tenascin

Summary

Summary: Hexameric extracellular matrix glycoprotein transiently expressed in many developing organs and often re-expressed in tumors. It is present in the central and peripheral nervous systems as well as in smooth muscle and tendons. (From Kreis & Vale, Guidebook to the Extracellular Matrix and Adhesion Proteins, 1993, p93)

Top Publications

  1. Schliemann C, Wiedmer A, Pedretti M, Szczepanowski M, Klapper W, Neri D. Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma. Leuk Res. 2009;33:1718-22 pubmed publisher
    ..are clinical-stage human monoclonal antibodies, which selectively recognize splice isoforms of fibronectin and tenascin-C in the modified extracellular matrix of neoplastic lesions...
  2. Lambropoulou M, Limberis V, Koutlaki N, Simopoulou M, Ntanovasilis D, Vandoros G, et al. Differential expression of tenascin-C in the developing human lung: an immunohistochemical study. Clin Exp Med. 2009;9:333-8 pubmed publisher
    ..One of the mesenchymal ECM proteins, tenascin, is reported to be transiently expressed during embryonic tissue development, and is absent or much reduced in ..
  3. Treloar H, Ray A, Dinglasan L, Schachner M, Greer C. Tenascin-C is an inhibitory boundary molecule in the developing olfactory bulb. J Neurosci. 2009;29:9405-16 pubmed publisher
    We recently described the boundary-like expression pattern of the extracellular matrix molecule tenascin-C (Tnc) in the developing mouse olfactory bulb (OB) (Shay et al., 2008)...
  4. Berndt A, Köllner R, Richter P, Franz M, Voigt A, Berndt A, et al. A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies. Histochem Cell Biol. 2010;133:467-75 pubmed publisher
    Tumour angioneogenesis is associated with the reexpression of oncofetal fibronectin (oncFn) and tenascin-C (oncTn-C) splice variants, which may serve as targets for antibody-based pharmacodelivery...
  5. Huang J, Cheng Y, Lin Y, Lin H, Su C, Juliano R, et al. Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression. J Immunol. 2010;185:1450-9 pubmed publisher
    ..Glioma cells, but not MCF-7 and HepG2 cells, expressed tenascin-C...
  6. Dufresne D, Hamdan F, Rosenfeld J, Torchia B, Rosenblatt B, Michaud J, et al. Homozygous deletion of Tenascin-R in a patient with intellectual disability. J Med Genet. 2012;49:451-4 pubmed publisher
    TNR encodes Tenascin-R, an extracellular matrix glycoprotein that is primarily expressed in the central nervous system...
  7. Lv S, Bu T, Kayser J, Bausch A, Li H. Towards constructing extracellular matrix-mimetic hydrogels: an elastic hydrogel constructed from tandem modular proteins containing tenascin FnIII domains. Acta Biomater. 2013;9:6481-91 pubmed publisher
    ..However, their use for such purposes has not been explored extensively. Tenascin-C (TNC) is an ECM tandem modular protein and plays an important role in mechanotransduction by regulating ..
  8. Ambort D, Brellier F, Becker Pauly C, Stöcker W, Andrejevic Blant S, Chiquet M, et al. Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading. Matrix Biol. 2010;29:31-42 pubmed publisher
    ..Here, we investigated the susceptibility of tenascin-C to cleavage by meprinbeta and the functional properties of its proteolytic fragments...
  9. Guttery D, Hancox R, Mulligan K, Hughes S, Lambe S, Pringle J, et al. Association of invasion-promoting tenascin-C additional domains with breast cancers in young women. Breast Cancer Res. 2010;12:R57 pubmed publisher
    b>Tenascin-C (TNC) is a large extracellular matrix glycoprotein that shows prominent stromal expression in many solid tumours...

More Information

Publications103 found, 100 shown here

  1. Ma S, Yang D, Li D, Tang B, Sun M, Yang Y. Cardiac extracellular matrix tenascin-C deposition during fibronectin degradation. Biochem Biophys Res Commun. 2011;409:321-7 pubmed publisher
    b>Tenascin-C (TN-C) might aggravate left ventricular remodeling after myocardial infarction (MI). Our previous study demonstrated that ventricular remodeling after MI is linked with the degradation of fibronectin (FN)...
  2. To W, Midwood K. Identification of novel and distinct binding sites within tenascin-C for soluble and fibrillar fibronectin. J Biol Chem. 2011;286:14881-91 pubmed publisher
    Interactions between fibronectin and tenascin-C within the extracellular matrix provide specific environmental cues that dictate tissue structure and cell function...
  3. Kayan A, Cinar M, Uddin M, Phatsara C, Wimmers K, Ponsuksili S, et al. Polymorphism and expression of the porcine Tenascin C gene associated with meat and carcass quality. Meat Sci. 2011;89:76-83 pubmed publisher
    The research aimed to screen for polymorphism, expression of Tenascin C (TNC) and association with meat and carcass quality traits. Three single nucleotide polymorphisms were detected. In a Duroc×Pietrain F2 cross (DuPi) population, g...
  4. Brellier F, Martina E, Chiquet M, Ferralli J, van der Heyden M, Orend G, et al. The adhesion modulating properties of tenascin-W. Int J Biol Sci. 2012;8:187-94 pubmed
    Tenascins are extracellular matrix glycoproteins associated with cell motility, proliferation and differentiation. Tenascin-C inhibits cell spreading by binding to fibronectin; tenascin-R and tenascin-X also have anti-adhesive properties ..
  5. Imanaka Yoshida K. Tenascin-C in cardiovascular tissue remodeling: from development to inflammation and repair. Circ J. 2012;76:2513-20 pubmed
    b>Tenascin-C (TN-C) is a matricellular protein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues, and may regulate cell behavior and matrix organization during tissue remodeling...
  6. Ellis S, Heazlewood S, Williams B, Reitsma A, Grassinger J, Borg J, et al. The role of Tenascin C in the lymphoid progenitor cell niche. Exp Hematol. 2013;41:1050-61 pubmed publisher
    ..Mice devoid of the extracellular matrix molecule Tenascin-C (TNC) were reported to develop normally...
  7. Chiquet M, Gelman L, Lutz R, Maier S. From mechanotransduction to extracellular matrix gene expression in fibroblasts. Biochim Biophys Acta. 2009;1793:911-20 pubmed publisher
    ..actin dynamics directly to the expression of specific genes, among them the extracellular matrix protein tenascin-C...
  8. Liesker J, Ten Hacken N, Zeinstra Smith M, Rutgers S, Postma D, Timens W. Reticular basement membrane in asthma and COPD: similar thickness, yet different composition. Int J Chron Obstruct Pulmon Dis. 2009;4:127-35 pubmed
    ..sections of bronchial biopsies were stained with hematoxylin/eosin and for collagen I, III, IV, V, laminin and tenascin. RBM thickening was assessed by digital image analysis...
  9. Kaarteenaho R, Sormunen R, Paakko P. Variable expression of tenascin-C, osteopontin and fibronectin in inflammatory myofibroblastic tumour of the lung. APMIS. 2010;118:91-100 pubmed publisher
    The aim of this study was to analyse the expression of tenascin-C, osteopontin and fibronectin in inflammatory myofibroblastic tumour of the lung, which is a rare tumour of unknown aetiology...
  10. Minear M, Crosslin D, Sutton B, Connelly J, Nelson S, Gadson Watson S, et al. Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease. Hum Genet. 2011;129:641-54 pubmed publisher
    b>Tenascin-C (TNC) is an extracellular matrix protein implicated in biological processes important for atherosclerotic plaque development and progression, including smooth muscle cell migration and proliferation...
  11. Tsukada B, Terasaki F, Shimomura H, Otsuka K, Otsuka K, Katashima T, et al. High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty: expression of tenascin C as a possible marker for inflammation. Hum Pathol. 2009;40:1015-22 pubmed publisher
    ..to analyze the incidence of chronic myocarditis in dilated cardiomyopathy and to evaluate the diagnostic value of tenascin C for assessing inflammatory activity in the resected myocardium...
  12. Brinckmann J, Hunzelmann N, Kahle B, Rohwedel J, Kramer J, Gibson M, et al. Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta. Lab Invest. 2010;90:739-52 pubmed publisher
    ..Double labelling of fibrillin-2 and tenascin-C, which is also expressed in wound healing and sclerosis, showed co-localization of both proteins...
  13. Fukunaga Kalabis M, Martinez G, Nguyen T, Kim D, Santiago Walker A, Roesch A, et al. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene. 2010;29:6115-24 pubmed publisher
    b>Tenascin-C (TNC) is highly expressed in melanoma; however, little is known about its functions. Recent studies indicate that TNC has a role within the stem cell niche...
  14. Wang Y, Man Y, Ding Y, Ma B, Qiu X, Fan Q, et al. Mechanical strain and growth factors regulate expression of tenascin-C by OS cells additively. Oncol Res. 2013;20:509-16 pubmed publisher
    Osteosarcoma (OS) is a kind of malignancy wherein the tumor cells form malignant bone-like or bone tissue. Tenascin-C (TN-C), an important extracellular matrix (ECM) protein, plays an indispensable role in tumor development...
  15. Tanaka S, Sumioka T, Fujita N, Kitano A, Okada Y, Yamanaka O, et al. Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C. Mol Vis. 2010;16:1194-205 pubmed
    To investigate the role of tenascin-C in epithelial-mesenchymal transition (EMT) of the lens epithelium during wound healing in mice...
  16. Ando K, Takahashi M, Yamagishi T, Miyagawa Tomita S, Imanaka Yoshida K, Yoshida T, et al. Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development. Differentiation. 2011;81:299-306 pubmed publisher
    b>Tenascin C (TNC) is an extracellular glycoprotein that is thought to be involved in tissue remodeling during organogenesis and regeneration...
  17. Midwood K, Hussenet T, Langlois B, Orend G. Advances in tenascin-C biology. Cell Mol Life Sci. 2011;68:3175-99 pubmed publisher
    b>Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury...
  18. Matsumoto K, Satoh K, Maniwa T, Araki A, Maruyama R, Oda T. Noticeable decreased expression of tenascin-X in calcific aortic valves. Connect Tissue Res. 2012;53:460-8 pubmed publisher
    ..Among them, ?-2-HS-glycoprotein showed the greatest increase in expression (6.54-fold) and tenascin-X showed the greatest decrease in expression (0.37-fold)...
  19. Huijing P, Voermans N, Baan G, Busé T, van Engelen B, de Haan A. Muscle characteristics and altered myofascial force transmission in tenascin-X-deficient mice, a mouse model of Ehlers-Danlos syndrome. J Appl Physiol (1985). 2010;109:986-95 pubmed publisher
    The Ehlers-Danlos syndrome is a group of inherited connective tissue disorders caused by defects in collagens or tenascin-X (TNX)...
  20. Yu Y, Cristofanilli M, Valiveti A, Ma L, Yoo M, Morellini F, et al. The extracellular matrix glycoprotein tenascin-C promotes locomotor recovery after spinal cord injury in adult zebrafish. Neuroscience. 2011;183:238-50 pubmed publisher
    ..In the current study, the extracellular matrix glycoprotein tenascin-C was studied in the zebrafish spinal cord injury model to assess the often disparate functions of this ..
  21. Paron I, Berchtold S, Vörös J, Shamarla M, Erkan M, Hofler H, et al. Tenascin-C enhances pancreatic cancer cell growth and motility and affects cell adhesion through activation of the integrin pathway. PLoS ONE. 2011;6:e21684 pubmed publisher
    Pancreatic cancer (PDAC) is characterized by an abundant fibrous tissue rich in Tenascin-C (TNC), a large ECM glycoprotein mainly synthesized by pancreatic stellate cells (PSCs)...
  22. Degen M, Goulet S, Ferralli J, Roth M, Tamm M, Chiquet Ehrismann R. Opposite effect of fluticasone and salmeterol on fibronectin and tenascin-C expression in primary human lung fibroblasts. Clin Exp Allergy. 2009;39:688-99 pubmed publisher
    ..we investigated the effect of fluticasone and salmeterol, either alone or in combination, on fibronectin and tenascin-C protein, isoform, and mRNA levels in primary human lung fibroblasts...
  23. O Connell J, Sugimoto H, Cooke V, Macdonald B, Mehta A, LeBleu V, et al. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci U S A. 2011;108:16002-7 pubmed publisher
    ..with a concomitant decrease in the expression of several ECM molecules and growth factors, particularly Tenascin-C and VEGF-A...
  24. Akbareian S, Nagy N, Steiger C, Mably J, Miller S, Hotta R, et al. Enteric neural crest-derived cells promote their migration by modifying their microenvironment through tenascin-C production. Dev Biol. 2013;382:446-56 pubmed publisher
    ..We identified the extracellular matrix glycoprotein tenascin-C (TNC) as an important regulator of ENCC development...
  25. Asparuhova M, Ferralli J, Chiquet M, Chiquet Ehrismann R. The transcriptional regulator megakaryoblastic leukemia-1 mediates serum response factor-independent activation of tenascin-C transcription by mechanical stress. FASEB J. 2011;25:3477-88 pubmed publisher
    The extracellular matrix protein tenascin-C (TNC) is up-regulated in processes influenced by mechanical stress, such as inflammation, tissue remodeling, wound healing, and tumorigenesis...
  26. Nakoshi Y, Hasegawa M, Akeda K, Iino T, Sudo A, Yoshida T, et al. Distribution and role of tenascin-C in human osteoarthritic cartilage. J Orthop Sci. 2010;15:666-73 pubmed publisher
    b>Tenascin-C (TN-C) is expressed in the cartilage of osteoarthritis (OA). We examined whether TN-C was involved in cartilage repair of the diseased joints...
  27. Ko H, Choi K, Lee C, Kim S. A multimodal nanoparticle-based cancer imaging probe simultaneously targeting nucleolin, integrin ?v?3 and tenascin-C proteins. Biomaterials. 2011;32:1130-8 pubmed publisher
    ..The results demonstrated that the SMART cancer probe will be useful for the diagnosis of different cancers as a cancer master probe. ..
  28. Szalai E, Felszeghy S, Hegyi Z, Modis L, Berta A, Kaarniranta K. Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies. Mol Vis. 2012;18:1927-36 pubmed
    ..of human granular and lattice type I corneal stromal dystrophies, the expression patterns of fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 were compared in human corneal stromal dystrophy samples...
  29. Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, et al. Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2010;298:H1072-8 pubmed publisher
    b>Tenascin-C (TN-C) is an extracellular matrix glycoprotein with high bioactivity. It is expressed at low levels in normal adult heart, but upregulated under pathological conditions, such as myocardial infarction (MI). Recently, we (Ref...
  30. Czopka T, von Holst A, Schmidt G, Ffrench Constant C, Faissner A. Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway. Glia. 2009;57:1790-801 pubmed publisher
    ..Here, we compared the roles of the two related extracellular matrix (ECM) glycoproteins Tenascin C (Tnc) and Tenascin R (Tnr) in oligodendrocyte differentiation...
  31. Dugu L, Hayashida S, Nakahara T, Xie L, Iwashita Y, Liu X, et al. Aberrant expression of tenascin-c and neuronatin in malignant peripheral nerve sheath tumors. Eur J Dermatol. 2010;20:580-4 pubmed publisher
    ..However, its expression in NFs and MPNSTs is unknown. Since an overexpression of tenascin-C (Tn-C), an extracellular matrix component, has been observed in neural malignancies, we investigated the ..
  32. Sumioka T, Fujita N, Kitano A, Okada Y, Saika S. Impaired angiogenic response in the cornea of mice lacking tenascin C. Invest Ophthalmol Vis Sci. 2011;52:2462-7 pubmed publisher
    This study investigated the effects of loss of tenascin C (TNC) in the development of neovascularization in a corneal stroma in mice...
  33. Gueders M, Hirst S, Quesada Calvo F, Paulissen G, Hacha J, Gilles C, et al. Matrix metalloproteinase-19 deficiency promotes tenascin-C accumulation and allergen-induced airway inflammation. Am J Respir Cell Mol Biol. 2010;43:286-95 pubmed publisher
    ..MMP-19 is newly described, and it preferentially cleaves matrix proteins such as collagens and tenascin-C. The role of MMP-19 in asthma has not been described to date...
  34. Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N, et al. Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem. 2010;285:2028-39 pubmed publisher
    ..Here we show that periostin, a matricellular protein, promotes incorporation of tenascin-C into the ECM and organizes a meshwork architecture of the ECM...
  35. Sarkar S, Yong V. Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix. Carcinogenesis. 2010;31:311-7 pubmed publisher
    ..have reported that in a three-dimensional matrix of type 1 collagen (3D-CL) gel, the extracellular matrix protein tenascin-C (TN) increased the invasiveness of glioma cells through the downstream production of matrix metalloproteinase (..
  36. Wang B, Liu K, Lin H, Bellam N, Ling S, Lin W. 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol. 2010;30:1508-27 pubmed publisher
    ..b>Tenascin-C, an extracellular matrix protein involved in tumor initiation and progression and a known 14-3-3tau inducer, ..
  37. Schaff M, Receveur N, Bourdon C, Wurtz V, Denis C, Orend G, et al. Novel function of tenascin-C, a matrix protein relevant to atherosclerosis, in platelet recruitment and activation under flow. Arterioscler Thromb Vasc Biol. 2011;31:117-24 pubmed publisher
    ..In this context, we explored platelet adhesion and activation to tenascin-C (TN-C), a matrix protein preferentially found within atheroma...
  38. Liabeuf S, Barreto D, Kretschmer A, Barreto F, Renard C, Andrejak M, et al. High circulating levels of large splice variants of tenascin-C is associated with mortality and cardiovascular disease in chronic kidney disease patients. Atherosclerosis. 2011;215:116-24 pubmed publisher
    b>Tenascin-C (TN-C) is an adhesion-modulating extracellular matrix glycoprotein which is overexpressed in various organs under disease conditions (infection and inflammation)...
  39. Brissett M, Veraldi K, Pilewski J, Medsger T, Feghali Bostwick C. Localized expression of tenascin in systemic sclerosis-associated pulmonary fibrosis and its regulation by insulin-like growth factor binding protein 3. Arthritis Rheum. 2012;64:272-80 pubmed publisher
    ..growth factor binding protein 3 (IGFBP-3) in mediating the effects of transforming growth factor ? (TGF?) on tenascin-C (TN-C) production and to assess the levels of TN-C in vivo in patients with systemic sclerosis (SSc)-associated ..
  40. Piccinini A, Midwood K. Endogenous control of immunity against infection: tenascin-C regulates TLR4-mediated inflammation via microRNA-155. Cell Rep. 2012;2:914-26 pubmed publisher
    ..b>Tenascin-C is an extracellular matrix glycoprotein that is specifically induced upon injury and infection...
  41. Fujimoto M, Suzuki H, Shiba M, Shimojo N, Imanaka Yoshida K, Yoshida T, et al. Tenascin-C induces prolonged constriction of cerebral arteries in rats. Neurobiol Dis. 2013;55:104-9 pubmed publisher
    b>Tenascin-C (TNC), a matricellular protein, is induced in association with cerebral vasospasm after subarachnoid hemorrhage...
  42. Tucker R, Ferralli J, Schittny J, Chiquet Ehrismann R. Tenascin-C and tenascin-W in whisker follicle stem cell niches: possible roles in regulating stem cell proliferation and migration. J Cell Sci. 2013;126:5111-5 pubmed publisher
    ..Using immunohistochemistry, we found the glycoprotein tenascin-C in the fibrous capsule of mouse whisker follicles, along the glassy membrane and in the trabecular region ..
  43. Chen J, Chen Z, Chen M, Li D, Li Z, Xiong Y, et al. Role of fibrillar Tenascin-C in metastatic pancreatic cancer. Int J Oncol. 2009;34:1029-36 pubmed
    ..In the tumor, upregulation of Tenascin-C (Tn-C) expression potentially can alter tumor behavior...
  44. Midwood K, Sacre S, Piccinini A, Inglis J, Trebaul A, Chan E, et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med. 2009;15:774-80 pubmed publisher
    ..b>Tenascin-C (encoded by Tnc) is an extracellular matrix glycoprotein specifically expressed at areas of inflammation and ..
  45. Wang Y, Zheng L, Ma B, Zhou Y, Fan Q. Generation and identification of monoclonal antibodies against FNIII domain D of human tenascin-C. Hybridoma (Larchmt). 2010;29:13-6 pubmed publisher
    b>Tenascin-C (TN-C), a key component of extracellular matrix (ECM), is strongly expressed in fetal and cancer tissues...
  46. Franz M, Brehm B, Richter P, Gruen K, Neri D, Kosmehl H, et al. Changes in extra cellular matrix remodelling and re-expression of fibronectin and tenascin-C splicing variants in human myocardial tissue of the right atrial auricle: implications for a targeted therapy of cardiovascular diseases using human SIP form. J Mol Histol. 2010;41:39-50 pubmed publisher
    ..are accompanied by changes in the extracellular matrix (ECM) including the re-expression of fibronectin and tenascin-C splicing variants...
  47. Fitch P, Howie S, Wallace W. Oxidative damage and TGF-? differentially induce lung epithelial cell sonic hedgehog and tenascin-C expression: implications for the regulation of lung remodelling in idiopathic interstitial lung disease. Int J Exp Pathol. 2011;92:8-17 pubmed publisher
    ..with lung damage and repair) was functional and whether the damage associated extracellular matrix protein tenascin-C was present in activated Type-II AECs in all three iILDs...
  48. Beckmann J, Vitobello A, Ferralli J, Kenzelmann Broz D, Rijli F, Chiquet Ehrismann R. Human teneurin-1 is a direct target of the homeobox transcription factor EMX2 at a novel alternate promoter. BMC Dev Biol. 2011;11:35 pubmed publisher
    ..We identify and characterize the EMX2 dependent promoter element of human teneurin-1. ..
  49. Zheng L, Michelson Y, Freger V, Avraham Z, Venken K, Bellen H, et al. Drosophila Ten-m and filamin affect motor neuron growth cone guidance. PLoS ONE. 2011;6:e22956 pubmed publisher
    The Drosophila Ten-m (also called Tenascin-major, or odd Oz (odz)) gene has been associated with a pair-rule phenotype...
  50. Liu R, He Y, Li B, Liu J, Ren Y, Han W, et al. Tenascin-C produced by oxidized LDL-stimulated macrophages increases foam cell formation through Toll-like receptor-4. Mol Cells. 2012;34:35-41 pubmed publisher
    ..Here, we show that tenascin-C (TN-C) can stimulate foam cell formation and this can be inhibited by a TLR4-blocking antibody or CD36 gene ..
  51. Xie K, Liu Y, Hao W, Walter S, Penke B, Hartmann T, et al. Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice. Neurobiol Aging. 2013;34:2389-98 pubmed publisher
    ..b>Tenascin-C (tnc) is an extracellular matrix protein that is upregulated in inflammation and induces further inflammatory ..
  52. Michele M, Faissner A. Tenascin-C stimulates contactin-dependent neurite outgrowth via activation of phospholipase C. Mol Cell Neurosci. 2009;41:397-408 pubmed publisher
    b>Tenascin-C (Tnc) is transiently expressed during neural development...
  53. Margaron Y, Bostan L, Exposito J, Malbouyres M, Trunfio Sfarghiu A, Berthier Y, et al. Tenascin-X increases the stiffness of collagen gels without affecting fibrillogenesis. Biophys Chem. 2010;147:87-91 pubmed publisher
    b>Tenascin-X is an extracellular matrix protein whose absence leads to an Ehlers-Danlos Syndrome in humans, mainly characterised by connective tissue defects including the disorganisation of fibrillar networks, a reduced collagen deposition,..
  54. Chiao Y, Zamilpa R, Lopez E, Dai Q, Escobar G, Hakala K, et al. In vivo matrix metalloproteinase-7 substrates identified in the left ventricle post-myocardial infarction using proteomics. J Proteome Res. 2010;9:2649-57 pubmed publisher
    ..05). Fibronectin and tenascin-C, known in vitro substrates of MMP-7, were identified in spots that showed lower intensity in the null...
  55. Celik A, Kocyigit I, Calapkorur B, Korkmaz H, Doganay E, Elcik D, et al. Tenascin-C may be a predictor of acute pulmonary thromboembolism. J Atheroscler Thromb. 2011;18:487-93 pubmed
    ..We found no data about the relation between tenascin-C and acute PTE in the litera-ture...
  56. Kimura T, Yoshimura K, Aoki H, Imanaka Yoshida K, Yoshida T, Ikeda Y, et al. Tenascin-C is expressed in abdominal aortic aneurysm tissue with an active degradation process. Pathol Int. 2011;61:559-64 pubmed publisher
    ..Currently no biomarkers have been established to indicate the disease status of AAA. Tenascin-C (TN-C) is a matricellular protein that is synthesized under pathological conditions...
  57. Zarrabi M, Javidi M, Jafarian A, Joushan B. Immunohistochemical expression of fibronectin and tenascin in human tooth pulp capped with mineral trioxide aggregate and a novel endodontic cement. J Endod. 2011;37:1613-8 pubmed publisher
    The purpose of the present study was the immunohistochemical study of fibronectin (FN) and tenascin (TN) in human tooth pulp capped with mineral trioxide aggregate (MTA) and novel endodontic cement (NEC) (calcium enriched mixture cement) ..
  58. De Laporte L, Rice J, Tortelli F, Hubbell J. Tenascin C promiscuously binds growth factors via its fifth fibronectin type III-like domain. PLoS ONE. 2013;8:e62076 pubmed publisher
    b>Tenascin C (TNC) is an extracellular matrix protein that is upregulated during development as well as tissue remodeling. TNC is comprised of multiple independent folding domains, including 15 fibronectin type III-like (TNCIII) domains...
  59. Zhao Y, Zhao F, Zong L, Zhang P, Guan L, Zhang J, et al. Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. PLoS ONE. 2013;8:e69549 pubmed publisher
    ..TNC encodes tenascin-C, a member of the extracellular matrix (ECM), is present in the basilar membrane (BM), and the osseous spiral ..
  60. Yuan Y, Nymoen D, Stavnes H, Rosnes A, Bjørang O, Wu C, et al. Tenascin-X is a novel diagnostic marker of malignant mesothelioma. Am J Surg Pathol. 2009;33:1673-82 pubmed publisher
    b>Tenascin XB (TNXB) was previously identified as a gene that is more highly expressed in malignant mesothelioma compared with ovarian/peritoneal serous carcinoma based on gene expression array analysis...
  61. Okamura N, Hasegawa M, Nakoshi Y, Iino T, Sudo A, Imanaka Yoshida K, et al. Deficiency of tenascin-C delays articular cartilage repair in mice. Osteoarthritis Cartilage. 2010;18:839-48 pubmed publisher
    In human articular cartilage, tenascin-C (TN-C) expression decreases during maturation of chondrocytes, and almost disappears in adults; however, it reappears in damaged cartilage...
  62. Fujie S, Maita H, Ariga H, Matsumoto K. Tenascin-X induces cell detachment through p38 mitogen-activated protein kinase activation. Biol Pharm Bull. 2009;32:1795-9 pubmed
    Extracellular matrix glycoprotein tenascin-X (TNX) is the largest member of the tenascin family...
  63. Taraseviciute A, Vincent B, Schedin P, Jones P. Quantitative analysis of three-dimensional human mammary epithelial tissue architecture reveals a role for tenascin-C in regulating c-met function. Am J Pathol. 2010;176:827-38 pubmed publisher
    ..To address this question, we focused on tenascin-C (TN-C), a stromal extracellular matrix glycoprotein whose expression increases with disease severity...
  64. Goh F, Piccinini A, Krausgruber T, Udalova I, Midwood K. Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation. J Immunol. 2010;184:2655-62 pubmed publisher
    ..The extracellular matrix glycoprotein tenascin-C is an endogenous activator of innate immunity that promotes the synthesis of inflammatory cytokines via ..
  65. Guttery D, Shaw J, Lloyd K, Pringle J, Walker R. Expression of tenascin-C and its isoforms in the breast. Cancer Metastasis Rev. 2010;29:595-606 pubmed publisher
    b>Tenascin-C (TNC) is an extracellular matrix glycoprotein which is frequently up-regulated in a variety of pathological conditions including chronic inflammation and cancer...
  66. Brellier F, Hostettler K, Hotz H, Ozcakir C, Çöloğlu S, Togbe D, et al. Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator. FEBS Lett. 2011;585:913-20 pubmed publisher
    We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression...
  67. Pajala A, Melkko J, Leppilahti J, Ohtonen P, Soini Y, Risteli J. Tenascin-C and type I and III collagen expression in total Achilles tendon rupture. An immunohistochemical study. Histol Histopathol. 2009;24:1207-11 pubmed publisher
    ..b>Tenascin-C has been shown to be present in the tissue pathology and changes in tissue loading...
  68. Yagi H, Yanagisawa M, Suzuki Y, Nakatani Y, Ariga T, Kato K, et al. HNK-1 epitope-carrying tenascin-C spliced variant regulates the proliferation of mouse embryonic neural stem cells. J Biol Chem. 2010;285:37293-301 pubmed publisher
    ..it was revealed that the HNK-1 epitopes were almost exclusively displayed on an extracellular matrix protein, tenascin-C (TNC), in the mouse embryonic NSCs...
  69. Yamamoto M, Okui N, Tatebe M, Shinohara T, Hirata H. Regeneration of the perineurium after microsurgical resection examined with immunolabeling for tenascin-C and alpha smooth muscle actin. J Anat. 2011;218:413-25 pubmed publisher
    ..Our hypothesis is that the regenerative process of the perineurium can be demonstrated by immunolabeling for tenascin-C and alpha smooth muscle actin after microsurgical resection of the perineurium in vivo...
  70. Löfdahl M, Kaarteenaho R, Lappi Blanco E, Tornling G, Sköld M. Tenascin-C and alpha-smooth muscle actin positive cells are increased in the large airways in patients with COPD. Respir Res. 2011;12:48 pubmed publisher
    ..We studied the expression of tenascin-C (Tn-C) and alpha smooth muscle actin (?-SMA), which act as a marker of myofibroblasts, in large airways from ..
  71. Matsumoto K. Phosphorylation of extracellular matrix tenascin-X detected by differential mass tagging followed by nanoLC-MALDI-TOF/TOF-MS/MS using ProteinPilot software. Connect Tissue Res. 2012;53:106-16 pubmed publisher
    ..Among the 22 proteins, it was found that extracellular matrix tenascin-X is phosphorylated, although there is little quantitative change by the serum stimulation...
  72. Kanayama M, Morimoto J, Matsui Y, Ikesue M, Danzaki K, Kurotaki D, et al. ?9?1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. J Immunol. 2011;187:5851-64 pubmed publisher
    The interaction between matricellular proteins such as tenascin-C (TN-C) and osteopontin (OPN) and integrins has been implicated in the pathology of rheumatoid arthritis in which Th17 cells are recognized as primary pathogenic cells...
  73. Galler K, Junker K, Franz M, Hentschel J, Richter P, Gajda M, et al. Differential vascular expression and regulation of oncofetal tenascin-C and fibronectin variants in renal cell carcinoma (RCC): implications for an individualized angiogenesis-related targeted drug delivery. Histochem Cell Biol. 2012;137:195-204 pubmed publisher
    The study was aimed at determining the vascular expression of oncofetal fibronectin (oncfFn) and tenascin-C (oncfTn-C) isoforms in renal cell carcinoma (RCC) and its metastases which are well-known targets for antibody-based ..
  74. Ruhmann M, Piccinini A, Kong P, Midwood K. Endogenous activation of adaptive immunity: tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease. Arthritis Rheum. 2012;64:2179-90 pubmed publisher
    ..b>Tenascin-C is an arthritogenic extracellular matrix glycoprotein that is not expressed in healthy synovium but is elevated ..
  75. Malabanan K, Sheahan A, Khachigian L. Platelet-derived growth factor-BB mediates cell migration through induction of activating transcription factor 4 and tenascin-C. Am J Pathol. 2012;180:2590-7 pubmed publisher
    ..PDGF-BB also stimulates the expression of tenascin-C (TN-C), an extracellular matrix glycoprotein that regulates the activity of focal adhesion complexes, ..
  76. Inoue K, Jinnin M, Hara Y, Makino K, Kajihara I, Makino T, et al. Serum levels of tenascin-C in collagen diseases. J Dermatol. 2013;40:715-9 pubmed publisher
    ..Among them, large molecular weight variant tenascin-C is known to be specifically expressed in pathological conditions...
  77. Tucker R, Chiquet Ehrismann R. The regulation of tenascin expression by tissue microenvironments. Biochim Biophys Acta. 2009;1793:888-92 pubmed publisher
    Tenascins are a family of four extracellular matrix proteins: tenascin-C, X, R and W...
  78. Cohen E, Ihida Stansbury K, Lu M, Panettieri R, Jones P, Morrisey E. Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest. 2009;119:2538-49 pubmed publisher
    ..the effect on Pdgfr expression was, in part, mediated by direct transcriptional regulation of the ECM protein tenascin C (Tnc), which was necessary and sufficient for Pdgfralpha/beta expression in lung explants...
  79. Franz M, Berndt A, Altendorf Hofmann A, Fiedler N, Richter P, Schumm J, et al. Serum levels of large tenascin-C variants, matrix metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus eccentric left ventricular hypertrophy. Eur J Heart Fail. 2009;11:1057-62 pubmed publisher
    ..The role of matrix metalloproteinases (MMPs), tissue inhibitors of matrix metalloproteinases (TIMPs), and tenascin-C (Tn-C) splice variants in concentric vs. eccentric left ventricular remodelling has not been investigated...
  80. Chen W, Kim M, Shanbhag S, Arai A, VanRyzin C, McDonnell N, et al. The phenotypic spectrum of contiguous deletion of CYP21A2 and tenascin XB: quadricuspid aortic valve and other midline defects. Am J Med Genet A. 2009;149A:2803-8 pubmed publisher
    ..The genes encoding 21-hydroxylase, CYP21A2, and tenascin-X (TNX), TNXB, are located within the HLA complex, in a region of high gene density termed the RCCX module...
  81. Czopka T, von Holst A, Ffrench Constant C, Faissner A. Regulatory mechanisms that mediate tenascin C-dependent inhibition of oligodendrocyte precursor differentiation. J Neurosci. 2010;30:12310-22 pubmed publisher
    ..In the present study, we investigated the signaling pathway elicited by the ECM glycoprotein tenascin C (Tnc)...
  82. Franz M, Grün K, Richter P, Brehm B, Fritzenwanger M, Hekmat K, et al. Extra cellular matrix remodelling after heterotopic rat heart transplantation: gene expression profiling and involvement of ED-A+ fibronectin, alpha-smooth muscle actin and B+ tenascin-C in chronic cardiac allograft rejection. Histochem Cell Biol. 2010;134:503-17 pubmed publisher
    ..role of ED-A domain containing fibronectin (ED-A(+) Fn), alpha smooth muscle actin (ASMA) and B domain containing tenascin-C (B(+) Tn-C). A model of chronic rejection after heterotopic rat heart transplantation was used...
  83. Nagaharu K, Zhang X, Yoshida T, Katoh D, Hanamura N, Kozuka Y, et al. Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells. Am J Pathol. 2011;178:754-63 pubmed publisher
    b>Tenascin C (TNC) is an extracellular matrix glycoprotein up-regulated in solid tumors. Higher TNC expression is shown in invading fronts of breast cancer, which correlates with poorer patient outcome...
  84. Pezzolo A, Parodi F, Marimpietri D, Raffaghello L, Cocco C, Pistorio A, et al. Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells. Cell Res. 2011;21:1470-86 pubmed publisher
    ..Oct-4(+) cells expressed stem cell-related, neural progenitor-related and NB-related markers, including surface Tenascin C (TNC), that was absent from perinecrotic Oct-4(+) cells and bulk tumor cells...
  85. Grahovac J, Becker D, Wells A. Melanoma cell invasiveness is promoted at least in part by the epidermal growth factor-like repeats of tenascin-C. J Invest Dermatol. 2013;133:210-20 pubmed publisher
    b>Tenascin-C (TNC), overexpressed in invasive growths, has been implicated in progression of melanoma, but the source and function of this molecule are not well defined...
  86. Takahashi Y, Sawada G, Kurashige J, Matsumura T, Uchi R, Ueo H, et al. Tumor-derived tenascin-C promotes the epithelial-mesenchymal transition in colorectal cancer cells. Anticancer Res. 2013;33:1927-34 pubmed
    b>Tenascin-C (TNC) is an extracellular matrix glycoprotein, usually derived from myofibroblasts in the cancer microenvironment. Recently, however, the significance of tumor-derived TNC in initiation of cancer metastasis was disclosed...
  87. Hood B, Grahovac J, Flint M, Sun M, Charro N, Becker D, et al. Proteomic analysis of laser microdissected melanoma cells from skin organ cultures. J Proteome Res. 2010;9:3656-63 pubmed publisher
    ..This concordance demonstrates the value of SOCs for conducting proteomic investigations of the melanoma microenvironment. ..
  88. Veillet A, Haag J, Remfert J, Meilahn A, Samuelson D, Gould M. Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression. Cancer Prev Res (Phila). 2011;4:97-106 pubmed publisher
    ..b>Tenascin c (Tnc) was identified as a candidate gene due to its reduced expression in thymus and ovarian tissues of Mcs5c ..
  89. Alves T, da Fonseca A, Nunes S, da Silva A, Dubois L, Faria J, et al. Tenascin-C in the extracellular matrix promotes the selection of highly proliferative and tubulogenesis-defective endothelial cells. Exp Cell Res. 2011;317:2073-85 pubmed publisher
    ..The matricellular protein tenascin-C (TN-C) is overexpressed in remodeling tissues and cancer...
  90. Seifert A, Monaghan J, Voss S, Maden M. Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates. PLoS ONE. 2012;7:e32875 pubmed publisher
    ..Analysis of newly forming dermal ECM suggests that low levels of fibronectin and high levels of tenascin-C promote regeneration in lieu of scarring...
  91. Okuda H, Tatsumi K, Morita S, Shibukawa Y, Korekane H, Horii Hayashi N, et al. Chondroitin sulfate proteoglycan tenascin-R regulates glutamate uptake by adult brain astrocytes. J Biol Chem. 2014;289:2620-31 pubmed publisher
    ..One of the purified proteins was identified as tenascin-R (TNR) by mass spectrometric analysis...
  92. Alcaraz L, Exposito J, Chuvin N, Pommier R, Cluzel C, Martel S, et al. Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-?. J Cell Biol. 2014;205:409-28 pubmed publisher
    ..We show that the fibrinogen-like (FBG) domain of the matrix glycoprotein tenascin-X (TNX) interacts physically with the small latent TGF-? complex in vitro and in vivo, thus regulating the ..