mrna cleavage and polyadenylation factors


Summary: Factors that are involved in directing the cleavage and POLYADENYLATION of the of MESSENGER RNA near the site of the RNA 3' POLYADENYLATION SIGNALS.

Top Publications

  1. Ansari A, Hampsey M. A role for the CPF 3'-end processing machinery in RNAP II-dependent gene looping. Genes Dev. 2005;19:2969-78 pubmed
  2. Meinhart A, Cramer P. Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors. Nature. 2004;430:223-6 pubmed
    ..The model suggests that, during the mRNA transcription-processing cycle, compact spiral regions in the CTD are unravelled and regenerated in a phosphorylation-dependent manner. ..
  3. Zhang D, Mosley A, Ramisetty S, Rodríguez Molina J, Washburn M, Ansari A. Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination. J Biol Chem. 2012;287:8541-51 pubmed publisher
    ..An inability to remove these marks prevents Pol II from terminating efficiently and will likely impede subsequent assembly into the pre-initiation complex. ..
  4. Mariconti L, Loll B, Schlinkmann K, Wengi A, Meinhart A, Dichtl B. Coupled RNA polymerase II transcription and 3' end formation with yeast whole-cell extracts. RNA. 2010;16:2205-17 pubmed publisher
    ..The in vitro transcription/processing system presented here should provide a useful tool to further define the role of factors involved in coupling. ..
  5. Xing D, Zhao H, Li Q. Arabidopsis CLP1-SIMILAR PROTEIN3, an ortholog of human polyadenylation factor CLP1, functions in gametophyte, embryo, and postembryonic development. Plant Physiol. 2008;148:2059-69 pubmed publisher
    ..These observations indicate that Arabidopsis CLPS3 might be involved in the processing of pre-mRNAs encoded by a distinct subset of genes that are important in plant development. ..
  6. Ryan K, Bauer D. Finishing touches: post-translational modification of protein factors involved in mammalian pre-mRNA 3' end formation. Int J Biochem Cell Biol. 2008;40:2384-96 pubmed publisher
    ..The roles of these covalent but reversible modifications in other systems suggest that 3' end formation in mammals relies upon post-translational modification for proper function and regulation. ..
  7. Pitini V, Arrigo C, Altavilla G, Naro C, Righi M. Imatinib-induced apoptosis in the eosinophils of patients with a hypereosinophilic syndrome: a surrogate marker of response?. Leuk Res. 2007;31:725-6 pubmed
  8. Burns D, Richter J. CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation. Genes Dev. 2008;22:3449-60 pubmed publisher
    ..Together, these results suggest that CPEB controls senescence and bioenergetics in human cells at least in part by modulating p53 mRNA polyadenylation-induced translation. ..
  9. Yamada Y, Cancelas J. FIP1L1/PDGFR alpha-associated systemic mastocytosis. Int Arch Allergy Immunol. 2010;152 Suppl 1:101-5 pubmed publisher
    ..Current findings of FIP1L1/PDGFR alpha-positive HES/CEL are reviewed focusing on aberrant mast cell development leading to SM...

More Information


  1. Forbes K, Addepalli B, Hunt A. An Arabidopsis Fip1 homolog interacts with RNA and provides conceptual links with a number of other polyadenylation factor subunits. J Biol Chem. 2006;281:176-86 pubmed
    ..These results indicate that the Arabidopsis Fip1, like its human counterpart, is an RNA-binding protein. Moreover, they provide conceptual links between PAP and several other Arabidopsis polyadenylation factor subunit homologs. ..
  2. Narita T, Yung T, Yamamoto J, Tsuboi Y, Tanabe H, Tanaka K, et al. NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs. Mol Cell. 2007;26:349-65 pubmed
    ..Our results point to a surprising role of NELF in the 3' end processing of histone mRNAs and also suggest that NELF is a new factor that coordinates different mRNA processing steps during transcription. ..
  3. Richter J. CPEB: a life in translation. Trends Biochem Sci. 2007;32:279-85 pubmed
    ..These observations underscore the growing complexities of CPEB involvement in cell function. ..
  4. Calvo O, Manley J. The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription. EMBO J. 2005;24:1009-20 pubmed
    ..Our data provide evidence that Rna15 and Sub1 are present along the length of several genes and that Sub1 facilitates elongation by influencing enzymes that modify RNAP II. ..
  5. Liu F, Marquardt S, Lister C, Swiezewski S, Dean C. Targeted 3' processing of antisense transcripts triggers Arabidopsis FLC chromatin silencing. Science. 2010;327:94-7 pubmed publisher
    ..Targeted 3' processing of antisense transcripts may be a common mechanism triggering transcriptional silencing of the corresponding sense gene. ..
  6. St André O, Lemieux C, Perreault A, Lackner D, Bahler J, Bachand F. Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast. J Biol Chem. 2010;285:27859-68 pubmed publisher
    ..Our findings have therefore uncovered a mode of gene regulation whereby a poly(A)-binding protein promotes RNA degradation in the nucleus to prevent untimely expression. ..
  7. He X, Moore C. Regulation of yeast mRNA 3' end processing by phosphorylation. Mol Cell. 2005;19:619-29 pubmed
    ..These results support a model in which poly(A) synthesis is controlled by cycles of phosphorylation and dephosphorylation that require the action of Glc7. ..
  8. McPheeters D, Cremona N, Sunder S, Chen H, Averbeck N, Leatherwood J, et al. A complex gene regulatory mechanism that operates at the nexus of multiple RNA processing decisions. Nat Struct Mol Biol. 2009;16:255-64 pubmed publisher
    ..This highly integrated regulatory strategy may ensure a rapid response to adverse conditions, thereby guaranteeing survival. ..
  9. Wagner E, Marzluff W. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. Mol Cell Biol. 2006;26:6702-12 pubmed
  10. Zhang Z, Fu J, Gilmour D. CTD-dependent dismantling of the RNA polymerase II elongation complex by the pre-mRNA 3'-end processing factor, Pcf11. Genes Dev. 2005;19:1572-80 pubmed
    ..We posit that conformational changes in the CTD are transduced through Pcf11 to the nascent transcript to cause termination. ..
  11. Jin Y, Chen Q, Lu Z, Chen B, Pan J. Triptolide abrogates oncogene FIP1L1-PDGFRalpha addiction and induces apoptosis in hypereosinophilic syndrome. Cancer Sci. 2009;100:2210-7 pubmed publisher
    ..Our results suggest that triptolide may be a promising agent in the treatment of HES. ..
  12. McEvoy M, Cao G, Montero Llopis P, Kundel M, Jones K, Hofler C, et al. Cytoplasmic polyadenylation element binding protein 1-mediated mRNA translation in Purkinje neurons is required for cerebellar long-term depression and motor coordination. J Neurosci. 2007;27:6400-11 pubmed
    ..Finally, mCPEB1-AA mice displayed a significant impairment of motor coordination and a motor learning delay. ..
  13. Mapendano C, Lykke Andersen S, Kjems J, Bertrand E, Jensen T. Crosstalk between mRNA 3' end processing and transcription initiation. Mol Cell. 2010;40:410-22 pubmed publisher
    ..Our data demonstrate that 3' end formation stimulates transcription initiation and suggest that coordinated recycling of factors from a gene terminator back to the promoter is essential for sustaining continued transcription. ..
  14. Nedea E, Nalbant D, Xia D, Theoharis N, Suter B, Richardson C, et al. The Glc7 phosphatase subunit of the cleavage and polyadenylation factor is essential for transcription termination on snoRNA genes. Mol Cell. 2008;29:577-87 pubmed publisher
    ..Swd2 is also a subunit of the Set1c histone H3K4 methyltransferase complex and is required for its stability and optimal methyltransferase activity. ..
  15. Hafer N, Xu S, Bhat K, Schedl P. The Drosophila CPEB protein Orb2 has a novel expression pattern and is important for asymmetric cell division and nervous system function. Genetics. 2011;189:907-21 pubmed publisher
    ..We also show that orb2 funtions in asymmetric division of stem cells and precursor cells during the development of the embryonic nervous system and mesoderm. ..
  16. Buitenhuis M, Verhagen L, Cools J, Coffer P. Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation. Cancer Res. 2007;67:3759-66 pubmed
  17. Yang Q, Coseno M, Gilmartin G, DOUBLIE S. Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. Structure. 2011;19:368-77 pubmed publisher
    ..The intrinsic ability of CFI(m) to direct RNA looping may provide a mechanism for its function in the regulation of alternative poly(A) site selection. ..
  18. Galimberti S, Ciabatti E, Ottimo F, Rossi A, Trombi L, Carulli G, et al. Cell clonality in hypereosinophilic syndrome: what pathogenetic role?. Clin Exp Rheumatol. 2007;25:17-22 pubmed
    ..In l-HES, T-lymphocytes could be involved in the pathogenesis through several cytokines, including IL5...
  19. Holbein S, Scola S, Loll B, Dichtl B, Hubner W, Meinhart A, et al. The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PLoS ONE. 2011;6:e29139 pubmed publisher
    ..Our results support a structural role for the Clp1 P-loop motif. ATP binding by Clp1 likely contributes to CF IA formation and cross-factor interactions during the dynamic process of 3' end formation. ..
  20. Leeper T, Qu X, Lu C, Moore C, Varani G. Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1. J Mol Biol. 2010;401:334-49 pubmed publisher
    ..Mutations in the regions of these contacts disrupt 3'-end processing, suggesting that they may structurally organize the ribonucleoprotein complexes responsible for RNA processing. ..
  21. Gruber A, Martin G, Keller W, Zavolan M. Cleavage factor Im is a key regulator of 3' UTR length. RNA Biol. 2012;9:1405-12 pubmed publisher
    ..More specifically, we demonstrate that the loss-of-function of CF Im 68 and CF Im 25 but not of CF Im 59 leads to a transcriptome-wide increase in the use of proximal polyadenylation sites in HEK293 cells. ..
  22. Gorgoni B, Andrews S, Schaller A, Schumperli D, Gray N, Muller B. The stem-loop binding protein stimulates histone translation at an early step in the initiation pathway. RNA. 2005;11:1030-42 pubmed
    ..We propose a model in which a novel factor contacts eIF4E bound to the 5' cap and SLBP bound to the 3' end simultaneously, mediating formation of an alternative end-to-end complex. ..
  23. Si K, Choi Y, White Grindley E, Majumdar A, Kandel E. Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation. Cell. 2010;140:421-35 pubmed publisher
    ..These results are consistent with the idea that ApCPEB can act as a self-sustaining prion-like protein in the nervous system and thereby might allow the activity-dependent change in synaptic efficacy to persist for long periods of time...
  24. Zhao X, McKillop Smith S, Muller B. The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells. J Cell Sci. 2004;117:6043-51 pubmed
    ..These findings indicate that human HBP/SLBP is essential for the coordinate synthesis of DNA and histone proteins and is required for progression through the cell division cycle. ..
  25. Zhang Y, Zhang M, Zhang Y. Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue. Biochem J. 2011;434:435-44 pubmed publisher
    ..Mutagenesis studies in this groove established the functional roles of five residues (Met17, Pro46, Asp51, Tyr77 and Met85) that are essential specifically for substrate recognition. ..
  26. Cardinale S, Cisterna B, Bonetti P, Aringhieri C, Biggiogera M, Barabino S. Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit. Mol Biol Cell. 2007;18:1282-92 pubmed
    ..These findings suggest that paraspeckles are a functional compartment involved in RNA metabolism in the cell nucleus...
  27. Mandel C, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley J, et al. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature. 2006;444:953-6 pubmed
    ..Our studies provide the first direct experimental evidence that CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. ..
  28. Sullivan K, Mullen T, Marzluff W, Wagner E. Knockdown of SLBP results in nuclear retention of histone mRNA. RNA. 2009;15:459-72 pubmed publisher
    ..The processed histone mRNA in SLBP knockdown cells is not rapidly degraded when DNA replication is inhibited. These results suggest a previously undescribed role for SLBP in histone mRNA export. ..
  29. Kim H, Erickson B, Luo W, Seward D, Graber J, Pollock D, et al. Gene-specific RNA polymerase II phosphorylation and the CTD code. Nat Struct Mol Biol. 2010;17:1279-86 pubmed publisher
    ..Nrd1 and Pcf11 frequently colocalize, suggesting functional overlap. Unexpectedly, Pcf11 is enriched at centromeres and Pol III-transcribed genes. ..
  30. Mayer A, Schreieck A, Lidschreiber M, Leike K, Martin D, Cramer P. The spt5 C-terminal region recruits yeast 3' RNA cleavage factor I. Mol Cell Biol. 2012;32:1321-31 pubmed publisher
    ..Consistent with this model, the CTR interacts with CFI in vitro but is not required for pA site recognition and transcription termination in vivo. ..
  31. Keall R, Whitelaw S, Pettitt J, Müller B. Histone gene expression and histone mRNA 3' end structure in Caenorhabditis elegans. BMC Mol Biol. 2007;8:51 pubmed
    ..elegans histone mRNA levels are elevated at periods of active cell division, indicating that histone gene expression is linked to DNA replication. ..
  32. Perez Canadillas J. Grabbing the message: structural basis of mRNA 3'UTR recognition by Hrp1. EMBO J. 2006;25:3167-78 pubmed
    ..Altogether, the Hrp1-PEE structure represents one of the first steps towards understanding of the assembly of the cleavage and polyadenylation machinery at the atomic level. ..
  33. Qu X, Lykke Andersen S, Nasser T, Saguez C, Bertrand E, Jensen T, et al. Assembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylation. Mol Cell Biol. 2009;29:5327-38 pubmed publisher
    ..Our results indicate a function for nuclear mRNP assembly factors in releasing the 3'-end processing complex once polyadenylation is complete. ..
  34. Krishnamurthy S, Ghazy M, Moore C, Hampsey M. Functional interaction of the Ess1 prolyl isomerase with components of the RNA polymerase II initiation and termination machineries. Mol Cell Biol. 2009;29:2925-34 pubmed publisher
  35. El Kaderi B, Medler S, Raghunayakula S, Ansari A. Gene looping is conferred by activator-dependent interaction of transcription initiation and termination machineries. J Biol Chem. 2009;284:25015-25 pubmed publisher
    ..Coimmunoprecipitation revealed a physical interaction of Rna15 with TFIIB. We propose that the activators facilitate gene looping through their interaction with TFIIB during transcriptional activation of genes. ..
  36. Kennedy S, Frazier M, Steiniger M, Mast A, Marzluff W, Redinbo M. Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin. J Mol Biol. 2009;392:115-28 pubmed publisher
    ..Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process. ..
  37. Gotlib J, Cools J. Five years since the discovery of FIP1L1-PDGFRA: what we have learned about the fusion and other molecularly defined eosinophilias. Leukemia. 2008;22:1999-2010 pubmed publisher
  38. Lin C, Evans V, Shen S, Xing Y, Richter J. The nuclear experience of CPEB: implications for RNA processing and translational control. RNA. 2010;16:338-48 pubmed publisher
    ..We propose that CPEB, together with Maskin, binds mRNA in the nucleus to ensure tight translational repression upon export to the cytoplasm. In addition, we propose that nuclear CPEB regulates specific pre-mRNA alternative splicing. ..
  39. Cevher M, Zhang X, Fernandez S, Kim S, Baquero J, Nilsson P, et al. Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage. EMBO J. 2010;29:1674-87 pubmed publisher
  40. Mayer A, Lidschreiber M, Siebert M, Leike K, Söding J, Cramer P. Uniform transitions of the general RNA polymerase II transcription complex. Nat Struct Mol Biol. 2010;17:1272-8 pubmed publisher
    ..Transitions are uniform and independent of gene length, type and expression. ..
  41. Kahn J, Dutoit Lefevre V, Duban Deweer S, Chafey P, Pottiez G, Lefranc D, et al. Comparative proteomic analysis of blood eosinophils reveals redox signaling modifications in patients with FIP1L1-PDGFRA-associated chronic eosinophilic leukemia. J Proteome Res. 2011;10:1468-80 pubmed publisher
  42. Li H, Tong S, Li X, Shi H, Ying Z, Gao Y, et al. Structural basis of pre-mRNA recognition by the human cleavage factor Im complex. Cell Res. 2011;21:1039-51 pubmed publisher
  43. Haddad R, Maurice F, Viphakone N, Voisinet Hakil F, Fribourg S, Minvielle Sebastia L. An essential role for Clp1 in assembly of polyadenylation complex CF IA and Pol II transcription termination. Nucleic Acids Res. 2012;40:1226-39 pubmed publisher
    ..We postulate that Clp1p transmits conformational changes to RNA Pol II through Pcf11p to couple transcription termination and 3'-end processing. These rearrangements likely rely on the correct orientation of ATP within Clp1p. ..
  44. Tian B, Graber J. Signals for pre-mRNA cleavage and polyadenylation. Wiley Interdiscip Rev RNA. 2012;3:385-96 pubmed publisher
    ..Here we review histories and current models of these elements in a broad range of species. ..
  45. Zofall M, Yamanaka S, REYES TURCU F, Zhang K, Rubin C, Grewal S. RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation. Science. 2012;335:96-100 pubmed publisher
    ..Our analyses uncover unexpected regulatory roles for mRNA-processing factors that assemble dynamic heterochromatin to modulate gene expression. ..
  46. Fukumitsu H, Soumiya H, Furukawa S. Knockdown of pre-mRNA cleavage factor Im 25 kDa promotes neurite outgrowth. Biochem Biophys Res Commun. 2012;425:848-53 pubmed publisher
    ..Taken together, our results indicate that endogenous CFIm may promote neuritogenesis in developing neurons by coordinating events upstream of NGF-induced RhoA inactivation. ..
  47. Tashiro S, Asano T, Kanoh J, Ishikawa F. Transcription-induced chromatin association of RNA surveillance factors mediates facultative heterochromatin formation in fission yeast. Genes Cells. 2013;18:327-39 pubmed publisher
    ..Mmi1 remains associated in cells lacking Red1, suggesting that the recruitment of Red1 follows the chromatin association of Mmi1. Overall, we provide detailed insights into the facultative heterochromatin regulation in fission yeast...
  48. Wagner E, Berkow A, Marzluff W. Expression of an RNAi-resistant SLBP restores proper S-phase progression. Biochem Soc Trans. 2005;33:471-3 pubmed
    ..Thus SLBP is required for efficient DNA replication probably because a decreased ability to assemble chromatin results in a decrease in the rate of DNA replication. ..
  49. DERMODY J, Dreyfuss J, Villen J, Ogundipe B, Gygi S, Park P, et al. Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation. PLoS ONE. 2008;3:e3273 pubmed publisher
    ..This work defines a novel role for Npl3 in elongation and its regulation by phosphorylation. ..
  50. Millevoi S, Loulergue C, Dettwiler S, Karaa S, Keller W, Antoniou M, et al. An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries. EMBO J. 2006;25:4854-64 pubmed
    ..These results therefore uncover a direct role of the U2AF 65/CF I(m) 59 interaction in the functional coordination of splicing and 3' end processing. ..
  51. Zhang Z, Gilmour D. Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript. Mol Cell. 2006;21:65-74 pubmed
    ..These results provide a biochemical basis for the dependency of termination on pausing and the CTD in metazoans. ..
  52. Pardanani A, Ketterling R, Li C, Patnaik M, Wolanskyj A, Elliott M, et al. FIP1L1-PDGFRA in eosinophilic disorders: prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature. Leuk Res. 2006;30:965-70 pubmed
    ..Lastly, we present a comprehensive review of the literature pertaining to FIP1L1-PDGFRA in order to address several key aspects of this mutation from a clinical standpoint. ..
  53. Cakmakci N, Lerner R, Wagner E, Zheng L, Marzluff W. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. Mol Cell Biol. 2008;28:1182-94 pubmed
    ..SLIP1 may function by bridging the 3' end of the histone mRNA with the 5' end of the mRNA, similar to the mechanism of translation of polyadenylated mRNAs. ..
  54. Burgstaller S, Kreil S, Waghorn K, Metzgeroth G, Preudhomme C, Zoi K, et al. The severity of FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia is associated with polymorphic variation at the IL5RA locus. Leukemia. 2007;21:2428-32 pubmed
    ..001). These data suggest that the variations in IL5RA expression are linked to constitutional IL5RA genotype and severity of FIP1L1-PDGFRA disease...
  55. Zhang Z, Klatt A, Henderson A, Gilmour D. Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression. Genes Dev. 2007;21:1609-14 pubmed
    ..Hence, Pcf11 can act as a negative elongation factor to repress RNA Pol II gene expression in eukaryotic cells. ..
  56. Hershkovits G, Bangio H, Cohen R, Katcoff D. Recruitment of mRNA cleavage/polyadenylation machinery by the yeast chromatin protein Sin1p/Spt2p. Proc Natl Acad Sci U S A. 2006;103:9808-13 pubmed
    ..It is synthetically lethal with Cdc73p, which is involved in the recruitment of the complex. This report shows that a chromatin component is involved in 3' end processing of RNA. ..
  57. Chen H, Futcher B, Leatherwood J. The fission yeast RNA binding protein Mmi1 regulates meiotic genes by controlling intron specific splicing and polyadenylation coupled RNA turnover. PLoS ONE. 2011;6:e26804 pubmed publisher
    ..Inactivation of Mmi1 in meiosis allows meiotic expression, through splicing and RNA stabilization, of at least 29 target genes, which are apparently constitutively transcribed. ..
  58. Kubo T, Wada T, Yamaguchi Y, Shimizu A, Handa H. Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs. Nucleic Acids Res. 2006;34:6264-71 pubmed
    ..We found three likely poly(A) sites in the CFIm25 3'-UTR, suggesting alternative polyadenylation. Our results indicate that alternative poly(A) site selection is a well-regulated process in vivo. ..
  59. Groisman I, Ivshina M, Marin V, Kennedy N, Davis R, Richter J. Control of cellular senescence by CPEB. Genes Dev. 2006;20:2701-12 pubmed
    ..Thus, CPEB appears to act as a translational repressor protein to control myc translation and resulting cellular senescence. ..
  60. Ruepp M, Schumperli D, Barabino S. mRNA 3' end processing and more--multiple functions of mammalian cleavage factor I-68. Wiley Interdiscip Rev RNA. 2011;2:79-91 pubmed publisher
    ..In particular, we discuss evidence for new functions of the mammalian cleavage factor I subunit CF I(m) 68 in histone RNA 3(') processing and in the export of mature mRNAs from the nucleus to the cytoplasm. ..
  61. Martinson H. An active role for splicing in 3'-end formation. Wiley Interdiscip Rev RNA. 2011;2:459-70 pubmed publisher
    ..However, the U1 snRNP can also bind elsewhere in the transcript, apart from splice sites, to regulate CP by direct interaction with the CP factors. ..
  62. Zhelkovsky A, Tacahashi Y, Nasser T, He X, Sterzer U, Jensen T, et al. The role of the Brr5/Ysh1 C-terminal domain and its homolog Syc1 in mRNA 3'-end processing in Saccharomyces cerevisiae. RNA. 2006;12:435-45 pubmed
    ..Our findings suggest that Syc1, by mimicking the essential Brr5 C-terminus, serves as a negative regulator of mRNA 3'-end formation. ..
  63. von Bubnoff N, Sandherr M, Schlimok G, Andreesen R, Peschel C, Duyster J. Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. Leukemia. 2005;19:286-7 pubmed
  64. Majumdar A, Cesario W, White Grindley E, Jiang H, Ren F, Khan M, et al. Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory. Cell. 2012;148:515-29 pubmed publisher
    ..However the mutant flies failed to stabilize memory beyond 48 hr. These results support the idea that amyloid-like oligomers of neuronal CPEB are critical for the persistence of long-term memory. ..
  65. Sasayama T, Marumoto T, Kunitoku N, Zhang D, Tamaki N, Kohmura E, et al. Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1. Genes Cells. 2005;10:627-38 pubmed
    ..Our results suggest a function of ectopically over-expressed Aurora-A that might be relevant for carcinogenesis. ..
  66. Yang X, Sabath I, Debski J, Kaus Drobek M, Dadlez M, Marzluff W, et al. A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing. Mol Cell Biol. 2013;33:28-37 pubmed publisher
  67. Heinrich S, Lindquist S. Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB). Proc Natl Acad Sci U S A. 2011;108:2999-3004 pubmed publisher
    ..These biochemical memories might be used in the local homeostatic maintenance of long-term learning-related changes in synaptic morphology and function...
  68. Noble C, Beuth B, Taylor I. Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor. Nucleic Acids Res. 2007;35:87-99 pubmed
    ..Moreover, we suggest that this complex represents a stabilized ATP bound form of Clp1 that requires the participation of other non-CFIA processing factors in order to initiate timely ATP hydrolysis during 3' end processing. ..
  69. Shimazu T, Horinouchi S, Yoshida M. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. J Biol Chem. 2007;282:4470-8 pubmed
    ..These results suggest that CBP and HDACs regulate the 3'-end processing machinery and modulate the localization of PAP through the acetylation and deacetylation cycle. ..
  70. Pan J, Quintas Cardama A, Manshouri T, Giles F, Lamb P, Tefferi A, et al. The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1. Leukemia. 2007;21:1395-404 pubmed
    ..Our data establish EXEL-0862 as a solid candidate for the targeted treatment of patients with FIP1L1-PDGFR-alpha-positive HES. ..
  71. Legrand P, Pinaud N, Minvielle Sebastia L, Fribourg S. The structure of the CstF-77 homodimer provides insights into CstF assembly. Nucleic Acids Res. 2007;35:4515-22 pubmed
    ..Mapping experiments identify the C-terminal region of Rna14p, the yeast counterpart of CstF-77, as the docking domain for Rna15p, the yeast CstF-64 homologue. ..
  72. Barnard D, Ryan K, Manley J, Richter J. Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation. Cell. 2004;119:641-51 pubmed
    ..The identification of these factors has broad implications for biological process that employ polyadenylation-regulated translation, such as gametogenesis, cell cycle progression, and synaptic plasticity. ..
  73. Mastushita Sakai T, White Grindley E, Samuelson J, Seidel C, Si K. Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover. Proc Natl Acad Sci U S A. 2010;107:11987-92 pubmed publisher
    ..These targets suggest that the persistent form of the memory trace might be comprised of molecules that maintain a sustained, permissive environment for synaptic growth in an activated synapse. ..
  74. Minshall N, Reiter M, Weil D, Standart N. CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes. J Biol Chem. 2007;282:37389-401 pubmed
    ..Altogether, our data suggest that CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T and eIF4E1b. ..
  75. Reyes Reyes M, Hampsey M. Role for the Ssu72 C-terminal domain phosphatase in RNA polymerase II transcription elongation. Mol Cell Biol. 2007;27:926-36 pubmed
  76. Coseno M, Martin G, Berger C, Gilmartin G, Keller W, DOUBLIE S. Crystal structure of the 25 kDa subunit of human cleavage factor Im. Nucleic Acids Res. 2008;36:3474-83 pubmed publisher
  77. Lierman E, Michaux L, Beullens E, Pierre P, Marynen P, Cools J, et al. FIP1L1-PDGFRalpha D842V, a novel panresistant mutant, emerging after treatment of FIP1L1-PDGFRalpha T674I eosinophilic leukemia with single agent sorafenib. Leukemia. 2009;23:845-51 pubmed publisher
    ..The identification of new PDGFR inhibitors will be required to overcome resistance by this D842V mutant...
  78. Noble C, Walker P, Calder L, Taylor I. Rna14-Rna15 assembly mediates the RNA-binding capability of Saccharomyces cerevisiae cleavage factor IA. Nucleic Acids Res. 2004;32:3364-75 pubmed
    ..cerevisiae GAL7 gene. Based on these structural and thermodynamic data, we propose that CFIA assembly regulates RNA-binding activity. ..
  79. Baumgartner C, Gleixner K, Peter B, Ferenc V, Gruze A, Remsing Rix L, et al. Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha. Exp Hematol. 2008;36:1244-53 pubmed publisher
    ..Based on this observation, dasatinib may be considered as a new interesting treatment option for patients with CEL. ..
  80. Wilczynska A, Aigueperse C, Kress M, Dautry F, Weil D. The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules. J Cell Sci. 2005;118:981-92 pubmed
    ..This dynamic connection between the two structures sheds new light on the compartmentalization of mRNA metabolism in the cytoplasm. ..
  81. Marzluff W. Metazoan replication-dependent histone mRNAs: a distinct set of RNA polymerase II transcripts. Curr Opin Cell Biol. 2005;17:274-80 pubmed
    ..Recently several novel factors, including components of the U7 snRNP, as well as proteins involved in regulation of histone gene expression, have been described. ..
  82. Tan Wong S, Zaugg J, Camblong J, Xu Z, Zhang D, Mischo H, et al. Gene loops enhance transcriptional directionality. Science. 2012;338:671-5 pubmed publisher
    ..Similarly, inactivation of individual gene loops by gene mutation enhances SRT synthesis. We demonstrate that gene-loop conformation enforces transcriptional directionality on otherwise bidirectional promoters. ..
  83. Kim Guisbert K, Duncan K, Li H, Guthrie C. Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles. RNA. 2005;11:383-93 pubmed
    ..These specialized associations of the hnRNP proteins of Saccharomyces cerevisiae suggest the opportunity to regulate the processing of particular transcripts between transcription and translation. ..
  84. Piccioni F, Zappavigna V, Verrotti A. Translational regulation during oogenesis and early development: the cap-poly(A) tail relationship. C R Biol. 2005;328:863-81 pubmed
    ..Here we review how capping and polyadenylation of mRNAs modulate interaction with multiple regulatory factors, thus controlling translation during oogenesis and early development. ..
  85. Ishihara K, Kitamura H, Hiraizumi K, Kaneko M, Takahashi A, Zee O, et al. Mechanisms for the proliferation of eosinophilic leukemia cells by FIP1L1-PDGFRalpha. Biochem Biophys Res Commun. 2008;366:1007-11 pubmed
  86. Hsin J, Sheth A, Manley J. RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. Science. 2011;334:683-6 pubmed publisher
    ..Our data thus illustrate how a CTD modification can play a highly specific role in facilitating efficient gene expression. ..