group ii chaperonins


Summary: A subcategory of chaperonins found in ARCHAEA and the CYTOSOL of eukaryotic cells. Group II chaperonins form a barrel-shaped macromolecular structure that is distinct from GROUP I CHAPERONINS in that it does not utilize a separate lid like structure to enclose proteins.

Top Publications

  1. Gruel N, Benhamo V, Bhalshankar J, Popova T, Freneaux P, Arnould L, et al. Polarity gene alterations in pure invasive micropapillary carcinomas of the breast. Breast Cancer Res. 2014;16:R46 pubmed publisher
  2. Yamamoto Y, Uno Y, Sha E, Ikegami K, Ishii N, Dohmae N, et al. Asymmetry in the function and dynamics of the cytosolic group II chaperonin CCT/TRiC. PLoS ONE. 2017;12:e0176054 pubmed publisher
    ..ATP binding induces tilting motion followed by rotational motion in the CtCCT molecule, like the archaeal group II chaperonins. When gold nanocrystals were attached onto two subunits in the high ATPase activity hemisphere, the CtCCT ..
  3. Scott C, Marsden A, Rebagliati M, Zhang Q, Chamling X, Searby C, et al. Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein. PLoS Genet. 2017;13:e1006936 pubmed publisher
    ..Our work identifies a new function for BBS6 in nuclear-cytoplasmic transport, and provides insight into the disease mechanism underlying the congenital heart defects in McKusick-Kaufman syndrome patients. ..
  4. Lopez T, Dalton K, Tomlinson A, Pande V, Frydman J. An information theoretic framework reveals a tunable allosteric network in group II chaperonins. Nat Struct Mol Biol. 2017;24:726-733 pubmed publisher
    ATP-dependent allosteric regulation of the ring-shaped group II chaperonins remains ill defined, in part because their complex oligomeric topology has limited the success of structural techniques in suggesting allosteric determinants...