Summary: A secretory proteinase inhibitory protein that was initially purified from human SKIN. It is found in a variety mucosal secretions and is present at high levels in SPUTUM. Elafin may play a role in the innate immunity (IMMUNITY, INNATE) response of the LUNG.

Top Publications

  1. Zhang Y, Sun S, Chen J, Ren P, Hu Y, Cao Z, et al. Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway. Tumour Biol. 2014;35:1619-25 pubmed
    ..Therefore, these findings should be useful for understanding the apoptotic cellular mechanism mediated by oxymatrine and might offer a therapeutic potential advantage for human osteosarcoma chemoprevention or chemotherapy. ..
  2. Caruso J, Karakas C, Zhang J, Yi M, Albarracin C, Sahin A, et al. Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence. Breast Cancer Res. 2014;16:3417 pubmed
    b>Elafin is an endogenous serine protease inhibitor. The majority of breast cancer cell lines lack elafin expression compared to human mammary epithelial cells...
  3. Myntti T, Rahkonen L, Nupponen I, Pätäri Sampo A, Tikkanen M, Sorsa T, et al. Amniotic Fluid Infection in Preterm Pregnancies with Intact Membranes. Dis Markers. 2017;2017:8167276 pubmed publisher
    ..MMP-8), MMP-9, myeloperoxidase (MPO), and interleukin-6; Cascade 2: neutrophil elastase (HNE), elafin, and MMP-9; Cascade 3: MMP-2, tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), MMP-8/TIMP-1 molar ratio, ..
  4. Gao F, Wang F, Liu R, Xue F, Zhang J, Xu G, et al. Epigenetic silencing of miR-130a ameliorates hemangioma by targeting tissue factor pathway inhibitor 2 through FAK/PI3K/Rac1/mdm2 signaling. Int J Oncol. 2017;50:1821-1831 pubmed publisher
    ..Thus, miR-130a may serve as a potential therapeutic strategy for the treatment of hemangioma. ..