cystatin m


Summary: A cystatin subtype that has a diverse tissue distribution, target specificity, and functions as an endogenous inhibitor of lysosomal cysteine proteases.

Top Publications

  1. Lunde N, Haugen M, Bodin Larsen K, Damgaard I, Pettersen S, Kasem R, et al. Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions. Biochimie. 2017;139:27-37 pubmed publisher
    ..In conclusion, glycosylation of prolegumain is necessary for correct processing to active forms and internalization, whereas the inhibitory property of cystatin E/M is independent of the glycosylation status. ..
  2. Oortveld M, van Vlijmen Willems I, Kersten F, Cheng T, Verdoes M, van Erp P, et al. Cathepsin B as a potential cystatin M/E target in the mouse hair follicle. FASEB J. 2017;31:4286-4294 pubmed publisher
    Deficiency of the cysteine protease inhibitor cystatin M/E (Cst6) in mice leads to disturbed epidermal cornification, impaired barrier function, and neonatal lethality...
  3. Wallin H, Apelqvist J, Andersson F, Ekström U, Abrahamson M. Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells. J Biol Chem. 2017;292:14413-14424 pubmed publisher
    ..Thus, cystatin E/M appears to be a good candidate to efficiently down-regulate the increased legumain activity, possibly important for the malignant phenotype of melanoma cells. ..