Summary: A family of histone molecular chaperones that play roles in sperm CHROMATIN decondensation and CHROMATIN ASSEMBLY in fertilized eggs. They were originally discovered in XENOPUS egg extracts as histone-binding factors that mediate nucleosome formation in vitro.

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  1. Dworetzky S, Lanford R, Feldherr C. The effects of variations in the number and sequence of targeting signals on nuclear uptake. J Cell Biol. 1988;107:1279-87 pubmed
    ..It was also determined, by performing coinjection experiments, that individual pores are capable of recognizing and transporting proteins that contain different nuclear targeting signals. ..
  2. Piccaluga P, Sabattini E, Bacci F, Agostinelli C, Righi S, Salmi F, et al. Cytoplasmic mutated nucleophosmin (NPM1) in blast crisis of chronic myeloid leukaemia. Leukemia. 2009;23:1370-1 pubmed publisher