protease nexins


Summary: Extracellular protease inhibitors that are secreted from FIBROBLASTS. They form a covalent complex with SERINE PROTEASES and can mediate their cellular internalization and degradation.

Top Publications

  1. Bhasin R, Van Nostrand W, Saitoh T, Donets M, Barnes E, Quitschke W, et al. Expression of active secreted forms of human amyloid beta-protein precursor by recombinant baculovirus-infected insect cells. Proc Natl Acad Sci U S A. 1991;88:10307-11 pubmed
    ..Thus, the appropriately sized, secreted recombinant APP proteins produced in this expression system are biologically active. ..