myelin basic protein

Summary

Summary: An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.

Top Publications

  1. Ota K, Matsui M, Milford E, Mackin G, Weiner H, Hafler D. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 1990;346:183-7 pubmed
    ..b>Myelin basic protein has been studied as a potential autoantigen in the disease because of its role as an encephalitogen in ..
  2. Boudesocque L, Forni L, Martinez A, Nuzillard J, Giraud M, Renault J. Purification of dirucotide, a synthetic 17-aminoacid peptide, by ion exchange centrifugal partition chromatography. J Chromatogr A. 2017;1513:78-83 pubmed publisher
    ..Critical impurities were efficiently eliminated and dirucotide was recovered in high yield and purity (69% and 98%, respectively) and with a productivity of 2.29g per liter of stationary phase per hour. ..
  3. Grigoletto J, Pukaß K, Gamliel A, Davidi D, Katz Brull R, Richter Landsberg C, et al. Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss. Acta Neuropathol Commun. 2017;5:37 pubmed publisher
    ..An age and disease-dependent loss of myelin basic protein (MBP) signal was detected by immunohistochemistry in striatal striosomes (patches)...
  4. Schluesener H, Wekerle H. Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations. J Immunol. 1985;135:3128-33 pubmed
  5. Biehl R, Richter D. Slow internal protein dynamics in solution. J Phys Condens Matter. 2014;26:503103 pubmed
    ..Here we focus on these large-scale domain fluctuations and show how the structure and dynamics of proteins can be assessed by small-angle neutron scattering and NSE. ..
  6. Linthicum D, Mackay I, Wilson A, Horvath L, Carnegie P. Detection of antibodies to central nervous system antigens by solid phase radioimmunoassay. J Neurosci Res. 1981;6:567-78 pubmed
    ..Serum antibodies from rabbits immunized against myelin, myelin basic protein (MBP), glial acidic fibrillary protein (GFAP), astroglioma cells, and cerebellar cells were easily detected,..
  7. LoPresti P, Szuchet S, Papasozomenos S, Zinkowski R, Binder L. Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes. Proc Natl Acad Sci U S A. 1995;92:10369-73 pubmed
    ..By showing that tau is distributed in a pattern similar to that of myelin basic protein, our results suggest a possible involvement of tau in some aspect of myelination...
  8. Zhou Y, Simpson S, Charlesworth J, van der Mei I, Lucas R, Ponsonby A, et al. Variation within MBP gene predicts disease course in multiple sclerosis. Brain Behav. 2017;7:e00670 pubmed publisher
    ..b>Myelin basic protein (MBP) is a major component of the myelin sheath of CNS neurons and may play a central role in demyelinating ..
  9. Steinman L. Myelin-specific CD8 T cells in the pathogenesis of experimental allergic encephalitis and multiple sclerosis. J Exp Med. 2001;194:F27-30 pubmed

More Information

Publications50

  1. Beniac D, Luckevich M, Czarnota G, Tompkins T, Ridsdale R, Ottensmeyer F, et al. Three-dimensional structure of myelin basic protein. I. Reconstruction via angular reconstitution of randomly oriented single particles. J Biol Chem. 1997;272:4261-8 pubmed
    b>Myelin basic protein (MBP) plays an integral role in the structure and function of the myelin sheath. In humans and cattle, an 18...
  2. Ozgen H, Kahya N, de Jonge J, Smith G, Harauz G, Hoekstra D, et al. Regulation of cell proliferation by nucleocytoplasmic dynamics of postnatal and embryonic exon-II-containing MBP isoforms. Biochim Biophys Acta. 2014;1843:517-30 pubmed
    ..protein required for formation of myelin, produced by oligodendrocytes in the central nervous system, is myelin basic protein (MBP)...
  3. Song J, Li X, Li Y, Che J, Li X, Zhao X, et al. Biodegradable and biocompatible cationic polymer delivering microRNA-221/222 promotes nerve regeneration after sciatic nerve crush. Int J Nanomedicine. 2017;12:4195-4208 pubmed publisher
    ..The upregulation of miR-221/222 in SCs promoted the expression of nerve growth factor and myelin basic protein in vitro...
  4. Chevalier D, Allen B. Purification of myelin basic protein from bovine brain. Protein Expr Purif. 2000;18:229-34 pubmed
    b>Myelin basic protein (MBP) is a commonly used substrate for in vitro determination of numerous protein kinase activities...
  5. Cochary E, Bizzozero O, Sapirstein V, Nolan C, Fischer I. Presence of the plasma membrane proteolipid (plasmolipin) in myelin. J Neurochem. 1990;55:602-10 pubmed
    ..cycles of myelin purification, similar to the enrichment of myelin proteolipid apoprotein (PLP) and myelin basic protein (MBP). In contrast, levels of Na+,K(+)-ATPase and a 70-kDa protein were decreased...
  6. Nait Oumesmar B, Decker L, Lachapelle F, Avellana Adalid V, Bachelin C, Baron van Evercooren A. Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination. Eur J Neurosci. 1999;11:4357-66 pubmed
    ..These data indicate that, in addition to the resident population of quiescent oligodendrocyte progenitors of the adult CNS, neural precursors from the adult SVZ constitute a source of oligodendrocytes for myelin repair. ..
  7. Moalem G, Leibowitz Amit R, Yoles E, Mor F, Cohen I, Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med. 1999;5:49-55 pubmed
    ..T cells specific to a central nervous system self antigen, such as myelin basic protein, can indeed induce experimental autoimmune encephalomyelitis, but such T cells may nevertheless appear in ..
  8. Falk K, Rotzschke O, Santambrogio L, Dorf M, Brosnan C, Strominger J. Induction and suppression of an autoimmune disease by oligomerized T cell epitopes: enhanced in vivo potency of encephalitogenic peptides. J Exp Med. 2000;191:717-30 pubmed
    T cell epitope peptides derived from proteolipid protein (PLP139-151) or myelin basic protein (MBP86-100) induce experimental autoimmune encephalomyelitis (EAE) in "susceptible" strains of mice (e.g., SJL/J)...
  9. Qi Y, Dawson G. Effects of hypoxia on oligodendrocyte signal transduction. J Neurochem. 1993;61:1097-104 pubmed
    ..and subjected to 6 h of hypoxia, show reversible inhibition of synthesis of alpha-hydroxy fatty acid and myelin basic protein but a dramatic induction of a 22-kDa protein, suggesting that this is a good model to study the mechanism ..
  10. Lassmann H, Schmied M, Vass K, Hickey W. Bone marrow derived elements and resident microglia in brain inflammation. Glia. 1993;7:19-24 pubmed
    ..Finally, resident microglia express the macrophage activation antigen ED1. Thus, microglia cells appear to function as effector cells in EAE lesions. ..
  11. Hunt M, Lu P, Tuszynski M. Myelination of axons emerging from neural progenitor grafts after spinal cord injury. Exp Neurol. 2017;296:69-73 pubmed publisher
    ..These findings indicate that axons emerging from early stage neural grafts into the injured spinal cord recapitulate both the small/medium size range and myelin thickness of intact spinal cord axons. ..
  12. Domingues R, Fernandes G, Leite F, Tilbery C, Thomaz R, Silva G, et al. The cerebrospinal fluid in multiple sclerosis: far beyond the bands. Einstein (Sao Paulo). 2017;15:100-104 pubmed publisher
  13. Kibler R, Fritz R, Chou F, Jen Chou C H -, Peacocke N, Brown N, et al. Immune response of Lewis rats to peptide C1 (residues 68-88) of guinea pig and rat myelin basic proteins. J Exp Med. 1977;146:1323-31 pubmed
  14. Wendling U, Walczak H, Dorr J, Jaboci C, Weller M, Krammer P, et al. Expression of TRAIL receptors in human autoreactive and foreign antigen-specific T cells. Cell Death Differ. 2000;7:637-44 pubmed
    ..Upon stimulation, levels of death-inducing TRAIL receptors decreased whereas TRAIL was up-regulated on the cell surface. In contrast to CD95, the role of TRAIL receptors in MS might not involve regulation of T cell vulnerability. ..
  15. Stepanov A, Lomakin Y, Gabibov A, Belogurov A. Peptides Against Autoimmune Neurodegeneration. Curr Med Chem. 2017;24:1761-1771 pubmed publisher
    ..In this report, we summarize recent advances in utilizing short polypeptides - mostly fragments of autoantigens - in the treatment of autoimmune neurodegeneration. ..
  16. Wrathall J, Li W, Hudson L. Myelin gene expression after experimental contusive spinal cord injury. J Neurosci. 1998;18:8780-93 pubmed
    ..with oligonucleotide probes to proteolipid protein (PLP), the major protein in central myelin; myelin basic protein (MBP), a major component of central myelin and a minor component of peripheral myelin; and protein zero (P0)..
  17. Kojima K, Wekerle H, Lassmann H, Berger T, Linington C. Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, S100 beta. J Neural Transm Suppl. 1997;49:43-51 pubmed
  18. Wauben M, van der Kraan M, Grosfeld Stulemeyer M, Joosten I. Definition of an extended MHC class II-peptide binding motif for the autoimmune disease-associated Lewis rat RT1.BL molecule. Int Immunol. 1997;9:281-90 pubmed
    ..The motif and search profiles will greatly facilitate the prediction of modulatory peptides based on autoimmune-associated T cell epitopes and the identification of target structures in experimental autoimmune diseases in Lewis rats. ..
  19. Kamradt T, Soloway P, Perkins D, Gefter M. Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein. J Immunol. 1991;147:3296-302 pubmed
    ..Our data show that PT is not a superantigen. Staphylococcal enterotoxin B, a V beta 8.2-specific superantigen, does not enhance the immune response to the encephalitogenic peptide. ..
  20. Martini R, Schachner M. Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve. J Cell Biol. 1986;103:2439-48 pubmed
    ..L1, N-CAM, and myelin-associated glycoprotein (MAG), their shared carbohydrate epitope L2/HNK-1, and the myelin basic protein (MBP) were studied by pre- and post-embedding immunoelectron microscopic labeling procedures in developing ..
  21. Berlet H, Bischoff H, Weinhardt F. Divalent metals of myelin and their differential binding by myelin basic protein of bovine central nervous system. Neurosci Lett. 1994;179:75-8 pubmed
    ..Binding of these metal ions by isolated myelin basic protein (MBP, M(r) 18,500) of bovine CNS was concurrently assessed by centrifugal equilibrium dialysis...
  22. Bauer J, Bradl M, Hickley W, Forss Petter S, Breitschopf H, Linington C, et al. T-cell apoptosis in inflammatory brain lesions: destruction of T cells does not depend on antigen recognition. Am J Pathol. 1998;153:715-24 pubmed
  23. Gonzalez Gronow M, Fiedler J, Farias Gomez C, Wang F, Ray R, Ferrell P, et al. Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains. Biochem Biophys Res Commun. 2017;490:855-860 pubmed publisher
    b>Myelin basic protein (MBP) is a key component of myelin, the specialized lipid membrane that encases the axons of all neurons. Both plasminogen (Pg) and tissue-type plasminogen activator (t-PA) bind to MBP with high affinity...
  24. Krogsgaard M, Wucherpfennig K, Cannella B, Hansen B, Svejgaard A, Pyrdol J, et al. Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex. J Exp Med. 2000;191:1395-412 pubmed
    ..antibodies from HLA-DR2-transgenic mice immunized with HLA-DR2 molecules complexed with an immunodominant myelin basic protein (MBP) peptide (residues 85-99)...
  25. Aberg F, Kozlova E. Metastasis-associated mts1 (S100A4) protein in the developing and adult central nervous system. J Comp Neurol. 2000;424:269-82 pubmed
    ..between Mts1 immunoreactivity and the development of CNS fiber tracts by combining staining for Mts1 and myelin basic protein (MBP). Mts1 immunoreactivity appeared postnatally in recently myelinated areas...
  26. Kääb G, Brandl G, Marx A, Wekerle H, Bradl M. The myelin basic protein-specific T cell repertoire in (transgenic) Lewis rat/SCID mouse chimeras: preferential V beta 8.2 T cell receptor usage depends on an intact Lewis thymic microenvironment. Eur J Immunol. 1996;26:981-8 pubmed
    In the Lewis rat, myelin basic protein (MBP)-specific, encephalitogenic T cells preferentially recognize sequence 68-88, and use the V beta 8.2 gene to encode their T cell receptors...
  27. Yang T, Zheng Q, Wang S, Fang L, Liu L, Zhao H, et al. Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice. BMC Complement Altern Med. 2017;17:240 pubmed publisher
    ..Th17 cells were counted by flow cytometric (FCM). The expressions of nerve-glial antigen (NG) 2 and myelin basic protein (MBP) were measured by immunohistochemical staining...
  28. Olivares Villagómez D, Wang Y, Lafaille J. Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med. 1998;188:1883-94 pubmed
    ..Using two transgenic mouse lines expressing identical myelin basic protein (MBP)-specific T cell receptor (TCR) genes, we have previously shown that mice bearing exclusively MBP-..
  29. Javier R, Kunishita T, Koike F, Tabira T. Semple rabies vaccine: presence of myelin basic protein and proteolipid protein and its activity in experimental allergic encephalomyelitis. J Neurol Sci. 1989;93:221-30 pubmed
    b>Myelin basic protein (MBP) as a cause of postvaccinal encephalomyelitis (PVE) due to Semple rabies vaccine (SRV) has been suggested in previous reports. No actual measurement of MBP in SRV was done...
  30. Bessonov K, Vassall K, Harauz G. Docking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP)-Insights into a noncanonical and fuzzy interaction. Proteins. 2017;85:1336-1350 pubmed publisher
    The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38-S107 (denoted as x?2-peptide, murine sequence numbering), were studied in silico via ..
  31. Itoyama Y, Sternberger N, Webster H, Quarles R, Cohen S, Richardson E. Immunocytochemical observations on the distribution of myelin-associated glycoprotein and myelin basic protein in multiple sclerosis lesions. Ann Neurol. 1980;7:167-77 pubmed
    ..In shadow plaques, BP antiserum stained some oligodendroglia. Their appearance and location among thinly myelinated axons suggested that these oligondendroglia were forming new sheaths around previously demyelinated axons. ..
  32. da Silva T, Eira J, Lopes A, Malheiro A, Sousa V, Luoma A, et al. Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination. J Clin Invest. 2014;124:2560-70 pubmed publisher
    ..In addition, these studies identify a mechanism by which the lack of a membrane phospholipid causes neuropathology, implicating plasmalogens as regulators of membrane and cell signaling. ..
  33. Smith B, Galbiati F, Castelvetri L, Givogri M, Lopez Rosas A, Bongarzone E. Peripheral neuropathy in the Twitcher mouse involves the activation of axonal caspase 3. ASN Neuro. 2011;3: pubmed publisher
    ..Analysis of the temporal-expression profile of MBP (myelin basic protein) isoforms showed unexpected increases of the 14, 17 and 18...
  34. Araque A, Navarrete M. Development. Electrically driven insulation in the central nervous system. Science. 2011;333:1587-8 pubmed publisher
  35. Adamus G, Amundson D, Vainiene M, Ariail K, Machnicki M, Weinberg A, et al. Myelin basic protein specific T-helper cells induce experimental anterior uveitis. J Neurosci Res. 1996;44:513-8 pubmed
    ..Many of those T cells were distributed in the iris and the anterior chamber. These findings indicate that these MBP-specific T cells may play a critical role in EAE as well as in AU. ..
  36. Petković F, Campbell I, Gonzalez B, Castellano B. Reduced cuprizone-induced cerebellar demyelination in mice with astrocyte-targeted production of IL-6 is associated with chronically activated, but less responsive microglia. J Neuroimmunol. 2017;310:97-102 pubmed publisher
  37. Awatramani R, Scherer S, Grinspan J, Collarini E, Skoff R, O HAGAN D, et al. Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination. J Neurosci. 1997;17:6657-68 pubmed
    ..Gtx mRNA accumulates in parallel with the RNAs encoding the major structural proteins of myelin, myelin basic protein (MBP), and proteolipid protein (PLP) during postnatal brain development; Gtx mRNA decreases in parallel ..
  38. Verhagen C, Mor F, Cohen I. T cell immunity to myelin basic protein induces anterior uveitis in Lewis rats. J Neuroimmunol. 1994;53:65-71 pubmed
    ..We now report that anterior uveitis (AU) can be produced by T cell immunity to myelin basic protein (BP) and accompanies experimental autoimmune encephalomyelitis (EAE)...
  39. Tabira T, Itoyama Y, Kuroiwa Y. The role of locally retained antigens in chronic relapsing experimental allergic encephalomyelitis in guinea pigs. Prog Clin Biol Res. 1984;146:43-8 pubmed
  40. Martin R, McFarland H, McFarlin D. Immunological aspects of demyelinating diseases. Annu Rev Immunol. 1992;10:153-87 pubmed
    ..The results of these studies are reviewed and the potential implications of these findings for the pathogenesis and future therapy of MS are examined. ..
  41. Myers K, Sprent J, Dougherty J, Ron Y. Synergy between encephalitogenic T cells and myelin basic protein-specific antibodies in the induction of experimental autoimmune encephalomyelitis. J Neuroimmunol. 1992;41:1-8 pubmed
    ..induced demyelinating disease mediated by CD4+ T cells specific for various myelin proteins including myelin basic protein (MBP) and myelin proteolipid protein (PLP)...