Summary: A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.

Top Publications

  1. Chen J, Singh K, Mukherjee B, Sodek J. Developmental expression of osteopontin (OPN) mRNA in rat tissues: evidence for a role for OPN in bone formation and resorption. Matrix. 1993;13:113-23 pubmed
    b>Osteopontin (OPN) is a 34-kDa, highly-phosphorylated glycoprotein with cell attachment properties that is a prominent constituent of the bone matrix...
  2. Momiyama Y, Ohmori R, Fayad Z, Kihara T, Tanaka N, Kato R, et al. Associations between plasma osteopontin levels and the severities of coronary and aortic atherosclerosis. Atherosclerosis. 2010;210:668-70 pubmed publisher
  3. Weinreb M, Shinar D, Rodan G. Different pattern of alkaline phosphatase, osteopontin, and osteocalcin expression in developing rat bone visualized by in situ hybridization. J Bone Miner Res. 1990;5:831-42 pubmed
    Alkaline phosphatase (AP), osteopontin (OP), and osteocalcin (OC) are expressed during osteoblastic differentiation. However, previous studies suggested differences in the timing and possibly the site of their expression...
  4. Aherrahrou R, Aherrahrou Z, Schunkert H, Erdmann J. Coronary artery disease associated gene Phactr1 modulates severity of vascular calcification in vitro. Biochem Biophys Res Commun. 2017;491:396-402 pubmed publisher
    ..Down-regulation of Phactr1 decreased calcification. Decreased expression of the osteogenic marker osteopontin confirmed this finding at the molecular level...
  5. Zhang Y, Zhao S, Zhu Z, Wang Y, Liu J, Zhang Z, et al. Cx43- and Smad-Mediated TGF-?/ BMP Signaling Pathway Promotes Cartilage Differentiation of Bone Marrow Mesenchymal Stem Cells and Inhibits Osteoblast Differentiation. Cell Physiol Biochem. 2017;42:1277-1293 pubmed publisher
    ..the glycosaminoglycan content of the extracellular matrix and the expression of type II collagen, Col2a1, osteopontin (OPN) and osteocalcin (OC) were higher in the AdBMP2, AdSmad1, AdCx43 + AdSmad1 and AdCx43 + AdSmad1 + AdBMP2 ..
  6. Wang M, Han J, Marcar L, Black J, Liu Q, Li X, et al. Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. Cancer Res. 2017;77:2018-2028 pubmed publisher
    ..Mechanistic investigations defined a pathway involving osteopontin and the EGFR in promoting this phenotype...
  7. Wachters J, Schrijvers M, Slagter Menkema L, Mastik M, de Bock G, Langendijk J, et al. Prognostic significance of HIF-1a, CA-IX, and OPN in T1-T2 laryngeal carcinoma treated with radiotherapy. Laryngoscope. 2013;123:2154-60 pubmed
    ..2008) could not be confirmed. The absence of prognostic significance for HIF-1a and CA-IX toward local control in supraglottic LSCC, unlike glottic LSCC, suggests that supraglottic LSCC might represent another biological entity. ..
  8. Psyrri A, Kalogeras K, Wirtz R, Kouvatseas G, Karayannopoulou G, Goussia A, et al. Association of osteopontin with specific prognostic factors and survival in adjuvant breast cancer trials of the Hellenic Cooperative Oncology Group. J Transl Med. 2017;15:30 pubmed publisher
    ..b>Osteopontin (OPN) is a matricellular protein that has been suggested to be a potential biomarker in BC...
  9. Marques D, Grativol J, Alves da Silva Peres R, da Rocha Matos A, Gimba E. Osteopontin-c isoform levels are associated with SR and hnRNP differential expression in ovarian cancer cell lines. Tumour Biol. 2017;39:1010428317725442 pubmed publisher
    b>Osteopontin-c splicing isoform activates ovarian cancer progression features...

More Information


  1. Piao Z, Yuan H. Osteopontin exacerbates Pseudomonas aeruginosa-induced bacteremia in mice. Cell Immunol. 2017;318:23-28 pubmed publisher
    b>Osteopontin (OPN) is a multifunctional protein involved in various pathophysiological processes. However, the role of OPN in Pseudomonas aeruginosa-related sepsis is not yet clear...
  2. Liu X, Sun Y, Li H, Li Y, Li M, Yuan Y, et al. Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury. BMC Neurosci. 2017;18:30 pubmed publisher
    ..These results shed new light on the role of Spp1 in nerve degeneration and regeneration during WD. ..
  3. Kitagori K, Yoshifuji H. Osteopontin in systemic lupus erythematosus. Nihon Rinsho Meneki Gakkai Kaishi. 2017;40:118-123 pubmed publisher
    ..In addition, OPN N-half in urine decreased after the treatment of LN, suggesting that OPN N-half in urine could be a biomarker for evaluating disease activity of LN. ..
  4. Bastos A, Blunck C, Emerenciano M, Gimba E. Osteopontin and their roles in hematological malignancies: Splice variants on the new avenues. Cancer Lett. 2017;408:138-143 pubmed publisher
    b>Osteopontin (OPN) is a protein expressed in several tissues, including bone marrow, in which it performs distinct roles, such as modulating hematopoietic stem cell niche and bone remodeling...
  5. Liu L, Luo Q, Sun J, Wang A, Shi Y, Ju Y, et al. Decreased nuclear stiffness via FAK-ERK1/2 signaling is necessary for osteopontin-promoted migration of bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2017;355:172-181 pubmed publisher
    ..Our previous study indicated that osteopontin (OPN) significantly promotes the migration of rat BMSCs...
  6. Wang J, Li J, Yang L, Zhou Y, Wang Y. Dose-dependence of PTH-related peptide-1 on the osteogenic induction of MC3T3-E1 cells in vitro. Medicine (Baltimore). 2017;96:e6637 pubmed publisher
    ..alkaline phosphatase (ALP), and ALP activity, osteocalcin concentration, and collagen type I (Col-I), osteopontin (OPN), and osteocalcin (OCN) mRNA expression by RT-PCR and protein expression by western blotting were observed ..
  7. Bhardwaj R, Bhardwaj A, Tandon C, Dhawan D, Bijarnia R, Kaur T. Implication of hyperoxaluria on osteopontin and ER stress mediated apoptosis in renal tissue of rats. Exp Mol Pathol. 2017;102:384-390 pubmed publisher
    ..Many studies have linked osteopontin expression with apoptosis and inflammation but so far its association with apoptosis with regard to ..
  8. Kanayama M, Xu S, Danzaki K, Gibson J, Inoue M, Gregory S, et al. Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nat Immunol. 2017;18:973-984 pubmed publisher
    The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity...
  9. Lu X, Ding Y, Niu Q, Xuan S, Yang Y, Jin Y, et al. ClC-3 chloride channel mediates the role of parathyroid hormone [1-34] on osteogenic differentiation of osteoblasts. PLoS ONE. 2017;12:e0176196 pubmed publisher
    ..From the above data, we conclude that the expression of ClC-3 chloride channels in osteoblasts helps them respond to PTH stimulation, which mediates osteogenic differentiation. ..
  10. Marycz K, Smieszek A, Jeleń M, Chrząstek K, Grzesiak J, Meissner J. The effect of the bioactive sphingolipids S1P and C1P on multipotent stromal cells--new opportunities in regenerative medicine. Cell Mol Biol Lett. 2015;20:510-33 pubmed publisher
    ..Our data demonstrated that in an appropriate combination, the bioactive sphingolipids S1P and C1P may find wide application in regenerative medicine, particularly in bone regeneration with the use of MSCs. ..
  11. Song X, Yang C, Zhang H, Wang J, Sun X, Hu L, et al. Hypoxia-Inducible Factor-1? (HIF-1?) Expression on Endothelial Cells in Juvenile Nasopharyngeal Angiofibroma: A Review of 70 cases and Tissue Microarray Analysis. Ann Otol Rhinol Laryngol. 2018;127:357-366 pubmed publisher
    ..factor-1? (HIF-1?) and its related molecules (cellular repressor of E1A-stimulated genes [CREG], osteopontin [OPN], proto-oncogene tyrosine-protein kinase Src [c-Src], and vascular endothelial growth factor [VEGF]) in ..
  12. Johansson C, Roser K, Bolind P, Donath K, Albrektsson T. Bone-tissue formation and integration of titanium implants: an evaluation with newly developed enzyme and immunohistochemical techniques. Clin Implant Dent Relat Res. 1999;1:33-40 pubmed
    ..This novel technique now may be used to describe the state of bone regeneration in the interface zone associated with implant research. ..
  13. Sheng X, Zhou D, Liu Q, Lou S, Song Q, Zhou Y. BRMS1 inhibits expression of NF-kappaB subunit p65, uPA and OPN in ovarian cancer cells. Eur J Gynaecol Oncol. 2014;35:236-42 pubmed
    ..Protein levels of nuclear factor-kappaB (NF-kappaB) subunit p65, osteopontin (OPN) and urokinase-type plasminogen activator (uPA) were evaluated by Western blot, immunofluorescence and ..
  14. Honore P, Jacobs R, Hendrickx I, De Waele E, Van Gorp V, Spapen H. Biomarker validity in the critically ill: all must face the (continuous) renal replacement challenge!. Crit Care. 2015;19:426 pubmed publisher
  15. Shao L, Zhang B, Wang L, Wu L, Kan Q, Fan K. MMP-9-cleaved osteopontin isoform mediates tumor immune escape by inducing expansion of myeloid-derived suppressor cells. Biochem Biophys Res Commun. 2017;493:1478-1484 pubmed publisher
    As an extracellular matrix protein, osteopontin (OPN) has been shown to play an important role in regulation of the immune response to tumors...
  16. De Filippis A, Buommino E, Domenico M, Feola A, Brunetti Pierri R, Rizzo A. Chlamydia trachomatis induces an upregulation of molecular biomarkers podoplanin, Wilms' tumour gene 1, osteopontin and inflammatory cytokines in human mesothelial cells. Microbiology. 2017;163:654-663 pubmed publisher
    ..inflammatory tumour cytokines and upregulates molecular biomarkers such as podoplanin, Wilms' tumour gene 1 and osteopontin in primary cultures of mesothelial cells (Mes1) and human mesothelioma cells (NCI)...
  17. Cavarretta E, Condorelli G. miR-21 and cardiac fibrosis: another brick in the wall?. Eur Heart J. 2015;36:2139-41 pubmed publisher
  18. Zurita A, Gagnon R, Liu Y, Tran H, Figlin R, Hutson T, et al. Integrating cytokines and angiogenic factors and tumour bulk with selected clinical criteria improves determination of prognosis in advanced renal cell carcinoma. Br J Cancer. 2017;117:478-484 pubmed publisher
    ..Seven preselected plasma CAFs (interleukin-6, interleukin-8, osteopontin, VEGF, hepatocyte growth factor, tissue inhibitor of metalloproteinases (TIMP-1), and E-selectin) were measured ..
  19. Hu J, Li G, Zhang P, Zhuang X, Hu G. A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis. 2017;8:e2679 pubmed publisher
    ..Mechanically, CD44v, but not CD44s, responds to osteopontin (OPN) in the lung environment to enhance cancer cell invasiveness and promote lung metastasis...
  20. Higashihori N, Lehnertz B, Sampaio A, Underhill T, Rossi F, Richman J. Methyltransferase G9A Regulates Osteogenesis via Twist Gene Repression. J Dent Res. 2017;96:1136-1144 pubmed publisher
    ..At E14.5, the nonosteogenic mesenchyme expressed TWIST, whereas the ossification center had strong RUNX2 and osteopontin expression...
  21. Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, et al. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 2017;95:817-833.e4 pubmed publisher
    ..AAV-assisted co-expression of two soluble proteins, namely insulin-like growth factor 1 (IGF1) and osteopontin (OPN), in cortical neurons leads to robust CST regrowth and the recovery of CST-dependent behavioral ..
  22. Zeng C, Gao S, Lei G. Response to 'OPN gene polymorphisms influence the risk of knee OA and OPN levels in synovial fluid in a Chinese population'. Arthritis Res Ther. 2014;16:433 pubmed
  23. Rullo O, Woo J, Parsa M, Hoftman A, Maranian P, Elashoff D, et al. Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus. Arthritis Res Ther. 2013;15:R18 pubmed publisher
    b>Osteopontin (OPN) has been implicated as a mediator of Th17 regulation via type I interferon (IFN) receptor signaling and in macrophage activity at sites of tissue repair...
  24. Kaleta B, Boguska A. Sildenafil, a Phosphodiesterase Type 5 Inhibitor, Downregulates Osteopontin in Human Peripheral Blood Mononuclear Cells. Arch Immunol Ther Exp (Warsz). 2017;65:347-353 pubmed publisher
    The aim of this study was to investigate the ability of sildenafil to regulate osteopontin (OPN) gene and protein in peripheral blood mononuclear cells (PBMCs) from healthy blood donors...
  25. Pio G, Xia Y, Piaseczny M, Chu J, Allan A. Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells. PLoS ONE. 2017;12:e0177640 pubmed publisher
    ..Specifically, we focused on bone-derived osteopontin and its ability to promote the migration and stem-like phenotype of breast cancer cells...
  26. Dressen K, Hermann N, Manekeller S, Walgenbach Bruenagel G, Schildberg F, Hettwer K, et al. Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer. Anticancer Res. 2017;37:2477-2486 pubmed
    ..893) compared to the biomarkers alone. Differential diagnosis of CRC can be improved by new biomarker classes and their combination assessed by novel multiplex immunoassay. ..
  27. Chenu C, Colucci S, Grano M, Zigrino P, Barattolo R, Zambonin G, et al. Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells. J Cell Biol. 1994;127:1149-58 pubmed
    ..Osteocalcin promoted adhesion and spreading of these cells, triggering the release of bone sialoprotein (BSP), osteopontin (OPN) and fibronectin (FN), that in turn induced the clustering in focal adhesions of beta 1 and beta 3 ..
  28. Sakaue T, Suzuki J, Hamaguchi M, Suehiro C, Tanino A, Nagao T, et al. Perivascular Adipose Tissue Angiotensin II Type 1 Receptor Promotes Vascular Inflammation and Aneurysm Formation. Hypertension. 2017;70:780-789 pubmed publisher
    ..Moreover, osteopontin expression and gelatinolytic activity were considerably lower in ApoE-/- AT1a-/-
  29. Addison W, McKee M. ASARM mineralization hypothesis: a bridge to progress. J Bone Miner Res. 2010;25:1191-2 pubmed publisher
  30. Motyl K, Rosen C. The skeleton and the sympathetic nervous system: it's about time!. J Clin Endocrinol Metab. 2012;97:3908-11 pubmed publisher
  31. Thomas S, Anderson S, Gordon K, Oyama T, Shankland S, Johnson R. Tubulointerstitial disease in aging: evidence for underlying peritubular capillary damage, a potential role for renal ischemia. J Am Soc Nephrol. 1998;9:231-42 pubmed
    ..myofibroblast activation, macrophage infiltration with increased immunostaining for the adhesive proteins osteopontin and intercellular adhesion molecule-1, and collagen IV deposition...
  32. Lytle K, Wong C, Jump D. Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice. PLoS ONE. 2017;12:e0173376 pubmed publisher
    ..While these studies establish that DHA supplementation of the WD blocks WD-induced NASH progression, DHA alone does not promote full remission of diet-induced MetS or NASH. ..
  33. Ito M, Makino N, Matsuda A, Ikeda Y, Kakizaki Y, Saito Y, et al. High Glucose Accelerates Cell Proliferation and Increases the Secretion and mRNA Expression of Osteopontin in Human Pancreatic Duct Epithelial Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..Recently, it has become evident that patients suffering from diabetes and obesity show increased expression of osteopontin (OPN)...
  34. Liu W, Xia W, Fan Y, Wang H, Zuo K, Lai Y, et al. Elevated serum osteopontin level is associated with blood eosinophilia and asthma comorbidity in patients with allergic rhinitis. J Allergy Clin Immunol. 2012;130:1416-8.e6 pubmed publisher
  35. Bandiera E, Zanotti L, Fabricio A, Bucca E, Squarcina E, Romani C, et al. Cancer antigen 125, human epididymis 4, kallikrein 6, osteopontin and soluble mesothelin-related peptide immunocomplexed with immunoglobulin M in epithelial ovarian cancer diagnosis. Clin Chem Lab Med. 2013;51:1815-24 pubmed publisher
    Human epididymis protein 4 (HE4), kallikrein 6 (KLK6), osteopontin (OPN) and soluble mesothelin-related peptide (SMRP) are new promising biomarkers that could integrate CA125 in epithelial ovarian cancer (EOC) diagnosis...
  36. Smuthkochorn S, Palomo J, Hans M, Jones C, Palomo L. Gingival crevicular fluid bone turnover biomarkers: How postmenopausal women respond to orthodontic activation. Am J Orthod Dentofacial Orthop. 2017;152:33-37 pubmed publisher
    ..This confers a level of security associated with orthodontic activation. Future studies are warranted to construct biomarker curves throughout orthodontic therapy. ..
  37. Hussain S, Palmer D, Syn W, Sacco J, Greensmith R, Elmetwali T, et al. Gene expression profiling in bladder cancer identifies potential therapeutic targets. Int J Oncol. 2017;50:1147-1159 pubmed publisher
    ..b>Osteopontin (OPN) expression was validated by immunohistochemistry...
  38. Kyriakides T, Pegoraro E, Hoffman E, Piva L, Cagnin S, Lanfranchi G, et al. SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy: predicting the severity of Duchenne muscular dystrophy: implications for treatment. Neurology. 2011;77:1858; author reply 1858-9 pubmed publisher
  39. Rosenberg M, Meyer F, Gruenig E, Schuster T, Lutz M, Lossnitzer D, et al. Osteopontin (OPN) improves risk stratification in pulmonary hypertension (PH). Int J Cardiol. 2012;155:504-5 pubmed publisher
  40. Zhang Y, Du W, Chen Z, Xiang C. Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma. Exp Cell Res. 2017;359:449-457 pubmed publisher
    ..These results highlight the importance of SPP1 in mediating macrophage polarization and lung cancer evasion, suggesting a potential therapeutic target for lung cancer. ..
  41. Riccardo F, Arigoni M, Buson G, Zago E, Iezzi M, Longo D, et al. Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers. BMC Genomics. 2014;15 Suppl 3:S1 pubmed publisher
    ..Our study provided a complete transcription overview of the K-ras(LA1)/p53(R172H?g) mouse NSCLC model. This approach allowed the detection of ADORA3 as a potential target for antibody-based therapy in p53 mutated tumors. ..
  42. Wang G, Xie L, Hu J, Lu H, Liu X, Cao Y, et al. Osteopontin, Bone Morphogenetic Protein-4, and Vitamin D Receptor Gene Polymorphisms in the Susceptibility and Clinical Severity of Spinal Tuberculosis. Cell Physiol Biochem. 2017;41:1881-1893 pubmed publisher
    ..This study investigated the clinical significances of bone morphogenetic protein-4 (BMP-4), osteopontin (OPN), and vitamin D receptor (VDR) gene polymorphism, mRNA and protein expression in spinal TB patients...
  43. Raimondo A, Lembo S, Di Caprio R, Donnarumma G, Monfrecola G, Balato N, et al. Psoriatic cutaneous inflammation promotes human monocyte differentiation into active osteoclasts, facilitating bone damage. Eur J Immunol. 2017;47:1062-1074 pubmed publisher
    ..Our data demonstrate that psoriatic cutaneous inflammation contributes to bone damage...
  44. Hao C, Cui Y, Hu M, Zhi X, Zhang L, Li W, et al. OPN-a Splicing Variant Expression in Non-small Cell Lung Cancer and its Effects on the Bone Metastatic Abilities of Lung Cancer Cells In Vitro. Anticancer Res. 2017;37:2245-2254 pubmed
    b>Osteopontin (OPN) is known to be involved in the development of certain cancers, including non-small cell lung cancer (NSCLC). However, its role in tumour progression remains unclear...
  45. Halling Linder C, Ek Rylander B, Krumpel M, Norgård M, Narisawa S, Millán J, et al. Bone Alkaline Phosphatase and Tartrate-Resistant Acid Phosphatase: Potential Co-regulators of Bone Mineralization. Calcif Tissue Int. 2017;101:92-101 pubmed publisher
    Phosphorylated osteopontin (OPN) inhibits hydroxyapatite crystal formation and growth, and bone alkaline phosphatase (BALP) promotes extracellular mineralization via the release of inorganic phosphate from the mineralization inhibitor ..
  46. Grbčić P, Tomljanović I, Klobučar M, Kraljevic Pavelic S, Lucin K, Sedic M. Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling. Biochem Biophys Res Commun. 2017;487:782-788 pubmed publisher
    ..by dual Sphk 1/2 inhibition could include abrogation of FAK-regulated IGF-1R activity and down-regulation of osteopontin expression culminating in the inhibition of NF-?B activity and its downstream signalling mediated by sirtuin 1 ..
  47. Hermann N, Dressen K, Schroeder L, Debald M, Schildberg F, Walgenbach Bruenagel G, et al. Diagnostic relevance of a novel multiplex immunoassay panel in breast cancer. Tumour Biol. 2017;39:1010428317711381 pubmed publisher
    ..cancer antigen 125, hepatocyte growth factor, soluble Fas, tumor necrosis factor-?, stem cell factor, and osteopontin. As most markers were also elevated in benign breast diseases, only cancer antigen 15-3 showed significant ..
  48. Luukkonen J, Pascual L, Patlaka C, Lång P, Turunen S, Halleen J, et al. Increased amount of phosphorylated proinflammatory osteopontin in rheumatoid arthritis synovia is associated to decreased tartrate-resistant acid phosphatase 5B/5A ratio. PLoS ONE. 2017;12:e0182904 pubmed publisher
    b>Osteopontin (OPN) is an immunoregulatory protein which production increases in both rheumatoid arthritis (RA) and osteoarthritis (OA)...
  49. Yang X, Sun J, Xia D, Can X, Liu L, Zhang J, et al. Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis. Cell Physiol Biochem. 2017;42:185-197 pubmed publisher
    ..Therefore, the aim of this study was to clarify the role of Capn4 in EOC. We evaluated Capn4 and osteopontin (OPN) expression in EOC cell lines and tissues from patients with ovarian cancer by western blotting and ..
  50. Mohammadi S, Zahedpanah M, Ghaffari S, Shaiegan M, Nikbakht M, Nikugoftar M. Osteopontin plays a unique role in resistance of CD34+/CD123+ human leukemia cell lines KG1a to parthenolide. Life Sci. 2017;189:89-95 pubmed publisher
    ..cytotoxic for leukemia-like KG1a cells and if it involves in certain molecular-mediated resistance, especially osteopontin (OPN)...
  51. Lenton S, Grimaldo M, Roosen Runge F, Schreiber F, Nylander T, Clegg R, et al. Effect of Phosphorylation on a Human-like Osteopontin Peptide. Biophys J. 2017;112:1586-1596 pubmed publisher
    ..b>Osteopontin, selected for this study due to its key role in biomineralization, is expressed in many species and tissues to ..
  52. Shan M, You R, Yuan X, Frazier M, Porter P, Seryshev A, et al. Agonistic induction of PPAR? reverses cigarette smoke-induced emphysema. J Clin Invest. 2014;124:1371-81 pubmed publisher
    ..mDC-dependent activation of T cell subsets requires expression of the SPP1 gene, which encodes osteopontin (OPN), a pleiotropic cytokine implicated in autoimmune responses...
  53. Zou J, Shi Z, Xu H, Li X. In Vitro Studies on the Degradability, Bioactivity, and Cell Differentiation of PRP/AZ31B Mg Alloys Composite Scaffold. Biomed Res Int. 2017;2017:5763173 pubmed publisher
    ..In summary, the in vitro study implied that AZ31B combined with PRP could remarkably improve cell seeding, attachment, proliferation, and differentiation. ..
  54. Möbius P, Preidl R, Weber M, Amann K, Neukam F, Wehrhan F. Re-expression of pro-fibrotic, embryonic preserved mediators in irradiated arterial vessels of the head and neck region. Strahlenther Onkol. 2017;193:951-960 pubmed publisher
    ..Fibrogenesis is associated with re-expression of embryonic preserved tissue developmental mediators: osteopontin (OPN), regulated by sex-determining region Y?box 9 (Sox9), and homeobox A9 (HoxA9) play important roles in ..
  55. Choi E, Lee J, Baek S, Kim S. Gene expression profile altered by orthodontic tooth movement during healing of surgical alveolar defect. Am J Orthod Dentofacial Orthop. 2017;151:1107-1115 pubmed publisher
    ..It would be a basis on selecting putative genes to be therapeutically applied for tissue-friendly accelerated orthodontics in the future. ..
  56. McRobb L, McGrath K, Tsatralis T, Liong E, Tan J, Hughes G, et al. Estrogen Receptor Control of Atherosclerotic Calcification and Smooth Muscle Cell Osteogenic Differentiation. Arterioscler Thromb Vasc Biol. 2017;37:1127-1137 pubmed publisher
    ..increased collagen I and II, osteocalcin and bone sialoprotein, and reduced matrix Gla protein and osteopontin. Antagonism or RNA silencing of estrogen receptor alpha, ER?, or both further increased VSMC mineralization...
  57. Quattrocelli M, Capote J, Ohiri J, Warner J, Vo A, Earley J, et al. Genetic modifiers of muscular dystrophy act on sarcolemmal resealing and recovery from injury. PLoS Genet. 2017;13:e1007070 pubmed publisher
    ..Two genetic modifiers of Duchenne Muscular Dystrophy implicate the transforming growth factor ? (TGF?) pathway, osteopontin encoded by the SPP1 gene and latent TGF? binding protein 4 (LTBP4)...