histone chaperones


Summary: Proteins involved in the assembly and disassembly of HISTONES into NUCLEOSOMES.

Top Publications

  1. Masel J. Q&A: Evolutionary capacitance. BMC Biol. 2013;11:103 pubmed publisher
  2. Krishnan S, Smits A, Vermeulen M, Reinberg D. Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis. Mol Cell. 2017;67:579-593.e6 pubmed publisher
    ..Our findings also elucidate the functional implications of the decades-old observation of mitotic linker histone phosphorylation, serving as a paradigm to explore the role of linker histones in bio-signaling processes. ..
  3. Hong W, Ye J, Chen M, Yan Y, Zhou G, Yang X, et al. Trichloroethylene induces biphasic concentration-dependent changes in cell proliferation and the expression of SET-associated proteins in human hepatic L-02 cells. Biomed Environ Sci. 2013;26:618-21 pubmed publisher
  4. Herz H, Garruss A, Shilatifard A. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci. 2013;38:621-39 pubmed publisher
  5. Tripathi A, Singh K, Pareek A, Singla Pareek S. Histone chaperones in Arabidopsis and rice: genome-wide identification, phylogeny, architecture and transcriptional regulation. BMC Plant Biol. 2015;15:42 pubmed publisher
    b>Histone chaperones modulate chromatin architecture and hence play a pivotal role in epigenetic regulation of gene expression. In contrast to their animal and yeast counterparts, not much is known about plant histone chaperones...
  6. Lee J, Lake R, Kirk J, Bohr V, Fan H, Hohng S. NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB. Nucleic Acids Res. 2017;45:4696-4707 pubmed publisher
    ..CSB alone remodels nucleosomes ?10-fold slower than the ACF remodeling complex. Strikingly, NAP1-like histone chaperones interact with CSB and greatly enhance CSB-mediated chromatin remodeling...
  7. Zhu R, Iwabuchi M, Ohsumi K. The WD40 Domain of HIRA Is Essential for RI-nucleosome Assembly in Xenopus Egg Extracts. Cell Struct Funct. 2017;42:37-48 pubmed publisher
    b>Histone chaperones are a group of histone-binding proteins that facilitate the assembly of nucleosomes, the fundamental structural units of chromatin in eukaryotes...
  8. Liu C, Wang T, Bai Y, Wang J. Electrostatic forces govern the binding mechanism of intrinsically disordered histone chaperones. PLoS ONE. 2017;12:e0178405 pubmed publisher
    ..Z-H2B. Both the intra-chain and inter-chain electrostatic interactions have direct impacts on the native collapsed structure and binding mechanism. ..
  9. Sobral L, Coletta R, Alberici L, Curti C, Leopoldino A. SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line. FEBS J. 2017;284:2774-2785 pubmed publisher
    ..Overall, our results show that SEToverexpression promotes morphological and oncogenic cell transformation of an oral keratinocyte cell. ..

More Information


  1. McDaniel S, Strahl B. Shaping the cellular landscape with Set2/SETD2 methylation. Cell Mol Life Sci. 2017;74:3317-3334 pubmed publisher
    ..3, have recently been found to underlie cancer development. This review will summarize the latest insights into the functions of Set2/SETD2 in genome regulation and cancer development. ..
  2. Li Y, Jiao J. Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin. J Cell Biol. 2017;216:1975-1992 pubmed publisher
    ..This finding represents a novel epigenetic mechanism underlying the histone code and has profound and lasting implications for diseases and neurobiology. ..
  3. Hung M, Chen K. Reprogramming the oncogenic response: SET protein as a potential therapeutic target in cancer. Expert Opin Ther Targets. 2017;21:685-694 pubmed publisher
    ..However, more studies are required to clarify the best strategy to combine SET antagonists with other anti-cancer treatments and to explore possible biomarkers that predict responsiveness. ..
  4. Warren C, Shechter D. Fly Fishing for Histones: Catch and Release by Histone Chaperone Intrinsically Disordered Regions and Acidic Stretches. J Mol Biol. 2017;429:2401-2426 pubmed publisher
    ..b>Histone chaperones are a non-catalytic group of proteins that are central to the processes of nucleosome assembly and ..
  5. Gómez Herreros F, Margaritis T, Rodríguez Galán O, Pelechano V, Begley V, Millán Zambrano G, et al. The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation. Nucleic Acids Res. 2017;45:9302-9318 pubmed publisher
    ..On the whole, this work uncovers a feedback control of ribosome biogenesis by fine-tuning transcription elongation in ribosome assembly factor-coding genes. ..