synaptophysin

Summary

Summary: A MARVEL domain-containing protein found in the presynaptic vesicles of NEURONS and NEUROENDOCRINE CELLS. It is commonly used as an immunocytochemical marker for neuroendocrine differentiation.

Top Publications

  1. Lin D, Cao L, Wang Z, Li J, Washington J, Zuo Z. Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats. Behav Brain Res. 2012;228:319-27 pubmed publisher
    ..synaptic density as well as the expression of NeuN (a neuronal protein), drebrin (a dendritic spine protein), synaptophysin (a synaptic protein), activated caspase 3 and caspase-activated DNase in the hippocampus at 29 days after ..
  2. Luo J, Zhang L, Ning N, Jiang H, Yu S. Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat. Behav Brain Res. 2013;253:48-53 pubmed publisher
    ..Moreover, the expression of brain-derived neurotrophic factor (BDNF), PSD-95 and synaptophysin were decreased in the amygdala of CUMS rats. Chronic administration of neotrofin (60mg/kg, i.p...
  3. Tampellini D, Capetillo Zarate E, Dumont M, Huang Z, Yu F, Lin M, et al. Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice. J Neurosci. 2010;30:14299-304 pubmed publisher
    ..An interval of prolonged synaptic inhibition exacerbated loss of synaptophysin compared with synaptically more active brain in AD transgenic but not wild-type mice...
  4. Liu J, Chang L, Roselli F, Almeida O, Gao X, Wang X, et al. Amyloid-? induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors. J Alzheimers Dis. 2010;22:541-56 pubmed publisher
    ..In this report, we show that soluble A? downregulates the levels of two synaptic proteins, PSD-95 and synaptophysin, and that this effect can be blocked by MK-801 (NMDAR antagonist) and ifenprodil (NR2B antagonist)...
  5. Kashiwagi K, Ishii J, Sakaeda M, Arimasu Y, Shimoyamada H, Sato H, et al. Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells. Pathol Int. 2012;62:232-45 pubmed publisher
    Neural cell adhesion molecule 1 (NCAM1), synaptophysin (SYPT), and chromogranin A (CGA) are immunohistochemical markers for diagnosing lung neuroendocrine tumors (LNETs)...
  6. Sharrad D, Gai W, Brookes S. Selective coexpression of synaptic proteins, ?-synuclein, cysteine string protein-?, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum. J Comp Neurol. 2013;521:2523-37 pubmed publisher
    ..to quantify which neurons in the guinea pig ileum expressed ?-synuclein, cysteine string protein-? (CSP?), synaptophysin, synaptotagmin-1, or synaptobrevin-2 in their axons...
  7. Piret G, Perez M, Prinz C. Neurite outgrowth and synaptophysin expression of postnatal CNS neurons on GaP nanowire arrays in long-term retinal cell culture. Biomaterials. 2013;34:875-87 pubmed publisher
    ..On nanowires, neurons extended numerous long and branched neurites that expressed the synaptic vesicle marker synaptophysin. The longest nanowires (4 ?m long) allowed a greater attachment and neurite elongation and our analysis ..
  8. Gordon S, Leube R, Cousin M. Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosis. J Neurosci. 2011;31:14032-6 pubmed publisher
    The integral synaptic vesicle (SV) protein synaptophysin forms ∼10% of total SV protein content, but has no known function in SV physiology...
  9. Zhang H, Zhang X, Wang W, Xue Q, Lu H, Huang J, et al. Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats. PLoS ONE. 2012;7:e46666 pubmed publisher
    ..injection of complete Freund's adjuvant (CFA) in the spinal dorsal horns of rats by interacting with synaptophysin, a well known membrane protein mediating the endocytosis-exocytosis cycle of synaptic vesicles as a molecular ..

More Information

Publications62

  1. Kwon S, Chapman E. Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles. J Biol Chem. 2012;287:35658-68 pubmed publisher
    ..For example, the three major synaptic vesicle glycoproteins, synaptotagmin 1, synaptophysin, and SV2, represent ?30% of the total copy number of vesicle proteins...
  2. Jin I, Udo H, Hawkins R. Rapid increase in clusters of synaptophysin at onset of homosynaptic potentiation in Aplysia. Proc Natl Acad Sci U S A. 2011;108:11656-61 pubmed publisher
    ..and a rapid (under 10 min) increase in the number of clusters of the presynaptic vesicle-associated protein synaptophysin. These results indicate that rapid recruitment of synaptic components is not limited to hippocampal ..
  3. He S, Yang J. Maturation of neurotransmission in the developing rat cochlea: immunohistochemical evidence from differential expression of synaptophysin and synaptobrevin 2. Eur J Histochem. 2011;55:e2 pubmed publisher
    b>Synaptophysin and synaptobrevin 2 associate closely with packaging and storage of synaptic vesicles and transmitter release, and both play important roles in the development of rat cochlea...
  4. Ojo B, Rezaie P, Gabbott P, Davies H, Colyer F, Cowley T, et al. Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL. Brain Behav Immun. 2012;26:778-88 pubmed publisher
    ..evidence suggests that there is a concomitant age-related decrease in expression of the presynaptic protein, synaptophysin, and the neuronal glycoprotein CD200, which, by interacting with its receptor, plays a role in maintaining ..
  5. Briones A, Gagno S, Martisova E, Dobarro M, Aisa B, Solas M, et al. Stress-induced anhedonia is associated with an increase in Alzheimer's disease-related markers. Br J Pharmacol. 2012;165:897-907 pubmed publisher
    ..Biochemical markers affected by stress, PKB, ERK and synaptophysin, and those associated with AD, amyloid ?-protein (A?), ?-secretase (BACE1) and ? phosphorylation, were ..
  6. Kwon S, Chapman E. Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron. 2011;70:847-54 pubmed publisher
    Despite being the most abundant synaptic vesicle membrane protein, the function of synaptophysin remains enigmatic...
  7. Gordon S, Cousin M. X-linked intellectual disability-associated mutations in synaptophysin disrupt synaptobrevin II retrieval. J Neurosci. 2013;33:13695-700 pubmed publisher
    b>Synaptophysin is an integral synaptic vesicle (SV) protein that accounts for ?10% of total SV protein cargo...
  8. Pontén E, Fredriksson A, Gordh T, Eriksson P, Viberg H. Neonatal exposure to propofol affects BDNF but not CaMKII, GAP-43, synaptophysin and tau in the neonatal brain and causes an altered behavioural response to diazepam in the adult mouse brain. Behav Brain Res. 2011;223:75-80 pubmed publisher
    ..e. BDNF, CaMKII, GAP-43, synaptophysin and tau), and adult spontaneous motor and anxiety-like behaviours in response to diazepam, after neonatal ..
  9. Seo H, Kim D, Park H, Lee S, Park S. Early motor balance and coordination training increased synaptophysin in subcortical regions of the ischemic rat brain. J Korean Med Sci. 2010;25:1638-45 pubmed publisher
    ..Both Rota-rod and treadmill training increased the expression of synaptophysin in subcortical regions of the ischemic hemisphere including the hippocampus, dentate gyrus, and thalamus, but ..
  10. Llorente R, Miguel Blanco C, Aisa B, Lachize S, Borcel E, Meijer O, et al. Long term sex-dependent psychoneuroendocrine effects of maternal deprivation and juvenile unpredictable stress in rats. J Neuroendocrinol. 2011;23:329-44 pubmed publisher
    ..The expression of hippocampal glucocorticoid (GR) and mineralocorticoid (MR) receptors, as well as of synaptophysin, neural cell adhesion molecule and brain-derived neurotrophic factor, was analysed by in situ hybridisation in ..
  11. Garringer H, Murrell J, Sammeta N, Gnezda A, Ghetti B, Vidal R. Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. PLoS ONE. 2013;8:e56426 pubmed publisher
    ..Tg-FDD-Tau mice also showed a significant decrease in synaptophysin levels, occurring before widespread deposition of fibrillar ADan and tau can be observed...
  12. Li W, Liu L, Liu Y, Luo J, Lin J, Li X, et al. Effects of electroconvulsive stimulation on long-term potentiation and synaptophysin in the hippocampus of rats with depressive behavior. J ECT. 2012;28:111-7 pubmed publisher
    To evaluate the effects of electroconvulsive stimulation (ECS) on long-term potentiation (LTP) and synaptophysin (SYP) in the hippocampus of rats under chronic unpredictable mild stress (CUMS)...
  13. Russell C, Semerdjieva S, Empson R, Austen B, Beesley P, Alifragis P. Amyloid-? acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. PLoS ONE. 2012;7:e43201 pubmed publisher
    ..results demonstrate that with time, A?42 can be detected at the presynaptic terminals where it interacts with Synaptophysin. Furthermore, data from dissociated hippocampal neurons as well as biochemical data provide evidence that A?42 ..
  14. Mallozzi C, D Amore C, Camerini S, Macchia G, Crescenzi M, Petrucci T, et al. Phosphorylation and nitration of tyrosine residues affect functional properties of Synaptophysin and Dynamin I, two proteins involved in exo-endocytosis of synaptic vesicles. Biochim Biophys Acta. 2013;1833:110-21 pubmed publisher
    ..We previously demonstrated that the tyrosine residues in the C-terminal domain of the SV protein Synaptophysin (SYP) are targets of peroxynitrite (PN)...
  15. Li J, Deng J, Sheng W, Zuo Z. Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice. Pharmacol Biochem Behav. 2012;101:564-74 pubmed publisher
    ..The db/db mice had increased A? levels. Metformin attenuated the reduction of synaptophysin, a synaptic protein, in the db/db mouse hippocampus...
  16. Nie J, Zhou M, Lu C, Hu X, Wan B, Yang B, et al. Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model. Int Immunopharmacol. 2012;13:175-80 pubmed publisher
    ..In this study, we observed the effects of triptolide on synaptophysin expression in AD cellular model...
  17. Gilabert Juan J, Castillo Gomez E, Pérez Rando M, Molto M, Nacher J. Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice. Exp Neurol. 2011;232:33-40 pubmed publisher
    ..The expression of GAD67, synaptophysin and PSA-NCAM was also studied in specific amygdaloid nuclei using immunohistochemistry...
  18. Vitry S, Ausseil J, Hocquemiller M, Bigou S, Dos Santos Coura R, Heard J. Enhanced degradation of synaptophysin by the proteasome in mucopolysaccharidosis type IIIB. Mol Cell Neurosci. 2009;41:8-18 pubmed publisher
    ..We report that synaptophysin, the most abundant protein of the synaptic vesicle membrane, was detected at low levels in the rostral cortex ..
  19. Schmitt U, Tanimoto N, Seeliger M, Schaeffel F, Leube R. Detection of behavioral alterations and learning deficits in mice lacking synaptophysin. Neuroscience. 2009;162:234-43 pubmed publisher
    The integral membrane protein synaptophysin is one of the most abundant polypeptide components of synaptic vesicles...
  20. Pereno G, Beltramino C. Timed changes of synaptic zinc, synaptophysin and MAP2 in medial extended amygdala of epileptic animals are suggestive of reactive neuroplasticity. Brain Res. 2010;1328:130-8 pubmed publisher
    ..However, in the amygdala this synaptic reorganization has been not studied. The changes in Zn density, synaptophysin and MAP(2) as markers of reactive synaptogenesis in medial extended amygdala induced by kainic acid (KA) as a ..
  21. Rademacher D, Napier T, Meredith G. Context modulates the expression of conditioned motor sensitization, cellular activation and synaptophysin immunoreactivity. Eur J Neurosci. 2007;26:2661-8 pubmed
    ..conditioned motor sensitization is accompanied by cellular activation (measured by Fos immunoreactivity) and synaptophysin immunoreactivity in reward-related brain areas...
  22. Glueckert R, Bitsche M, Miller J, Zhu Y, Prieskorn D, Altschuler R, et al. Deafferentation-associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain-derived neurotrophic factor and acidic fibroblast growth factor. J Comp Neurol. 2008;507:1602-21 pubmed publisher
    ..and efferent nerve fibers following deafness in guinea pigs using specific markers (parvalbumin for afferents, synaptophysin for efferent fibers) and the effect of brain derived neurotrophic factor (BDNF) in combination with acidic ..
  23. Sawaki M, Yokoi K, Nagasaka T, Watanabe R, Kagawa C, Takada H, et al. Prognostic importance of neuroendocrine differentiation in Japanese breast cancer patients. Surg Today. 2010;40:831-5 pubmed publisher
    ..University Hospital, for NED, defined as positive reactivity for four markers: neuron-specific enolase (NSE), synaptophysin, CD57, and chromogranin A (CGA)...
  24. González Jamett A, Báez Matus X, Hevia M, Guerra M, Olivares M, Martinez A, et al. The association of dynamin with synaptophysin regulates quantal size and duration of exocytotic events in chromaffin cells. J Neurosci. 2010;30:10683-91 pubmed publisher
    Although synaptophysin is one of the most abundant integral proteins of synaptic vesicle membranes, its contribution to neurotransmitter release remains unclear...
  25. Chindewa R, Lapanantasin S, Sanvarinda Y, Chongthammakun S. Pueraria mirifica, phytoestrogen-induced change in synaptophysin expression via estrogen receptor in rat hippocampal neuron. J Med Assoc Thai. 2008;91:208-14 pubmed
    ..To examine Pueraria mirifica (Leguminosae) containing-phytoestrogen effect on synaptic density and involvement of estrogen receptor...
  26. Ito H, Atsuzawa K, Morishita R, Usuda N, Sudo K, Iwamoto I, et al. Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. J Neurochem. 2009;108:867-80 pubmed publisher
    ..b>Synaptophysin is reported to associate with and recruit VAMP2 to synaptic vesicles and dissociate prior to forming the SNARE ..
  27. Xin H, Li Y, Shen L, Liu X, Wang X, Zhang J, et al. Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse. PLoS ONE. 2010;5:e9027 pubmed publisher
    ..zone (IBZ) compared with control PBS treated mice, concurrently with increases of myelinated axons and synaptophysin. In vitro, MSCs significantly increased tPA levels and concomitantly reduced plasminogen activator inhibitor 1 ..
  28. Gong J, Dong J, Wang Y, Xu H, Wei W, Zhong J, et al. Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate caveolin-1 and down-regulate synaptophysin in rat hippocampus. J Neuroendocrinol. 2010;22:129-39 pubmed publisher
    ..In the present study, we implicate hippocampal caveolin-1 and synaptophysin in developmental iodine deficiency and hypothyroidism...
  29. Castillo Gomez E, Gomez Climent M, Varea E, Guirado R, Blasco Ibáñez J, Crespo C, et al. Dopamine acting through D2 receptors modulates the expression of PSA-NCAM, a molecule related to neuronal structural plasticity, in the medial prefrontal cortex of adult rats. Exp Neurol. 2008;214:97-111 pubmed publisher
    ..Pharmacological manipulation of serotonin levels regulates synaptophysin and PSA-NCAM expression in the adult mPFC...
  30. Li M, Cui Z, Niu Y, Liu B, Fan W, Yu D, et al. Synaptogenesis in the developing mouse visual cortex. Brain Res Bull. 2010;81:107-13 pubmed publisher
    ..Immunostaining and DiI diolistic assay were also employed in order to evaluate synaptophysin expression and dendritic spine development...
  31. Fang S, Yan B, Wang D, Bi X, Zhang Y, He J, et al. Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice. Biochem Cell Biol. 2010;88:655-63 pubmed publisher
    ..Our preliminary data found that 5 mg.kg-1.d-1 of venlafaxine treatment prevented decreased synaptophysin (SYP) in the hippocampus, which results from chronic restrained stress in the rat model...
  32. Henriksson R, Kuzmin A, Okvist A, Harper C, Sheedy D, Garrick T, et al. Elevated synaptophysin I in the prefrontal cortex of human chronic alcoholics. Synapse. 2008;62:829-33 pubmed publisher
    ..of ethanol dependence in humans, we used semiquantitative immunoblotting to compare the immunoreactivities of synaptophysin I, syntaxin 1A, synaptosome-associated protein 25, and vesicle-associated membrane protein in the prefrontal ..
  33. Larsen M, Hay Schmidt A, Rønn L, Mikkelsen J. Temporal expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat hippocampus after treatment with selective and mixed monoaminergic antidepressants. Eur J Pharmacol. 2008;578:114-22 pubmed
    ..Here, we also determined the effects on the expression of two other genes (synaptophysin and growth-associated protein-43 (GAP-43)) known to be involved in synapse formation and axonal growth and ..
  34. Nithianantharajah J, Murphy M. Auditory specific fear conditioning results in increased levels of synaptophysin in the basolateral amygdala. Neurobiol Learn Mem. 2008;90:36-43 pubmed publisher
    ..for potential brain changes associated with this model by measuring levels of the synaptic vesicle protein, synaptophysin, in the basolateral nuclei of the amygdala following auditory fear conditioning...
  35. Tschernatsch M, Klotz M, Probst C, Hosch J, Valtorta F, Diener M, et al. Synaptophysin is an autoantigen in paraneoplastic neuropathy. J Neuroimmunol. 2008;197:81-6 pubmed publisher
    ..In indirect immunofluorescence test, the patient's serum colocalised with the synaptic protein synaptophysin in the cerebellum and myenteric plexus of the gut...
  36. Matsumoto M, Nakagawa T, Kojima K, Sakamoto T, Fujiyama F, Ito J. Potential of embryonic stem cell-derived neurons for synapse formation with auditory hair cells. J Neurosci Res. 2008;86:3075-85 pubmed publisher
    ..Immunohistochemical analyses revealed the expression of synapsin 1 and synaptophysin in the nerve endings of ESC-derived neurons adjacent to IHCs, indicating the formation of synaptic connections...
  37. Ekici M, Schmitz F, Hohl M, Seigel G, Thiel G. Chromatin structure and expression of synapsin I and synaptophysin in retinal precursor cells. Neurochem Int. 2008;53:165-72 pubmed publisher
    Synapsin I and synaptophysin are major proteins of small synaptic vesicles. In neurons the transcriptional repressor REST is a major regulator of synapsin I and synaptophysin gene transcription...
  38. Al Noori S, Sanders N, Taborsky G, Wilkinson C, Zavosh A, West C, et al. Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1446-54 pubmed publisher
    ..Finally, we observed a significant decrease in the presynaptic marker synaptophysin within the PVN of RH-treated vs...
  39. Righi L, Sapino A, Marchio C, Papotti M, Bussolati G. Neuroendocrine differentiation in breast cancer: established facts and unresolved problems. Semin Diagn Pathol. 2010;27:69-76 pubmed
    ..Chromogranin A and synaptophysin have been considered as the most sensitive and specific neuroendocrine markers in NEBC...
  40. Vlachos A, Korkotian E, Schonfeld E, Copanaki E, Deller T, Segal M. Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons. J Neurosci. 2009;29:1017-33 pubmed publisher
    ..Thus, SP plays a crucial role in the calcium store-associated ability of neurons to undergo long-term plasticity. ..
  41. Hedberg M, Clos M, Ratia M, Gonzalez D, Lithner C, Camps P, et al. Effect of huprine X on ?-amyloid, synaptophysin and ?7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice. Neurodegener Dis. 2010;7:379-88 pubmed publisher
    ..12 ?mol/kg, i.p., 21 days) or saline at 6-7 months. Human ?-amyloid (A?) was measured by ELISA, synaptophysin by Western blot and ?7 neuronal nicotinic acetylcholine receptors (nAChRs) were analyzed by [(125)I]?-..
  42. Pollonini G, Gao V, Rabe A, Palminiello S, Albertini G, Alberini C. Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. Neuroscience. 2008;156:99-106 pubmed publisher
    ..We found abnormal expression of the synaptic proteins synaptophysin, microtubule-associated protein 2 (MAP2) and cyclin-dependent kinase 5 (CDK5) and of the neurotrophin-3 (NT-3)...
  43. Mallozzi C, Ceccarini M, Camerini S, Macchia G, Crescenzi M, Petrucci T, et al. Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src. J Neurochem. 2009;111:859-69 pubmed publisher
    ..In this study we show that, following peroxynitrite treatment, the synaptic vesicle protein synaptophysin (SYP) can be both phosphorylated and nitrated in a dose-dependent manner...
  44. Law A, Pei Q, Walker M, Gordon Andrews H, Weickert C, Feldon J, et al. Early parental deprivation in the marmoset monkey produces long-term changes in hippocampal expression of genes involved in synaptic plasticity and implicated in mood disorder. Neuropsychopharmacology. 2009;34:1381-94 pubmed publisher
    ..Brain-derived neurotrophic factor (BDNF), synaptophysin, vesicular glutamate transporter 1 (VGluT1), microtubule-associated protein-2, and spinophilin transcripts ..
  45. Elfving B, Bonefeld B, Rosenberg R, Wegener G. Differential expression of synaptic vesicle proteins after repeated electroconvulsive seizures in rat frontal cortex and hippocampus. Synapse. 2008;62:662-70 pubmed publisher
    ..We suggest that these genes are highly important in the long-term therapeutic effect of ECS, and thus it can be hypothesized that the SVPs are involved in the pathophysiology of depression. ..
  46. Hescham S, Grace L, Kellaway L, Bugarith K, Russell V. Effect of exercise on synaptophysin and calcium/calmodulin-dependent protein kinase levels in prefrontal cortex and hippocampus of a rat model of developmental stress. Metab Brain Dis. 2009;24:701-9 pubmed publisher
    ..aim of the present study was to determine whether maternal separation alters expression of synaptic markers, synaptophysin and calcium/calmodulin-dependent protein kinase II (CaMKII), in rat hippocampus and prefrontal cortex...
  47. Glantz L, Gilmore J, Hamer R, Lieberman J, Jarskog L. Synaptophysin and postsynaptic density protein 95 in the human prefrontal cortex from mid-gestation into early adulthood. Neuroscience. 2007;149:582-91 pubmed
    ..was to examine synaptic density in human PFC across development by measuring two synaptic marker proteins: synaptophysin (presynaptic), and postsynaptic density protein 95 (PSD-95; postsynaptic)...
  48. Sabha M, Emirandetti A, Cullheim S, de Oliveira A. MHC I expression and synaptic plasticity in different mice strains after axotomy. Synapse. 2008;62:137-48 pubmed
    ..Our results suggest that a more prominent expression of MHC I in the first week after lesion may positively influence the regenerative outcome associated with a more effective axonal regrowth...
  49. Cui X, Chopp M, Zacharek A, Roberts C, Buller B, Ion M, et al. Niacin treatment of stroke increases synaptic plasticity and axon growth in rats. Stroke. 2010;41:2044-9 pubmed publisher
    ..The expression of synaptophysin, Nogo receptor, Bielschowsky silver, brain-derived neurotrophic factor, and its receptor tropomyosin-related ..
  50. Bartolome M, Zuluaga P, Carricondo F, Gil Loyzaga P. Immunocytochemical detection of synaptophysin in C57BL/6 mice cochlea during aging process. Brain Res Rev. 2009;60:341-8 pubmed
    ..However, little is still known about aging effects on synapses in this receptor. Synaptophysin (Syp) is a 38 kDa Ca2+ binding glycoprotein widely found in presynaptic membrane and vesicles...
  51. Ather M, Abbas F, Faruqui N, Israr M, Pervez S. Correlation of three immunohistochemically detected markers of neuroendocrine differentiation with clinical predictors of disease progression in prostate cancer. BMC Urol. 2008;8:21 pubmed publisher
    ..e. Chromogranin A (CgA), Neuron specific enolase (NSE) and Synaptophysin (Syn)...
  52. Chen J, Zacharek A, Cui X, Shehadah A, Jiang H, Roberts C, et al. Treatment of stroke with a synthetic liver X receptor agonist, TO901317, promotes synaptic plasticity and axonal regeneration in mice. J Cereb Blood Flow Metab. 2010;30:102-9 pubmed publisher
    ..Axonal damage and regeneration were evaluated by immunostaining. TO901317 significantly increased synaptophysin expression and axonal regeneration, as well as decreased the expressions of amyloid betaA4 precursor protein ..
  53. Paner G, McKenney J, Epstein J, Amin M. Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant morphologic overlap with small cell carcinoma. Am J Surg Pathol. 2008;32:1022-8 pubmed publisher
    ..All tumors showed immunohistochemical expression for desmin, myogenin, and/or MyoD1. Synaptophysin was performed in 4 cases, and 3 showed weak cytoplasmic immunoreactivity...