sorting nexins


Summary: A large family of phosphatidylinositol phosphate-binding proteins that are involved in mediating intracellular transport and sorting of proteins via a variety of endocytic pathways.

Top Publications

  1. Børglum A, Demontis D, Grove J, Pallesen J, Hollegaard M, Pedersen C, et al. Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Mol Psychiatry. 2014;19:325-33 pubmed publisher
    ..3 × 10(-7)) in CTNNA3, a gene not previously implicated in schizophrenia, stressing the importance of including environmental factors in genetic studies. ..
  2. Ghai R, Tello Lafoz M, Norwood S, Yang Z, Clairfeuille T, Teasdale R, et al. Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. J Cell Sci. 2015;128:553-65 pubmed
  3. Cervantes Anaya N, Ponciano Gómez A, López Álvarez G, Gonzalez Reyes C, Hernández García S, Cabañas Cortés M, et al. Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats. Tumour Biol. 2017;39:1010428317695932 pubmed publisher
    ..These results suggest that sorting nexin 10 is a potential liver cancer marker exhibiting characteristics of a putative suppressor protein that is likely regulated by microRNA-30d. ..
  4. Pan X, Zaarur N, Singh M, MORIN P, Kandror K. Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes. Mol Biol Cell. 2017;28:1667-1675 pubmed publisher
    ..We suggest that sortilin- and retromer-mediated Glut4 retrieval from endosomes may represent a step in the Glut4 pathway vulnerable to the development of insulin resistance and diabetes. ..
  5. Bergant M, Peternel S, Pim D, Broniarczyk J, Banks L. Characterizing the spatio-temporal role of sorting nexin 17 in human papillomavirus trafficking. J Gen Virol. 2017;98:715-725 pubmed publisher
  6. Su K, Xu T, Yu Z, Zhu J, Zhang Y, Wu M, et al. Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain. FEBS Lett. 2017;591:2011-2018 pubmed publisher
    ..We also present the crystal structure of zSNX25-PX. Combined with biochemical experiments, we further identify a potential PI3P-binding region and propose a novel PI-binding model based on dimerization in the PX domain of SNXs. ..
  7. Feng S, Streets A, Nesin V, Tran U, Nie H, Onopiuk M, et al. The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex. J Am Soc Nephrol. 2017;28:2973-2984 pubmed publisher
    ..Molecular targeting of proteins involved in the endosomal sorting of PC1 and PC2 could lead to new therapeutic approaches in ADPKD. ..
  8. Jitsukawa S, Kamekura R, Kawata K, Ito F, Sato A, Matsumiya H, et al. Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression. J Pathol. 2017;243:342-353 pubmed publisher
    ..Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  9. Daste F, Walrant A, Holst M, Gadsby J, Mason J, Lee J, et al. Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature. J Cell Biol. 2017;216:3745-3765 pubmed publisher

More Information


  1. McNally K, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, et al. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nat Cell Biol. 2017;19:1214-1225 pubmed publisher
    ..Our identification of retriever establishes a major endosomal retrieval and recycling pathway. ..
  2. Rabouille C. Retriever fetches integrins from endosomes. Nat Cell Biol. 2017;19:1144-1146 pubmed publisher
    ..Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of ?5?1 integrins. ..