stathmin

Summary

Summary: A ubiquitous phosphoprotein that serves as an intracellular substrate for a variety of SIGNAL TRANSDUCTION PATHWAYS. PHOSPHORYLATION of stathmin occurs during CELL CYCLE progression, and stathmin functions as a microtubule-destabilizing protein that promotes MICROTUBULE depolymerization during INTERPHASE and late MITOSIS. Stathmin is expressed at very high levels in a variety of human CANCERS.

Top Publications

  1. Maucuer A, Camonis J, Sobel A. Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995;92:3100-4 pubmed
    b>Stathmin is a ubiquitous, cytosolic 19-kDa protein, which is phosphorylated on up to four sites in response to many regulatory signals within cells...
  2. Takahashi K, Suzuki K. Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex. Cell Signal. 2009;21:695-703 pubmed publisher
    ..Concomitantly, phosphorylation of tubulin-bound stathmin/Op18 at serine 25 (Ser25) and Ser38, microtubule growth, and stathmin/Op18 binding to kinesin-WAVE2 complex were ..
  3. Li N, Jiang P, Du W, Wu Z, Li C, Qiao M, et al. Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules. Proc Natl Acad Sci U S A. 2011;108:12851-6 pubmed publisher
    ..Here we report that Siva1 interacts with stathmin, a microtubule destabilizer...
  4. Ozon S, El Mestikawy S, Sobel A. Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain. J Neurosci Res. 1999;56:553-64 pubmed
    b>Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and previously described as a relay integrating diverse intracellular signaling pathways...
  5. Liu H, Zhang R, Ko S, Oyajobi B, Papasian C, Deng H, et al. Microtubule assembly affects bone mass by regulating both osteoblast and osteoclast functions: stathmin deficiency produces an osteopenic phenotype in mice. J Bone Miner Res. 2011;26:2052-67 pubmed publisher
    ..elucidate the role of microtubules in bone homeostasis, we characterized the skeletal phenotype of mice null for stathmin, an endogenous protein that inhibits microtubule assembly...
  6. Levy A, Devignot V, Fukata Y, Fukata M, Sobel A, Chauvin S. Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases. Mol Biol Cell. 2011;22:1930-42 pubmed publisher
    ..The neuronal microtubule-regulatory phosphoproteins of the stathmin family (SCG10/stathmin 2, SCLIP/stathmin 3, and RB3/stathmin 4) are peripheral proteins that fulfill specific and ..
  7. Balasubramani M, Nakao C, Uechi G, Cardamone J, Kamath K, Leslie K, et al. Characterization and detection of cellular and proteomic alterations in stable stathmin-overexpressing, taxol-resistant BT549 breast cancer cells using offgel IEF/PAGE difference gel electrophoresis. Mutat Res. 2011;722:154-64 pubmed publisher
    b>Stathmin/oncoprotein 18, a protein that regulates microtubule dynamics, is highly expressed in a number of tumors including leukemia, lymphoma, neuroblastoma, breast, ovarian, and prostate cancers...
  8. Sobel A. Stathmin: a relay phosphoprotein for multiple signal transduction?. Trends Biochem Sci. 1991;16:301-5 pubmed
    b>Stathmin is a ubiquitous, phylogenetically conserved protein present in the cytoplasm of cells in a variety of unphosphorylated and phosphorylated forms...
  9. Wang X, Chen Y, Han Q, Chan C, Wang H, Liu Z, et al. Proteomic identification of molecular targets of gambogic acid: role of stathmin in hepatocellular carcinoma. Proteomics. 2009;9:242-53 pubmed publisher
    ..protein beta subunit 1 were upregulated by both xanthones, whilst the expression of 14-3-3 protein sigma and stathmin 1 (STMN1) were downregulated...

More Information

Publications62

  1. Gadea B, Ruderman J. Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin. Proc Natl Acad Sci U S A. 2006;103:4493-8 pubmed
    Oncoprotein 18/Stathmin (Op18) is a microtubule-destabilizing protein that is inhibited by phosphorylation in response to many types of signals...
  2. Kouzu Y, Uzawa K, Koike H, Saito K, Nakashima D, Higo M, et al. Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis. Br J Cancer. 2006;94:717-23 pubmed
    b>Stathmin is an intracellular phosphoprotein that is overexpressed in a number of human malignancies...
  3. Ringhoff D, Cassimeris L. Stathmin regulates centrosomal nucleation of microtubules and tubulin dimer/polymer partitioning. Mol Biol Cell. 2009;20:3451-8 pubmed publisher
    b>Stathmin is a microtubule-destabilizing protein ubiquitously expressed in vertebrates and highly expressed in many cancers...
  4. Mizumura K, Takeda K, Hashimoto S, Horie T, Ichijo H. Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade. J Cell Physiol. 2006;206:363-70 pubmed
    ..Here we have identified oncoprotein 18 (Op18)/stathmin as a potential target of the ASK1-p38 cascade...
  5. Jeon T, Han M, Lee Y, Lee Y, Kim G, Song G, et al. Overexpression of stathmin1 in the diffuse type of gastric cancer and its roles in proliferation and migration of gastric cancer cells. Br J Cancer. 2010;102:710-8 pubmed publisher
    ..These results suggest that stathmin1 can be a good prognostic factor for recurrence-free survival rate and is a therapeutic target in diffuse-type gastric cancer. ..
  6. Gin D, Kim H, Lee D, Lee S, Seong A, Hwang J, et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin up-regulates stathmin 1 in the eye: suggestive evidence for the involvement of stathmin 1 in accelerated eye opening in mice induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Lett. 2010;196:87-94 pubmed publisher
    ..translationally controlled tumor protein (TCTP) and 60S acidic ribosomal protein p2 (RLA2) were reduced, while stathmin 1(STMN1) was increased, at both protein and mRNA levels...
  7. Zheng P, Liu Y, Chen L, Liu X, Xiao Z, Zhao L, et al. Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer. J Proteome Res. 2010;9:4897-905 pubmed publisher
    ..We identified 39 PRL-3 associated proteins based on proteomic strategy. Stathmin, a key oncoprotein, was proved to be a new PRL-3 associated protein...
  8. Howell B, Larsson N, Gullberg M, Cassimeris L. Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin. Mol Biol Cell. 1999;10:105-18 pubmed
    Oncoprotein 18/stathmin (Op18) has been identified recently as a protein that destabilizes microtubules, but the mechanism of destabilization is currently controversial...
  9. Tan H, Wu W, Ng Y, Zhang X, Yan B, Ong C, et al. Proteomic analysis of colorectal cancer metastasis: stathmin-1 revealed as a player in cancer cell migration and prognostic marker. J Proteome Res. 2012;11:1433-45 pubmed publisher
    ..Among these proteins, stathmin-1 (STMN1) was found to be highly up-regulated in E1 as compared to HCT-116 and was thus selected for further ..
  10. Belmont L, Mitchison T, Deacon H. Catastrophic revelations about Op18/stathmin. Trends Biochem Sci. 1996;21:197-8 pubmed
  11. Li L, Cohen S. Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell. 1996;85:319-29 pubmed
    ..The protein encoded by tsg101 cDNA encodes a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated previously in tumorigenesis...
  12. Zhao F, Hu Y, Zhang Y, Zhu Q, Zhang X, Luo J, et al. Abnormal expression of stathmin 1 in brain tissue of patients with intractable temporal lobe epilepsy and a rat model. Synapse. 2012;66:781-91 pubmed publisher
    Microtubule dynamics have been shown to contribute to neurite outgrowth, branching, and guidance. Stathmin 1 is a potent microtubule-destabilizing factor that is involved in the regulation of microtubule dynamics and plays an essential ..
  13. Bhagirath D, Abrol N, Khan R, Sharma M, Seth A, Sharma A. Expression of CD147, BIGH3 and Stathmin and their potential role as diagnostic marker in patients with urothelial carcinoma of the bladder. Clin Chim Acta. 2012;413:1641-6 pubmed publisher
    ..an Extracellular matrix protein (ECM) which interacts with various ECM component in different tissue system and Stathmin(STMN1) is cytosolic microtubule destabilising protein also called as Oncoprotein18 due to its role in tumour ..
  14. Bsibsi M, Bajramovic J, Vogt M, Van Duijvenvoorden E, Baghat A, Persoon Deen C, et al. The microtubule regulator stathmin is an endogenous protein agonist for TLR3. J Immunol. 2010;184:6929-37 pubmed publisher
    ..functional screening of a transcript library from brain tumors revealed that the microtubule regulator stathmin is an activator of TLR3-dependent signaling in astrocytes, inducing the same set of neuroprotective factors as ..
  15. Chen P, Lin S, Tsai S, Lin J, Chen M, Wang J, et al. Regulation of microtubule dynamics through phosphorylation on stathmin by Epstein-Barr virus kinase BGLF4. J Biol Chem. 2010;285:10053-63 pubmed publisher
    b>Stathmin is an important microtubule (MT)-destabilizing protein, and its activity is differently attenuated by phosphorylation at one or more of its four phosphorylatable serine residues (Ser-16, Ser-25, Ser-38, and Ser-63)...
  16. Kang W, Tong J, Chan A, Lung R, Chau S, Wong Q, et al. Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer. PLoS ONE. 2012;7:e33919 pubmed publisher
    ..Our findings supported an oncogenic role of STMN1 in gastric cancer. STMN1 might serve as a prognostic marker and a potential therapeutic target for gastric cancer. ..
  17. Sonego M, Schiappacassi M, Lovisa S, Dall Acqua A, Bagnoli M, Lovat F, et al. Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer. EMBO Mol Med. 2013;5:707-22 pubmed publisher
    b>Stathmin is a p53-target gene, frequently overexpressed in late stages of human cancer progression. Type II High Grade Epithelial Ovarian Carcinomas (HG-EOC) represents the only clear exception to this observation...
  18. Yoshie M, Kashima H, Bessho T, Takeichi M, Isaka K, Tamura K. Expression of stathmin, a microtubule regulatory protein, is associated with the migration and differentiation of cultured early trophoblasts. Hum Reprod. 2008;23:2766-74 pubmed publisher
    The microtubule-destabilizing protein stathmin is expressed by the villous cytotrophoblasts and invasive extravillous trophoblasts (EVTs) in the first-trimester human placenta...
  19. Rubin C, French D, Atweh G. Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy. Exp Hematol. 2003;31:389-97 pubmed
    ..b>Stathmin is a major microtubule-regulatory protein that plays an important role in the regulation of the mitotic spindle...
  20. Nakashima D, Uzawa K, Kasamatsu A, Koike H, Endo Y, Saito K, et al. Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands. Int J Cancer. 2006;118:704-13 pubmed
    ..Maspin and stathmin were selected for further analyses...
  21. Holmfeldt P, Brannstrom K, Stenmark S, Gullberg M. Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells. Mol Biol Cell. 2006;17:2921-30 pubmed
    Op18/stathmin (Op18) is a phosphorylation-regulated microtubule destabilizer that is frequently overexpressed in tumors...
  22. Ng D, Lin B, Lim C, Huang G, Zhang T, Poli V, et al. Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol. 2006;172:245-57 pubmed
    ..In this study, we reveal an interaction between Stat3 and the microtubule (MT)-destabilizing protein stathmin. Stathmin did not overtly affect ligand-stimulated Stat3 activation...
  23. Andersen S, Ashford A, Tournebize R, Gavet O, Sobel A, Hyman A, et al. Mitotic chromatin regulates phosphorylation of Stathmin/Op18. Nature. 1997;389:640-3 pubmed
    ..It has been shown that Stathmin/Op18 inhibits microtubule polymerization in vitro by interaction with tubulin, and that overexpression in tissue ..
  24. Hsieh S, Huang S, Yu M, Yeh T, Chen T, Lin Y, et al. Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma. Mol Carcinog. 2010;49:476-87 pubmed publisher
    ..Overexpression of STMN1 promoted polyploidy formation, tumor-cell invasion, and intrahepatic metastasis, suggesting that STMN1 can be a target for anti-cancer therapy of human hepatoma. ..
  25. Antonsson B, Kassel D, Ruchti E, Grenningloh G. Differences in phosphorylation of human and chicken stathmin by MAP kinase. J Cell Biochem. 2001;80:346-52 pubmed
    b>Stathmin/Op18 is a highly conserved 19 kDa cytosolic phosphoprotein. Human and chicken stathmin share 93% identity with only 11 amino acid substitutions...
  26. Niethammer P, Bastiaens P, Karsenti E. Stathmin-tubulin interaction gradients in motile and mitotic cells. Science. 2004;303:1862-6 pubmed
    ..intracellular gradients by monitoring the interaction between tubulin and a regulator of microtubule dynamics, stathmin, using a fluorescence resonance energy transfer (FRET) biosensor...
  27. Higuero A, Sánchez Ruiloba L, Doglio L, Portillo F, Abad Rodriguez J, Dotti C, et al. Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development. J Biol Chem. 2010;285:1343-57 pubmed publisher
    ..neuronal morphogenesis is well established (microtubule-associated proteins 1b, 1a, and 2 and two members of the stathmin family)...
  28. Santamaria E, Mora M, Munoz J, Sánchez Quiles V, Fernández Irigoyen J, Prieto J, et al. Regulation of stathmin phosphorylation in mouse liver progenitor-29 cells during proteasome inhibition. Proteomics. 2009;9:4495-506 pubmed publisher
    ..Alterations in NDRG1 and stathmin suggest new mechanisms associated to proteasome inhibitor-induced apoptosis in MLP-29 cells...
  29. Mistry S, Atweh G. Therapeutic interactions between stathmin inhibition and chemotherapeutic agents in prostate cancer. Mol Cancer Ther. 2006;5:3248-57 pubmed
    ..b>Stathmin is overexpressed in many types of human cancer, including prostate cancer...
  30. Xi W, Rui W, Fang L, Ke D, Ping G, Hui Zhong Z. Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients. J Cancer Res Clin Oncol. 2009;135:837-46 pubmed publisher
    b>Stathmin (Oncoprotein18), a ubiquitous and highly conserved 19-kDa cytosolic phosphoprotein, has been reported to play a critical role in mitosis and possibly other cellular processes, which is associated with tumor carcinogenesis and ..
  31. Singer S, Ehemann V, Brauckhoff A, Keith M, Vreden S, Schirmacher P, et al. Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis. Hepatology. 2007;46:759-68 pubmed
    The microtubule (MT)-destabilizing protein stathmin/Op18 has previously been described to be negatively regulated by p53 and to be highly expressed in several tumor entities...
  32. Parker C, Hunt J, Diener K, McGinley M, Soriano B, Keesler G, et al. Identification of stathmin as a novel substrate for p38 delta. Biochem Biophys Res Commun. 1998;249:791-6 pubmed
    ..Utilizing in a solution kinase assay, we identified a novel p38 delta substrate as stathmin. Stathmin is a cytoplasmic protein that was previously reported to be a substrate of several intracellular ..
  33. Mistry S, Bank A, Atweh G. Synergistic antiangiogenic effects of stathmin inhibition and taxol exposure. Mol Cancer Res. 2007;5:773-82 pubmed
    b>Stathmin is one of the key regulators of the microtubule cytoskeleton and the mitotic spindle in eukaryotic cells. It is expressed at high levels in a wide variety of human cancers and may provide an attractive target for cancer therapy...
  34. Long M, Yin G, Liu L, Lin F, Wang X, Ren J, et al. Adenovirus-mediated Aurora A shRNA driven by stathmin promoter suppressed tumor growth and enhanced paclitaxel chemotherapy sensitivity in human breast carcinoma cells. Cancer Gene Ther. 2012;19:271-81 pubmed publisher
    ..In this study, we developed a novel tumor-specific RNA interference adenovirus system targeting Aurora A by using stathmin promoter and investigated the effects of it on the proliferation, apoptosis and chemotherapy sensitivity in human ..
  35. Maucuer A, Moreau J, Mechali M, Sobel A. Stathmin gene family: phylogenetic conservation and developmental regulation in Xenopus. J Biol Chem. 1993;268:16420-9 pubmed
    The ubiquitous cytoplasmic phosphoprotein stathmin was proposed to play a general role as an intracellular relay integrating diverse signals regulating the proliferation, differentiation, and functions of cells (Sobel, A...
  36. Wei S, Lin F, Wang X, Gao P, Zhang H. Prognostic significance of stathmin expression in correlation with metastasis and clinicopathological characteristics in human ovarian carcinoma. Acta Histochem. 2008;110:59-65 pubmed
    b>Stathmin, also called oncoprotein 18, is a founding member of the family of microtubule-destabilizing proteins that play a critical role in the regulation of mitosis...
  37. Byrne F, Yang L, Phillips P, Hansford L, Fletcher J, Ormandy C, et al. RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model. Oncogene. 2014;33:882-90 pubmed publisher
    Metastatic neuroblastoma is an aggressive childhood cancer of neural crest origin. Stathmin, a microtubule destabilizing protein, is highly expressed in neuroblastoma although its functional role in this malignancy has not been addressed...
  38. Park H, Gusarova G, Wang Z, Carr J, Li J, Kim K, et al. Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med. 2011;3:21-34 pubmed publisher
    ..FoxM1b activates the Akt-Snail1 pathway and stimulates expression of Stathmin, lysyl oxidase, lysyl oxidase like-2 and several other genes involved in metastasis...
  39. Ehlis A, Bauernschmitt K, Dresler T, Hahn T, Herrmann M, Röser C, et al. Influence of a genetic variant of the neuronal growth associated protein Stathmin 1 on cognitive and affective control processes: an event-related potential study. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:291-302 pubmed publisher
    b>Stathmin 1 (STMN1) is a neuronal growth associated protein (NGAP) that is involved in microtubule dynamics and plays an important role in neurite outgrowth and synaptic plasticity...
  40. Beretta L, Dobransky T, Sobel A. Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2. J Biol Chem. 1993;268:20076-84 pubmed
    b>Stathmin is a ubiquitous, highly conserved phosphoprotein which most likely acts as a relay integrating various intracellular pathways regulating cell proliferation, differentiation, and functions...
  41. Curmi P, Andersen S, Lachkar S, Gavet O, Karsenti E, Knossow M, et al. The stathmin/tubulin interaction in vitro. J Biol Chem. 1997;272:25029-36 pubmed
    b>Stathmin is a highly conserved ubiquitous cytoplasmic protein, phosphorylated in response to extracellular signals and during the cell cycle...
  42. Phadke A, Jay C, Wang Z, Chen S, Liu S, Haddock C, et al. In vivo safety and antitumor efficacy of bifunctional small hairpin RNAs specific for the human Stathmin 1 oncoprotein. DNA Cell Biol. 2011;30:715-26 pubmed publisher
    ..We have generated a novel bi-shRNA using the miR30 scaffold that is highly effective for knockdown of human stathmin (STMN1) mRNA. STMN1 overexpression well documented in human solid cancers correlates with their poor prognosis...
  43. Chen G, Wang H, Gharib T, Huang C, Thomas D, Shedden K, et al. Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas. Mol Cell Proteomics. 2003;2:107-16 pubmed
  44. Wik E, Birkeland E, Trovik J, Werner H, Hoivik E, Mjos S, et al. High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition. Clin Cancer Res. 2013;19:2331-41 pubmed publisher
    High Stathmin expression has recently been associated with clinical progress in endometrial cancers. Stathmin protein activity is modulated by phosphorylation, and the Serine38 site is one of four Stathmin phospho-sites...
  45. Dominguez F, Garrido Gomez T, Lopez J, Camafeita E, Quiñonero A, Pellicer A, et al. Proteomic analysis of the human receptive versus non-receptive endometrium using differential in-gel electrophoresis and MALDI-MS unveils stathmin 1 and annexin A2 as differentially regulated. Hum Reprod. 2009;24:2607-17 pubmed publisher
    ..and database searching revealed 32 differentially expressed proteins, although only annexin A2 and stathmin 1 were consistently regulated in the two experiments performed...
  46. Fang L, Min L, Lin Y, Ping G, Rui W, Ying Z, et al. Downregulation of stathmin expression is mediated directly by Egr1 and associated with p53 activity in lung cancer cell line A549. Cell Signal. 2010;22:166-73 pubmed publisher
    b>Stathmin is overexpressed in a variety of assessed human malignancies and is correlated with tumor progression and poor prognosis...
  47. Shi X, Wang D, Ding K, Lu Z, Jin Y, Zhang J, et al. GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. Cancer Biol Ther. 2010;9:640-50 pubmed
    ..Op18/stathmin is an oncoprotein that regulates microtubule stabilization...
  48. Steinmetz M, Jahnke W, Towbin H, Garcia Echeverria C, Voshol H, Muller D, et al. Phosphorylation disrupts the central helix in Op18/stathmin and suppresses binding to tubulin. EMBO Rep. 2001;2:505-10 pubmed
    ..Oncoprotein 18/stathmin (Op18) is a globally disordered phosphoprotein that is involved in the regulation of the microtubule (MT) ..
  49. Lin Y, Li C, Shan B, Wang W, Saito S, Xu J, et al. Reduced stathmin-1 expression in natural killer cells associated with spontaneous abortion. Am J Pathol. 2011;178:506-14 pubmed publisher
    ..In this study, the stathmin-1 expression pattern was evaluated in uterine natural killer (uNK) cells purified from CBA/J×DBA/2J matings...
  50. Grenningloh G, Soehrman S, Bondallaz P, Ruchti E, Cadas H. Role of the microtubule destabilizing proteins SCG10 and stathmin in neuronal growth. J Neurobiol. 2004;58:60-9 pubmed
    The related proteins SCG10 and stathmin are highly expressed in the developing nervous system. Recently it was discovered that they are potent microtubule destabilizing factors...
  51. Baik S, Yun H, Lee H, Lee M, Jung S, Kim J, et al. Identification of stathmin 1 expression induced by Epstein-Barr virus in human B lymphocytes. Cell Prolif. 2007;40:268-81 pubmed
    ..Among them, we verified the differential expression of several oncogenes such as stathmin 1 (STMN1), RAB27A, RAB9A, BACH1 and BACH2 using quantitative real-time reverse transcriptase-polymerase chain ..
  52. Polager S, Ginsberg D. E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress. J Biol Chem. 2003;278:1443-9 pubmed
    ..the genotoxic agent doxorubicin is E2F-dependent and involves a decrease in expression of two mitotic regulators, Stathmin and AIM-1...
  53. Doye V, le Gouvello S, Dobransky T, Chneiweiss H, Beretta L, Sobel A. Expression of transfected stathmin cDNA reveals novel phosphorylated forms associated with developmental and functional cell regulation. Biochem J. 1992;287 ( Pt 2):549-54 pubmed
    b>Stathmin is a ubiquitous, highly conserved phosphoprotein, which most likely acts as an intracellular relay integrating various transduction pathways triggered by extracellular signals...