tight junction proteins


Summary: Proteins that take part in the formation or structure of TIGHT JUNCTIONS.

Top Publications

  1. Shimizu H, Wilkin M, Woodcock S, Bonfini A, Hung Y, Mazaleyrat S, et al. The Drosophila ZO-1 protein Polychaetoid suppresses Deltex-regulated Notch activity to modulate germline stem cell niche formation. Open Biol. 2017;7: pubmed publisher
    ..Thus, together, our results suggest an alternative means by which external cues can tune Notch signalling through Pyd regulation of Dx-induced Notch trafficking. ..
  2. Radloff J, Zakrzewski S, Pieper R, Markov A, Amasheh S. Porcine milk induces a strengthening of barrier function in porcine jejunal epithelium in vitro. Ann N Y Acad Sci. 2017;1397:110-118 pubmed publisher
    ..a variety of components that have been shown to affect the expression and localization of epithelial tight junction proteins and therefore the intestinal barrier...
  3. Fehrholz M, Seidenspinner S, Kunzmann S. Expression of surfactant protein B is dependent on cell density in H441 lung epithelial cells. PLoS ONE. 2017;12:e0184556 pubmed publisher
    ..The expression of SP-B, SP-B transcription factors, and tight junction proteins were determined by qPCR and immunoblotting...
  4. Xu H, Xiong J, Xu J, Li S, Zhou Y, Chen D, et al. Mosapride Stabilizes Intestinal Microbiota to Reduce Bacterial Translocation and Endotoxemia in CCl4-Induced Cirrhotic Rats. Dig Dis Sci. 2017;62:2801-2811 pubmed publisher
    ..Fecal DNA fingerprints were obtained by ERIC-PCR. The expressions of tight junction proteins were evaluated by western blotting...
  5. Sauer R, Kirchner J, Yang S, Hu L, Leinders M, Sommer C, et al. Blood-spinal cord barrier breakdown and pericyte deficiency in peripheral neuropathy. Ann N Y Acad Sci. 2017;1405:71-88 pubmed publisher
    ..Messenger RNA (mRNA) expression of tight junction proteins (TJPs) occludin, claudin-1, claudin-5, claudin-19, tricellulin, and ZO-1 significantly declines 7-14 days ..
  6. Ying Q, Wu G. Molecular mechanisms involved in podocyte EMT and concomitant diabetic kidney diseases: an update. Ren Fail. 2017;39:474-483 pubmed publisher
    ..Therefore, the purpose of this paper is to update the research progress of these underlying signaling pathways and expound the podocyte EMT-related DKDs. ..
  7. Isidro R, Lopez A, Cruz M, Gonzalez Torres M, Chompré G, Isidro A, et al. The Probiotic VSL#3 Modulates Colonic Macrophages, Inflammation, and Microflora in Acute Trinitrobenzene Sulfonic Acid Colitis. J Histochem Cytochem. 2017;65:445-461 pubmed publisher
    ..In summary, the probiotic VSL#3 reduces colitis severity, colonic macrophage infiltration, and serum cytokine levels, but does not dampen the pro-inflammatory phenotype of M1 macrophages. ..
  8. Mazzoni J, Smith J, Shahriar S, Cutforth T, Ceja B, Agalliu D. The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels. Neuron. 2017;96:1055-1069.e6 pubmed publisher
    ..Apcdd1 thus serves to precisely modulate Wnt/Norrin signaling activity in the retinal endothelium and coordinate the timing of both vascular pruning and barrier maturation. ..
  9. Loughner C, Tiwari A, Kenchegowda D, Swamynathan S, Swamynathan S. Spatiotemporally Controlled Ablation of Klf5 Results in Dysregulated Epithelial Homeostasis in Adult Mouse Corneas. Invest Ophthalmol Vis Sci. 2017;58:4683-4693 pubmed publisher
    ..controls in Klf5Δ/ΔCE corneas, which displayed increased fluorescein uptake, downregulation of tight junction proteins Tjp1 and Gkn1, desmosomal Dsg1a, and basement membrane Lama3 and Lamb1, suggesting defective permeability ..

More Information


  1. Takano K, Kakuki T, Kaneko Y, Kohno T, Kikuchi S, Himi T, et al. Histone deacetylase inhibition prevents cell death induced by loss of tricellular tight junction proteins in temperature-sensitive mouse cochlear cells. PLoS ONE. 2017;12:e0182291 pubmed publisher
    ..Collectively, these findings suggest that both tTJ proteins TRIC and LSR have crucial roles for the differentiated cochlear cell survival, and that HDAC inhibitors may be potential therapeutic agents to prevent hearing loss. ..
  2. Lee K, Nam M, Lee H, Hong C, Lee K. Protective effects of chebulic acid on alveolar epithelial damage induced by urban particulate matter. BMC Complement Altern Med. 2017;17:373 pubmed publisher
    ..These data showed that CA resulted in decreased UPM-induced ROS formation, and the protected the integrity of the tight junctions against UPM exposure to PAE barrier. ..
  3. Dang T, Yoon N, Chasiotis H, Dunford E, Feng Q, He P, et al. Transendothelial movement of adiponectin is restricted by glucocorticoids. J Endocrinol. 2017;234:101-114 pubmed publisher
  4. Sheng Z, Gao N, Wang Z, Cui X, Zhou D, Fan D, et al. Sertoli Cells Are Susceptible to ZIKV Infection in Mouse Testis. Front Cell Infect Microbiol. 2017;7:272 pubmed publisher
    ..These results also imply that long-term impact of ZIKV infection on human male reproductive system requires close monitoring. ..
  5. Cording J, Arslan B, Staat C, Dithmer S, Krug S, Krüger A, et al. Trictide, a tricellulin-derived peptide to overcome cellular barriers. Ann N Y Acad Sci. 2017;1405:89-101 pubmed publisher
    ..In conclusion, trictide is a novel and promising tool for overcoming cellular barriers at bTJs and tTJs with the potential to transiently improve drug delivery. ..
  6. Vasileva E, Sluysmans S, Bochaton Piallat M, Citi S. Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions. Ann N Y Acad Sci. 2017;1405:160-176 pubmed publisher
    ..and co-immunoprecipitation assays show that PLEKHA7 and PDZD11 are significantly more associated with the tight junction proteins cingulin and ZO-1 in aortic endothelium-derived (meEC) cells but not kidney collecting duct epithelial (..
  7. Hsu Y, Hung J, Chang W, Lin Y, Pan Y, Tsai P, et al. Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1. Oncogene. 2017;36:4929-4942 pubmed publisher
  8. Falero Perez J, Park S, Sorenson C, Sheibani N. PEDF expression affects retinal endothelial cell proangiogenic properties through alterations in cell adhesive mechanisms. Am J Physiol Cell Physiol. 2017;313:C405-C420 pubmed publisher
  9. Yan H, Ajuwon K. Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. PLoS ONE. 2017;12:e0179586 pubmed publisher
    The intestinal epithelial barrier, composed of epithelial cells, tight junction proteins and intestinal secretions, prevents passage of luminal substances and antigens through the paracellular space...
  10. Tan S, Shan Y, Wang Y, Lin Y, Liao S, Deng Z, et al. Exacerbation of oxygen-glucose deprivation-induced blood-brain barrier disruption: potential pathogenic role of interleukin-9 in ischemic stroke. Clin Sci (Lond). 2017;131:1499-1513 pubmed publisher
    ..In in vitro experiments using bEnd.3 cells, exogenously administered IL-9 exacerbated the loss of tight junction proteins (TJPs) in cells subjected to OGD plus reoxygenation (RO)...
  11. Stamatovic S, Johnson A, Sladojevic N, Keep R, Andjelkovic A. Endocytosis of tight junction proteins and the regulation of degradation and recycling. Ann N Y Acad Sci. 2017;1397:54-65 pubmed publisher
    ..A greater understanding of these processes may allow for the development of methods to modulate barrier permeability for drug delivery or prevent barrier dysfunction in disease states. ..