hmga1b protein


Summary: An AT-hook motif-containing protein (AT-HOOK MOTIFS) that binds to the minor grove of AT-rich regions of DNA. It is a truncated form of HMGA1a protein that is produced by alternative-splicing of the HMGA1 gene. It may function as an architectural chromatin binding protein that is involved in transcriptional regulation.

Top Publications

  1. Kaddar T, Rouault J, Chien W, Chebel A, Gadoux M, Salles G, et al. Two new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferation. Biol Cell. 2009;101:511-24 pubmed publisher
    ..In addition, we also showed that the inhibition of cyclin E expression was due, at least in part, to a decrease in its mRNA stability. ..
  2. Larsson L, Jäwert F, Magnusson B, Hassèus B, Kjeller G. Expression of high mobility group A proteins in oral leukoplakia. Anticancer Res. 2013;33:4261-6 pubmed
    ..This is, to our knowledge, the first study showing the expression of HMGA proteins in healthy and non-healthy oral mucosa. ..
  3. Murua Escobar H, Soller J, Richter A, Meyer B, Winkler S, Flohr A, et al. The canine HMGA1. Gene. 2004;330:93-9 pubmed
    ..Furthermore, we compared the coding sequence(s) (CDS) of both splice variants for 12 different breeds, screened them for single nucleotide polymorphisms (SNPs) and characterised a basic expression pattern. ..
  4. Fedele M, Palmieri D, Fusco A. HMGA2: A pituitary tumour subtype-specific oncogene?. Mol Cell Endocrinol. 2010;326:19-24 pubmed publisher
    ..Different HMGA-dependent potential drives of pituitary oncogenesis are discussed as future research directions in the field. ..
  5. Sharma A, Ray R, Rajeswari M. High-mobility group A1 (HMGA1) protein expression correlates with cisplatin-induced cell death in squamous cell carcinoma of skin. Cancer Invest. 2010;28:340-9 pubmed publisher
    ..Present results indicate a strong association of HMGA1 with Cisplatin-linked tumor regression. Therefore, HMGA1 could be a potential target in designing therapeutic strategies against cancer. ..
  6. Baldassarre G, Battista S, Belletti B, Thakur S, Pentimalli F, Trapasso F, et al. Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma. Mol Cell Biol. 2003;23:2225-38 pubmed
    ..Here we report that both in vitro and in vivo HMGA1b protein binds to and inhibits the activity of both human and mouse BRCA1 promoters...
  7. Zhang Q, Wang Y. Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. J Proteome Res. 2007;6:4711-9 pubmed
  8. Bush B, Brock A, Deng J, Nelson R, Sumter T. The Wnt/?-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer. Cell Biochem Funct. 2013;31:228-36 pubmed publisher
    ..Collectively, these findings strongly implicate Wnt/?-catenin/TCF-4 signalling in regulating HMGA1 to further expand the extensive regulatory network affected by Wnt/?-catenin/TCF-4 signalling. ..
  9. Dhar A, Hu J, Reeves R, Resar L, Colburn N. Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation. Oncogene. 2004;23:4466-76 pubmed

More Information


  1. Tran J, Zamdborg L, Ahlf D, Lee J, Catherman A, Durbin K, et al. Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature. 2011;480:254-8 pubmed publisher
    ..The technology promises to improve the link between proteomics data and complex phenotypes in basic biology and disease research. ..
  2. Akhter M, Sharma A, Rajeswari M. Interaction of adriamycin with a promoter region of hmga1 and its inhibitory effect on HMGA1 expression in A431 human squamous carcinoma cell line. Mol Biosyst. 2011;7:1336-46 pubmed publisher
    ..Therefore, it appears that hmg a1 is a novel potential chemotherapeutic target in treating carcinomas of epithelial origin like prostate, breast, thyroid etc. ..
  3. Zou Y, Wang Y. Mass spectrometric analysis of high-mobility group proteins and their post-translational modifications in normal and cancerous human breast tissues. J Proteome Res. 2007;6:2304-14 pubmed
    ..Furthermore, a more complex spectrum of PTMs on HMGA1 proteins was correlated with a more aggressive malignancy in human breast cancer tissues. ..
  4. Zou Y, Webb K, Perna A, Zhang Q, Clarke S, Wang Y. A mass spectrometric study on the in vitro methylation of HMGA1a and HMGA1b proteins by PRMTs: methylation specificity, the effect of binding to AT-rich duplex DNA, and the effect of C-terminal phosphorylation. Biochemistry. 2007;46:7896-906 pubmed
    ..Our results suggest that PRMT1 might be involved in the previously reported methylation of Arg25 in HMGA1a in vivo. ..
  5. Cottingham K. Tissues tell the real tale of breast cancer. J Proteome Res. 2007;6:2052 pubmed
  6. Mustata G, Follis A, Hammoudeh D, Metallo S, Wang H, Prochownik E, et al. Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model. J Med Chem. 2009;52:1247-50 pubmed publisher
    ..These studies demonstrate the applicability of pharmacophore modeling to the identification of novel and potentially more puissant inhibitors of the c-Myc oncoprotein. ..
  7. Zhang Q, Zhang K, Zou Y, Perna A, Wang Y. A quantitative study on the in vitro and in vivo acetylation of high mobility group A1 proteins. J Am Soc Mass Spectrom. 2007;18:1569-78 pubmed
    ..Our results showed that all the above five lysine residues were also acetylated in vivo, with Lys-64, Lys-66 and Lys-70 in HMGA1a exhibiting higher levels of acetylation than Lys-14 and Lys-73. ..
  8. De Martino I, Visone R, Fedele M, Petrocca F, Palmieri D, Martinez Hoyos J, et al. Regulation of microRNA expression by HMGA1 proteins. Oncogene. 2009;28:1432-42 pubmed publisher
    ..Finally, ATXN1 and STC1 gene products have been identified as targets of miR-101b. Therefore, it is reasonable to hypothesize that HMGA1 proteins are involved in several functions by regulating miRNA expression. ..
  9. Cleynen I, Van de Ven W. The HMGA proteins: a myriad of functions (Review). Int J Oncol. 2008;32:289-305 pubmed
    ..To provide clarity in the abundance of articles on this topic, this review gives a general overview of the nuclear functions and regulation of the HMGA genes and corresponding proteins. ..
  10. Zou Y, Wang Y. Tandem mass spectrometry for the examination of the posttranslational modifications of high-mobility group A1 proteins: symmetric and asymmetric dimethylation of Arg25 in HMGA1a protein. Biochemistry. 2005;44:6293-301 pubmed
    ..We also found that the HMGA1b protein was phosphorylated at the corresponding sites, that is, Ser90, Ser91 and Ser87...
  11. Cerignoli F, Ambrosi C, Mellone M, Assimi I, Di Marcotullio L, Gulino A, et al. HMGA molecules in neuroblastic tumors. Ann N Y Acad Sci. 2004;1028:122-32 pubmed
    ..Our studies indicate that HMGA molecules might be biologically and pathologically relevant factors in neuroblastic tumor development and progression. ..
  12. Chau K, Manfioletti G, Cheung Chau K, Fusco A, Dhomen N, Sowden J, et al. Derepression of HMGA2 gene expression in retinoblastoma is associated with cell proliferation. Mol Med. 2003;9:154-65 pubmed
    ..Our discovery of derepression of HMGA2 gene expression in retinoblastoma provides the 1st evidence that this protein might contribute to neoplastic transformation of retina cells. ..
  13. Li Y, Lu J, Prochownik E. Dual role for SUMO E2 conjugase Ubc9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor. J Biol Chem. 2007;282:13363-71 pubmed
    ..These findings are consistent with the idea that Ubc9 can act as both a positive and negative regulator of proliferation and transformation via its non-SUMO-dependent interaction with HMGA1 proteins. ..
  14. Sarhadi V, Wikman H, Salmenkivi K, Kuosma E, Sioris T, Salo J, et al. Increased expression of high mobility group A proteins in lung cancer. J Pathol. 2006;209:206-12 pubmed
    ..As HMGA proteins were expressed in about 90% of lung carcinomas and their expression was inversely associated with survival, they may provide useful markers for lung cancer diagnosis and prognosis. ..
  15. Morikawa T, Manabe T, Ito Y, Yamada S, Yoshimi A, Nagai T, et al. The expression of HMGA1a is increased in lymphoblastoid cell lines from schizophrenia patients. Neurochem Int. 2010;56:736-9 pubmed publisher
    ..The present study is the first to report a significant upregulation of HMGA1a in schizophrenia, suggesting its potential roles in both transcription and splicing of target genes linked with schizophrenia. ..
  16. Edberg D, Adkins J, Springer D, Reeves R. Dynamic and differential in vivo modifications of the isoform HMGA1a and HMGA1b chromatin proteins. J Biol Chem. 2005;280:8961-73 pubmed
  17. Beitzel B, Bushman F. Construction and analysis of cells lacking the HMGA gene family. Nucleic Acids Res. 2003;31:5025-32 pubmed
    ..We conclude that HMGA proteins are not strictly required for growth control or retroviral integration in DT40 cells and may well be redundant with other factors. ..