ribosomal protein s6

Summary

Summary: A ribosomal protein that may play a role in controlling cell growth and proliferation. It is a major substrate of RIBOSOMAL PROTEIN S6 KINASES and plays a role in regulating the translation (TRANSLATION, GENETIC) of RNAs that contain an RNA 5' TERMINAL OLIGOPYRIMIDINE SEQUENCE.

Top Publications

  1. Kawano F, Matsuoka Y, Oke Y, Higo Y, Terada M, Wang X, et al. Role(s) of nucleoli and phosphorylation of ribosomal protein S6 and/or HSP27 in the regulation of muscle mass. Am J Physiol Cell Physiol. 2007;293:C35-44 pubmed
    ..and domain, the number of nucleoli in a single myonucleus, and the levels in the phosphorylation of the ribosomal protein S6 (S6) and 27-kDa heat shock protein (HSP27) were studied in rat soleus...
  2. Chan Y, Wool I. The primary structure of rat ribosomal protein S6. J Biol Chem. 1988;263:2891-6 pubmed
    The amino acid sequence of rat ribosomal protein S6, the major phosphoprotein in the organelle, was deduced from the sequence of nucleotides in two recombinant cDNAs and confirmed from the sequence of amino acids in portions of the ..
  3. Ly C, Arechiga A, Melo J, Walsh C, Ong S. Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. Cancer Res. 2003;63:5716-22 pubmed
    ..substrate motif of serine/threonine kinases with bioinformatics, we found that the translational regulators ribosomal protein S6 and 4E-BP1 are constitutively phosphorylated in CML cells...
  4. Stewart M, Denell R. Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth. Mol Cell Biol. 1993;13:2524-35 pubmed
    ..Surprisingly, these mutations are due to P element insertions in the 5' regulatory region of the Drosophila gene encoding ribosomal protein S6 and cause a reduction of S6 transcript abundance in mutant larvae.
  5. Gong Y, Ishida Takahashi R, Villanueva E, Fingar D, Munzberg H, Myers M. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem. 2007;282:31019-27 pubmed
    ..Here we demonstrate that leptin stimulates the phosphorylation of STAT5 and ribosomal protein S6 in the hypothalamic arcuate nucleus in mice...
  6. Haglund E, Lind J, Oman T, Ohman A, Mäler L, Oliveberg M. The HD-exchange motions of ribosomal protein S6 are insensitive to reversal of the protein-folding pathway. Proc Natl Acad Sci U S A. 2009;106:21619-24 pubmed publisher
    ..A typical example is the ribosomal protein S6, which comprises two folding nuclei (sigma1 and sigma2) defining two competing pathways in the folding ..
  7. Cloughesy T, Yoshimoto K, Nghiemphu P, Brown K, Dang J, Zhu S, et al. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 2008;5:e8 pubmed publisher
    ..The short-term treatment endpoints used in this neoadjuvant trial design identified the importance of monitoring target inhibition and negative feedback to guide future clinical development. http://www.ClinicalTrials.gov (#NCT00047073). ..
  8. Welle S, Burgess K, Mehta S. Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice. Am J Physiol Endocrinol Metab. 2009;296:E567-72 pubmed publisher
    ..JA16 increased phosphorylation of p70 S6 kinase (S6K) and ribosomal protein S6 (rpS6) 1.9-fold (P < 0.05)...
  9. Robb V, Astrinidis A, Henske E. Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas. Mod Pathol. 2006;19:839-46 pubmed
    ..Phospho-ribosomal protein S6 (Ser235/236) immunohistochemistry was performed on five lymphangioleiomyomatosis-associated angiomyolipomas,..

More Information

Publications63

  1. Williams A, Werner Fraczek J, Chang I, Bailey Serres J. Regulated phosphorylation of 40S ribosomal protein S6 in root tips of maize. Plant Physiol. 2003;132:2086-97 pubmed
    b>Ribosomal protein S6 (RPS6) is located in the mRNA binding site of the 40S subunit of cytosolic ribosomes. Two maize (Zea mays) rps6 genes were identified that encode polypeptides (30 kD, 11...
  2. Roux P, Shahbazian D, Vu H, Holz M, Cohen M, Taunton J, et al. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem. 2007;282:14056-64 pubmed
    ..These data demonstrate that RSK provides an mTOR-independent pathway linking the Ras/ERK signaling cascade to the translational machinery. ..
  3. Volarevic S, Stewart M, Ledermann B, Zilberman F, Terracciano L, Montini E, et al. Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science. 2000;288:2045-7 pubmed
    ..To test this possibility, we conditionally deleted the gene encoding 40S ribosomal protein S6 in the liver of adult mice...
  4. Yang C, Zhang C, Dittman J, Whitham S. Differential requirement of ribosomal protein S6 by plant RNA viruses with different translation initiation strategies. Virology. 2009;390:163-73 pubmed publisher
    ..These results demonstrate that cap-independent TuMV and TBSV require RPS6 for their accumulation, whereas accumulation of TMV is independent of RPS6. ..
  5. Hasgall P, Hoogewijs D, Faza M, Panse V, Wenger R, Camenisch G. The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation. PLoS ONE. 2011;6:e22107 pubmed publisher
    ..Importantly, downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6.
  6. Knight Z, Tan K, Birsoy K, Schmidt S, Garrison J, Wysocki R, et al. Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell. 2012;151:1126-37 pubmed publisher
    ..Here, we show that ribosomal protein S6, a structural component of the ribosome, becomes phosphorylated in neurons activated by a wide range of ..
  7. Watson K, Konrad K, Woods D, Bryant P. Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. Proc Natl Acad Sci U S A. 1992;89:11302-6 pubmed
    ..The results reveal a regulatory function of this ribosomal protein in the hematopoietic system of Drosophila that may be related to its developmentally regulated phosphorylation. ..
  8. Ruvinsky I, Katz M, Dreazen A, Gielchinsky Y, Saada A, Freedman N, et al. Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit. PLoS ONE. 2009;4:e5618 pubmed publisher
    Mice, whose ribosomal protein S6 cannot be phosphorylated due to replacement of all five phosphorylatable serine residues by alanines (rpS6(P-/-)), are viable and fertile...
  9. Chang Y, Traugh J. Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation. J Biol Chem. 1997;272:28252-7 pubmed
    ..in response to insulin is concomitant with increased phosphorylation of initiation factors 4B and 4G and ribosomal protein S6 (Morley, S. J., and Traugh, J. A...
  10. Goncharova E, Goncharov D, Eszterhas A, Hunter D, Glassberg M, Yeung R, et al. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem. 2002;277:30958-67 pubmed
    ..We found that ribosomal protein S6 (S6), which exerts translational control of protein synthesis and is required for cell growth, is ..
  11. Morimoto T, Suzuki Y, Yamaguchi I. Effects of partial suppression of ribosomal protein S6 on organ formation in Arabidopsis thaliana. Biosci Biotechnol Biochem. 2002;66:2437-43 pubmed
    ..The inserted DNA was a 3'-fragment of the ribosomal protein S6 gene with antisense orientation...
  12. Chung J, Choi H, Kim S, Hong K, Min S, Nam M, et al. Proteomic and biochemical analyses reveal the activation of unfolded protein response, ERK-1/2 and ribosomal protein S6 signaling in experimental autoimmune myocarditis rat model. BMC Genomics. 2011;12:520 pubmed publisher
    ..rat heart tissues, the amounts and activities of extracellular signal-regulated kinase (ERK)-1/2 and ribosomal protein S6 (rpS6) were significantly increased...
  13. Rozeman L, Szuhai K, Schrage Y, Rosenberg C, Tanke H, Taminiau A, et al. Array-comparative genomic hybridization of central chondrosarcoma: identification of ribosomal protein S6 and cyclin-dependent kinase 4 as candidate target genes for genomic aberrations. Cancer. 2006;107:380-8 pubmed
    ..Recurrent chondrosarcomas can be of a higher grade compared with primary tumors, suggesting possible progression...
  14. Kang W, Icho T, Isono S, Kitakawa M, Isono K. Characterization of the gene rimK responsible for the addition of glutamic acid residues to the C-terminus of ribosomal protein S6 in Escherichia coli K12. Mol Gen Genet. 1989;217:281-8 pubmed
    b>Ribosomal protein S6 of wild-type strains of Escherichia coli contains up to six glutamic acid residues at its C-terminus...
  15. Aguilar V, Alliouachene S, Sotiropoulos A, Sobering A, Athea Y, Djouadi F, et al. S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metab. 2007;5:476-87 pubmed
    ..These data indicate that S6K1 controls the energy state of the cell and the AMPK-dependent metabolic program, providing a mechanism for cell mass accumulation under high-calorie diet. ..
  16. Montgomery S, Berglund P, Beard C, Johnston R. Ribosomal protein S6 associates with alphavirus nonstructural protein 2 and mediates expression from alphavirus messages. J Virol. 2006;80:7729-39 pubmed
    ..We demonstrate here that nsP2 associates with ribosomal protein S6 (RpS6) and that nsP2 is present in the ribosome-containing fractions of a polysome gradient, suggesting ..
  17. Kim S, Jang Y, Chau G, Pyo S, Um S. Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma. Mod Pathol. 2013;26:327-35 pubmed publisher
    b>Ribosomal protein S6 is a key regulator of 40S ribosome biogenesis, and its phosphorylation is closely related to cell growth capacity...
  18. Bandi H, Ferrari S, Krieg J, Meyer H, Thomas G. Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum. J Biol Chem. 1993;268:4530-3 pubmed
    All of the phosphorylation sites in 40 S ribosomal protein S6 derived from serum-stimulated Swiss mouse 3T3 cells are found within a small cyanogen bromide (CNBr) peptide derived from the carboxyl terminus, Lys218-Lys249...
  19. Pata I, Metspalu A. Structural characterization of the mouse ribosomal protein S6-encoding gene. Gene. 1996;175:241-5 pubmed
    ..Besides the single-copy Rsp6 there are up to 15 S6 family members, most likely processed pseudogenes. Characterization of the Rps6 provides a basis to study the functions of the mammalian S6 by gene targeting. ..
  20. Radimerski T, Mini T, Schneider U, Wettenhall R, Thomas G, Jeno P. Identification of insulin-induced sites of ribosomal protein S6 phosphorylation in Drosophila melanogaster. Biochemistry. 2000;39:5766-74 pubmed
    ..multiply phosphorylated protein was the larger of two Drosophila melanogaster orthologues of mammalian 40S ribosomal protein S6, termed here DS6A...
  21. Chauvin C, Koka V, Nouschi A, Mieulet V, Hoareau Aveilla C, Dreazen A, et al. Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program. Oncogene. 2014;33:474-83 pubmed publisher
    ..S6Ks phosphorylate ribosomal protein S6 (rpS6) and additional proteins involved in the translational machinery, although the functional roles of ..
  22. Hellyer N, Nokleby J, Thicke B, Zhan W, Sieck G, Mantilla C. Reduced ribosomal protein s6 phosphorylation after progressive resistance exercise in growing adolescent rats. J Strength Cond Res. 2012;26:1657-66 pubmed publisher
    ..In addition, we observed that the ratio of phosphorylated-to-unphosphorylated ribosomal protein S6 (rpS6) was reduced over sixfold in PRE animals (p < 0...
  23. Deli A, Schipany K, Rosner M, Hoger H, Pollak A, Li L, et al. Blocking mTORC1 activity by rapamycin leads to impairment of spatial memory retrieval but not acquisition in C57BL/6J mice. Behav Brain Res. 2012;229:320-4 pubmed publisher
    ..The current study extends knowledge on rapamycin in memory mechanisms and challenges work on deeper insights into the role of mTOR in different phases of memory formation and retrieval. ..
  24. An W, Cowburn R, Li L, Braak H, Alafuzoff I, Iqbal K, et al. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am J Pathol. 2003;163:591-607 pubmed
    ..The levels of ribosomal protein S6 as well as the levels of markers for the proteolytic system were also significantly increased in AD as ..
  25. Hutchinson J, Shanware N, Chang H, Tibbetts R. Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. J Biol Chem. 2011;286:8688-96 pubmed publisher
    b>Ribosomal protein S6 (rpS6) is a critical component of the 40 S ribosomal subunit that mediates translation initiation at the 5'-m(7)GpppG cap of mRNA...
  26. Schumacher A, Velentza A, Watterson D, Dresios J. Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis. Biochemistry. 2006;45:13614-21 pubmed
    ..We report here that the mammalian 40S ribosomal protein S6 is a DAPK substrate...
  27. Jeon Y, Kim I, Hong S, Nan H, Kim H, Lee H, et al. Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling. Oncogene. 2008;27:4344-52 pubmed publisher
    ..by TRAIL, we performed a functional genetic screening and rescued TRAIL-resistant Jurkat clones harboring ribosomal protein S6 (rpS6) cDNA in anti-sense frame...
  28. Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich Rain M, Nir T, et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev. 2005;19:2199-211 pubmed
    ..These mice suffer from diminished levels of pancreatic insulin, hypoinsulinemia, and impaired glucose tolerance. ..
  29. Khalaileh A, Dreazen A, Khatib A, Apel R, Swisa A, Kidess Bassir N, et al. Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer. Cancer Res. 2013;73:1811-20 pubmed publisher
    ..Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer...
  30. Stewart M, Denell R. The Drosophila ribosomal protein S6 gene includes a 3' triplication that arose by unequal crossing-over. Mol Biol Evol. 1993;10:1041-7 pubmed
    b>Ribosomal protein S6 (rpS6) is the major phosphoprotein of the small ribosomal subunit of eukaryotes and is phosphorylated in response to treatment with mitogens and other stimuli...
  31. Kimball S, Shantz L, Horetsky R, Jefferson L. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. J Biol Chem. 1999;274:11647-52 pubmed
    ..have been implicated in the regulation of specific mRNA translation: eukaryotic initiation factor eIF4E and ribosomal protein S6. Increased phosphorylation of eIF4E as well as its overexpression are associated with stimulation of ..
  32. Boylan J, Anand P, Gruppuso P. Ribosomal protein S6 phosphorylation and function during late gestation liver development in the rat. J Biol Chem. 2001;276:44457-63 pubmed
    The phosphorylation of ribosomal protein S6 is thought to be required for biosynthesis of the cell's translational apparatus, a critical component of cell growth and proliferation...
  33. Cota D, Proulx K, Smith K, Kozma S, Thomas G, Woods S, et al. Hypothalamic mTOR signaling regulates food intake. Science. 2006;312:927-30 pubmed
    ..Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake. ..
  34. Hernandez V, Higgins L, Schwientek M, Fallon A. The histone-like C-terminal extension in ribosomal protein S6 in Aedes and Anopheles mosquitoes is encoded within the distal portion of exon 3. Insect Biochem Mol Biol. 2003;33:901-10 pubmed
    In eukaryotic cells, ribosomal protein S6 (RPS6) is the major phosphorylated protein on the small ribosomal subunit...
  35. Panic L, Tamarut S, Sticker Jantscheff M, Barkic M, Solter D, Uzelac M, et al. Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol. 2006;26:8880-91 pubmed
    ..importance of this process during mouse oogenesis and embryonic development, we deleted one allele of the ribosomal protein S6 gene in growing oocytes and generated S6-heterozygous embryos...
  36. Lekmine F, Sassano A, Uddin S, Smith J, Majchrzak B, Brachmann S, et al. Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res. 2004;295:173-82 pubmed
  37. Arsham A, Howell J, Simon M. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem. 2003;278:29655-60 pubmed
    ..These data demonstrate a new mode of regulation of the mTOR pathway and position this pathway as a powerful point of control by O2 of cellular metabolism and energetics. ..
  38. Horiguchi G, Kodama H, Iba K. Mutations in a gene for plastid ribosomal protein S6-like protein reveal a novel developmental process required for the correct organization of lateral root meristem in Arabidopsis. Plant J. 2003;33:521-9 pubmed
    ..Map-based cloning of RFC3 gene revealed that it encodes a plastid-localized ribosomal protein S6-like protein and provides a potential link between control of plastid gene expression and LR development.
  39. Schmidt C, Lipsius E, Kruppa J. Nuclear and nucleolar targeting of human ribosomal protein S6. Mol Biol Cell. 1995;6:1875-85 pubmed
    Chimeric proteins were constructed to define the nuclear localization signals (NLSs) of human ribosomal protein S6. The complete cDNA sequence, different cDNA fragments and oligonucleotides of the human ribosomal proteins S6, respectively,..
  40. Stoycheva A, Brooks C, Onuchic J. Gatekeepers in the ribosomal protein s6: thermodynamics, kinetics, and folding pathways revealed by a minimalist protein model. J Mol Biol. 2004;340:571-85 pubmed
    We investigate the effect of structural gatekeepers on the folding of the ribosomal protein S6. Folding thermodynamics and early refolding kinetics are studied for this system utilizing computer simulations of a minimalist protein model...
  41. Sarkar S, Smith L, Logan S, Simpkins J. Estrogen-induced activation of extracellular signal-regulated kinase signaling triggers dendritic resident mRNA translation. Neuroscience. 2010;170:1080-5 pubmed publisher
    ..Taken together, our results provide a novel mechanism by which E2 may trigger local protein synthesis of ?-CaMKII in the dendrites, which is necessary for modulation of synaptic plasticity. ..
  42. Bertran Gonzalez J, Chieng B, Laurent V, Valjent E, Balleine B. Striatal cholinergic interneurons display activity-related phosphorylation of ribosomal protein S6. PLoS ONE. 2012;7:e53195 pubmed publisher
    ..We report a strong and sustained phosphorylation of ribosomal protein S6 on its serine 240 and 244 residues (p-Ser²???²??-S6rp), a protein integrant of the ribosomal machinery ..
  43. Valjent E, Bertran Gonzalez J, Bowling H, Lopez S, Santini E, Matamales M, et al. Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32. Neuropsychopharmacology. 2011;36:2561-70 pubmed publisher
    ..In this study, we have examined the effect of haloperidol on the state of phosphorylation of the ribosomal protein S6 (rpS6), a component of the small 40S ribosomal subunit...
  44. Meyuhas O. Physiological roles of ribosomal protein S6: one of its kind. Int Rev Cell Mol Biol. 2008;268:1-37 pubmed publisher
    The phosphorylation of ribosomal protein S6 (rpS6), which occurs in response to a wide variety of stimuli on five evolutionarily conserved serine residues, has attracted much attention since its discovery more than three decades ago...
  45. Ruvinsky I, Meyuhas O. Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci. 2006;31:342-8 pubmed
    ..of this network include the mammalian target of rapamycin (mTOR) and its downstream effectors - the ribosomal protein S6 kinase (S6K) and the translational repressor eukaryotic initiation factor 4E-binding protein...
  46. Lindahl M, Svensson L, Liljas A, Sedelnikova S, Eliseikina I, Fomenkova N, et al. Crystal structure of the ribosomal protein S6 from Thermus thermophilus. EMBO J. 1994;13:1249-54 pubmed
    The amino acid sequence and crystal structure of the ribosomal protein S6 from the small ribosomal subunit of Thermus thermophilus have been determined. S6 is a small protein with 101 amino acid residues...
  47. Robertson E, Aggison L, Nicholson A. Phosphorylation of elongation factor G and ribosomal protein S6 in bacteriophage T7-infected Escherichia coli. Mol Microbiol. 1994;11:1045-57 pubmed
    ..two-dimensional gel electrophoresis and specific immunoprecipitation, we show that elongation factor G and ribosomal protein S6 are phosphorylated following T7 infection...
  48. Tang H, Hornstein E, Stolovich M, Levy G, Livingstone M, Templeton D, et al. Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol Cell Biol. 2001;21:8671-83 pubmed
  49. Chow S, Minden M, Hedley D. Constitutive phosphorylation of the S6 ribosomal protein via mTOR and ERK signaling in the peripheral blasts of acute leukemia patients. Exp Hematol. 2006;34:1183-91 pubmed
    ..As well as identifying aberrant signal transduction in leukemia patients, the flow cytometry methodology has potential for the pharmacodynamic monitoring of novel agents that inhibit ERK or PI3-kinase/Akt/mTOR signaling. ..
  50. Chen W, Dittmer D. Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol. 2011;85:9495-505 pubmed publisher
    ..Here, we show that ribosomal protein S6 (RPS6) interacts with LANA...
  51. Hagner P, Mazan Mamczarz K, Dai B, Balzer E, Corl S, Martin S, et al. Ribosomal protein S6 is highly expressed in non-Hodgkin lymphoma and associates with mRNA containing a 5' terminal oligopyrimidine tract. Oncogene. 2011;30:1531-41 pubmed publisher
    ..In this study, we demonstrate that ribosomal protein S6 (RPS6) is highly expressed in primary diffuse large B-cell lymphoma (DLBCL) samples...
  52. Hsieh A, Costa M, Zollo O, Davis C, Feldman M, Testa J, et al. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 2010;17:249-61 pubmed publisher
    ..Thus, the 4EBP-eIF4E axis downstream of mTOR is a druggable mediator of translational control and Akt-mediated tumorigenesis that has important implications for the treatment of human cancers. ..
  53. Guo Y, Jiang W, Wu P, Liu Y, Zhou X, Kuang S, et al. The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-?B, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngod. Fish Shellfish Immunol. 2017;65:145-168 pubmed publisher
    ..antibacterial peptides, anti-inflammatory cytokines, inhibitor of ?B? (I?B?), target of rapamycin (TOR) and ribosomal protein S6 kinase 1 (S6K1), whereas up-regulated the mRNA levels of pro-inflammatory cytokines, nuclear factor kappa B ..
  54. Corcoran R, ROTHENBERG S, Hata A, Faber A, Piris A, Nazarian R, et al. TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma. Sci Transl Med. 2013;5:196ra98 pubmed publisher
    ..of TORC1 activity in response to RAF or MEK inhibitors, as measured by decreased phosphorylation of ribosomal protein S6 (P-S6), effectively predicted induction of cell death by the inhibitor in BRAF-mutant melanoma cell lines...