adaptor protein complex subunits


Summary: The subunits that make up the large, medium and small chains of adaptor proteins.

Top Publications

  1. Heldwein E, Macia E, Wang J, Yin H, Kirchhausen T, Harrison S. Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A. 2004;101:14108-13 pubmed
    ..We show that directed mutations of residues at a particular corner of the gamma chain prevent recruitment to the TGN in cells and diminish PI-4-P-dependent, but not Arf1-dependent, liposome binding in vitro. ..
  2. Nevin W, Dacks J. Repeated secondary loss of adaptin complex genes in the Apicomplexa. Parasitol Int. 2009;58:86-94 pubmed publisher
  3. Inagaki F, Yuzawa S. [Structural biology of signal transduction mediated by Grb2]. Seikagaku. 2002;74:1229-36 pubmed
  4. FOLSCH H. The building blocks for basolateral vesicles in polarized epithelial cells. Trends Cell Biol. 2005;15:222-8 pubmed
  5. Conboy L, Murphy K, Regan C. Amyloid precursor protein expression in the rat hippocampal dentate gyrus modulates during memory consolidation. J Neurochem. 2005;95:1677-88 pubmed
  6. Starr D, Fischer J. KASH 'n Karry: the KASH domain family of cargo-specific cytoskeletal adaptor proteins. Bioessays. 2005;27:1136-46 pubmed
  7. Dobenecker M, Schmedt C, Okada M, Tarakhovsky A. The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function. Mol Cell Biol. 2005;25:10533-42 pubmed
    ..Our results indicate that Cbp is dispensable for the recruitment of Csk to the membrane and that another Csk adaptor, yet to be discovered, compensates for the loss of Cbp. ..
  8. Deinhardt K, Berninghausen O, Willison H, Hopkins C, Schiavo G. Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J Cell Biol. 2006;174:459-71 pubmed
  9. Nakatsu F, Ohno H. Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. Cell Struct Funct. 2003;28:419-29 pubmed
    ..The application of a variety of methodologies have gradually revealed the physiological role of AP complexes. ..

More Information


  1. Ma Y, Takeuchi M, Sugiura R, Sio S, Kuno T. Deletion mutants of AP-1 adaptin subunits display distinct phenotypes in fission yeast. Genes Cells. 2009;14:1015-28 pubmed publisher
    ..Altogether, results suggest that the four subunits are all essential for the heterotetrameric complex formation and for the AP-1 function in exit transport from endosomes. ..
  2. Paolini L, Radeghieri A, Civini S, Caimi L, Ricotta D. The epsilon hinge-ear region regulates membrane localization of the AP-4 complex. Traffic. 2011;12:1604-19 pubmed publisher
    ..We conclude that the terminal hinge region and the appendage of the AP-4 epsilon subunit are involved in membrane association in a process that is controlled by phosphorylation and dephosphorylation events. ..
  3. Niu Y, Wang M, Liang S, Zhou F, Miao Y. Expression and localization of silkworm adaptor protein complex-1 subunits, which were down-regulated post baculovirus infection. Mol Biol Rep. 2012;39:10775-83 pubmed publisher
    ..GFP-tagged fusion proteins indicated that AP-1 located in the peripheral plasma area. Furthermore, the BmNPV infection in B. mori cells had differentiated effect on the expression level of AP-1 subunits. ..
  4. Radhakrishnan K, Baltes J, Creemers J, Schu P. Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit ?1A. J Cell Sci. 2013;126:1155-63 pubmed publisher
    ..PREPL is highly expressed in brain and at lower levels in muscle and kidney. Its deficiency causes hypotonia and growth hormone hyposecretion, supporting essential PREPL functions in AP-1-dependent secretory pathways. ..
  5. Wang K, Patel C, Wang J, Wang J, Wang X, Luo P, et al. Yeast surface display of antibodies via the heterodimeric interaction of two coiled-coil adapters. J Immunol Methods. 2010;354:11-9 pubmed publisher
    ..When the adapter-directed phage and yeast display modules are combined, it is possible to expand the adapter-directed display to a novel cross-species display that can shuttle between phage and yeast systems. ..
  6. Rivero M, Kulakova L, Touz M. Long double-stranded RNA produces specific gene downregulation in Giardia lamblia. J Parasitol. 2010;96:815-9 pubmed publisher
    ..Our results suggest that the ability of dsRNA antisense to inhibit the expression of these specific types of proteins is indicative of a gene-specific mechanism. ..
  7. Hirst J, Barlow L, Francisco G, Sahlender D, Seaman M, Dacks J, et al. The fifth adaptor protein complex. PLoS Biol. 2011;9:e1001170 pubmed publisher
    ..Thus, AP-5 is an evolutionarily ancient complex, which is involved in endosomal sorting, and which has links with hereditary spastic paraplegia. ..