tumor protein p73


Summary: A homolog of p53 TUMOR SUPPRESSOR PROTEIN that encodes full-length trans-activating and N-terminally-truncated (DeltaN) isoforms. Detection of splice variants and isoforms in the nervous system (human TELENCEPHALON, CHOROID PLEXUS; CEREBROSPINAL FLUID), embryonic tissue, human BREAST CANCER; OVARIAN CANCER, suggest roles in cellular differentiation.

Top Publications

  1. Zhu A, Li Y, Song W, Xu Y, Yang F, Zhang W, et al. Antiproliferative Effect of Androgen Receptor Inhibition in Mesenchymal Stem-Like Triple-Negative Breast Cancer. Cell Physiol Biochem. 2016;38:1003-14 pubmed publisher
  2. Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang J, Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J Cell Sci. 2000;113 ( Pt 10):1661-70 pubmed
    ..Because p53 and p73 are linked to different upstream pathways, this family of transcription factors might regulate a common set of genes in response to different extracellular signals and developmental cues. ..
  3. Irwin M, Kaelin W. p53 family update: p73 and p63 develop their own identities. Cell Growth Differ. 2001;12:337-49 pubmed
  4. Belyi V, Levine A. One billion years of p53/p63/p73 evolution. Proc Natl Acad Sci U S A. 2009;106:17609-10 pubmed publisher
  5. Alexandrova E, Talos F, Moll U. p73 is dispensable for commitment to neural stem cell fate, but is essential for neural stem cell maintenance and for blocking premature differentiation. Cell Death Differ. 2013;20:368 pubmed publisher
  6. Zhang Y, Yan W, Jung Y, Chen X. PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition. PLoS ONE. 2013;8:e66464 pubmed publisher
    ..Together, our data suggest that PUMA cooperates with p21 to regulate normal acinus formation and EMT. ..
  7. Salomoni P. Metabolic modulation of neurogenesis: role of glutaminase-2. Cell Cycle. 2014;13:15 pubmed publisher
  8. Li S, Huang Y, Huang Y, Fu Y, Tang D, Kang R, et al. The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation. J Exp Clin Cancer Res. 2017;36:51 pubmed publisher
    ..Our data indicated that TP73-AS1 might be an oncogenic lncRNA that promoted proliferation of HCC and could be regarded as a therapeutic target in human HCC. ..
  9. Su J, Zhou X, Yin X, Wang L, Zhao Z, Hou Y, et al. The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer. Biochem Pharmacol. 2017;140:28-40 pubmed publisher
    ..These results suggested that inhibition of NEDD4 might be beneficial to the antitumor properties of curcumin on PC treatments. ..

More Information


  1. Sinha N, Panda P, Naik P, Das D, Mukhopadhyay S, Maiti T, et al. Abrus agglutinin promotes irreparable DNA damage by triggering ROS generation followed by ATM-p73 mediated apoptosis in oral squamous cell carcinoma. Mol Carcinog. 2017;56:2400-2413 pubmed publisher
    ..In conclusion, we established a connection among ROS, ATM and p73 in AGG-induced apoptosis, which might be useful in enhancing the therapeutic targeting of p53 deficient oral squamous cell carcinoma. ..
  2. Liu P, Garbutt C, Hornicek F, Liu F, Duan Z. Aberration of p73 Promoter Methylation in Chondrosarcoma. Anticancer Res. 2017;37:2939-2945 pubmed
    ..p73 is epigenetically silenced in CS due to promoter methylation, which suggests the utility of p73 methylation as a biomarker. ..
  3. Ng K, Chan L, Chai S, Tong M, Guan X, Lee N, et al. TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma. Cancer Res. 2017;77:4602-4612 pubmed publisher
    ..i>Cancer Res; 77(17); 4602-12. ©2017 AACR. ..
  4. Li C, Park S, Zhang X, Eisenberg L, Zhao H, Darzynkiewicz Z, et al. Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism. J Biol Chem. 2017;292:16746-16759 pubmed publisher
    ..On the basis of these findings and our previous studies, we propose that Gene 33 is a proximal regulator of DDR that promotes DNA repair. ..