nogo proteins


Summary: Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.

Top Publications

  1. Shepherd D, Tsai S, Cappucci S, Wu J, Farrer R, Kartje G. The Subventricular Zone Response to Stroke Is Not a Therapeutic Target of Anti-Nogo-A Immunotherapy. J Neuropathol Exp Neurol. 2017;76:683-696 pubmed publisher
    ..Our results suggest that the SVZ is not a therapeutic target of anti-Nogo-A immunotherapy, and contribute to our understanding of the SVZ response to cortical stroke. ..
  2. Liu L, Zhu L, Zou Y, Liu W, Zhang X, Wei X, et al. Panax notoginseng saponins promotes stroke recovery by influencing expression of Nogo-A, NgR and p75NGF, in vitro and in vivo. Biol Pharm Bull. 2014;37:560-8 pubmed
    ..This may be the mechanism of Panax notoginseng saponins that contributes to the recovery of nerve function, which plays an important role in brain protection after cerebral infarction. ..
  3. Yan X, Huang G, Liu Q, Zheng J, Chen H, Huang Q, et al. Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice. Pharm Biol. 2017;55:1171-1176 pubmed publisher
    ..37?±?1.17?pg/mL) and IL-10 (116.80?±?6.91?pg/mL vs. 72.33?±?9.35?pg/mL) were elevated after WFA administration. This study demonstrated that WFA has a neuroprotective role by inhibition of apoptosis and inflammation after SCI in mice. ..
  4. Li L, Deng B, Li S, Liu Z, Jiang T, Xiao Z, et al. TAT-PEP, a novel blocker of PirB, enhances the recovery of cognitive function in mice after transient global cerebral ischemia. Behav Brain Res. 2017;326:322-330 pubmed publisher
    ..These studies reveal the mechanism of PirB on stroke and offer a potential therapeutic method for cerebral ischemia in humans. ..
  5. Chen K, Marsh B, Cowan M, Al Joboori Y, Gigout S, Smith C, et al. Sequential therapy of anti-Nogo-A antibody treatment and treadmill training leads to cumulative improvements after spinal cord injury in rats. Exp Neurol. 2017;292:135-144 pubmed publisher
  6. Alhusban A, Kozak A, Pillai B, Ahmed H, Sayed M, Johnson M, et al. Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension. PLoS ONE. 2017;12:e0178867 pubmed publisher
    ..Candesartan induced prorecovery signaling was mediated through eNOS. This effect was not maintained at 7 days after experimental ischemia. ..
  7. Takase H, Kurihara Y, Yokoyama T, Kawahara N, Takei K. LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice. PLoS ONE. 2017;12:e0184258 pubmed publisher
    ..Thus, our data suggest that LOTUS overexpression accelerates neuronal plasticity in the brainstem and cervical spinal cord after stroke and LOTUS administration is useful for future therapeutic strategies. ..
  8. Buffo A, Zagrebelsky M, Huber A, Skerra A, Schwab M, Strata P, et al. Application of neutralizing antibodies against NI-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured purkinje cell axons. J Neurosci. 2000;20:2275-86 pubmed
    ..Together with previous observations, this suggests that these molecules regulate axonal plasticity to maintain the proper targeting of terminal arbors within specific gray matter regions. ..
  9. Chen C, Zhang W, Lou B, Pan J, Cao Y, Zhong F, et al. [Effect of Electroacupuncture stimulation of acupoints of the Pericardium Meridian on serum NGF and Nogo-A contents and cerebral NGF and Nogo-A expression in cerebral ischemia rats]. Zhen Ci Yan Jiu. 2015;40:94-8 pubmed

More Information


  1. Fang L, Wang Y, Zheng Q, Yang T, Zhao P, Zhao H, et al. Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis. BMC Complement Altern Med. 2017;17:346 pubmed publisher
    ..BSYSC could attenuate axonal injury and promote repair of axonal damage in EAE mice in part through the down-regulation of NogoA/NgR and RhoA/ROCK signaling pathways. ..
  2. Lei H, Wang J, Dang Q, Yang F, Liu X, Zhang J, et al. Neuropsychiatric involvement in lupus is associated with the Nogo-a/NgR1 pathway. J Neuroimmunol. 2017;311:22-28 pubmed publisher
    ..Treatment with the Nogo-66 antagonist promoted myelin repair, improved cognition and memory, and downregulated pro-inflammatory factors. Our data imply the Nogo-a/NgR1 pathway is involved in NPSLE. ..
  3. Kempf A, Boda E, Kwok J, Fritz R, Grande V, Kaelin A, et al. Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. Dev Cell. 2017;43:24-34.e5 pubmed publisher
    ..We thereby identify the HSPG family members syndecan-3 and syndecan-4 as functional receptors for Nogo-A-?20. Finally, we show in explant cultures ex vivo that Nogo-A-?20 promotes the migration of neuroblasts via HSPGs but not S1PR2. ..