rna recognition motif proteins


Summary: A family of RNA-BINDING PROTEINS that contain an RNA RECOGNITION MOTIF and two ribonucleoprotein (RNP) domains which bind RNA, in addition to other domains that allow for high affinity binding, sequence specificity, and protein interactions. Examples of RNA recognition motif proteins include HETEROGENEOUS NUCLEAR RIBONUCLEARPROTEINS (hnRNP) and EMBRYONIC LETHAL ABNORMAL-VISION (ELAV) proteins.

Top Publications

  1. Lu W, Cheng F, Yan W, Li X, Yao X, Song W, et al. Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017;36:4719-4731 pubmed publisher
    ..Collectively, this study demonstrates that pharmacologic inhibition of CypA offers a potential therapeutic strategy via specific activation of p53-72R in NSCLC. ..
  2. Galan A, Lozano G, Piñeiro D, Martinez Salas E. G3BP1 interacts directly with the FMDV IRES and negatively regulates translation. FEBS J. 2017;284:3202-3217 pubmed publisher
    ..Our results highlight the IRES-binding capacity of G3BP1 and illustrate its function as a translation inhibitor. ..
  3. Erickson S, Lykke Andersen J. Cytoplasmic mRNP granules at a glance. J Cell Sci. 2011;124:293-7 pubmed publisher
  4. Haag S, Schindler M, Berndt L, Brennicke A, Takenaka M, Weber G. Crystal structures of the Arabidopsis thaliana organellar RNA editing factors MORF1 and MORF9. Nucleic Acids Res. 2017;45:4915-4928 pubmed publisher
  5. Jung D, Ahn J, Rhee B, Kim J. Mutational analysis of the RNA helicase Dhh1 in Ste12 expression and yeast mating. J Microbiol. 2017;55:373-378 pubmed publisher
    ..The P-body accumulation induced by treatment with ?-mating factor required ATPase, RNA-binding and the Q/P-rich C-terminal domains of Dhh1. ..
  6. Wang X, Chang L, Wang H, Su A, Wu Z. Dcp1a and GW182 Induce Distinct Cellular Aggregates and Have Different Effects on microRNA Pathway. DNA Cell Biol. 2017;36:565-570 pubmed publisher
    ..Our results suggest that overexpressed Dcp1a and GW182 can form different cytoplasmic aggregates and play distinct biological roles in the miRNA pathway. ..