Summary: A member of the CELF PROTEINS family which binds GU rich elements (GREs) and CUG-triplet repeats in the 3'UTR of mammalian mRNA transcripts that undergo rapid turnover. It also binds AU-rich elements (AREs or EDEN-like) in the 3'UTR of JUN and FOS mRNAs. Mutations in the human CELF1 gene are associated with MYOTONIC DYSTROPHY type 1.
Bai Z, Chai X, Yoon M, Kim H, Lo K, Zhang Z, et al
. Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators. PLoS Biol. 2017;15:e2002176 pubmed publisher
..Together, these studies provide a comprehensive data framework to interrogate the transcriptomic changes accompanying energy homeostasis transition in adipose tissue. ..
Kim J, Kwon H, Ryu D, Nam M, Shim B, Kim J, et al
. Inhibition of CUG-binding protein 1 and activation of caspases are critically involved in piperazine derivative BK10007S induced apoptosis in hepatocellular carcinoma cells. PLoS ONE. 2017;12:e0186490 pubmed publisher
..Overall, these findings provide scientific evidences that BK10007S induces apoptosis via inhibition of CUGBP1 and activation of caspases in hepatocellular carcinomas as a potent anticancer candidate. ..
Valanejad L, Lewis K, Wright M, Jiang Y, D Souza A, Karns R, et al
. FXR-Gankyrin axis is involved in development of pediatric liver cancer. Carcinogenesis. 2017;38:738-747 pubmed publisher
..Our data provide a strong basis for development of FXR-Gank-based therapy for treatment of patients with hepatoblastoma. ..
Zhang Y, Zhang Y, Xiao L, Yu T, Li J, Rao J, et al
. Cooperative Repression of Insulin-Like Growth Factor Type 2 Receptor Translation by MicroRNA 195 and RNA-Binding Protein CUGBP1. Mol Cell Biol. 2017;37: pubmed publisher
..These findings indicate that IGF2R expression is controlled posttranscriptionally by two factors that associate with Igf2r mRNA and suggest that miR-195 and CUGBP1 dampen IGF signaling by inhibiting IGF2R translation. ..
Xia H, Chen D, Wu Q, Wu G, Zhou Y, Zhang Y, et al
. CELF1 preferentially binds to exon-intron boundary and regulates alternative splicing in HeLa cells. Biochim Biophys Acta Gene Regul Mech. 2017;1860:911-921 pubmed publisher
..In addition, we found that CELF1 globally regulates the alternative splicing by binding the exon-intron boundary in HeLa cells, which will deepen our understanding of the regulatory roles of CELF1 in the pre-mRNA splicing process. ..
Chang K, Cheng C, King P, Liu S, Wang G. CELF1 Mediates Connexin 43 mRNA Degradation in Dilated Cardiomyopathy. Circ Res. 2017;121:1140-1152 pubmed publisher
..Our results suggest a mechanism for increased CELF1 expression downregulating Cx43 mRNA level and a pathogenic role for elevated CELF1 level in the DCM heart. ..
Lewis K, Valanejad L, Cast A, Wright M, Wei C, Iakova P, et al
. RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner. Mol Cell Biol. 2017;37: pubmed publisher
..Thus, this work presents evidence that de-ph-S302-CUGBP1 is a tumor suppressor protein and that the Gank-UPS-mediated reduction of CUGBP1 is a key event in the development of liver cancer. ..