qb snare proteins

Summary

Summary: A subfamily of Q-SNARE PROTEINS which occupy the same position in the SNARE complex as the N-terminal SNARE domain of SNAP-25 and which also are most similar to the N-terminal region of SNAP-25 in their AMINO ACID SEQUENCE.

Top Publications

  1. Hashiguchi Y, Niihama M, Takahashi T, Saito C, Nakano A, Tasaka M, et al. Loss-of-function mutations of retromer large subunit genes suppress the phenotype of an Arabidopsis zig mutant that lacks Qb-SNARE VTI11. Plant Cell. 2010;22:159-72 pubmed publisher
    ..The data suggest the existence of functionally specialized paralogous VPS35 genes that nevertheless share common functions. ..
  2. Kato N, Fujikawa Y, Fuselier T, Adamou Dodo R, Nishitani A, Sato M. Luminescence detection of SNARE-SNARE interaction in Arabidopsis protoplasts. Plant Mol Biol. 2010;72:433-44 pubmed publisher
    ..In general, this article demonstrated the method that can generate new biological insight of the SNARE protein interactions in plant cells. ..
  3. Zouhar J, Rojo E, Bassham D. AtVPS45 is a positive regulator of the SYP41/SYP61/VTI12 SNARE complex involved in trafficking of vacuolar cargo. Plant Physiol. 2009;149:1668-78 pubmed publisher
    ..We propose that AtVPS45 is essential for recycling of the vacuolar sorting receptors back to the TGN and that blocking this step underlies the defects in vacuolar cargo trafficking observed in the silenced lines. ..
  4. Perry R, Mast F, Rachubinski R. Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis. Eukaryot Cell. 2009;8:830-43 pubmed publisher
  5. Zhang J, Fu Y, Zhao Y, Li F, Qian A, Wu B, et al. [Genetic analysis of genitourinary malformations]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:134-8 pubmed publisher
    ..Neither of the mutations was found in the normal controls. The results suggested that mutation(s) of gene(s) from chromosomal region 22q11.2 may play an important role in the genesis of genitourinary malformations. ..
  6. Chen S, Barbieri J. Engineering botulinum neurotoxin to extend therapeutic intervention. Proc Natl Acad Sci U S A. 2009;106:9180-4 pubmed publisher
    ..These studies show the feasibility of genetically modifying LCs to target a nonneuronal SNARE protein that extends therapeutic potential for treatment of human hypersecretion diseases. ..
  7. Jägerström S, Polesie S, Wickström Y, Johansson B, Schroder H, Højlund K, et al. Lipid droplets interact with mitochondria using SNAP23. Cell Biol Int. 2009;33:934-40 pubmed publisher
    ..Finally, ablation of SNAP23 using siRNA reduced complex formation and beta oxidation, which suggests that the LD-mitochondria complex is functional in the cell. ..
  8. Meyer D, Pajonk S, Micali C, O Connell R, Schulze Lefert P. Extracellular transport and integration of plant secretory proteins into pathogen-induced cell wall compartments. Plant J. 2009;57:986-99 pubmed publisher
  9. Greaves J, Gorleku O, Salaun C, Chamberlain L. Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases. J Biol Chem. 2010;285:24629-38 pubmed publisher
    ..Finally, we demonstrate that overexpression of specific Golgi-localized DHHC proteins active against SNAP25/23 proteins perturbs the normal secretion of human growth hormone from PC12 cells. ..

More Information

Publications22

  1. Kawaguchi T, Tamori Y, Kanda H, Yoshikawa M, Tateya S, Nishino N, et al. The t-SNAREs syntaxin4 and SNAP23 but not v-SNARE VAMP2 are indispensable to tether GLUT4 vesicles at the plasma membrane in adipocyte. Biochem Biophys Res Commun. 2010;391:1336-41 pubmed publisher
  2. Boström P, Andersson L, Li L, Perkins R, Højlund K, Boren J, et al. The assembly of lipid droplets and its relation to cellular insulin sensitivity. Biochem Soc Trans. 2009;37:981-5 pubmed publisher
    ..Thus both SNAP-23 and syntaxin-5 are highly involved in the development of insulin resistance. ..
  3. Feldmann A, Winterstein C, White R, Trotter J, Krämer Albers E. Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes. J Neurosci Res. 2009;87:1760-72 pubmed publisher
  4. Rao S, Huynh C, Proux Gillardeaux V, Galli T, Andrews N. Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis. J Biol Chem. 2004;279:20471-9 pubmed
  5. Shirakawa M, Ueda H, Shimada T, Nishiyama C, Hara Nishimura I. Vacuolar SNAREs function in the formation of the leaf vascular network by regulating auxin distribution. Plant Cell Physiol. 2009;50:1319-28 pubmed publisher
    ..Our findings demonstrate that the PVC-vacuole pathway is required for the formation of auxin maxima, which regulates the polar localization of PIN1, which, in turn, is required for the formation of the leaf vascular network. ..
  6. Siddiqi S, Mani A, Siddiqi S. The identification of the SNARE complex required for the fusion of VLDL-transport vesicle with hepatic cis-Golgi. Biochem J. 2010;429:391-401 pubmed publisher
    ..Antibodies against each SNARE component significantly inhibited VTV-Golgi fusion. We conclude that the SNARE complex required for VTV-Golgi fusion is composed of Sec22b, syntaxin 5, rBet1 and GOS28. ..
  7. Dressel R, Elsner L, Novota P, Kanwar N, Fischer von Mollard G. The exocytosis of lytic granules is impaired in Vti1b- or Vamp8-deficient CTL leading to a reduced cytotoxic activity following antigen-specific activation. J Immunol. 2010;185:1005-14 pubmed publisher
    ..However, a deficiency can apparently be compensated and affects only transiently the cytotoxic activity of CTL during their development to armed effector cells. ..
  8. Bao Y, Liu Y, Xu D, Huang J, Wang Z, Wang J, et al. [Preparation, characterization and application of rice Qb-SNARE protein OsNPSN11 polyclonal antibody]. Yi Chuan. 2010;32:961-5 pubmed
    ..This indicated that the antibody can be used for expres-sion analysis in transgenic rice. ..
  9. Kean M, Williams K, Skalski M, Myers D, Burtnik A, Foster D, et al. VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. J Cell Sci. 2009;122:4089-98 pubmed publisher
    ..The results reveal the importance of VAMP3, syntaxin-13 and SNAP23 in the trafficking of MMP during degradation of ECM substrates and subsequent cellular invasion. ..
  10. Nishimoto Morita K, Shin H, Mitsuhashi H, Kitamura M, Zhang Q, Johannes L, et al. Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes. J Biol Chem. 2009;284:10583-92 pubmed publisher
    ..Furthermore, we have obtained evidence suggesting that a SNARE complex containing Vti1a, syntaxin 6, and syntaxin 16 is involved in Shiga toxin transport downstream of ARL1. ..
  11. Schardt A, Brinkmann B, Mitkovski M, Sereda M, Werner H, Nave K. The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia. J Neurosci Res. 2009;87:3465-79 pubmed publisher
    ..We suggest that Rab3A may regulate SNAP-29-mediated membrane fusion during myelination. ..
  12. Furuta N, Fujita N, Noda T, Yoshimori T, Amano A. Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Mol Biol Cell. 2010;21:1001-10 pubmed publisher
    ..These findings strongly suggest that the combinational SNARE proteins VAMP8 and Vti1b mediate the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential event for autophagic degradation. ..
  13. Suh Y, Terashima A, Petralia R, Wenthold R, Isaac J, Roche K, et al. A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking. Nat Neurosci. 2010;13:338-43 pubmed publisher
    ..SNAP-23 is therefore important for the functional regulation of postsynaptic glutamate receptors. ..