Summary: A layer of protein coating adsorbed by NANOPARTICLES upon entry into PLASMA or other protein-containing biological fluids, which affects how nanoparticles are internalized by cells and cleared from the body.
NÃ¤reoja T, Rosenholm J, LamminmÃ¤ki U, HÃ¤nninen P. Super-sensitive time-resolved fluoroimmunoassay for thyroid-stimulating hormone utilizing europium(III) nanoparticle labels achieved by protein corona stabilization, short binding time, and serum preprocessing. Anal Bioanal Chem. 2017;409:3407-3416 pubmed publisher
..The sensitivity enhancement was achieved by stabilization of the protein corona of the nanoparticle bioconjugates and a spot-coated configuration of the active solid-phase that reduced ..
Lundqvist M, Augustsson C, Lilja M, Lundkvist K, Dahlback B, Linse S, et al
. The nanoparticle protein corona formed in human blood or human blood fractions. PLoS ONE. 2017;12:e0175871 pubmed publisher
The protein corona formed around nanoparticles in protein-rich fluids plays an important role for nanoparticle biocompatibility, as found in several studies during the last decade...
Hamad Schifferli K. Exploiting the novel properties of protein coronas: emerging applications in nanomedicine. Nanomedicine (Lond). 2015;10:1663-74 pubmed publisher
..b>Protein corona composition changes with the environment and time, and also the physical properties of the underlying ..
Carrillo Carrión C, Carril M, Parak W. Techniques for the experimental investigation of the protein corona. Curr Opin Biotechnol. 2017;46:106-113 pubmed publisher
..with mass spectrometry, will be compared with indirect analysis, in which instead information about the protein corona is gathered from changes in the properties of the nanoparticles...
Chandran P, Riviere J, Monteiro Riviere N. Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells. Nanotoxicology. 2017;11:507-519 pubmed publisher
Nguyen V, Lee B. Protein corona: a new approach for nanomedicine design. Int J Nanomedicine. 2017;12:3137-3151 pubmed publisher
..In this review, we mainly focus on the formation of protein corona and its potential applications in pharmaceutical sciences such as prediction modeling based on NP-adsorbed ..
Zyuzin M, Yan Y, Hartmann R, Gause K, Nazarenus M, Cui J, et al
. Role of the Protein Corona Derived from Human Plasma in Cellular Interactions between Nanoporous Human Serum Albumin Particles and Endothelial Cells. Bioconjug Chem. 2017;28:2062-2068 pubmed publisher
The presence of a protein corona on various synthetic nanomaterials has been shown to strongly influence how they interact with cells...