lamins

Summary

Summary: Nuclear matrix proteins that are structural components of the NUCLEAR LAMINA. They are found in most multicellular organisms.

Top Publications

  1. Osouda S, Nakamura Y, de Saint Phalle B, McConnell M, Horigome T, Sugiyama S, et al. Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. Dev Biol. 2005;284:219-32 pubmed
    To elucidate the function of metazoan B-type lamins during development, new null mutations of the Drosophila B-type lamin gene, lamDm(0), were analyzed in parallel with the misg(sz18) mutation, a lamDm(0) allele reported previously...
  2. Fiserova J, Goldberg M. Relationships at the nuclear envelope: lamins and nuclear pore complexes in animals and plants. Biochem Soc Trans. 2010;38:829-31 pubmed publisher
    ..The present review concentrates on the structural and functional lamina-NPC relationship in animal cells and its potential implications to plants...
  3. Pickersgill H, Kalverda B, de Wit E, Talhout W, Fornerod M, van Steensel B. Characterization of the Drosophila melanogaster genome at the nuclear lamina. Nat Genet. 2006;38:1005-14 pubmed
    ..This genome-wide analysis gives clear insight into the nature and dynamic behavior of the genome at the nuclear lamina, and implies that intergenic DNA functions in the global organization of chromatin in the nucleus. ..
  4. Izumi M, Vaughan O, Hutchison C, Gilbert D. Head and/or CaaX domain deletions of lamin proteins disrupt preformed lamin A and C but not lamin B structure in mammalian cells. Mol Biol Cell. 2000;11:4323-37 pubmed
    The nuclear lamina is an important determinant of nuclear architecture. Mutations in A-type but not B-type lamins cause a range of human genetic disorders, including muscular dystrophy...
  5. Burke B, Stewart C. Life at the edge: the nuclear envelope and human disease. Nat Rev Mol Cell Biol. 2002;3:575-85 pubmed
  6. Herrmann H, Strelkov S. History and phylogeny of intermediate filaments: now in insects. BMC Biol. 2011;9:16 pubmed publisher
    Intermediate filaments include the nuclear lamins, which are universal in metazoans, and the cytoplasmic intermediate filaments, which are much more varied and form cell type-specific networks in animal cells...
  7. Ruchaud S, Korfali N, Villa P, Kottke T, Dingwall C, Kaufmann S, et al. Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J. 2002;21:1967-77 pubmed
    ..Transfection of exogenous caspase-6 into the clone reversed this phenotype. Lamins A and C, which are caspase-6-only substrates, were cleaved by the wild-type and heterozygous apoptotic extracts ..
  8. Bruston F, Delbarre E, Ostlund C, Worman H, Buendia B, Duband Goulet I. Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin. FEBS Lett. 2010;584:2999-3004 pubmed publisher
    ..We show that progerin tail has a reduced DNA/chromatin binding capacity and modified trimethylated H3K27 binding pattern, offering a molecular mechanism for heterochromatin alterations related to HGPS. ..
  9. Beaudouin J, Gerlich D, Daigle N, Eils R, Ellenberg J. Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina. Cell. 2002;108:83-96 pubmed
    ..NE fragments remaining on chromosomes were removed toward the centrosomes in a microtubule-dependent manner, suggesting a mechanism mediated by a minus-end-directed motor. ..

More Information

Publications62

  1. Raharjo W, Enarson P, Sullivan T, Stewart C, Burke B. Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy. J Cell Sci. 2001;114:4447-57 pubmed
    ..and N195K) and autosomal dominant Emery-Dreifuss muscular dystrophy (L530P) modify the assembly properties of lamins A and C and cause partial mislocalization of emerin, an inner nuclear membrane protein, in HeLa cells...
  2. Hofemeister H, Kuhn C, Franke W, Weber K, Stick R. Conservation of the gene structure and membrane-targeting signals of germ cell-specific lamin LIII in amphibians and fish. Eur J Cell Biol. 2002;81:51-60 pubmed
    Targeting of nuclear lamins to the inner nuclear membrane requires CaaX motif-dependent posttranslational isoprenylation and carboxyl methylation. We previously have shown that two variants of lamin LIII (i.e...
  3. Broers J, Ramaekers F, Bonne G, Yaou R, Hutchison C. Nuclear lamins: laminopathies and their role in premature ageing. Physiol Rev. 2006;86:967-1008 pubmed
    It has been demonstrated that nuclear lamins are important proteins in maintaining cellular as well as nuclear integrity, and in maintaining chromatin organization in the nucleus...
  4. Worman H, Bonne G. "Laminopathies": a wide spectrum of human diseases. Exp Cell Res. 2007;313:2121-33 pubmed
    Mutations in genes encoding the intermediate filament nuclear lamins and associated proteins cause a wide spectrum of diseases sometimes called "laminopathies...
  5. Lloyd D, Trembath R, Shackleton S. A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. Hum Mol Genet. 2002;11:769-77 pubmed
    The gene encoding nuclear lamins A and C is mutated in at least three inherited disorders...
  6. Dechat T, Gesson K, Foisner R. Lamina-independent lamins in the nuclear interior serve important functions. Cold Spring Harb Symp Quant Biol. 2010;75:533-43 pubmed publisher
    Nuclear lamins were originally described as the main constituents of the nuclear lamina, a filamentous meshwork closely associated with the inner nuclear membrane...
  7. Parnaik V, Chaturvedi P, Muralikrishna B. Lamins, laminopathies and disease mechanisms: possible role for proteasomal degradation of key regulatory proteins. J Biosci. 2011;36:471-9 pubmed
    b>Lamins are major structural proteins of the nucleus and are essential for nuclear integrity and organization of nuclear functions...
  8. Kr ger A, Batsios P, Baumann O, Luckert E, Schwarz H, Stick R, et al. Characterization of NE81, the first lamin-like nucleoskeleton protein in a unicellular organism. Mol Biol Cell. 2012;23:360-70 pubmed publisher
    b>Lamins build the nuclear lamina and are required for chromatin organization, gene expression, cell cycle progression, and mechanical stabilization. Despite these universal functions, lamins have so far been found only in metazoans...
  9. DuBois K, Alsford S, Holden J, Buisson J, Swiderski M, Bart J, et al. NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. PLoS Biol. 2012;10:e1001287 pubmed publisher
    ..This suggests a metazoan-specific origin for lamins, and therefore that distinct protein elements must compose the nucleoskeleton in other lineages...
  10. Dhe Paganon S, Werner E, Chi Y, Shoelson S. Structure of the globular tail of nuclear lamin. J Biol Chem. 2002;277:17381-4 pubmed
    The nuclear lamins form a two-dimensional matrix that provides integrity to the cell nucleus and participates in nuclear activities...
  11. Lee K, Starr D, Cohen M, Liu J, Han M, Wilson K, et al. Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Mol Biol Cell. 2002;13:892-901 pubmed
    ..UNC-84 is not required for centrosome attachment to the nucleus because centrosomes are localized normally in unc-84 hyp7 cells despite a nuclear migration defect. Models for UNC-84 localization are discussed. ..
  12. Hanif M, Rosengardten Y, Sagelius H, Rozell B, Eriksson M. Differential expression of A-type and B-type lamins during hair cycling. PLoS ONE. 2009;4:e4114 pubmed publisher
    ..Our immunohistochemical staining for lamins A/C and B in wild-type mice revealed strong expression in the basal cell layer of the epidermis, the outer root ..
  13. Shimi T, Butin Israeli V, Adam S, Goldman R. Nuclear lamins in cell regulation and disease. Cold Spring Harb Symp Quant Biol. 2010;75:525-31 pubmed publisher
    The nuclear lamins are type V intermediate filament proteins that form meshworks at the inner aspect of the nuclear envelope and are also present throughout the nuclear interior...
  14. Barboro P, D Arrigo C, Diaspro A, Mormino M, Alberti I, Parodi S, et al. Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold. Exp Cell Res. 2002;279:202-18 pubmed
    ..when the nuclear matrix is isolated from rat hepatocytes in the presence of an inhibitor of RNase activity both lamins and the nuclear mitotic apparatus protein (NuMA) preferentially localize within the electron-dense domains of the ..
  15. Melcer S, Gruenbaum Y, Krohne G. Invertebrate lamins. Exp Cell Res. 2007;313:2157-66 pubmed
    b>Lamins are the main component of the nuclear lamina and considered to be the ancestors of all intermediate filament proteins...
  16. Dechat T, Gajewski A, Korbei B, Gerlich D, Daigle N, Haraguchi T, et al. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. J Cell Sci. 2004;117:6117-28 pubmed
    ..2alpha is a LEM (lamina-associated polypeptide emerin MAN1) family protein associated with nucleoplasmic A-type lamins and chromatin...
  17. Shin J, Spinler K, Swift J, Chasis J, Mohandas N, Discher D. Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proc Natl Acad Sci U S A. 2013;110:18892-7 pubmed publisher
    ..00006). B-type lamins are highly variable and predominate only in CD34(+) cells, but migration through micropores and nuclear ..
  18. Schirmer E, Foisner R. Proteins that associate with lamins: many faces, many functions. Exp Cell Res. 2007;313:2167-79 pubmed
    ..proteins tightly associated with the peripheral lamin scaffold as well as proteins forming stable complexes with lamins in the nucleoplasm...
  19. Butin Israeli V, Adam S, Goldman A, Goldman R. Nuclear lamin functions and disease. Trends Genet. 2012;28:464-71 pubmed publisher
    ..senescence and normal organ development and function depend on the type V intermediate filament proteins, the lamins, which are major structural proteins of the nucleus...
  20. Scott E, O Hare P. Fate of the inner nuclear membrane protein lamin B receptor and nuclear lamins in herpes simplex virus type 1 infection. J Virol. 2001;75:8818-30 pubmed
    ..We followed the distribution of the inner nuclear membrane protein lamin B receptor (LBR) and lamins A and B(2) tagged with green fluorescent protein (GFP) in live infected cells...
  21. Novelli G, Muchir A, Sangiuolo F, Helbling Leclerc A, D Apice M, Massart C, et al. Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C. Am J Hum Genet. 2002;71:426-31 pubmed
    ..The LMNA gene encoding two nuclear envelope proteins (lamins A and C [lamin A/C]) maps to chromosome 1q21 and has been associated with five distinct pathologies, including ..
  22. Mounkes L, Stewart C. Aging and nuclear organization: lamins and progeria. Curr Opin Cell Biol. 2004;16:322-7 pubmed
    The discoveries of at least eight human diseases arising from mutations in LMNA, which encodes the nuclear A-type lamins, have revealed the nuclear envelope as an organelle associated with a variety of fundamental cellular processes...
  23. Goldman R, Gruenbaum Y, Moir R, Shumaker D, Spann T. Nuclear lamins: building blocks of nuclear architecture. Genes Dev. 2002;16:533-47 pubmed
  24. Kennedy B, Barbie D, Classon M, Dyson N, Harlow E. Nuclear organization of DNA replication in primary mammalian cells. Genes Dev. 2000;14:2855-68 pubmed
    ..These findings indicate that in normal mammalian cells, the onset of DNA synthesis is coordinately regulated at a small number of previously unrecognized perinucleolar sites that are selected in early G(1)-phase. ..
  25. Gerace L, Huber M. Nuclear lamina at the crossroads of the cytoplasm and nucleus. J Struct Biol. 2012;177:24-31 pubmed publisher
    ..It is composed largely of a polymeric assembly of lamins, which comprise a distinct sequence homology class of the intermediate filament protein family...
  26. Slee E, Adrain C, Martin S. Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem. 2001;276:7320-6 pubmed
  27. Mattout A, Dechat T, Adam S, Goldman R, Gruenbaum Y. Nuclear lamins, diseases and aging. Curr Opin Cell Biol. 2006;18:335-41 pubmed
    Nuclear lamins are type V intermediate filament proteins. They are the major building blocks of the peripheral nuclear lamina, a complex meshwork of proteins underlying the inner nuclear membrane...
  28. Hutchison C. Lamins: building blocks or regulators of gene expression?. Nat Rev Mol Cell Biol. 2002;3:848-58 pubmed
    ..The lamins are thought to be the evolutionary progenitors of IF proteins and they have profound influences on both nuclear ..
  29. Clarke T, Bouquet J, Fu X, Kallesøe T, Schmid M, Thompson E. Rapidly evolving lamins in a chordate, Oikopleura dioica, with unusual nuclear architecture. Gene. 2007;396:159-69 pubmed
    Metazoan lamins are implicated in the organization of numerous critical nuclear processes...
  30. Wiesel N, Mattout A, Melcer S, Melamed Book N, Herrmann H, Medalia O, et al. Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins. Proc Natl Acad Sci U S A. 2008;105:180-5 pubmed
    b>Lamins are nuclear intermediate filament proteins and the major building blocks of the nuclear lamina...
  31. Zwerger M, Medalia O. From lamins to lamina: a structural perspective. Histochem Cell Biol. 2013;140:3-12 pubmed publisher
    ..Primarily, the nuclear lamina provides structural support for the nucleus and the nuclear envelope; however, lamins and their associated proteins are also involved in most of the nuclear processes, including DNA replication and ..
  32. Barboro P, D Arrigo C, Mormino M, Coradeghini R, Parodi S, Patrone E, et al. An intranuclear frame for chromatin compartmentalization and higher-order folding. J Cell Biochem. 2003;88:113-20 pubmed
    ..2002] Exp. Cell. Res. 279:202-218] have confirmed that lamins and the nuclear mitotic apparatus protein (NuMA) are localized inside the interphase nucleus in a polymerized form...
  33. Niebroj Dobosz I, Fidzianska A, Hausmanowa Petrusewicz I. Expression of emerin and lamins in muscle of patients with different forms of Emery-Dreifuss muscular dystrophy. Acta Myol. 2003;22:52-7 pubmed
    Emerin and lamins are nuclear proteins, which are missing or defective in Emery-Dreifuss muscular dystrophy (EDMD)...
  34. Zaremba Czogalla M, Gagat P, Kozioł K, Dubińska Magiera M, Sikora J, Dadlez M, et al. Identification of new in vivo phosphosites on lamin Dm - the evidence of heterogeneity of phosphorylation sites in different Drosophila tissues. Nucleus. 2011;2:478-88 pubmed publisher
    Changes in the nuclear structure and function during the cell cycle are thought to be correlated with lamins phosphorylation...
  35. Wilson K, Foisner R. Lamin-binding Proteins. Cold Spring Harb Perspect Biol. 2010;2:a000554 pubmed publisher
    A- and B-type lamins are the major intermediate filaments of the nucleus. Lamins engage in a plethora of stable and transient interactions, near the inner nuclear membrane and throughout the nucleus...
  36. de Noronha C, Sherman M, Lin H, Cavrois M, Moir R, Goldman R, et al. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science. 2001;294:1105-8 pubmed
    ..Intermittently, these herniations ruptured, resulting in the mixing of nuclear and cytoplasmic components. These Vpr-induced NE changes probably contribute to the observed cell-cycle arrest. ..
  37. Muck J, Kandasamy K, Englmann A, Günther M, Zink D. Perinuclear positioning of the inactive human cystic fibrosis gene depends on CTCF, A-type lamins and an active histone deacetylase. J Cell Biochem. 2012;113:2607-21 pubmed publisher
    ..Furthermore, knockdown experiments revealed that also A-type lamins were required for the perinuclear positioning of CFTR...
  38. Muchir A, Bonne G, van der Kooi A, van Meegen M, Baas F, Bolhuis P, et al. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Hum Mol Genet. 2000;9:1453-9 pubmed
    ..The disease gene of AD-EDMD is LMNA which encodes lamins A/C, two proteins of the nuclear envelope...
  39. Worman H, Foisner R. The nuclear envelope from basic biology to therapy. Biochem Soc Trans. 2010;38:253-6 pubmed publisher
    ..and physicians have developed a keen interest in the nuclear envelope since mutations in the genes encoding lamins and associated proteins have been shown to cause a diverse range of human diseases often called laminopathies or ..
  40. Rodriguez S, Eriksson M. Evidence for the involvement of lamins in aging. Curr Aging Sci. 2010;3:81-9 pubmed
    ..Hutchinson-Gilford progeria syndrome (HGPS), there has been an increasing interest in the potential role for lamins in the normal aging process...
  41. Prokocimer M, Davidovich M, Nissim Rafinia M, Wiesel Motiuk N, Bar D, Barkan R, et al. Nuclear lamins: key regulators of nuclear structure and activities. J Cell Mol Med. 2009;13:1059-85 pubmed publisher
    ..It contains lamins and lamin-associated proteins, including many integral proteins of the INM, chromatin modifying proteins, ..
  42. Herrmann H, Bär H, Kreplak L, Strelkov S, Aebi U. Intermediate filaments: from cell architecture to nanomechanics. Nat Rev Mol Cell Biol. 2007;8:562-73 pubmed
    ..However, the analysis of these various diseases suggests that IFs also have an important role in cell-type-specific physiological functions...
  43. Peric Hupkes D, van Steensel B. Role of the nuclear lamina in genome organization and gene expression. Cold Spring Harb Symp Quant Biol. 2010;75:517-24 pubmed publisher
    ..Here, we discuss new insights into various aspects of genome-nuclear lamina interactions, with emphasis on the links with gene regulation and with dynamics during cellular differentiation...
  44. Segura Totten M, Wilson K. Virology. HIV--breaking the rules for nuclear entry. Science. 2001;294:1016-7 pubmed
    ..These ruptures are sufficient to enable the preintegration complexes of invading virions to enter the nucleus and to integrate with host cell DNA. ..
  45. Moir R, Spann T. The structure and function of nuclear lamins: implications for disease. Cell Mol Life Sci. 2001;58:1748-57 pubmed
    The nuclear lamins polymerize to form the nuclear lamina, a fibrous structure found on the inner face of the nuclear membrane. The lamins also appear to form structures within the nucleoplasm...
  46. Burke B. Lamins and apoptosis: a two-way street?. J Cell Biol. 2001;153:F5-7 pubmed
  47. Dechat T, Korbei B, Vaughan O, Vlcek S, Hutchison C, Foisner R. Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins. J Cell Sci. 2000;113 Pt 19:3473-84 pubmed
    ..LAP2beta, LAP2alpha was found by confocal immunofluorescence microscopy to colocalize preferentially with A-type lamins in the newly formed nuclei assembled after mitosis...
  48. Schreiber K, Kennedy B. When lamins go bad: nuclear structure and disease. Cell. 2013;152:1365-75 pubmed publisher
    Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a group of phenotypically diverse genetic disorders known as laminopathies, which have symptoms that range from muscular dystrophy to neuropathy ..
  49. Herrmann H, Foisner R. Intermediate filaments: novel assembly models and exciting new functions for nuclear lamins. Cell Mol Life Sci. 2003;60:1607-12 pubmed
    ..Moreover, the past years have seen dramatic developments for the nuclear specific IF proteins, the lamins. While in the past lamins have been assumed to form only a structural scaffold at the nuclear periphery, their ..
  50. Hutchison C, Worman H. A-type lamins: guardians of the soma?. Nat Cell Biol. 2004;6:1062-7 pubmed
    The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies - inherited diseases that are linked to premature ageing...
  51. Zhong Z, Wilson K, Dahl K. Beyond lamins other structural components of the nucleoskeleton. Methods Cell Biol. 2010;98:97-119 pubmed publisher
    ..This chapter reviews nucleoskeletal components beyond lamins and summarizes specific methods and strategies useful for analyzing nuclear structural proteins including actin, ..
  52. Dittmer T, Misteli T. The lamin protein family. Genome Biol. 2011;12:222 pubmed publisher
    The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the inside of the nuclear membrane, where they provide a platform for the binding of proteins and chromatin and confer mechanical stability...
  53. Holaska J, Wilson K, Mansharamani M. The nuclear envelope, lamins and nuclear assembly. Curr Opin Cell Biol. 2002;14:357-64 pubmed
    The nuclear lamina is composed of both A- and B-type lamins and lamin-binding proteins. Many lamin-binding proteins are integral proteins of the inner nuclear membrane...