Summary: A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.

Top Publications

  1. Hanemann C, Kuhn G, Lie A, Gillen C, Bosse F, Spreyer P, et al. Expression of decorin mRNA in the nervous system of rat. J Histochem Cytochem. 1993;41:1383-91 pubmed the deduced amino acid sequence of the core protein of human dermatan/chondroitin sulfate proteoglycan decorin (PGII, PG40, PG-S2). Two transcripts of 1.3 and 1...
  2. Appunni S, Anand V, Khandelwal M, Seth A, Mathur S, Sharma A. Altered expression of small leucine-rich proteoglycans (Decorin, Biglycan and Lumican): Plausible diagnostic marker in urothelial carcinoma of bladder. Tumour Biol. 2017;39:1010428317699112 pubmed publisher
    ..Among small leucine rich proteoglycans, Decorin, Biglycan and Lumican are most commonly implicated markers, and their expression is well studied in various ..
  3. Neill T, Sharpe C, Owens R, Iozzo R. Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy. J Biol Chem. 2017;292:16211-16220 pubmed publisher
    ..b>Decorin, an archetypical small leucine-rich proteoglycan, initiates a protracted autophagic program downstream of VEGF ..
  4. Maccarana M, Svensson R, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, et al. Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS ONE. 2017;12:e0184028 pubmed publisher
    ..Also, decorin and biglycan were doubled in Aspn-/- skin...
  5. Sato E, Zhang L, Dorschner R, Adase C, Choudhury B, Gallo R. Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol. 2017;137:1774-1783 pubmed publisher
    ..a parathyroid hormone ligand family member that was recently identified to be expressed in the skin, can induce decorin expression and enhance wound repair...
  6. Ibrahim I, Serrano M, Ruest L, Svoboda K. Biglycan and Decorin Expression and Distribution in Palatal Adhesion. J Dent Res. 2017;96:1445-1450 pubmed publisher
    ..In this study, we identified 2 proteoglycans, biglycan and decorin, that were expressed in the palatal shelves prior to adhesion...