gata transcription factors

Summary

Summary: A family of transcription factors that contain two ZINC FINGER MOTIFS and bind to the DNA sequence (A/T)GATA(A/G).

Top Publications

  1. Pelletier B, Trott A, Morano K, Labbe S. Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. J Biol Chem. 2005;280:25146-61 pubmed
    ..Moreover, mutations that impair dimerization also negatively affect transcriptional repression. Together these findings reveal several novel features of Fep1, a non-canonical GATA factor required for iron homeostasis. ..
  2. Muratoglu S, Hough B, Mon S, Fossett N. The GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development. Dev Biol. 2007;311:636-49 pubmed
  3. Chiang Y, Zubo Y, Tapken W, Kim H, Lavanway A, Howard L, et al. Functional characterization of the GATA transcription factors GNC and CGA1 reveals their key role in chloroplast development, growth, and division in Arabidopsis. Plant Physiol. 2012;160:332-48 pubmed publisher
  4. Chun C, Brown J, Madhani H. A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host Microbe. 2011;9:243-251 pubmed publisher
    ..This genetic dissection provides evidence that capsule-independent antiphagocytic mechanisms are pivotal for successful mammalian infection by C. neoformans...
  5. Ishijima Y, Ohmori S, Uenishi A, Ohneda K. GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-?1. Genes Cells. 2012;17:285-301 pubmed publisher
    ..These data indicate that PLC-?1 is a target gene of GATA factors in mast cells and provide evidence that GATA1 and GATA2 control antigen-mediated mast cell degranulation by regulating the expression of PLC-?1. ..
  6. Takayama Y, Takahashi K. Differential regulation of repeated histone genes during the fission yeast cell cycle. Nucleic Acids Res. 2007;35:3223-37 pubmed
    ..These observations provide insight into the molecular mechanisms of differential regulation of transcripts from repeated histone genes in the fission yeast. ..
  7. Cunningham T, Andhare R, Cooper T. Nitrogen catabolite repression of DAL80 expression depends on the relative levels of Gat1p and Ure2p production in Saccharomyces cerevisiae. J Biol Chem. 2000;275:14408-14 pubmed
    ..e. with proline as the sole nitrogen source. Enhanced green fluorescent protein-Gat1p is nuclear when Gat1p-dependent transcription is high and cytoplasmic when it is inhibited by overproduction of Ure2p. ..
  8. Koh K, Rothman J. ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans. Development. 2001;128:2867-80 pubmed
    ..Collectively, these findings indicate that elt-5 and -6 function continuously throughout C. elegans development to regulate seam cell differentiation and cell fusion. ..
  9. Bi Y, Zhang Y, Signorelli T, Zhao R, Zhu T, Rothstein S. Genetic analysis of Arabidopsis GATA transcription factor gene family reveals a nitrate-inducible member important for chlorophyll synthesis and glucose sensitivity. Plant J. 2005;44:680-92 pubmed
    ..These observations suggest a function for GNC in regulating carbon and nitrogen metabolism. ..

More Information

Publications62

  1. Harrison K, Marzluf G. Characterization of DNA binding and the cysteine rich region of SRE, a GATA factor in Neurospora crassa involved in siderophore synthesis. Biochemistry. 2002;41:15288-95 pubmed
    ..The combined results of mobility shift assays, siderophore synthesis assays, and ornithine oxygenase enzyme activity determinations demonstrate that these mutants with cysteine substitutions have a dominant repressor phenotype. ..
  2. Napierala D, Sam K, Morello R, Zheng Q, Munivez E, Shivdasani R, et al. Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet. 2008;17:2244-54 pubmed publisher
    ..Collectively, these data suggest that skeletal dysplasia in TRPS is caused by dysregulation of chondrocyte and perichondrium development partially due to loss of Trps1 repression of Runx2. ..
  3. Cassata G, Shemer G, Morandi P, Donhauser R, Podbilewicz B, Baumeister R. ceh-16/engrailed patterns the embryonic epidermis of Caenorhabditis elegans. Development. 2005;132:739-49 pubmed
  4. Campbell K, Whissell G, Franch Marro X, Batlle E, Casanova J. Specific GATA factors act as conserved inducers of an endodermal-EMT. Dev Cell. 2011;21:1051-61 pubmed publisher
    ..Together, these results identify a set of GATA factors as a conserved alternative trigger to repress epithelial characteristics and confer migratory capabilities on epithelial cells in development and pathogenesis. ..
  5. Bresnick E, Katsumura K, Lee H, Johnson K, Perkins A. Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res. 2012;40:5819-31 pubmed publisher
    ..This article highlights GATA factor mechanistic principles, with a heavy emphasis on GATA-1 and GATA-2 functions in the hematopoietic system, and new links between GATA-2 dysregulation and human pathophysiologies. ..
  6. Fukushige T, Hawkins M, McGhee J. The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine. Dev Biol. 1998;198:286-302 pubmed
    ..We discuss whether elements of this regulatory network may be conserved in all metazoa. ..
  7. Rohlfing A, Miteva Y, Hannenhalli S, Lamitina T. Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans. PLoS ONE. 2010;5:e9010 pubmed publisher
    ..Computational, transgenic, and functional approaches revealed that two GATA transcription factors previously implicated in infection-induced transcriptional responses, elt-2 and elt-3, are also ..
  8. Maduro M, Hill R, Heid P, Newman Smith E, Zhu J, Priess J, et al. Genetic redundancy in endoderm specification within the genus Caenorhabditis. Dev Biol. 2005;284:509-22 pubmed
    ..briggsae end genes also function redundantly to specify endoderm. We propose that duplicated end genes have been maintained over long periods of evolution, owing in part to their synergistic function. ..
  9. Manfield I, Devlin P, Jen C, Westhead D, Gilmartin P. Conservation, convergence, and divergence of light-responsive, circadian-regulated, and tissue-specific expression patterns during evolution of the Arabidopsis GATA gene family. Plant Physiol. 2007;143:941-58 pubmed
    In vitro analyses of plant GATA transcription factors have implicated some proteins in light-mediated and circadian-regulated gene expression, and, more recently, the analysis of mutants has uncovered further diverse roles for plant GATA ..
  10. Krstic A, Kocic J, Ilic V, Mojsilovic S, Okic Dordevic I, Trivanovic D, et al. Effects of IL-17 on erythroid progenitors growth: involvement of MAPKs and GATA transcription factors. J Biol Regul Homeost Agents. 2012;26:641-52 pubmed
    ..aim of the present study was to investigate the involvement of other MAPKs, JNK and ERK1/2, as well as GATA transcription factors, in IL-17-mediated effects on murine bone marrow erythroid progenitors...
  11. Pelletier B, Beaudoin J, Philpott C, Labbe S. Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system. Nucleic Acids Res. 2003;31:4332-44 pubmed
    ..Taken together, these results demonstrate that Fep1 occupies a central role in coordinating transcriptional regulation of genes encoding components of the reductive and non-reductive iron transport systems in fission yeast. ..
  12. Gillis W, BOWERMAN B, Schneider S. The evolution of protostome GATA factors: molecular phylogenetics, synteny, and intron/exon structure reveal orthologous relationships. BMC Evol Biol. 2008;8:112 pubmed publisher
    Invertebrate and vertebrate GATA transcription factors play important roles in ectoderm and mesendoderm development, as well as in cardiovascular and blood cell fate specification...
  13. Wuelling M, Kaiser F, Buelens L, Braunholz D, Shivdasani R, Depping R, et al. Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol. 2009;328:40-53 pubmed publisher
    ..The differentiation of columnar and hypertrophic chondrocytes is supported by Trps1 independent of Gli3. Trps1 seems thus to organize chondrocyte differentiation interacting with different subsets of co-factors in distinct cell types. ..
  14. Pujol N, Zugasti O, Wong D, Couillault C, Kurz C, Schulenburg H, et al. Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides. PLoS Pathog. 2008;4:e1000105 pubmed publisher
    ..Our results suggest that selective pressure from pathogens influences intra-genomic diversification of AMPs and reveal an unexpected complexity in AMP regulation as part of the invertebrate innate immune response. ..
  15. Lebestky T, Chang T, Hartenstein V, Banerjee U. Specification of Drosophila hematopoietic lineage by conserved transcription factors. Science. 2000;288:146-9 pubmed
    ..Given the similarities of Srp and Lz to mammalian GATA and AML1 proteins, observations in Drosophila are likely to have broad implications for understanding mammalian hematopoiesis and leukemias. ..
  16. Scherzer C, Grass J, Liao Z, Pepivani I, Zheng B, Eklund A, et al. GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proc Natl Acad Sci U S A. 2008;105:10907-12 pubmed publisher
    ..This critical link between GATA factors and SNCA may enable therapies designed to lower alpha-synuclein production. ..
  17. Nishioka K, Itoh S, Suemoto H, Kanno S, Gai Z, Kawakatsu M, et al. Trps1 deficiency enlarges the proliferative zone of growth plate cartilage by upregulation of Pthrp. Bone. 2008;43:64-71 pubmed publisher
    ..Taken together, these data provide the first genetic evidence that lack of Trps1 leads to overexpression of PTHrP, and that Trps1 is required to maintain the normal organization of chondrocytes in the growth plate. ..
  18. Pelletier B, Beaudoin J, Mukai Y, Labbe S. Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe. J Biol Chem. 2002;277:22950-8 pubmed
    ..This suggests that in the presence of iron and Fep1, the Tup11 and Tup12 proteins may act as co-repressors for down-regulation of genes encoding components of the reductive iron transport machinery. ..
  19. Bai H, Sakurai T, Kim M, Muroi Y, Ideta A, Aoyagi Y, et al. Involvement of GATA transcription factors in the regulation of endogenous bovine interferon-tau gene transcription. Mol Reprod Dev. 2009;76:1143-52 pubmed publisher
    ..These data suggest that GATA2/3 is involved in trophoblast-specific regulation of bIFNT gene transcription. ..
  20. Pauli F, Liu Y, Kim Y, Chen P, Kim S. Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans. Development. 2006;133:287-95 pubmed
    ..We experimentally verified these results by showing that the GATA motif is required in cis and that GATA transcription factors are required in trans for expression of these intestinal genes.
  21. Shapira M, Hamlin B, Rong J, Chen K, Ronen M, Tan M. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci U S A. 2006;103:14086-91 pubmed
    ..genome-wide study performed in Caenorhabditis elegans, we identified a conserved function for endodermal GATA transcription factors in regulating local epithelial innate immune responses...
  22. Hayes S, Miller J, Hoshizaki D. serpent, a GATA-like transcription factor gene, induces fat-cell development in Drosophila melanogaster. Development. 2001;128:1193-200 pubmed
    ..In light of our results, we discuss the role of serpent in fat-cell specification and in cell fate choices. ..
  23. Lin W, Huang L, Yeh J, Hoheisel J, Lehrach H, Sun Y, et al. Expression of a Drosophila GATA transcription factor in multiple tissues in the developing embryos. Identification of homozygous lethal mutants with P-element insertion at the promoter region. J Biol Chem. 1995;270:25150-8 pubmed
    b>GATA transcription factors are DNA-binding proteins that recognize the core consensus sequence, WGATAR. Previous studies indicated that GATA factors play ann important role in the development of tissue-specific functions in vertebrates...
  24. Abel T, Michelson A, Maniatis T. A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development. 1993;119:623-33 pubmed
    ..Together with the established role of GATA factors during mammalian development, these results suggest that ABF may play a key role in the organogenesis of the fat body. ..
  25. Frandsen J, Gunn B, Muratoglu S, Fossett N, Newfeld S. Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune responses in Drosophila. Proc Natl Acad Sci U S A. 2008;105:14952-7 pubmed publisher
    ..These results also demonstrate that combining Drosophila and Salmonella genetics can provide novel opportunities for advancing our knowledge of hematopoiesis and innate immunity. ..
  26. Sher N, Yivgi Ohana N, Orly J. Transcriptional regulation of the cholesterol side chain cleavage cytochrome P450 gene (CYP11A1) revisited: binding of GATA, cyclic adenosine 3',5'-monophosphate response element-binding protein and activating protein (AP)-1 proteins to a distal nove. Mol Endocrinol. 2007;21:948-62 pubmed
    ..These observations suggest that placental regulation of P450scc expression is subjected to alternative signaling pathway(s) yet to be found. ..
  27. Hudson D, Guevara D, Yaish M, Hannam C, Long N, Clarke J, et al. GNC and CGA1 modulate chlorophyll biosynthesis and glutamate synthase (GLU1/Fd-GOGAT) expression in Arabidopsis. PLoS ONE. 2011;6:e26765 pubmed publisher
    ..The paralog GATA transcription factors GNC and CGA1/GNL up-regulated by light, nitrogen and cytokinin while also being repressed by GA ..
  28. Katoh M, Katoh M. Integrative genomic analyses of WNT11: transcriptional mechanisms based on canonical WNT signals and GATA transcription factors signaling. Int J Mol Med. 2009;24:247-51 pubmed
    ..Canonical WNT-to-WNT11 signaling loop is involved in cellular migration during embryogenesis as well as tumor invasion during carcinogenesis. ..
  29. Shankar K, Zhong Y, Kang P, Blackburn M, Soares M, Badger T, et al. RNA-seq analysis of the functional compartments within the rat placentation site. Endocrinology. 2012;153:1999-2011 pubmed publisher
    ..The present dataset provides a novel resource to understand zonal gene expression and function in the placenta. ..
  30. Hwang L, Seth E, Gilmore S, Sil A. SRE1 regulates iron-dependent and -independent pathways in the fungal pathogen Histoplasma capsulatum. Eukaryot Cell. 2012;11:16-25 pubmed publisher
    ..These data highlight the evolving realization that the effect of Sre1 orthologs on fungal biology extends beyond the iron regulon. ..
  31. Liao W, Ramon A, Fonzi W. GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. albicans. Fungal Genet Biol. 2008;45:514-26 pubmed
    ..We conclude that GLN3 has a broad role in nitrogen metabolism, partially overlapping, but distinct from that of GAT1, and that its function is important for the ability of C. albicans to survive within the host environment. ..
  32. Burmeister C, Lüersen K, Heinick A, Hussein A, Domagalski M, Walter R, et al. Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO-1). FASEB J. 2008;22:343-54 pubmed
    ..Specific silencing of the GSTO-1 by RNAi created worms with an increased sensitivity to several prooxidants, arsenite, and heat shock. We conclude that the stress-responsive GSTO-1 plays a key role in counteracting environmental stress. ..
  33. Zhu J, Fukushige T, McGhee J, Rothman J. Reprogramming of early embryonic blastomeres into endodermal progenitors by a Caenorhabditis elegans GATA factor. Genes Dev. 1998;12:3809-14 pubmed
    ..This suggests that a primary function of these maternal factors is to regulate zygotic end-1 expression, which is then sufficient to initiate the entire program for endoderm development. ..
  34. Oberegger H, Zadra I, Schoeser M, Abt B, Parson W, Haas H. Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization. Biochem Soc Trans. 2002;30:781-3 pubmed
    ..The functional characterization of these genes will help to unravel the pathways involved in siderophore biosynthesis and uptake...
  35. Fossett N, Hyman K, Gajewski K, Orkin S, Schulz R. Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Proc Natl Acad Sci U S A. 2003;100:11451-6 pubmed
    ..These findings provide definitive proof of the combinatorial regulation of hematopoiesis in Drosophila and an in vivo demonstration of GATA and Runx functional interaction in a blood cell commitment program. ..
  36. Fukushige T, Goszczynski B, Tian H, McGhee J. The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans. Genetics. 2003;165:575-88 pubmed
    ..Although elt-4 must confer (or must have conferred) some selective advantage to C. elegans, we suggest that its ultimate evolutionary fate will be disappearance from the C. elegans genome. ..
  37. Stanbrough M, Rowen D, Magasanik B. Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes. Proc Natl Acad Sci U S A. 1995;92:9450-4 pubmed
    ..The results further indicate that Gln3p is inactivated by an increase in the intracellular concentration of glutamine and that Nil1p is inactivated by an increase in intracellular glutamate. ..
  38. Chao L, Marletta M, Rine J. Sre1, an iron-modulated GATA DNA-binding protein of iron-uptake genes in the fungal pathogen Histoplasma capsulatum. Biochemistry. 2008;47:7274-83 pubmed publisher
    ..The loss of iron led to a approximately 2.5-fold decrease in DNA-binding affinity, indicating that iron was directly involved in SRE1 regulation of iron-uptake genes. ..
  39. Haas H, Zadra I, Stoffler G, Angermayr K. The Aspergillus nidulans GATA factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake. J Biol Chem. 1999;274:4613-9 pubmed
    ..These results demonstrate that SREA plays a central role in iron uptake in addition to siderophore biosynthesis. ..
  40. Gilleard J, Shafi Y, Barry J, McGhee J. ELT-3: A Caenorhabditis elegans GATA factor expressed in the embryonic epidermis during morphogenesis. Dev Biol. 1999;208:265-80 pubmed
    ..Many features of the elt-3 genomic and transcript structure are conserved between the two species, suggesting that elt-3 is likely to perform an evolutionarily significant function during development. ..
  41. Fukushige T, Goszczynski B, Yan J, McGhee J. Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine. Dev Biol. 2005;279:446-61 pubmed
    ..We suggest that pho-1 is required by the maternal intestine to assimilate some nutrient or cleavage product that is subsequently provided to the next generation of embryos. ..
  42. Lee I, Chow E, Morrow C, Djordjevic J, Fraser J. Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans. Genetics. 2011;188:309-23 pubmed publisher
    ..Since GATA transcription factors are known to play a key role in nitrogen metabolite repression, bioinformatic analyses of the C...
  43. Takahashi K, Takayama Y, Masuda F, Kobayashi Y, Saitoh S. Two distinct pathways responsible for the loading of CENP-A to centromeres in the fission yeast cell cycle. Philos Trans R Soc Lond B Biol Sci. 2005;360:595-606; discussion 606-7 pubmed
    ..Here, we discuss the functional relationship between the flexible loading mechanism of CENP-A and the plasticity of centromere chromatin formation in fission yeast. ..
  44. Schrettl M, Beckmann N, Varga J, Heinekamp T, Jacobsen I, Jöchl C, et al. HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS Pathog. 2010;6:e1001124 pubmed publisher
    ..Taken together, this study demonstrates that HapX-dependent adaption to conditions of iron starvation is crucial for virulence of A. fumigatus. ..
  45. Tokusumi Y, Tokusumi T, Stoller Conrad J, Schulz R. Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis. Development. 2010;137:3561-8 pubmed publisher
  46. Richter R, Behringer C, Müller I, Schwechheimer C. The GATA-type transcription factors GNC and GNL/CGA1 repress gibberellin signaling downstream from DELLA proteins and PHYTOCHROME-INTERACTING FACTORS. Genes Dev. 2010;24:2093-104 pubmed publisher
    ..These findings, together with the fact that gnc and gnl loss-of-function mutations suppress ga1 phenotypes, support the hypothesis that GNC and GNL are important repressors of GA signaling downstream from the DELLA and PIF regulators. ..
  47. Goszczynski B, McGhee J. Reevaluation of the role of the med-1 and med-2 genes in specifying the Caenorhabditis elegans endoderm. Genetics. 2005;171:545-55 pubmed
    ..Furthermore, we found no evidence for a maternal contribution of the med genes to endoderm specification. We conclude that the major pathway(s) for endoderm specification in C. elegans must be independent of the med-1 and med-2 genes. ..
  48. Smith J, McGarr P, Gilleard J. The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion. J Cell Sci. 2005;118:5709-19 pubmed
    ..These results suggest that elt-1 is a key regulator of neuronal function in larvae and adult worms. ..
  49. Harigae H. GATA transcription factors and hematological diseases. Tohoku J Exp Med. 2006;210:1-9 pubmed
    ..Based on these lines of evidence, some types of hematological diseases may be defined as transcription factor diseases. ..
  50. Mercier A, Labbe S. Both Php4 function and subcellular localization are regulated by iron via a multistep mechanism involving the glutaredoxin Grx4 and the exportin Crm1. J Biol Chem. 2009;284:20249-62 pubmed publisher
    ..Taken together, our findings indicate that Grx4 and Crm1 are novel components involved in the mechanism by which Php4 is inactivated by iron in a Fep1-independent manner. ..
  51. Senger K, Harris K, Levine M. GATA factors participate in tissue-specific immune responses in Drosophila larvae. Proc Natl Acad Sci U S A. 2006;103:15957-62 pubmed
    ..Based on this evidence we propose that dGATAe mediates a Toll-independent immune response in the midgut, providing a window into the first and perhaps most ancient line of animal defense. ..
  52. Kerry S, TeKippe M, Gaddis N, Aballay A. GATA transcription factor required for immunity to bacterial and fungal pathogens. PLoS ONE. 2006;1:e77 pubmed
    ..Our results indicate that ELT-2 is part of a multi-pathogen defense pathway that regulates innate immunity independently of the DAF-2/DAF-16 signaling pathway. ..
  53. Fantauzzo K, Tadin Strapps M, You Y, Mentzer S, Baumeister F, Cianfarani S, et al. A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice. Hum Mol Genet. 2008;17:3539-51 pubmed publisher
    ..Collectively, these results describe a position effect that downregulates TRPS1 expression as the probable cause of hypertrichosis in AS in humans and the Koa phenotype in mice...