ccaat enhancer binding protein delta


Summary: A member of the C-EBP protein family of transcription factors. It plays a key role in G0 PHASE mammary EPITHELIAL CELL growth arrest, and it is involved in transcriptional regulation of INTERLEUKIN 1; INTERLEUKIN 6; and TUMOR NECROSIS FACTOR-ALPHA.

Top Publications

  1. Hishida T, Nishizuka M, Osada S, Imagawa M. The role of C/EBPdelta in the early stages of adipogenesis. Biochimie. 2009;91:654-7 pubmed publisher
    ..Taken together, these findings show that C/EBPdelta is involved in MCE and gene expression in the early stages of adipocyte differentiation. ..
  2. Wang J, Sarkar T, Zhou M, Sharan S, Ritt D, Veenstra T, et al. CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. Proc Natl Acad Sci U S A. 2010;107:16131-6 pubmed publisher
    ..Furthermore, we report a function of IPO4 and nuclear import in the Fanconi anemia pathway of DNA repair. ..
  3. Bennett C, Nsengimana J, Bostock J, Cymbalista C, Futers T, Knight B, et al. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. Diab Vasc Dis Res. 2010;7:195-203 pubmed publisher
  4. Pawar S, Sarkar T, Balamurugan K, Sharan S, Wang J, Zhang Y, et al. C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression. Proc Natl Acad Sci U S A. 2010;107:9210-5 pubmed publisher
    ..These findings shed light on the role and regulation of APC/C, which is critical for most cellular processes. ..
  5. Si J, Yu X, Zhang Y, DeWille J. Myc interacts with Max and Miz1 to repress C/EBPdelta promoter activity and gene expression. Mol Cancer. 2010;9:92 pubmed publisher
    ..These results identify protein interactions that mediate Myc repression of C/EBPdelta, and possibly other tumor suppressor genes, and suggest new therapeutic targets to block Myc transcriptional repression and oncogenic function. ..
  6. Karlsen J, Borregaard N, Cowland J. Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C/EBP-beta nor C/EBP-delta. J Biol Chem. 2010;285:14088-100 pubmed publisher
    ..Co-stimulation with IL-17 leads to accumulation of IkappaB-zeta mRNA and IkappaB-zeta protein, which can bind to NF-kappaB on the LCN2 promoter and thus induce NGAL expression. ..
  7. Dabek J, Swiderski R, Głogowska Ligus J, Kułach A, Gasior Z. [Expression of genes connected with nuclear factor kappa B (NFkappaB) estimated by oligonucleotide microarray analysis HG-U133A in patients with acute myocardial infarction]. Pol Merkur Lekarski. 2009;27:265-72 pubmed
  8. Payne V, Au W, Lowe C, Rahman S, Friedman J, O Rahilly S, et al. C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis. Biochem J. 2009;425:215-23 pubmed publisher
    ..Moreover, the findings of the present study identify an important additional mechanism via which the C/EBP transcription factors may control a network of gene expression regulating adipogenesis, lipogenesis and insulin sensitivity. ..
  9. Sandhir R, Berman N. Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice. Neurochem Int. 2010;56:188-93 pubmed publisher
    ..In addition elevated C/EBPdelta levels following TBI in the aged brain may play a role in the link between TBI and Alzheimer's disease. ..

More Information


  1. Barron V, Zhu H, Hinman M, Ladd A, Lou H. The neurofibromatosis type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation. Nucleic Acids Res. 2010;38:253-64 pubmed publisher
    ..These studies, combined with our previous investigations demonstrating a role for Hu proteins and TIA-1/TIAR in controlling NF1 exon 23a inclusion, highlight the complex nature of regulation of this important alternative splicing event. ..
  2. Telgmann R, Dördelmann C, Brand E, Nicaud V, Hagedorn C, Pavenstadt H, et al. Molecular genetic analysis of a human insulin-like growth factor 1 promoter P1 variation. FASEB J. 2009;23:1303-13 pubmed publisher
    ..Whether -1411C>T is also associated with other IGF1-related disease phenotypes should be evaluated further in population studies. ..
  3. Zannetti C, Bonnay F, Takeshita F, Parroche P, Menetrier Caux C, Tommasino M, et al. C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity. J Biol Chem. 2010;285:34773-80 pubmed publisher
    ..These results shed new light on the mechanisms involved during TLR8-mediated innate immune response. ..
  4. Chen S, Ye J, Kijima I, Evans D. The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression. Proc Natl Acad Sci U S A. 2010;107:11032-7 pubmed publisher
    ..3/II. These findings provide an important basis for future clinical evaluations of LBH589 in hormone-dependent breast cancer...
  5. Liu Y, Wang S, Hsu T, Chen T, Chang W, Hung J. Inhibition of LPS-induced C/EBP delta by trichostatin A has a positive effect on LPS-induced cyclooxygenase 2 expression in RAW264.7 cells. J Cell Biochem. 2010;110:1430-8 pubmed publisher
  6. Ejarque Ortiz A, Gresa Arribas N, Straccia M, Mancera P, Solà C, Tusell J, et al. CCAAT/enhancer binding protein delta in microglial activation. J Neurosci Res. 2010;88:1113-23 pubmed publisher
    ..These results point to C/EBP delta as a putative key regulator of proinflammatory gene expression in microglial activation. ..
  7. Ranger J, Levy D, Shahalizadeh S, Hallett M, Muller W. Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression. Cancer Res. 2009;69:6823-30 pubmed publisher
    ..The decreased malignancy in Stat3-deficient tumors is attributed to a reduction in both angiogenic and inflammatory responses associated with a Stat3-dependent transcriptional cascade involving CCAAT/enhancer binding protein delta. ..
  8. Lu Y, Kim I, Lye E, Shen F, Suzuki N, Suzuki S, et al. Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines. J Immunol. 2009;182:7212-21 pubmed publisher
    ..Our results identify c-Rel and C/EBPbeta/delta as important transcription factors in a MyD88-dependent pathway that regulate the induction of proinflammatory cytokines. ..
  9. Shen F, Li N, Gade P, Kalvakolanu D, Weibley T, Doble B, et al. IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Sci Signal. 2009;2:ra8 pubmed publisher
    ..This detailed dissection is the first for the IL-17-mediated C/EBP pathway and the first known example of a negative signal mediated by IL-17RA. ..
  10. Barresi V, Vitarelli E, Cerasoli S, Barresi G. The cell growth inhibitory transcription factor C/EBPdelta is expressed in human meningiomas in association with low histological grade and proliferation index. J Neurooncol. 2010;97:233-40 pubmed publisher
    ..If further studies confirm its induction by inflammatory mediators, this might be exploited in novel therapies to prevent recurrences in meningiomas. ..
  11. Park J, Jung J, Seo M, Kang S, Lee Y, Kang K. DNER modulates adipogenesis of human adipose tissue-derived mesenchymal stem cells via regulation of cell proliferation. Cell Prolif. 2010;43:19-28 pubmed publisher
    ..These results indicate that DNER knockdown in hAMSC accelerated onset of adipogenic differentiation by bypassing mitotic clonal expansion during the early stages of adipogenesis. ..
  12. Kawaji A, Nishizuka M, Osada S, Imagawa M. TC10-like/TC10betaLong regulates adipogenesis by controlling mitotic clonal expansion. Biol Pharm Bull. 2010;33:404-9 pubmed
    ..The results strongly suggest that TCL/TC10betaL regulates adipocyte differentiation by controlling MCE and this regulatory effect is closely linked to C/EBPbeta and C/EBPdelta expression. ..
  13. Ali S, Singh N, Yildirim H, Ramji D. Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. Int J Biochem Cell Biol. 2010;42:113-9 pubmed publisher
    ..Taken together, these results suggest a potentially crucial role for NF-kappaB in the IL-1-induced expression of C/EBPdelta, and thereby downstream APP genes regulated by this transcription factor. ..
  14. Hour T, Lai Y, Kuan C, Chou C, Wang J, Tu H, et al. Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells. Biochem Pharmacol. 2010;80:325-34 pubmed publisher
    ..Furthermore, our data suggest that SOD inhibitors, which are already used as anti-angiogenic agents, may be suitable for combinatorial chemotherapy to prevent or treat cisplatin resistance in bladder and possibly other cancers. ..
  15. Chen Y, Yang C, Chang S, Hu M. C/EBP beta and C/EBP delta expression is elevated in the early phase of ethanol-induced hepatosteatosis in mice. Acta Pharmacol Sin. 2009;30:1138-43 pubmed publisher
    ..In addition, EtOH+HF enhances the expression of C/EBP delta in HepG2 cells. Thus, C/EBP delta might be a therapeutic target in alcoholic hepatosteatosis. ..
  16. Xiao J, Sun B, Cai G. Transient expression of interferon-inducible p204 in the early stage is required for adipogenesis in 3T3-L1 cells. Endocrinology. 2010;151:3141-53 pubmed publisher
    ..Collectively, our data indicate that the transient expression of p204 in the early stage is indispensable for adipocyte differentiation. Disruption of p204 expression patterns at this stage leads to irreversible damage in fat formation. ..
  17. Litvak V, Ramsey S, Rust A, Zak D, Kennedy K, Lampano A, et al. Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat Immunol. 2009;10:437-43 pubmed publisher
    ..Our results suggest a mechanism that enables the innate immune system to detect the duration of infection and to respond appropriately. ..
  18. Rathod M, Rogers P, Vangipuram S, McAllister E, Dhurandhar N. Adipogenic cascade can be induced without adipogenic media by a human adenovirus. Obesity (Silver Spring). 2009;17:657-64 pubmed publisher
    ..The results reveal that Ad36 is an MDI-independent exogenous regulator of the adipogenic process. Elucidating the molecular pathways involved may reveal novel regulatory controls of adipogenesis. ..
  19. Staiger J, Lueben M, Berrigan D, Malik R, Perkins S, Hursting S, et al. C/EBPbeta regulates body composition, energy balance-related hormones and tumor growth. Carcinogenesis. 2009;30:832-40 pubmed publisher
    ..Thus, C/EBPbeta contributes to endocrine expression of IGF-1, leptin and insulin, which modulate energy balance and can contribute to cancer progression by creating a favorable environment for tumor cell proliferation and survival. ..
  20. Lai C, Lee J, Ho C, Liu C, Wang J, Wang Y, et al. Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways. J Agric Food Chem. 2009;57:10990-8 pubmed publisher
    ..Taken together, rosmanol might contribute to the potent anti-inflammatory effect of rosemary and may have potential to be developed into an effective anti-inflammatory agent. ..