Genomes and Genes
tumor protein p73
Summary: A homolog of p53 TUMOR SUPPRESSOR PROTEIN that encodes full-length trans-activating and N-terminally-truncated (DeltaN) isoforms. Detection of splice variants and isoforms in the nervous system (human TELENCEPHALON, CHOROID PLEXUS; CEREBROSPINAL FLUID), embryonic tissue, human BREAST CANCER; OVARIAN CANCER, suggest roles in cellular differentiation.
- Sinha N, Panda P, Naik P, Das D, Mukhopadhyay S, Maiti T, et al. Abrus agglutinin promotes irreparable DNA damage by triggering ROS generation followed by ATM-p73 mediated apoptosis in oral squamous cell carcinoma. Mol Carcinog. 2017;56:2400-2413 pubmed publisher..In conclusion, we established a connection among ROS, ATM and p73 in AGG-induced apoptosis, which might be useful in enhancing the therapeutic targeting of p53 deficient oral squamous cell carcinoma. ..
- Liu P, Garbutt C, Hornicek F, Liu F, Duan Z. Aberration of p73 Promoter Methylation in Chondrosarcoma. Anticancer Res. 2017;37:2939-2945 pubmed..p73 is epigenetically silenced in CS due to promoter methylation, which suggests the utility of p73 methylation as a biomarker. ..
- Ng K, Chan L, Chai S, Tong M, Guan X, Lee N, et al. TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma. Cancer Res. 2017;77:4602-4612 pubmed publisher..i>Cancer Res; 77(17); 4602-12. Â©2017 AACR. ..
- Li C, Park S, Zhang X, Eisenberg L, Zhao H, Darzynkiewicz Z, et al. Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism. J Biol Chem. 2017;292:16746-16759 pubmed publisher..On the basis of these findings and our previous studies, we propose that Gene 33 is a proximal regulator of DDR that promotes DNA repair. ..