
  43. Wilkinson White L, Gamsjaeger R, Dastmalchi S, Wienert B, Stokes P, Crossley M, et al. Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1. Proc Natl Acad Sci U S A. 2011;108:14443-8 pubmed publisher
  44. Toki T, Kanezaki R, Adachi S, Fujino H, Xu G, Sato T, et al. The key role of stem cell factor/KIT signaling in the proliferation of blast cells from Down syndrome-related leukemia. Leukemia. 2009;23:95-103 pubmed publisher
    ..These results suggest the essential role of SCF/KIT signaling in the proliferation of DS-related leukemia and the possibility of therapeutic benefits of imatinib for TL patients. ..
  45. McKimmie C, Fraser A, Hansell C, Gutierrez L, Philipsen S, Connell L, et al. Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. J Immunol. 2008;181:8171-81 pubmed
    ..These data therefore alter our models of in vivo D6 function and suggest possible discrete, and novel, roles for D6 on lymphatic endothelial cells and leukocytes. ..
  46. Shimokawa N, Nishiyama C, Nakano N, Maeda K, Suzuki R, Hara M, et al. Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells. Immunogenetics. 2010;62:421-9 pubmed publisher
    ..These results indicate that GATA-1 suppresses PU.1 function but not PU.1 transcription. Thus, GATA-1 appears to determine cell fate by regulating several cell-specific transcription factors. ..
  47. Chen Z, Luo H, Basran R, Hsu T, Mang D, Nuntakarn L, et al. A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F. Mol Cell Biol. 2008;28:4386-93 pubmed publisher
    ..The T-to-G mutation in this motif disrupts GATA-1 binding and the associated repressor complex, abolishing its silencing effect and resulting in the up-regulation of gamma-globin gene expression in adults. ..
  48. Tijssen M, Cvejic A, Joshi A, Hannah R, Ferreira R, Forrai A, et al. Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20:597-609 pubmed publisher
    ..Multifactor ChIP-Seq analysis in primary human cells coupled with a high-throughput in vivo perturbation screen therefore offers a powerful strategy to identify essential regulators of complex mammalian differentiation processes...
  49. Yu L, Ji W, Zhang H, Renda M, He Y, Lin S, et al. SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. J Exp Med. 2010;207:1183-95 pubmed publisher
    ..Collectively, we conclude that SENP1 promotes GATA1 activation and subsequent erythropoiesis by deSUMOylating GATA1. ..
  50. Chickarmane V, Enver T, Peterson C. Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility. PLoS Comput Biol. 2009;5:e1000268 pubmed publisher
    ..The approach points to a framework for lineage commitment studies in general and could aid the search for lineage-determining genes. ..
  51. Xu J, Sankaran V, Ni M, Menne T, Puram R, Kim W, et al. Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev. 2010;24:783-98 pubmed publisher
    ..Our findings provide insight into the mechanism of BCL11A action and new clues for the developmental gene regulatory programs that function at the beta-globin locus...
  52. Chou S, Khandros E, Bailey L, Nichols K, Vakoc C, Yao Y, et al. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood. 2009;114:983-94 pubmed publisher
    ..Our findings indicate that GATA factors act sequentially to regulate lineage determination during hematopoiesis, in part by exerting variable repressive effects at the PU.1/Sfpi1 locus. ..
  53. Gregory G, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, et al. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood. 2010;115:2156-66 pubmed publisher
    ..Instead, the continuous presence of GATA1, FOG1, and NuRD is required to maintain lineage fidelity throughout MK-erythroid ontogeny...