versicans

Summary

Summary: HYALURONAN-containing proteoglycans found in the EXTRACELLULAR MATRIX of a variety of tissues and organs. Several versican isoforms exist due to multiple ALTERNATIVE SPLICING of the versican MESSENGER RNA.

Top Publications

  1. Chen Y, Zhao P, Borup R, Hoffman E. Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology. J Cell Biol. 2000;151:1321-36 pubmed
    ..Finally, our expression profiling results show that primary genetic defects can be identified by a reduction in the corresponding RNA. ..
  2. Higgins C, Richardson G, Ferdinando D, Westgate G, Jahoda C. Modelling the hair follicle dermal papilla using spheroid cell cultures. Exp Dermatol. 2010;19:546-8 pubmed publisher
    ..This method of DP cell culture may provide us with a tool to elucidate our understanding of signalling within the DP as it relates to induction, maintenance or even inhibition of hair growth. ..
  3. Curry T. ADAMTS1 and versican: partners in ovulation and fertilization. Biol Reprod. 2010;83:505-6 pubmed publisher
  4. Kintakas C, McCulloch D. Emerging roles for ADAMTS5 during development and disease. Matrix Biol. 2011;30:311-7 pubmed publisher
  5. Lopez J, Angulo J, Martin A, Sanchez Chapado M, González Corpas A, Colás B, et al. A DNA hypermethylation profile reveals new potential biomarkers for the evaluation of prognosis in urothelial bladder cancer. APMIS. 2017;125:787-796 pubmed publisher
    ..Combined hypermethylation of SOX1, PITX2, or CSPG2 signals patients at higher risk of death from bladder cancer. ..
  6. Hope C, Emmerich P, Papadas A, Pagenkopf A, Matkowskyj K, Van De Hey D, et al. Versican-Derived Matrikines Regulate Batf3-Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer. J Immunol. 2017;199:1933-1941 pubmed publisher
    ..Our findings provide a rationale for testing VCAN proteolysis as a predictive and/or prognostic immune biomarker and VCAN-derived matrikines as novel immunotherapy agents. ..
  7. Mantovani A. Cancer: Inflaming metastasis. Nature. 2009;457:36-7 pubmed publisher
  8. Muenst S, Mechera R, Däster S, Piscuoglio S, Ng C, Meier Abt F, et al. Pregnancy at early age is associated with a reduction of progesterone-responsive cells and epithelial Wnt signaling in human breast tissue. Oncotarget. 2017;8:22353-22360 pubmed publisher
    ..This results in a decreased proliferation of stem/progenitor cells; therefore, the Wnt signaling pathway may represent a potential target for breast cancer prevention in humans. ..
  9. de Wit M, Carvalho B, Delis van Diemen P, van Alphen C, Belien J, Meijer G, et al. Lumican and versican protein expression are associated with colorectal adenoma-to-carcinoma progression. PLoS ONE. 2017;12:e0174768 pubmed publisher
    ..03) and was associated with the presence of gain of 13q (71% versus 44%; P = 0.04). Epithelial lumican and stromal versican protein expression are increased during colorectal adenoma-to-carcinoma progression. ..

More Information

Publications10

  1. Akinfenwa P, Bond W, ILDEFONSO C, Hurwitz M, Hurwitz R. Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)/STAT and Src family kinase pathways. J Biol Chem. 2017;292:14381-14390 pubmed publisher