hsp20 heat shock proteins


Summary: A subfamily of small heat-shock proteins that are closely related to ALPHA B-CRYSTALLIN. Hsp20 heat-shock proteins can undergo PHOSPHORYLATION by CYCLIC GMP-DEPENDENT PROTEIN KINASES.

Top Publications

  1. Crippa V, Sau D, Rusmini P, Boncoraglio A, Onesto E, Bolzoni E, et al. The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Hum Mol Genet. 2010;19:3440-56 pubmed publisher
    ..Overall, these results indicate that the pharmacological modulation of HspB8 expression in motor neurons may have important implications to unravel the molecular mechanisms involved both in fALS and in sALS. ..
  2. Irobi J, Almeida Souza L, Asselbergh B, de Winter V, Goethals S, Dierick I, et al. Mutant HSPB8 causes motor neuron-specific neurite degeneration. Hum Mol Genet. 2010;19:3254-65 pubmed publisher
    ..These findings show that despite the ubiquitous presence of HSPB8, only motor neurons appear to be affected by the K141N and K141E mutations which explain the predominant motor neuron phenotype in distal HMN and CMT2L. ..
  3. Hashimoto R, Yumoto M, Watanabe M, Konishi M, Haraoka J, Miki T. Differential effects of an expected actin-tropomyosin binding region of heat shock protein 20 on the relaxation in skinned carotid artery and taenia cecum from guinea pig. J Smooth Muscle Res. 2009;45:63-74 pubmed
  4. Furnish E, Brophy C, Harris V, Macomson S, Winger J, Head G, et al. Treatment with transducible phosphopeptide analogues of the small heat shock-related protein, HSP20, after experimental subarachnoid hemorrhage: prevention and reversal of delayed decreases in cerebral perfusion. J Neurosurg. 2010;112:631-9 pubmed publisher
    ..Transduction of biologically active motifs of downstream regulators like HSP20 represents a potential novel treatment for SAH. ..
  5. McCollum A, Casagrande G, Kohn E. Caught in the middle: the role of Bag3 in disease. Biochem J. 2009;425:e1-3 pubmed publisher
    ..We will apply the findings of Fuchs et al. in this issue to reconcile the phenotypes of Bag3 homologue knockouts with the emerging role of Bag3 in autophagy. ..
  6. Mymrikov E, Bukach O, Seit Nebi A, Gusev N. The pivotal role of the beta 7 strand in the intersubunit contacts of different human small heat shock proteins. Cell Stress Chaperones. 2010;15:365-77 pubmed publisher
  7. Qian J, Ren X, Wang X, Zhang P, Jones W, Molkentin J, et al. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circ Res. 2009;105:1223-31 pubmed publisher
    ..Therefore, phosphorylation of Hsp20 at serine 16 may represent a potential therapeutic target in ischemic heart disease. ..
  8. Bagneris C, Bateman O, Naylor C, Cronin N, Boelens W, Keep N, et al. Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20. J Mol Biol. 2009;392:1242-52 pubmed publisher
    ..The empty pockets and groove provide a starting model for designing drugs to inhibit those sHsps that have a negative effect on cancer treatment. ..
  9. Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, et al. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells. 2009;27:3021-31 pubmed publisher
    ..Taken together, these data support the premise that genetic modification of MSCs before transplantation could be salutary for treating myocardial infarction. ..

More Information


  1. Ward B, Seal B, Brophy C, Panitch A. Design of a bioactive cell-penetrating peptide: when a transduction domain does more than transduce. J Pept Sci. 2009;15:668-74 pubmed publisher
    ..The results reported herein have wide implications for delivering therapeutics with CPPs and indicate that judicious choice of CPP is crucial to the ultimate therapeutic success. ..
  2. Kouguchi H, Matsumoto J, Katoh Y, Suzuki T, Oku Y, Yagi K. Echinococcus multilocularis: two-dimensional Western blotting method for the identification and expression analysis of immunogenic proteins in infected dogs. Exp Parasitol. 2010;124:238-43 pubmed publisher
    ..Furthermore, recombinant hsp20 showed specific reactivity to the sera from infected dogs, suggesting that this molecule may facilitate the development of a practical vaccine. ..
  3. Niwa M, Hara A, Taguchi A, Aoki H, Kozawa O, Mori H. Spatiotemporal expression of Hsp20 and its phosphorylation in hippocampal CA1 pyramidal neurons after transient forebrain ischemia. Neurol Res. 2009;31:721-7 pubmed publisher
    ..Phosphorylation of Hsp20 might contribute to the subacute phase but not to an acute phase. ..
  4. Cóceres V, Becher M, De Napoli M, Corvi M, Clemente M, Angel S. Evaluation of the antigenic value of recombinant Toxoplasma gondii HSP20 to detect specific immunoglobulin G antibodies in Toxoplasma infected humans. Exp Parasitol. 2010;126:263-6 pubmed publisher
    ..In conclusion, we demonstrated that T. gondii HSP20 elicits an important B-cell response during human infection, and could be suitable for the development of serodiagnosis tools. ..
  5. Seit Nebi A, Gusev N. Versatility of the small heat shock protein HSPB6 (Hsp20). Cell Stress Chaperones. 2010;15:233-6 pubmed publisher
    ..All of these processes are dependent on HSPB6 phosphorylation which in turn might be regulated by the formation of heterooligomeric complexes of HSPB6 with other small heat shock proteins. ..
  6. Axsen W, Styer C, Solnick J. Inhibition of heat shock protein expression by Helicobacter pylori. Microb Pathog. 2009;47:231-6 pubmed publisher
    ..Typhimurium up-regulated HSP expression. Since HSPs are thought to function as danger signals during microbial infection, H. pylori down-regulation of HSPs may be a mechanism of immune evasion that promotes chronic infection. ..
  7. Dreiza C, Komalavilas P, Furnish E, Flynn C, Sheller M, Smoke C, et al. The small heat shock protein, HSPB6, in muscle function and disease. Cell Stress Chaperones. 2010;15:1-11 pubmed publisher
    ..This review will focus on the physiologic and biochemical properties of HSPB6 in smooth, cardiac, and skeletal muscle; the putative mechanisms of action; and therapeutic implications. ..
  8. Wang X, Zingarelli B, O Connor M, Zhang P, Adeyemo A, Kranias E, et al. Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation. J Mol Cell Cardiol. 2009;47:382-90 pubmed publisher
    ..Thus, the increases in Hsp20 levels can protect against LPS-induced cardiac apoptosis and dysfunction, associated with inhibition of NF-kappaB activity, suggesting that Hsp20 may be a new therapeutic agent for the treatment of sepsis. ..
  9. Koga Y, Pelizzola M, Cheng E, Krauthammer M, Sznol M, Ariyan S, et al. Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Res. 2009;19:1462-70 pubmed publisher
    ..In conclusion, this study represents the first unbiased systematic effort to determine methylation markers in melanoma and revealed several novel genes regulated by promoter methylation that were not described in cancer cells before. ..
  10. Sanbe A, Daicho T, Mizutani R, Endo T, Miyauchi N, Yamauchi J, et al. Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy. PLoS ONE. 2009;4:e5351 pubmed publisher
    ..Expression of small HSPs such as HSPB8 and HSPB1 by GGA may be a new therapeutic strategy for patients with DRM. ..
  11. Ren X, Wu J, Wang X, Sartor M, Jones K, Qian J, et al. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation. 2009;119:2357-2366 pubmed publisher
    ..Our data demonstrate that miR-320 is involved in the regulation of I/R-induced cardiac injury and dysfunction via antithetical regulation of Hsp20. Thus, miR-320 may constitute a new therapeutic target for ischemic heart diseases. ..
  12. Ouyang Y, Chen J, Xie W, Wang L, Zhang Q. Comprehensive sequence and expression profile analysis of Hsp20 gene family in rice. Plant Mol Biol. 2009;70:341-57 pubmed publisher
    ..Our results suggest that the expression patterns of the OsHsp20 genes are diversified not only in developmental stages but also in variety level. ..
  13. Flynn C, Smoke C, Furnish E, Komalavilas P, Thresher J, Yi Z, et al. Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli. Protein Expr Purif. 2007;52:50-8 pubmed
    ..These results delineate strategies for the expression and activation of therapeutic molecules for intracellular protein based therapeutics. ..
  14. Fuchs M, Poirier D, Seguin S, Lambert H, Carra S, Charette S, et al. Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Biochem J. 2009;425:245-55 pubmed publisher
  15. Leong P, Chen N, Chiu P, Leung H, Ma C, Tang Q, et al. Long-term treatment with shengmai san-derived herbal supplement (Wei Kang Su) enhances antioxidant response in various tissues of rats with protection against carbon tetrachloride hepatotoxicity. J Med Food. 2010;13:427-38 pubmed publisher
    ..Long-term WKS treatment may prevent diseases by enhancing the resistance of mitochondria to oxidative stress. ..
  16. Somara S, Gilmont R, Varadarajan S, Bitar K. Phosphorylated HSP20 modulates the association of thin-filament binding proteins: caldesmon with tropomyosin in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2010;299:G1164-76 pubmed publisher
    ..We thus propose the crucial physiological relevance of molecular signaling switch (phosphorylation state of HSP27 and HSP20), which dictates 1) the phosphorylation states of TM and CaD and 2) their dissociations from each other. ..