stromal interaction molecules


Summary: Membrane-associated calcium-binding proteins that are characterized by N-terminal EF HAND MOTIFS and a STERILE ALPHA MOTIF. They function as sensors of ENDOPLASMIC RETICULUM calcium levels and translocate from the ER to the plasma membrane to activate CALCIUM CHANNELS in response to intracellular calcium depletion.

Top Publications

  1. Gudlur A, Hogan P. The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel. Adv Exp Med Biol. 2017;993:39-57 pubmed publisher
  2. Bollimuntha S, Pani B, Singh B. Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function. Adv Exp Med Biol. 2017;993:535-556 pubmed publisher
    ..We thus review the role of SOCE-regulated neuronal Ca2+ signaling in selecting neurodegenerative conditions. ..