selenoprotein w

Summary

Summary: A single SELENOCYSTEINE containing protein that binds reduced GLUTATHIONE and can act as an antioxidant.

Top Publications

  1. Kipp A, Frombach J, Deubel S, Brigelius Flohe R. Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis. Methods Enzymol. 2013;527:87-112 pubmed publisher
    ..At the protein level, SepW1 responded as well as GPx1 and at the mRNA level, even better. Thus, the outcome of selenium treatment strongly depends on the chemical form, the cell type, and the biomarker used for testing efficacy. ..
  2. Li J, Li H, Li S, Jiang Z, Xu S, Tang Z. Selenoprotein W gene expression in the gastrointestinal tract of chicken is affected by dietary selenium. Biometals. 2011;24:291-9 pubmed publisher
    b>Selenoprotein W (SelW) and selenium (Se) plays important roles in gastrointestinal function and that SelW expression in the gastrointestinal system of mammals is sensitive to Se levels...
  3. Pagmantidis V, Bermano G, Villette S, Broom I, Arthur J, Hesketh J. Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. FEBS Lett. 2005;579:792-6 pubmed
    ..05) falls in glutathione peroxidase (GPX) 1 mRNA (60-83%) and selenoprotein W mRNA (73%) levels, a small but significant fall in GPX4 mRNA (17-25%) but no significant change in GPX2...
  4. Amantana A, Vorachek W, Butler J, Ream W, Whanger P. Identification of putative transcription factor binding sites in rodent selenoprotein W promoter. J Inorg Biochem. 2004;98:1513-20 pubmed
    To understand transcriptional regulation of the selenoprotein W (SeW) gene, we used in vitro binding assays to identify transcription factors that may be involved in the transcriptional regulation of the SeW gene...
  5. Noh O, Park Y, Chung Y, Kim I. Transcriptional regulation of selenoprotein W by MyoD during early skeletal muscle differentiation. J Biol Chem. 2010;285:40496-507 pubmed publisher
    b>Selenoprotein W (SelW) is expressed in various tissues, but it is especially high in the skeletal muscle of mammals. Such tissue-specific protein expression implies regulation by a tissue-specific factor...
  6. Li J, Ruan H, Li H, Li S, Xu S, Tang Z. Molecular cloning, characterization and mRNA expression analysis of a novel selenoprotein: avian selenoprotein W from chicken. Mol Biol Rep. 2011;38:4015-22 pubmed publisher
    In this study, a novel avian selenoprotein W (SelW) gene was cloned from chicken cerebral tissue. The complete nucleotide sequence of the gene contained a 258 bp open reading frame encoding 85 amino acids...
  7. Hawkes W, Wang T, Alkan Z, Richter B, Dawson K. Selenoprotein W modulates control of cell cycle entry. Biol Trace Elem Res. 2009;131:229-44 pubmed publisher
    ..8 x 10(-16)). Selenoprotein W (SEPW1) was the only selenoprotein messenger RNA (mRNA) increased by both sodium selenite (specific) and high-..
  8. Loflin J, Lopez N, Whanger P, Kioussi C. Selenoprotein W during development and oxidative stress. J Inorg Biochem. 2006;100:1679-84 pubmed
    ..Selenium deficiency is harmful to brain, heart and skeletal muscles. Selenoprotein W, a member of the selenoprotein family was expressed in developing nervous system, skeletal muscles and heart ..
  9. Wang R, Sun B, Zhang Z, Li S, Xu S. Dietary selenium influences pancreatic tissue levels of selenoprotein W in chickens. J Inorg Biochem. 2011;105:1156-60 pubmed publisher
    Selenium (Se) influences the levels of selenoprotein W (SelW) in mammals. However, little is known about the pattern of SelW expression in the pancreatic tissue of birds...

More Information

Publications62

  1. Gao X, Xing H, Li S, Li J, Ying T, Xu S. Selenium regulates gene expression of selenoprotein W in chicken gastrointestinal tract. Biol Trace Elem Res. 2012;145:181-8 pubmed publisher
    b>Selenoprotein W (SelW) is an existing form of selenium (Se). Se influences the levels of SelW in mammals. However, little is known about the pattern of SelW expression in the gastrointestinal tract tissue of bird...
  2. Bauman A, Malencik D, Barofsky D, Barofsky E, Anderson S, Whanger P. Selective production of rat mutant selenoprotein W with and without bound glutathione. Biochem Biophys Res Commun. 2004;313:308-13 pubmed
    ..electrospray ionization mass spectrometry (ESI MS) analysis of a 6x His-tagged recombinant form of rat mutant selenoprotein W (RMSW) reveals that aerobic growth conditions primarily produce a form of RMSW without bound glutathione (10,..
  3. Gu Q, Ream W, Whanger P. Selenoprotein W gene regulation by selenium in L8 cells. Biometals. 2002;15:411-20 pubmed
    The effects of selenium on selenoprotein W gene expression were examined in cultured L8 rat skeletal muscle cells...
  4. Amantana A, Vorachek W, Butler J, Costa N, Whanger P. Effect of copper, zinc and cadmium on the promoter of selenoprotein W in glial and myoblast cells. J Inorg Biochem. 2002;91:356-62 pubmed
    Rat selenoprotein W (SeW) promoter activity was investigated using different concentrations of cadmium, copper, and zinc...
  5. Yeh J, Beilstein M, Andrews J, Whanger P. Tissue distribution and influence of selenium status on levels of selenoprotein W. FASEB J. 1995;9:392-6 pubmed
    Rabbits were immunized with two synthetic peptides based on hydrophilic regions of selenoprotein W from rat muscle...
  6. Jeong D, Kim T, Chung Y, Lee B, Kim I. Selenoprotein W is a glutathione-dependent antioxidant in vivo. FEBS Lett. 2002;517:225-8 pubmed
    The function of selenoprotein W (Se-W) was investigated by cloning the corresponding cDNA from mouse brain and expressing it in CHO cells and H1299 human lung cancer cells...
  7. Bellingham J, Gregory Evans K, Fox M, Gregory Evans C. Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P. Biochim Biophys Acta. 2003;1627:140-6 pubmed
    We have determined that the human SEPW1 (selenoprotein W) gene maps to chromosome 19q13.3, spans approximately 6.3 kb and comprises six exons, in contrast to the previously published five exons...
  8. Jeong D, Kim E, Kim T, Chung Y, Kim H, Kim I. Different distributions of selenoprotein W and thioredoxin during postnatal brain development and embryogenesis. Mol Cells. 2004;17:156-9 pubmed
    Whereas the levels of other selenoproteins in the brain decrease when selenium is deficient, the level of selenoprotein W (Se-W) is maintained, suggesting that it has a critical role in the brain...
  9. Xiao Long W, Chuan Ping Y, Kai X, Ou Jv Q. Selenoprotein W depletion in vitro might indicate that its main function is not as an antioxidative enzyme. Biochemistry (Mosc). 2010;75:201-7 pubmed
    Examination of the antioxidative homeostasis in skeletal muscle cells in the presence or absence of selenoprotein W (SelW) is necessary to understand the importance of SelW in the antioxidative system...
  10. Sengupta A, Carlson B, Labunskyy V, Gladyshev V, Hatfield D. Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells. Biochem Cell Biol. 2009;87:953-61 pubmed publisher
    ..Furthermore, we found that the loss of SelT elevates expression of another selenoprotein, selenoprotein W (SepW1)...
  11. Kim Y, Chai Y, Ryu J. Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion. Biochem Biophys Res Commun. 2005;330:1095-102 pubmed
    ..neuronal cell line, SH-SY5Y, to MeHg dose- and time-dependently impairs viability and mRNA expression of selenoprotein W (SeW) with a significant difference, unlike other selenoenzymes such as, SeP, GPX4, 5DI, and 5'DI...
  12. Musiani F, Ciurli S, Dikiy A. Interaction of selenoprotein W with 14-3-3 proteins: a computational approach. J Proteome Res. 2011;10:968-76 pubmed publisher
  13. Whanger P. Selenoprotein expression and function-selenoprotein W. Biochim Biophys Acta. 2009;1790:1448-52 pubmed publisher
    b>Selenoprotein W (SeW) is a small selenoprotein (85 to 88 amino acids) first identified in sheep suffering from selenium deficiency. The levels are highest in muscle, heart (except rodents) spleen and brain...
  14. Li J, Li H, Li S, Gao X, Xu S, Tang Z. Effects of Selenoprotein W gene expression by selenium involves regulation of mRNA stability in chicken embryos neurons. Biometals. 2012;25:459-68 pubmed publisher
    Selenium (Se) and Selenoprotein W (SelW) plays a pivotal role in the brain development, function, and degeneration and that SelW expression in the brain may be affected by Se...
  15. Chen J, Berry M. Selenium and selenoproteins in the brain and brain diseases. J Neurochem. 2003;86:1-12 pubmed
    ..mRNAs for other selenoproteins, including selenoprotein W, thioredoxin reductases, 15-kDa selenoprotein and type 2 iodothyronine deiodinase, are also detected in the ..
  16. Kryukov G, Gladyshev V. Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues. Genes Cells. 2000;5:1049-60 pubmed
    ..Our data also suggest that the utilization of Sec is more common in zebrafish than in previously characterized species, including mammals. ..
  17. Zhang Q, Chen L, Guo K, Zheng L, Liu B, Yu W, et al. Effects of different selenium levels on gene expression of a subset of selenoproteins and antioxidative capacity in mice. Biol Trace Elem Res. 2013;154:255-61 pubmed publisher
    ..mRNA levels of GPx isoforms 1 and 4 (GPx1 and GPx4), down-regulated GPx isoform 3 (GPx3), and upregulated selenoprotein W (SelW) mRNA expression...
  18. De Luisi A, Ferrucci A, Coluccia A, Ria R, Moschetta M, de Luca E, et al. Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma. Clin Cancer Res. 2011;17:1935-46 pubmed publisher
    ..This study provides information on the molecular mechanisms associated with the antimigratory and antiangiogenic effects of lenalidomide in primary MMECs, thus giving new avenues for effective endothelium-targeted therapies in MM. ..
  19. Han Y, Zhang Z, Su J, Zhang B, Li S, Xu S. Effects of chicken selenoprotein W on H2O2-induced apoptosis in CHO-K1 cells. Biol Trace Elem Res. 2012;147:395-402 pubmed publisher
    b>Selenoprotein W (SelW) is expressed in various tissues of many animals and acts as an oxidoreductase in mammals. However, little is known about the role of the SelW in birds...
  20. Novoselov S, Rao M, Onoshko N, Zhi H, Kryukov G, Xiang Y, et al. Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii. EMBO J. 2002;21:3681-93 pubmed
    ..reinhardtii, and directly identified two of them as phospholipid hydroperoxide glutathione peroxidase and selenoprotein W homologs. Moreover, a selenocysteyl-tRNA was isolated that recognized specifically the Sec codon UGA...
  21. Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, et al. Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem. 2011;286:9031-7 pubmed publisher
    ..Our results underscore a novel mechanism for epigenetic dysregulation in Lewy body diseases, which might underlie the decrease in DNA methylation reported for PD and DLB. ..
  22. Sun B, Wang R, Li J, Jiang Z, Xu S. Dietary selenium affects selenoprotein W gene expression in the liver of chicken. Biol Trace Elem Res. 2011;143:1516-23 pubmed publisher
    As selenium in the form of "Selenoprotein W (SelW)" is essential for the maintenance of normal liver function, the expression of SelW liver depends on the level of selenium supplied with the diet...
  23. Hawkes W, Alkan Z. Delayed cell cycle progression from SEPW1 depletion is p53- and p21-dependent in MCF-7 breast cancer cells. Biochem Biophys Res Commun. 2011;413:36-40 pubmed publisher
    ..b>Selenoprotein W (SEPW1) is a highly conserved small thioredoxin-like protein required for cell cycle progression...
  24. Rage F, Boulisfane N, Rihan K, Neel H, Gostan T, Bertrand E, et al. Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localization. RNA. 2013;19:1755-66 pubmed publisher
    ..Moreover, they localize in cell processes in an SMN-dependent manner. Thus, low SMN levels might result in localization deficiencies of mRNAs required for axonogenesis. ..
  25. Ruan H, Zhang Z, Wu Q, Yao H, Li J, Li S, et al. Selenium regulates gene expression of selenoprotein W in chicken skeletal muscle system. Biol Trace Elem Res. 2012;145:59-65 pubmed publisher
    b>Selenoprotein W (SelW) is abundantly expressed in skeletal muscles of mammals and necessary for the metabolism of skeletal muscles. However, its expression pattern in skeletal muscle system of birds is still uncovered...
  26. Kipp A, Banning A, van Schothorst E, Méplan C, Schomburg L, Evelo C, et al. Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon. Mol Nutr Food Res. 2009;53:1561-72 pubmed publisher
    ..Modulation of cancer-related pathways may contribute to the higher susceptibility to colon carcinogenesis in low selenium status. ..
  27. Gu Q, Beilstein M, Vendeland S, Lugade A, Ream W, Whanger P. Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species. Gene. 1997;193:187-96 pubmed
    ..The cDNAs encoding skeletal muscle selenoprotein W from human, rhesus monkey, sheep, rat, and mouse contained highly similar SECIS elements that retained ..
  28. Burk R, Hill K. Orphan selenoproteins. Bioessays. 1999;21:231-7 pubmed
    ..b>Selenoprotein W is a small intracellular protein that contains one selenocysteine...
  29. Abdulah R, Miyazaki K, Nakazawa M, Koyama H. Chemical forms of selenium for cancer prevention. J Trace Elem Med Biol. 2005;19:141-50 pubmed
    ..g., Se-methylselenocysteine and methylseleninic acid), are more efficacious than other Se compounds because of their chemoprevention activity. ..
  30. Ria R, Todoerti K, Berardi S, Coluccia A, De Luisi A, Mattioli M, et al. Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma. Clin Cancer Res. 2009;15:5369-78 pubmed publisher
  31. Khalid A, Khudhair N, He H, Peng Z, Yaguang T, Guixue Z. Effects of Dietary Selenium Supplementation on Seminiferous Tubules and SelW, GPx4, LHCGR, and ACE Expression in Chicken Testis. Biol Trace Elem Res. 2016;173:202-9 pubmed publisher
    ..effects of dietary selenium (Se) supplementation on the development of chicken testis and the expression of selenoprotein W (SelW), glutathione peroxidase4 (GPx4), luteinizing hormone/choriogonadotropin receptor (LHCGR), and ..
  32. Zhang J, Li J, Huang X, Bo S, Rihua W, Li S, et al. Dietary selenium regulation of transcript abundance of selenoprotein N and selenoprotein W in chicken muscle tissues. Biometals. 2012;25:297-307 pubmed publisher
    Selenium (Se), selenoprotein N (SelN) and selenoprotein W (SelW) play a crucial role in muscle disorders. Se status highly regulates selenoprotein mRNA levels...
  33. Wimmer U, Wang Y, Georgiev O, Schaffner W. Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione. Nucleic Acids Res. 2005;33:5715-27 pubmed
    ..MTF-1 is required for the basal expression of selenoprotein W, muscle 1 gene (Sepw1) that encodes a glutathione-binding and putative antioxidant protein, supporting a role ..
  34. Schriever S, Barnes K, Evenson J, Raines A, Sunde R. Selenium requirements are higher for glutathione peroxidase-1 mRNA than gpx1 activity in rat testis. Exp Biol Med (Maywood). 2009;234:513-21 pubmed publisher
    ..contrast, Gpx1 activity decreased to 28% of Se-adequate levels, and mRNA levels for Gpx1, Sepp1, and Sepw1 (selenoprotein W) decreased significantly in Se-deficient rats to 45, 46, and 55%, respectively, of Se-adequate plateau levels...
  35. Yu D, Li J, Zhang J, Gao X, Xu S. Effects of dietary selenium on selenoprotein W gene expression in the chicken immune organs. Biol Trace Elem Res. 2011;144:678-87 pubmed publisher
    b>Selenoprotein W (SelW) is expressed in the immune systems of mammals. However, its pattern of expression in the immune organs of birds is still unclear...
  36. Dodig S, Cepelak I. The facts and controversies about selenium. Acta Pharm. 2004;54:261-76 pubmed
    ..four glutathione peroxidases, three iodothyronine deiodinases, three thioredoxin reductases, selenoprotein P, selenoprotein W and selenophosphate synthetase...
  37. Hawkes W, Printsev I, Alkan Z. Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells. J Cell Biochem. 2012;113:61-9 pubmed publisher
    ..b>Selenoprotein W (SEPW1) is a highly conserved protein ubiquitously expressed in animals, bacteria, and archaea...
  38. Dikiy A, Novoselov S, Fomenko D, Sengupta A, Carlson B, Cerny R, et al. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry. 2007;46:6871-82 pubmed
    ..Rdx12 was found to interact with glutathione peroxidase 1, whereas 14-3-3 protein was identified as one of the targets of mammalian SelW, suggesting a mechanism for redox regulation of the 14-3-3 family of proteins. ..
  39. Whanger P. Selenoprotein W: a review. Cell Mol Life Sci. 2000;57:1846-52 pubmed
    Purification of selenoprotein W (Se-W) from rat and monkey muscles was shown to exist in multiple forms: with or without reduced glutathione and/or a 41-Da moiety (identity still unknown)...
  40. Xu M, Sun D, Li J, Xu S. Monoclonal antibodies against avian selenoprotein W. Hybridoma (Larchmt). 2011;30:563-6 pubmed publisher
    The Sel-W gene encoding avian selenoprotein W was cloned into the vector pGEX-6p-1 with GST tag. The recombinant protein Sel-W was expressed in Escherichia coli BL21 (DE3) after induction with 1 mM IPTG...
  41. Wu Q, Yao H, Zhang Z, Zhang B, Meng F, Xu S, et al. Possible correlation between selenoprotein W and myogenic regulatory factors in chicken embryonic myoblasts. Biol Trace Elem Res. 2012;150:166-72 pubmed publisher
    The biological function of selenium (Se) is mainly elicited through Se-containing proteins. Selenoprotein W (SelW), one member of the selenoprotein family, is essential for the normal function of the skeletal muscle system...
  42. Park Y, Jeon Y, Kim I. Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B. Biochim Biophys Acta. 2012;1823:2217-26 pubmed publisher
    b>Selenoprotein W (SelW) contains a highly reactive selenocysteine (Sec; U) in the CXXU motif corresponding to the CXXC motif in thioredoxin (Trx) and thus it appears to be involved in regulating the cellular redox state...
  43. Hawkes W, Alkan Z. Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway. J Biol Chem. 2012;287:27371-9 pubmed publisher
    b>Selenoprotein W (SEPW1) is a ubiquitous, highly conserved thioredoxin-like protein whose depletion causes a transient p53- and p21(Cip1)-dependent G(1)-phase cell cycle arrest in breast and prostate epithelial cells...
  44. Chung Y, Jeong D, Noh O, Park Y, Kang S, Lee M, et al. Antioxidative role of selenoprotein W in oxidant-induced mouse embryonic neuronal cell death. Mol Cells. 2009;27:609-13 pubmed publisher
    It has been reported that selenoprotein W (SelW) mRNA is highly expressed in the developing central nerve system of rats, and its expression is maintained until the early postnatal stage...
  45. Yao H, Wu Q, Zhang Z, Li S, Wang X, Lei X, et al. Selenoprotein W serves as an antioxidant in chicken myoblasts. Biochim Biophys Acta. 2013;1830:3112-20 pubmed publisher
    b>Selenoprotein W (SelW) was thought to play an antioxidant role in mammals...
  46. Whanger P. Selenium and the brain: a review. Nutr Neurosci. 2001;4:81-97 pubmed
    ..GPX activity and selenium content in the brain, there is no reduction in thioredoxin reductase activity or selenoprotein W levels...
  47. Kipp A, Banning A, van Schothorst E, Méplan C, Coort S, Evelo C, et al. Marginal selenium deficiency down-regulates inflammation-related genes in splenic leukocytes of the mouse. J Nutr Biochem. 2012;23:1170-7 pubmed publisher
    ..The selenoproteins found here to be sensitive to selenium intake in murine leukocytes might also be useful as biomarkers for a moderate selenium deficiency in humans. ..
  48. Whanger P. Selenoprotein W. Methods Enzymol. 2002;347:179-87 pubmed
  49. Behne D, Kyriakopoulos A. Mammalian selenium-containing proteins. Annu Rev Nutr. 2001;21:453-73 pubmed
    ..Selenoprotein P, selenoprotein W, a 15-kDa selenoprotein, an 18-kDa selenoprotein, and several selenoproteins identified in silico from ..
  50. Jeon Y, Park Y, Kwon J, Lee J, Kim I. Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W. Biochim Biophys Acta. 2013;1833:2135-42 pubmed publisher
    ..Recently, we reported that selenoprotein W (SelW) regulated the interaction between 14-3-3 and its target protein, CDC25B...
  51. Carlson B, Xu X, Gladyshev V, Hatfield D. Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA. J Biol Chem. 2005;280:5542-8 pubmed
    ..Overall, this study described a novel mechanism of regulation of protein expression by tRNA modification that is in turn regulated by levels of the trace element, selenium. ..
  52. Jeon Y, Park Y, Lee J, Hong J, Kim I. Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein. Biochim Biophys Acta. 2014;1843:1356-64 pubmed publisher
    b>Selenoprotein W (SelW) is expressed in various tissues, particularly in skeletal muscle...
  53. Vendeland S, Beilstein M, Yeh J, Ream W, Whanger P. Rat skeletal muscle selenoprotein W: cDNA clone and mRNA modulation by dietary selenium. Proc Natl Acad Sci U S A. 1995;92:8749-53 pubmed
    Rat skeletal muscle selenoprotein W cDNA was isolated and sequenced. The isolation strategy involved design of degenerate PCR primers from reverse translation of a partial peptide sequence...