Summary: A large family of transmembrane proteins found in TIGHT JUNCTIONS. They take part in the formation of paracellular barriers and pores that regulate paracellular permeability.

Top Publications

  1. Kinugasa T, Sakaguchi T, Gu X, Reinecker H. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology. 2000;118:1001-11 pubmed
    ..Expression of claudins, extracellular signal-related (ERK) mitogen-activated protein kinases (MAPKs), and activated ERK MAPKs was ..
  2. Yu Y, Liu Z, Liu X, Yang L, Geng X, Yang G, et al. Stress-Derived Corticotropin Releasing Factor Breaches Epithelial Endotoxin Tolerance. PLoS ONE. 2013;8:e65760 pubmed publisher
    ..Psychological stress-derived CRF can breach the established endotoxin tolerance in the intestinal mucosa. ..
  3. Twomey E, Yelshanskaya M, Grassucci R, Frank J, Sobolevsky A. Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature. 2017;549:60-65 pubmed publisher
    ..Our findings provide a framework for understanding gating across the family of ionotropic glutamate receptors and the role of AMPA receptors in excitatory neurotransmission. ..
  4. Bojrab D, Zhang B, Jiang H, Zhang L, Cohen D, Luo X, et al. Expression of Oligodendrocyte Marker during Peripheral-Central Transitional Zone Formation of the Postnatal Mouse Cochlear Nerve. Otolaryngol Head Neck Surg. 2017;157:488-492 pubmed publisher
    ..Expression of oligodendrocyte marker Oligo2 was observed peripherally to the formation of PCTZ, as determined by DIC microscopy. ..
  5. Wang Y, Mumm J, Herbst R, Kolbeck R, Wang Y. IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression. J Immunol. 2017;199:3316-3325 pubmed publisher
    ..These results provide novel mechanistic insights into the role of IL-22 in the regulation and maintenance of the intestinal epithelial barrier. ..
  6. Nadarajah L, Khosravi M, Dumitriu S, Klootwijk E, Kleta R, Yaqoob M, et al. A novel claudin-16 mutation, severe bone disease, and nephrocalcinosis. Lancet. 2014;383:98 pubmed publisher
  7. Jones R, Watson K, Bruce A, Nersesian S, Kitz J, Moorehead R. Re-expression of miR-200c suppresses proliferation, colony formation and in vivo tumor growth of murine claudin-low mammary tumor cells. Oncotarget. 2017;8:23727-23749 pubmed publisher
    ..With respect to tumor growth in vivo, re-expression of miR-200c was associated with a reduction in tumor vasculature and expression of Flt1 and Vegfc. Therefore, miR-200c is an important regulator of mesenchymal tumor cell growth. ..
  8. Bongers E, Shelton L, Milatz S, Verkaart S, Bech A, Schoots J, et al. A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients with CLDN10 Mutations. J Am Soc Nephrol. 2017;28:3118-3128 pubmed publisher
    ..These data suggest that pathogenic CLDN10 mutations affect TAL paracellular ion transport and cause a novel tight junction disease characterized by a non-BS, non-GS autosomal recessive hypokalemic-alkalotic salt-losing phenotype. ..
  9. Taylor N, Vick S, Iglesia M, Brickey W, Midkiff B, McKinnon K, et al. Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer. J Clin Invest. 2017;127:3472-3483 pubmed publisher

More Information


  1. Hahn Strömberg V, Askari S, Ahmad A, Befekadu R, Nilsson T. Expression of claudin 1, claudin 4, and claudin 7 in colorectal cancer and its relation with CLDN DNA methylation patterns. Tumour Biol. 2017;39:1010428317697569 pubmed publisher
    ..Methylation analysis was carried out using bisulfite pyrosequencing. Cell membrane staining intensity of all claudins was found significantly lower in colorectal cancer tissues when compared to paired normal mucosa (p ? 0.001)...
  2. Klar J, Piontek J, Milatz S, Tariq M, Jameel M, Breiderhoff T, et al. Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. PLoS Genet. 2017;13:e1006897 pubmed publisher
    b>Claudins constitute the major component of tight junctions and regulate paracellular permeability of epithelia. Claudin-10 occurs in two major isoforms that form paracellular channels with ion selectivity...
  3. Baumholtz A, Simard A, Nikolopoulou E, Oosenbrug M, Collins M, Piontek A, et al. Claudins are essential for cell shape changes and convergent extension movements during neural tube closure. Dev Biol. 2017;428:25-38 pubmed publisher
    ..Here, we show that claudins are essential for neural tube closure: the simultaneous removal of Cldn3, -4 and -8 from tight junctions caused ..
  4. Alberini G, Benfenati F, Maragliano L. A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations. PLoS ONE. 2017;12:e0184190 pubmed publisher
    ..of claudin-15-based paracellular channels has been proposed, suggesting a putative assembly that illustrates how claudins associate in the same cell (via cis interactions) and across adjacent cells (via trans interactions)...
  5. Rosenthal R, Günzel D, Theune D, Czichos C, Schulzke J, Fromm M. Water channels and barriers formed by claudins. Ann N Y Acad Sci. 2017;1397:100-109 pubmed publisher
    ..Studies of barrier-forming claudins, like claudin-1 and claudin-3, which tighten the paracellular pathway against ions and larger solutes, indicate ..
  6. Marunaka K, Furukawa C, Fujii N, Kimura T, Furuta T, Matsunaga T, et al. The RING finger- and PDZ domain-containing protein PDZRN3 controls localization of the Mg2+ regulator claudin-16 in renal tube epithelial cells. J Biol Chem. 2017;292:13034-13044 pubmed publisher
    ..These results suggest that PDZRN3 mediates endocytosis of dephosphorylated CLDN16 and represents an important component of the CLDN16-trafficking machinery in the kidney. ..
  7. Anandappa G, Chau I. Emerging Novel Therapeutic Agents in the Treatment of Patients with Gastroesophageal and Gastric Adenocarcinoma. Hematol Oncol Clin North Am. 2017;31:529-544 pubmed publisher
  8. Ashikari D, Takayama K, Obinata D, Takahashi S, Inoue S. CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration. Cancer Sci. 2017;108:1386-1393 pubmed publisher
    ..Taken together, these results indicate that CLDN8 functions as an AR downstream signal to facilitate the progression of prostate cancer. Claudin 8 may be a novel molecular target for prostate cancer therapy. ..
  9. Beggs M, Appel I, Svenningsen P, Skjødt K, Alexander R, Dimke H. Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation. Am J Physiol Renal Physiol. 2017;313:F629-F640 pubmed publisher
    ..However, no alterations in the expression of cation-permeable claudin-2, claudin-12, or claudins-15 were found in the intestine...
  10. Siemann D, Strange D, Maharaj P, Shi P, Verma S. Zika Virus Infects Human Sertoli Cells and Modulates the Integrity of the In Vitro Blood-Testis Barrier Model. J Virol. 2017;91: pubmed publisher
  11. Togami K, Yamaguchi K, Chono S, Tada H. Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosi. J Pharmacol Toxicol Methods. 2017;86:19-27 pubmed publisher
    ..NCI-H441, and Calu-3 cells, EMT markers including E-cadherin and vimentin and tight junction proteins including claudins-1, -3, and -5 were stained using immunofluorescence methods and detected using immunoblotting methods...
  12. López Juárez A, Titus H, Silbak S, Pressler J, Rizvi T, Bogard M, et al. Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior. Cell Rep. 2017;19:545-557 pubmed publisher
    ..We thus identify Notch as an Nf1 effector regulating myelin structure and behavior in a RASopathy and suggest that inhibition of Notch signaling may be a therapeutic strategy for NF1. ..
  13. Radloff J, Zakrzewski S, Pieper R, Markov A, Amasheh S. Porcine milk induces a strengthening of barrier function in porcine jejunal epithelium in vitro. Ann N Y Acad Sci. 2017;1397:110-118 pubmed publisher
    ..The functional effect might reflect a physiological protective mechanism, when offspring exclusively rely on their mother's milk and are exposed to a plethora of potentially barrier-perturbing factors. ..
  14. Twomey E, Yelshanskaya M, Grassucci R, Frank J, Sobolevsky A. Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes. Neuron. 2017;94:569-580.e5 pubmed publisher
    ..By comparing the AMPAR-GSG1L complex structures, we map conformational changes accompanying AMPAR recovery from desensitization and reveal structural bases for regulation of synaptic transmission by auxiliary subunits. ..
  15. Milatz S, Piontek J, Hempel C, Meoli L, Grohe C, Fromm A, et al. Tight junction strand formation by claudin-10 isoforms and claudin-10a/-10b chimeras. Ann N Y Acad Sci. 2017;1405:102-115 pubmed publisher
    b>Claudins are integral components of tight junctions (TJs) in epithelia and endothelia. When expressed in cell lines devoid of TJs, claudins are able to form TJ-like strands at contacts between adjacent cells...
  16. Suzuki H, Tani K, Fujiyoshi Y. Crystal structures of claudins: insights into their intermolecular interactions. Ann N Y Acad Sci. 2017;1397:25-34 pubmed publisher
    b>Claudins are four-transmembrane proteins that constitute the backbone of tight junction strands via self-polymerization in the apicolateral membranes of epithelial cells...
  17. García Hernández V, Quirós M, Nusrat A. Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation. Ann N Y Acad Sci. 2017;1397:66-79 pubmed publisher
    ..mediators influence transcriptional regulation, as well as endocytic trafficking, targeting, and retention of claudins in the TJ...
  18. Irudayanathan F, Wang N, Wang X, Nangia S. Architecture of the paracellular channels formed by claudins of the blood-brain barrier tight junctions. Ann N Y Acad Sci. 2017;1405:131-146 pubmed publisher
    ..Despite having a high degree of sequence and structural similarity, these two claudins form different types of cis-interactions...
  19. Haid S, Grethe C, Dill M, Heim M, Kaderali L, Pietschmann T. Isolate-dependent use of claudins for cell entry by hepatitis C virus. Hepatology. 2014;59:24-34 pubmed
    ..Broad CLDN tropism may facilitate viral escape from CLDN1-specific therapeutic strategies. ..
  20. Molina Jijón E, Rodríguez Muñoz R, González Ramírez R, Namorado Tónix C, Pedraza Chaverri J, Reyes J. Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats. PLoS ONE. 2017;12:e0177362 pubmed publisher
  21. Collins M, Ryan A. Manipulating claudin expression in avian embryos. Methods Mol Biol. 2011;762:195-212 pubmed publisher
    ..Here, we describe methodologies for manipulating claudin gene expression in specific target tissues during chick embryogenesis. ..
  22. Takasawa K, Takasawa A, Osanai M, Aoyama T, Ono Y, Kono T, et al. Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer. Cancer Lett. 2017;403:66-73 pubmed publisher
    ..These findings provide evidence for an oncogenic property of claudin-18 in bile duct carcinoma cells via modulation of EGFR/ERK signaling, indicating that claudin-18 is a possible therapeutic target for this malignancy. ..
  23. Watanabe Y. Functional Modulation of Tight Junction to Enhance the Permeability of Biological Products (Biologics) in Biomembranes. Yakugaku Zasshi. 2017;137:719-732 pubmed publisher
    ..We elucidated that a TJ modulator will interact with a major constituent protein, for instance claudins, in playing an essential role in the tissue-specific barrier function of the TJ...
  24. Colavito S, Zou M, Yan Q, Nguyen D, Stern D. Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway. Breast Cancer Res. 2014;16:444 pubmed publisher
    ..Our results uncover crosstalk between NFκB and GLI1 signals and suggest that targeting these pathways may be effective against the claudin-low breast cancer subtype. ..
  25. Gehne N, Lamik A, Lehmann M, Haseloff R, Andjelkovic A, Blasig I. Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops. PLoS ONE. 2017;12:e0182106 pubmed publisher
    b>Claudins (Cldns) are transmembrane tight junction (TJ) proteins that paracellularly seal endo- and epithelial barriers by their interactions within the TJs...
  26. Rozenblit M, Suárez Fariñas M, Shemer A, Khattri S, Gilleaudeau P, Sullivan Whalen M, et al. Residual genomic profile after cyclosporine treatment may offer insights into atopic dermatitis reoccurrence. J Allergy Clin Immunol. 2014;134:955-7 pubmed publisher
  27. Tanaka H, Tamura A, Suzuki K, Tsukita S. Site-specific distribution of claudin-based paracellular channels with roles in biological fluid flow and metabolism. Ann N Y Acad Sci. 2017;1405:44-52 pubmed publisher
    The claudins are a family of membrane proteins with at least 27 members in humans and mice...