promyelocytic leukemia protein


Summary: A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells.

Top Publications

  1. Brun S, Abella N, Berciano M, Tapia O, Jaumot M, Freire R, et al. SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage. PLoS ONE. 2017;12:e0178925 pubmed publisher
    ..Thus, SUMO and p21Cip1 regulate the transit of proteins through the nucleolus, and that disruption of nucleolar export by DNA damage induces SUMO and p21Cip1 to act as hub proteins to form a multiprotein complex in the nucleolus. ..
  2. Melnick A, Licht J. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood. 1999;93:3167-215 pubmed
  3. Ferbeyre G, de Stanchina E, Querido E, Baptiste N, Prives C, Lowe S. PML is induced by oncogenic ras and promotes premature senescence. Genes Dev. 2000;14:2015-27 pubmed
    ..These results imply that PML acts with Rb and p53 to promote ras-induced senescence and provide new insights into PML regulation and activity. ..
  4. Rashidi A, Fisher S. FISH-negative, cytogenetically cryptic acute promyelocytic leukemia. Blood Cancer J. 2015;5:e320 pubmed publisher
  5. Hsu K, Zhao X, Cheng X, Guan D, Mahabeleshwar G, Liu Y, et al. Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon ?-mediated inhibition of angiogenesis. J Biol Chem. 2017;292:10048-10060 pubmed publisher
    ..The interplay between PML, Stat1/Stat2, and Stat3 contributes to IFN?-mediated inhibition of angiogenesis, and disruption of this network results in aberrant IFN? signaling and altered angiostatic activity. ..
  6. Elsarraj H, Valdez K, Hong Y, Grimm S, Ricci L, Fan F, et al. NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer. Cancer Res. 2017;77:3802-3813 pubmed publisher
    ..i>Cancer Res; 77(14); 3802-13. ©2017 AACR. ..
  7. Wang Y, Chen J, Chang C, Jen J, Huang T, Chen C, et al. Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment. J Clin Invest. 2017;127:2982-2997 pubmed publisher
  8. Ashley C, Glass M, Abendroth A, McSharry B, Slobedman B. Nuclear domain 10 components upregulated via interferon during human cytomegalovirus infection potently regulate viral infection. J Gen Virol. 2017;98:1795-1805 pubmed publisher
    ..This ability of HCMV to overcome the potently anti-viral effects of IFN-? in ND10 expression deficient cells provides evidence that ND10 component upregulation is a key mediator of the anti-viral activity of IFN-?. ..
  9. Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov V, et al. Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation. J Biol Chem. 2017;292:15340-15351 pubmed publisher
    ..Moreover, SUBINs abrogated arsenic-induced degradation of promyelocytic leukemia protein. We propose that the availability of the new chain-selective SUMO inhibitors reported here will enable ..

More Information


  1. Nakano Y, Takahashi Fujigasaki J, Sengoku R, Kanemaru K, Arai T, Kanda T, et al. PML Nuclear Bodies Are Altered in Adult-Onset Neuronal Intranuclear Hyaline Inclusion Disease. J Neuropathol Exp Neurol. 2017;76:585-594 pubmed publisher
    ..These structures were consistently colocalized with promyelocytic leukemia protein (PML), an essential component of NBs, in particular when activated...