epithelial sodium channels


Summary: Sodium channels found on salt-reabsorbing EPITHELIAL CELLS that line the distal NEPHRON; the distal COLON; SALIVARY DUCTS; SWEAT GLANDS; and the LUNG. They are AMILORIDE-sensitive and play a critical role in the control of sodium balance, BLOOD VOLUME, and BLOOD PRESSURE.

Top Publications

  1. Rosenbaek J, Al Therwani S, Jensen J, Mose F, Wandall Frostholm C, Pedersen E, et al. Effect of sodium nitrite on renal function and sodium and water excretion and brachial and central blood pressure in healthy subjects: a dose-response study. Am J Physiol Renal Physiol. 2017;313:F378-F387 pubmed publisher
    ..The lack of increase in cGMP accompanying the increase in [Formula: see text] suggests a direct effect of nitrite or nitrate on the renal tubules and vascular bed with little or no systemic conversion to NO. ..
  2. Ekinci Z, Aytac M, Cheong H. A case of SCNN1A splicing mutation presenting as mild systemic pseudohypoaldosteronism type 1. J Pediatr Endocrinol Metab. 2013;26:1197-200 pubmed publisher
    ..In conclusion, the mutation in the patient is located at the splicing site and is definitely a new and pathogenic one, and the phenotype of the patient was milder as observed in a patient with missense mutation. ..
  3. Qi D, He J, Wang D, Deng W, Zhao Y, Ye Y, et al. 17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro. Respir Res. 2014;15:159 pubmed publisher
    ..These effects were mediated, at least partially, via activation of the PI3K/Akt/SGK1 signaling pathway. ..
  4. Fedan J, Thompson J, Meighan T, Zeidler Erdely P, Antonini J. Altered ion transport in normal human bronchial epithelial cells following exposure to chemically distinct metal welding fume particles. Toxicol Appl Pharmacol. 2017;326:1-6 pubmed publisher
    ..Enhanced Na+ absorption and decreased airway surface liquid could compromise defenses against infection. ..
  5. Zhao Y, Cheng L, Song Z, Deng X, He J, Deng W, et al. [Role of interleukin-17 in alveolar fluid clearance in mice with acute lung injury]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;37:494-498 pubmed
    ..Knocking out IL-17 in mice not only alleviates inflammation of the lung tissue following ALI but also reduces the loss of ENaC protein and promotes alveolar fluid clearance, mechanism of which is probably associated with LKB1. ..
  6. Salih M, Gautschi I, van Bemmelen M, Di Benedetto M, Brooks A, Lugtenberg D, et al. A Missense Mutation in the Extracellular Domain of αENaC Causes Liddle Syndrome. J Am Soc Nephrol. 2017;28:3291-3299 pubmed publisher
    ..This mutation may explain other cases of patients with resistant hypertension and also provides novel insight into ENaC activation, which is relevant for kidney sodium reabsorption and salt-sensitive hypertension. ..
  7. de Bragança A, Moreau R, de Brito T, Shimizu M, Canale D, de Jesus D, et al. Ecstasy induces reactive oxygen species, kidney water absorption and rhabdomyolysis in normal rats. Effect of N-acetylcysteine and Allopurinol in oxidative stress and muscle fiber damage. PLoS ONE. 2017;12:e0179199 pubmed publisher
    ..In addition, they showed that NAC and Allo protected against OS, but only Allo decreased rhabdomyolysis and hyperthermia. ..
  8. Ueda K, Nishimoto M, Hirohama D, Ayuzawa N, Kawarazaki W, Watanabe A, et al. Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent Hypertension. Hypertension. 2017;70:111-118 pubmed publisher
  9. Qian Y, Wong C, Xu J, Chen H, Zhang Y, Kang W, et al. Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation. Cancer Res. 2017;77:1968-1982 pubmed publisher
    ..i>Cancer Res; 77(8); 1968-82. ©2017 AACR. ..

More Information


  1. Zhang C, Wang L, Su X, Zhang J, Lin D, Wang W. ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice. Am J Physiol Renal Physiol. 2017;312:F682-F688 pubmed publisher
  2. Zhou X, Packialakshmi B, Xiao Y, Nurmukhambetova S, Lees J. Progression of experimental autoimmune encephalomyelitis is associated with up-regulation of major sodium transporters in the mouse kidney cortex under a normal salt diet. Cell Immunol. 2017;317:18-25 pubmed publisher
    ..These data suggest that EAE progression increases Na absorption by the renal cortex. ..
  3. Grimm P, Coleman R, Delpire E, Welling P. Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules. J Am Soc Nephrol. 2017;28:2597-2606 pubmed publisher
    ..Instead, a DCT-ASDN coupling process controls potassium balance in health and becomes aberrantly activated in FHHt. ..
  4. Montgomery D, Yu L, Ghazi Z, Thai T, Al Khalili O, Ma H, et al. ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins. Am J Physiol Cell Physiol. 2017;313:C42-C53 pubmed publisher
  5. Shi S, Buck T, Kinlough C, Marciszyn A, Hughey R, Chalfie M, et al. Regulation of the epithelial Na+ channel by paraoxonase-2. J Biol Chem. 2017;292:15927-15938 pubmed publisher
    ..Together, our data suggest that PON-2 regulates ENaC activity by modulating its intracellular trafficking and surface expression. ..
  6. Tarjus A, Maase M, Jeggle P, Martínez Martínez E, Fassot C, Loufrani L, et al. The endothelial ?ENaC contributes to vascular endothelial function in vivo. PLoS ONE. 2017;12:e0185319 pubmed publisher
    ..In endo-?ENaC KO mice, compensatory mechanisms occurred and steady state vascular function was not altered except for flow-mediated dilation. Our data suggest that endothelial ?ENaC contributes to vascular endothelial function in vivo. ..
  7. Palmer L, Andersen O. The two-membrane model of epithelial transport: Koefoed-Johnsen and Ussing (1958). J Gen Physiol. 2008;132:607-12 pubmed publisher
  8. Lewis B, Sultana R, Sharma R, Noël A, Langohr I, Patial S, et al. Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease. J Immunol. 2017;199:1170-1183 pubmed publisher
    ..Our data indicate that household smoking may predispose neonates with muco-obstructive lung disease to bacterial exacerbations. ..
  9. Scott D, Walker M, Sesma J, Wu B, Stuhlmiller T, Sabater J, et al. SPX-101 Is a Novel Epithelial Sodium Channel-targeted Therapeutic for Cystic Fibrosis That Restores Mucus Transport. Am J Respir Crit Care Med. 2017;196:734-744 pubmed publisher
    ..These data demonstrate that SPX-101 promotes durable reduction of ENaC membrane concentration, leading to significant improvements in mucus transport. ..
  10. Sasamoto K, Marunaka R, Niisato N, Sun H, Taruno A, Pezzotti G, et al. Analysis of Aprotinin, a Protease Inhibitor, Action on the Trafficking of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells Using a Mathematical Model. Cell Physiol Biochem. 2017;41:1865-1880 pubmed publisher
  11. Belviso S, Iuliano R, Amato R, Perrotti N, Menniti M. The human asparaginase enzyme (ASPG) inhibits growth in leukemic cells. PLoS ONE. 2017;12:e0178174 pubmed publisher
    ..Taken together our data suggest that ASPG, combining different enzymatic activities, should be considered a promising anti-cancer agent for inhibiting the growth of leukemia cells. ..
  12. Wang L, Song J, Wang S, Buggs J, Chen R, Zhang J, et al. Cross-sex transplantation alters gene expression and enhances inflammatory response in the transplanted kidneys. Am J Physiol Renal Physiol. 2017;313:F326-F338 pubmed publisher
    ..In conclusion, cross-sex-KTX alters gene expression levels and induces inflammatory responses, which might play an important role in long-term graft function. ..