occludin

Summary

Summary: A MARVEL domain protein that binds to and regulates PROTEIN PHOSPHATASE 1. Occludin plays an important role in the formation and regulation of the TIGHT JUNCTION paracellular permeability barrier.

Top Publications

  1. Li D, Mrsny R. Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. J Cell Biol. 2000;148:791-800 pubmed
    b>Occludin is an integral membrane protein of the epithelial cell tight junction (TJ). Its potential role in coordinating structural and functional events of TJ formation has been suggested recently...
  2. Henkel J, Beers D, Wen S, Bowser R, Appel S. Decreased mRNA expression of tight junction proteins in lumbar spinal cords of patients with ALS. Neurology. 2009;72:1614-6 pubmed publisher
  3. Gehne N, Lamik A, Lehmann M, Haseloff R, Andjelkovic A, Blasig I. Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops. PLoS ONE. 2017;12:e0182106 pubmed publisher
    ..Cldns and occludin are heterophilically and homophilically cross-over endocytosed into neighboring cells in large, double membrane ..
  4. Chi X, Zhao X, Wang W, Niu Y, Cheng M, Liu X, et al. Fusion expression of Occludin extracellular loops and an ?-helical bundle: A new research model for tight junction. PLoS ONE. 2017;12:e0175516 pubmed publisher
    ..Human occludin (OCLN) is a major component of TJs and an essential co-receptor for hepatitis C virus (HCV) cell entry...
  5. Chou H, Chen C. Neonatal hyperoxia disrupts the intestinal barrier and impairs intestinal function in rats. Exp Mol Pathol. 2017;102:415-421 pubmed publisher
    ..of epithelial injury markers [intestinal fatty acid binding protein (I-FABP)], intestinal barrier proteins [occludin and zonula occludens (ZO)-1], and inflammation biomarkers [Toll-like receptor 4 (TLR4) and nuclear factor-?B (NF-?..
  6. Duffy H, John G, Lee S, Brosnan C, Spray D. Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. J Neurosci. 2000;20:RC114 pubmed
    ..The integral membrane proteins of gap junctions are connexins, whereas TJs are a complex between occludin and members of a recently characterized multigene family, the claudins...
  7. Shi S, Qi Z, Ma Q, Pan R, Timmins G, Zhao Y, et al. Normobaric Hyperoxia Reduces Blood Occludin Fragments in Rats and Patients With Acute Ischemic Stroke. Stroke. 2017;48:2848-2854 pubmed publisher
    ..BBB permeability was determined. Occludin and claudin-5 in blood and cerebromicrovessels were measured...
  8. Chen C, Liu X, Li Y, Liang H, Li K, Li J, et al. Effects of Acupuncture on 1-chloro-2,4-dinitrochlorobenzene-induced Allergic Contact Dermatitis in Mice. J Acupunct Meridian Stud. 2017;10:252-260 pubmed publisher
    ..Acupuncture treatment also inhibited nuclear factor-?B p65, phosphorylation of I?B?, and phosphorylation of occludin proteins expression...
  9. Mongelli Sabino B, Canuto L, Collares Buzato C. Acute and chronic exposure to high levels of glucose modulates tight junction-associated epithelial barrier function in a renal tubular cell line. Life Sci. 2017;188:149-157 pubmed publisher
    ..3 as well as a significant increase in claudin-2 (particularly at 24h-exposure) and a time-dependent change in occludin/ZO-1 junctional content...

More Information

Publications24

  1. Baradaran Ghahfarokhi M, Amouheidari A, Shahbazi Gahrouei D, Baradaran Ghahfarokhi H, Tanderup K, Dörr W, et al. Evaluation of the Effects of Prostate Radiation Therapy on Occludin Expression and Ultrasonography Characteristics of the Bladder. Int J Radiat Oncol Biol Phys. 2017;99:963-971 pubmed publisher
    To evaluate the effects of radiation dose in prostate radiation therapy (RT) on occludin expression and ultrasonography characteristics of the bladder...
  2. Bäsler K, Galliano M, Bergmann S, Rohde H, Wladykowski E, Vidal Y Sy S, et al. Biphasic influence of Staphylococcus aureus on human epidermal tight junctions. Ann N Y Acad Sci. 2017;1405:53-70 pubmed publisher
    ..This is accompanied by occludin phosphorylation and sustained localization of occludin and claudin-4 at cell membranes...
  3. Setiawan M, Tan X, Goh T, Hin Fai Yam G, Mehta J. Inhibiting glycogen synthase kinase-3 and transforming growth factor-? signaling to promote epithelial transition of human adipose mesenchymal stem cells. Biochem Biophys Res Commun. 2017;490:1381-1388 pubmed publisher
    ..up-regulation of epithelial genes (E-cadherin, Epithelial Cell Adhesion Molecule EpCAM, Zonula Occludens-1 ZO-1, occludin, deltaN p63 ?Np63, Transcription Factor 4 TCF4 and Twist Family bHLH Transcription Factor TWIST), compared to ..
  4. Elhelw D, Riad S, Shawer H, El Ekiaby N, Salah A, Zekri A, et al. Ectopic delivery of miR-200c diminishes hepatitis C virus infectivity through transcriptional and translational repression of Occludin. Arch Virol. 2017;162:3283-3291 pubmed publisher
    b>Occludin (OCLN) is an essential factor for HCV entry through interacting with other surface receptors. The aim of this study was to investigate the epigenetic regulation of Occludin expression and to study its impact on viral infectivity...
  5. Saito T, Yano M, Ohki Y, Tomura M, Nakano N. Occludin Expression in Epidermal ?? T Cells in Response to Epidermal Stress Causes Them To Migrate into Draining Lymph Nodes. J Immunol. 2017;199:62-71 pubmed publisher
    ..In this study, we found that activated ?? T cells expressed occludin and migrated into draining lymph nodes in an occludin-dependent manner...
  6. Zetterberg H. Applying fluid biomarkers to Alzheimer's disease. Am J Physiol Cell Physiol. 2017;313:C3-C10 pubmed publisher
    ..The scope of this review is fluid biomarkers for AD and related pathologies. The purpose is to provide the reader with an updated account of currently available fluid biomarkers for AD and clinically relevant differential diagnoses. ..
  7. Liu X, Wang Z, Wang P, Yu B, Liu Y, Xue Y. Green tea polyphenols alleviate early BBB damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signaling. BMC Complement Altern Med. 2013;13:187 pubmed publisher
    ..We investigated the effects of GTPs on the expression of claudin-5, occludin, and ZO-1, and the corresponding cellular mechanisms involved in the early stage of cerebral ischemia...
  8. Sharmila G, Venkateswaran G. Protective effect of bacillopeptidase CFR5 from Bacillus subtilis CFR5 on cerulein-induced pancreatitis. Biochem Biophys Res Commun. 2017;491:455-462 pubmed publisher
    ..pancreatitis mediated disruption of intestinal barrier integrity by upregulating tight junction proteins (ZO-1, occludin), antimicrobial peptides (DEFB1, CRAMP), MUC-2, TFF3 expression and by enhancing SCFA's production...
  9. Chatard M, Puech C, Perek N, Roche F. Hydralazine is a Suitable Mimetic Agent of Hypoxia to Study the Impact of Hypoxic Stress on In Vitro Blood-Brain Barrier Model. Cell Physiol Biochem. 2017;42:1592-1602 pubmed publisher
    ..Our results demonstrated that hydralazine is a better mimetic agent and more suitable than CoCl2 because it had the same effect but without the cytotoxic effect on in vitro BBB cells. ..
  10. Chen X, Kitts D. Flavonoid composition of orange peel extract ameliorates alcohol-induced tight junction dysfunction in Caco-2 monolayer. Food Chem Toxicol. 2017;105:398-406 pubmed publisher
    ..increases in Caco-2 cell paracellular permeability and the dislocation of TJ proteins, including claudin 4, occludin, and zonulin occludin-1 (ZO-1), respectively...
  11. Volksdorf T, Heilmann J, Eming S, Schawjinski K, Zorn Kruppa M, Ueck C, et al. Tight Junction Proteins Claudin-1 and Occludin Are Important for Cutaneous Wound Healing. Am J Pathol. 2017;187:1301-1312 pubmed publisher
    ..These processes are essential for normal skin wound healing. Here, we investigated the TJ proteins claudin-1 and occludin in ex vivo skin wound healing models and tissue samples of acute and chronic human wounds and observed major ..
  12. Chang X, Zhao L, Wang J, Lu X, Zhang S. Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia. BMC Complement Altern Med. 2017;17:432 pubmed publisher
    ..The expression of tight junction (TJ) proteins, occludin and claudin-1, in the duodenum was determined by Western blot and immunofluorescence...
  13. Chen Q, Chen O, Martins I, Hou H, Zhao X, Blumberg J, et al. Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions. Food Funct. 2017;8:1144-1151 pubmed publisher
    ..mL-1 LCP significantly alleviated the TNF-? induced breakdown of the tight junction protein ZO-1 and occludin and inhibited MLC phosphorylation and MLCK expression. The activation of NF?B and Elk-1 was suppressed by LCP...
  14. Clairembault T, Leclair Visonneau L, Coron E, Bourreille A, Le Dily S, Vavasseur F, et al. Structural alterations of the intestinal epithelial barrier in Parkinson's disease. Acta Neuropathol Commun. 2015;3:12 pubmed publisher
    ..The expression and localization of the two tight junctions proteins ZO-1 and occludin were analyzed by Western blot and immunofluorescence, respectively...
  15. Luo P, Wang Y, Yang Y, Yang J. Hypoxia-induced hyperpermeability of rat glomerular endothelial cells involves HIF-2? mediated changes in the expression of occludin and ZO-1. Braz J Med Biol Res. 2018;51:e6201 pubmed publisher
    ..The expression level of HIF-2? and tight junction proteins (occludin and ZO-1) in rGENCs were examined following 5% oxygen density exposure at different treatment times...