Summary: A large superfamily of cell surface membrane proteins characterized by their four transmembrane domains. They play a role in a variety of processes such as cellular adhesion and motility. They may be involved in the organization of cell surface MEMBRANE MICRODOMAINS that regulate the activation of LEUKOCYTES.

Top Publications

  1. Yaseen I, Monk P, Partridge L. Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis. Biochem Soc Trans. 2017;45:465-475 pubmed publisher
    ..In this review, we discuss the available evidence for the potential role of Tspan2 and introduce possible strategies for disease targeting. ..
  2. Reyat J, Chimen M, Noy P, Szyroka J, Rainger G, Tomlinson M. ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration. J Immunol. 2017;199:666-676 pubmed publisher
    ..as six different molecular scissors with different substrate specificities, depending on which of six TspanC8 tetraspanins it is associated with, but TspanC8s remain unstudied in leukocyte transmigration...
  3. Inoue S, Kondo S, Parichy D, Watanabe M. Tetraspanin 3c requirement for pigment cell interactions and boundary formation in zebrafish adult pigment stripes. Pigment Cell Melanoma Res. 2014;27:190-200 pubmed
    ..Our results are the first to identify roles for a tetraspanin superfamily protein in skin pigment pattern formation and suggest new mechanisms for the establishment and maintenance of zebrafish stripe boundaries. ..
  4. Bétrian S, Ysebaert L, Heider K, Delord J, Fournie J, Quillet Mary A. Idelalisib improves CD37 antibody BI 836826 cytotoxicity against chemo-resistant /relapse-initiating CLL cells: a rationale for combination treatment. Blood Cancer J. 2016;6:e496 pubmed publisher
  5. Grudowska A, Czaplinska D, Polom W, Matuszewski M, Sadej R, Składanowski A. Tetraspanin CD151 mediates communication between PC3 prostate cancer cells and osteoblasts. Acta Biochim Pol. 2017;64:135-141 pubmed publisher
    ..This suggests that CD151 participates in communication between PC3 cells and bone microenvironment and the process can be considered as a significant step of PCa progression and metastasis. ..
  6. Sutphin G, Backer G, Sheehan S, Bean S, Corban C, Liu T, et al. Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity. Aging Cell. 2017;16:672-682 pubmed publisher
    ..elegans as a comparative tool for prioritizing human candidate aging genes, confirm age-associated gene expression data as valuable source of novel longevity determinants, and prioritize select genes for mechanistic follow-up. ..
  7. Wang J, Zhou Y, Li D, Sun X, Deng Y, Zhao Q. TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells. FEBS Lett. 2017;591:2905-2918 pubmed publisher
    b>Tetraspanins are commonly believed to act as 'molecular facilitators', not directly involved in signal transduction...
  8. Saint Pol J, Billard M, Dornier E, Eschenbrenner E, Danglot L, Boucheix C, et al. New insights into the tetraspanin Tspan5 using novel monoclonal antibodies. J Biol Chem. 2017;292:9551-9566 pubmed publisher
    Tspan5 is a member of a subgroup of tetraspanins referred to as TspanC8...
  9. Furuse M, Izumi Y. Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology. Ann N Y Acad Sci. 2017;1397:17-24 pubmed publisher

More Information


  1. Ménager M. TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells. Biochem Soc Trans. 2017;45:703-708 pubmed publisher
  2. Matthews A, Szyroka J, Collier R, Noy P, Tomlinson M. Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins. Biochem Soc Trans. 2017;45:719-730 pubmed publisher
    ..However, targetting ADAM10 is likely to result in toxic side effects. The tetraspanins are a superfamily of 33 four-transmembrane proteins in mammals which interact with and regulate specific ..
  3. Zuidscherwoude M, Worah K, van der Schaaf A, Buschow S, van Spriel A. Differential expression of tetraspanin superfamily members in dendritic cell subsets. PLoS ONE. 2017;12:e0184317 pubmed publisher
    Dendritic cells (DCs), which are essential for initiating immune responses, are comprised of different subsets. Tetraspanins organize dendritic cell membranes by facilitating protein-protein interactions within the so called tetraspanin ..
  4. Hemler M. Tetraspanin proteins promote multiple cancer stages. Nat Rev Cancer. 2014;14:49-60 pubmed
    ..Many studies show that the expression of tetraspanins correlates with tumour stage, tumour type and patient outcome...
  5. Turcotte M, Allard D, Mittal D, Bareche Y, Buisseret L, José V, et al. CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy. Cancer Res. 2017;77:5652-5663 pubmed publisher
    ..In conclusion, our findings establish CD73 in mediating resistance to trastuzumab and provide new insights into how CD73 is regulated in breast cancer. Cancer Res; 77(20); 5652-63. ©2017 AACR. ..
  6. van Deventer S, Dunlock V, van Spriel A. Molecular interactions shaping the tetraspanin web. Biochem Soc Trans. 2017;45:741-750 pubmed publisher
    ..Important mediators of this organization are tetraspanin proteins. Tetraspanins interact laterally among themselves and with partner proteins to control the spatial organization of membrane ..
  7. Rao F, Cai X, Cheng F, Cheng W, Fang X, Li N, et al. Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2017;58:2623-2629 pubmed publisher
  8. Pérez Martínez C, Maravillas Montero J, Meza Herrera I, Vences Catalan F, Zlotnik A, Santos Argumedo L. Tspan33 is Expressed in Transitional and Memory B Cells, but is not Responsible for High ADAM10 Expression. Scand J Immunol. 2017;86:23-30 pubmed publisher
    b>Tetraspanins are a family of transmembrane proteins that form membrane microdomains. They play important roles in migration, adhesion and other cellular processes...
  9. Maisonial Besset A, Witkowski T, Navarro Teulon I, Berthier Vergnes O, Fois G, Zhu Y, et al. Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer. Oncotarget. 2017;8:22034-22047 pubmed publisher
    ..2 treated tumors compared to controls. Overall, we provide a proof-of-concept for the use of [111In/177Lu]DOTA-Ts29.2 that specifically target in vivo aggressive TSPAN8-positive cells in CRC. ..
  10. Berditchevski F, Odintsova E. ErbB receptors and tetraspanins: Casting the net wider. Int J Biochem Cell Biol. 2016;77:68-71 pubmed publisher
  11. de Winde C, Veenbergen S, Young K, Xu Monette Z, Wang X, Xia Y, et al. Tetraspanin CD37 protects against the development of B cell lymphoma. J Clin Invest. 2016;126:653-66 pubmed publisher