fibromodulin

Summary

Summary: A small leucine-rich proteoglycan that contains 4 KERATAN SULFATE chains within the leucine repeat region. It interacts with COLLAGEN TYPE I and COLLAGEN TYPE II fibrils and may function to control the rate of EXTRACELLULAR MATRIX assembly. It also sequesters TRANSFORMING GROWTH FACTOR BETA in the extracellular matrix.

Top Publications

  1. Peffers M, Cillero Pastor B, Eijkel G, Clegg P, Heeren R. Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage. Arthritis Res Ther. 2014;16:R110 pubmed publisher
    ..Proteins including aggrecan core protein, fibromodulin, and cartilage oligomeric matrix protein were identified and localised...
  2. Olsson P, Kalamajski S, Maccarana M, Oldberg A, Rubin K. Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma. PLoS ONE. 2017;12:e0182973 pubmed publisher
    ..One of the proteins associated with dense extracellular matrices is fibromodulin, a collagen fibrillogenesis modulator expressed in tumor stroma but scarce in normal loose connective tissues...