vesicle associated membrane protein 3


Summary: A member of the vesicle associated membrane protein family. It has a broad tissue distribution and is involved in MEMBRANE FUSION events of the endocytic pathways.

Top Publications

  1. D SOUZA SCHOREY C, van Donselaar E, Hsu V, Yang C, Stahl P, Peters P. ARF6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigation. J Cell Biol. 1998;140:603-16 pubmed
    ..Taken together, our findings suggest that ARF activation is required for the targeted delivery of ARF6-positive, recycling endosomal vesicles to the plasma membrane. ..
  2. Feldmann A, Winterstein C, White R, Trotter J, Krämer Albers E. Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes. J Neurosci Res. 2009;87:1760-72 pubmed publisher
  3. Mazzolini J, Herit F, Bouchet J, Benmerah A, Benichou S, Niedergang F. Inhibition of phagocytosis in HIV-1-infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments. Blood. 2010;115:4226-36 pubmed publisher
    ..We conclude that HIV-1 impairs optimal phagosome formation through Nef-dependent perturbation of the endosomal remodeling relying on AP1. We therefore identified a mechanism of macrophage function down-regulation in infected cells. ..
  4. Sasai M, Linehan M, Iwasaki A. Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science. 2010;329:1530-4 pubmed publisher
    ..Our results reveal an intracellular mechanism for bifurcation of TLR9 signals by selective receptor trafficking within the endosomal system...
  5. Okayama M, Arakawa T, Tanimura A, Mizoguchi I, Tajima Y, Takuma T. Role of VAMP8/endobrevin in constitutive exocytotic pathway in HeLa cells. Cell Struct Funct. 2009;34:115-25 pubmed
    ..These results suggest that VAMP8 is not essential for constitutive exocytosis, although it can be involved in the exocytosis. ..
  6. Zhao P, Yang L, Lopez J, Fan J, Burchfield J, Bai L, et al. Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes. J Cell Sci. 2009;122:3472-80 pubmed publisher
    ..These data indicate a plasticity in the requirement for v-SNAREs in GLUT4 trafficking to the plasma membrane and further define an important role for the v-SNARE proteins in pre-fusion docking of vesicles. ..
  7. Fader C, Sánchez D, Mestre M, Colombo M. TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochim Biophys Acta. 2009;1793:1901-16 pubmed publisher
    ..Furthermore, VAMP7 and ATPase NSF, a protein required for SNAREs disassembly, participate in the fusion between MVBs with the plasma membrane to release the internal vesicles (i.e., exosomes) into the extracellular medium. ..
  8. Kean M, Williams K, Skalski M, Myers D, Burtnik A, Foster D, et al. VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. J Cell Sci. 2009;122:4089-98 pubmed publisher
    ..The results reveal the importance of VAMP3, syntaxin-13 and SNAP23 in the trafficking of MMP during degradation of ECM substrates and subsequent cellular invasion. ..
  9. Hager H, Roberts R, Cross E, Proux Gillardeaux V, Bader D. Identification of a novel Bves function: regulation of vesicular transport. EMBO J. 2010;29:532-45 pubmed publisher
    ..Thus, this study establishes a newly identified role for Bves in vesicular transport and reveals a novel, broadly applied mechanism governing SNARE protein function...

More Information


  1. Buratti E, De Conti L, Stuani C, Romano M, Baralle M, Baralle F. Nuclear factor TDP-43 can affect selected microRNA levels. FEBS J. 2010;277:2268-81 pubmed publisher
    ..Using microarray data and real-time PCR we have also identified several candidate transcripts whose expression levels are selectively affected by these TDP-43-miRNA interactions. ..
  2. McMahon H, Sudhof T. Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site. J Biol Chem. 1995;270:2213-7 pubmed
    ..Thus, alpha-SNAP probably functions in a late step of the membrane fusion reaction after the formation of the synaptobrevin-syntaxin-SNAP25 core complex. ..
  3. Rose A, Jeppesen J, Kiens B, Richter E. Effects of contraction on localization of GLUT4 and v-SNARE isoforms in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1228-37 pubmed publisher
    ..These findings suggest that VAMP2, VAMP5, and VAMP7 may be involved in translocation of GLUT4 during muscle contractions. ..