hsp110 heat shock proteins


Summary: A group of eukaryotic high-molecular mass heat-shock proteins that represent a subfamily of HSP70 HEAT-SHOCK PROTEINS. Hsp110 proteins prevent protein aggregation and can maintain denatured proteins in folding-competent states.

Top Publications

  1. Polier S, Hartl F, Bracher A. Interaction of the Hsp110 molecular chaperones from S. cerevisiae with substrate protein. J Mol Biol. 2010;401:696-707 pubmed publisher
    ..Under extreme stress conditions, Sse2p appears to take over the nucleotide exchange factor function of Sse1p and might promote the controlled aggregation of stress-denatured proteins. ..
  2. Park H, Park C, Choi B, Lim M, Heo S, Kim C, et al. Expression of heat shock protein 105 and 70 in malignant melanoma and benign melanocytic nevi. J Cutan Pathol. 2009;36:511-6 pubmed publisher
    ..In our study, HSP 105 is thought to be a more relevant tumor-associated antigen in malignant melanoma than is HSP 70. ..
  3. Hu T, Li D, Zhao Y. Development of the hsp110-heparanase vaccine to enhance antitumor immunity using the chaperoning properties of hsp110. Mol Immunol. 2009;47:298-301 pubmed publisher
    ..Thus, the use of the recombinant hsp110 and heparanase proteins to form into complex vaccine represents a novel and promising way for the therapeutical strategy of tumor...
  4. Mala J, Takeuchi S. Molecular cloning of OSP94: A significant biomarker protein of hypertensive human heart and a member of HSP110 family. Mol Biotechnol. 2009;42:175-94 pubmed publisher
    ..Structural predictions of OSP94 protein were also investigated. OSP94 is therefore recognized as a significant stress protein for investigations in hypertensive heart tissues and is a highly conserved protein in the HSP110 subfamily. ..
  5. Andréasson C, Rampelt H, Fiaux J, Druffel Augustin S, Bukau B. The endoplasmic reticulum Grp170 acts as a nucleotide exchange factor of Hsp70 via a mechanism similar to that of the cytosolic Hsp110. J Biol Chem. 2010;285:12445-53 pubmed publisher
    ..Thus, our findings demonstrate that despite some differences between Hsp110 and Grp170 proteins, they use a similar mechanism to trigger nucleotide exchange. ..
  6. Frahm J, Mattsson M, Simko M. Exposure to ELF magnetic fields modulate redox related protein expression in mouse macrophages. Toxicol Lett. 2010;192:330-6 pubmed publisher
    ..This suggests that ELF MF interacts with other cellular constituents than these chemicals, although induced pathways at least partially converge. ..
  7. Eroglu B, Moskophidis D, Mivechi N. Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta. Mol Cell Biol. 2010;30:4626-43 pubmed publisher
  8. Yamagishi N, Goto K, Nakagawa S, Saito Y, Hatayama T. Hsp105 reduces the protein aggregation and cytotoxicity by expanded-polyglutamine proteins through the induction of Hsp70. Exp Cell Res. 2010;316:2424-33 pubmed publisher
    ..These observations suggested that Hsp105alpha and Hsp105beta suppressed the expanded polyQ tract-induced protein aggregation and apoptosis through the induction of Hsp70. ..
  9. Wang X, Sun X, Chen X, Facciponte J, Repasky E, Kane J, et al. Superior antitumor response induced by large stress protein chaperoned protein antigen compared with peptide antigen. J Immunol. 2010;184:6309-19 pubmed publisher
    ..w. chaperones are superior to conventional chaperones as a vaccine platform to deliver large protein Ags, and provide a rationale for translating this recombinant chaperoning-based vaccine to future clinical investigation. ..

More Information


  1. Li C, Liu D, Yuan Y, Huang S, Shi M, Tao K, et al. Overexpression of Apg-2 increases cell proliferation and protects from oxidative damage in BaF3-BCR/ABL cells. Int J Oncol. 2010;36:899-904 pubmed
  2. Lu X, Kakkar V. The role of heat shock protein (HSP) in atherosclerosis: Pathophysiology and clinical opportunities. Curr Med Chem. 2010;17:957-73 pubmed
    ..The role of these HSPs, their protective vs. immunogenic properties with special emphasis on their potential as targets to develop therapeutic agent against atherosclerosis will be discussed. ..
  3. Yamagishi N, Fujii H, Saito Y, Hatayama T. Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3. FEBS J. 2009;276:5870-80 pubmed publisher
    ..This may represent the mechanism that connects the heat shock protein and STAT families for cell defense against deleterious stress. ..
  4. Burcham P, Raso A, Thompson C. Intermediate filament carbonylation during acute acrolein toxicity in A549 lung cells: functional consequences, chaperone redistribution, and protection by bisulfite. Antioxid Redox Signal. 2010;12:337-47 pubmed publisher
    ..These novel observations identify intermediate filaments as key targets for the reactive smoke constituent acrolein. ..
  5. Zhang S, Binari R, Zhou R, Perrimon N. A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics. 2010;184:1165-79 pubmed publisher
    ..Thus, other aggregates regulators isolated in our screen may identify additional genes involved in the protein-folding pathway and neurotoxicity. ..
  6. Ren F, Xu Y, Mao L, Ou R, Ding Z, Zhang X, et al. Heat shock protein 110 improves the antitumor effects of the cytotoxic T lymphocyte epitope E7(49-57) in mice. Cancer Biol Ther. 2010;9:134-41 pubmed
  7. Slaby O, Sobkova K, Svoboda M, Garajova I, Fabian P, Hrstka R, et al. Significant overexpression of Hsp110 gene during colorectal cancer progression. Oncol Rep. 2009;21:1235-41 pubmed
    ..031) and negative trend of HSP110 gene expression and overall survival of CRC patients. We suggest that HSP110 gene is a promising molecular predictor in CRC. ..
  8. Yuan J, Xiao L, Lu C, Zhang X, Liu T, Chen M, et al. Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation. Reprod Biol Endocrinol. 2009;7:23 pubmed publisher
    ..Temporal and spatial changes in Hsp105 expression in pregnant rat uterus may play a physiological role in regulating embryo implantation. ..